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Puteri, Cut Intan Annisa
Fakultas Farmasi, Universitas Muslim Nusantara Al Washliyah, Medan, Sumatera Utara
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Analgesic Activity Study of Ethanol Extract of Plantago Major L. in Mice (Mus Musculus L.) using Writhing Test Method Puteri, Cut Intan Annisa; Simahate, Sadjnah; Ningtias, Anggitha; Fauzi, Ziza Putri Aisyia; Karo-Karo, Sry Ulina; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7650

Abstract

Plantago major L. are known as weeds on plantations. Plantago major L. is effective to overcome pain because they contain secondary flavonoid metabolites that have the potential as pain relievers. The purpose of the experiment was to determine the analgesic effect of ethanol extract on Plantago major L. plant on male white mice. The experiment, phytochemical screening of ethanol and powder extracts from Plantago major L. plant, powder of simplicia characterization examination and analgesic effect using writhing test were carried out. As a pain inducer, 0.5% acetic acid is used intraperitoneally injected the lower abdomen of the mice and the amount of stretching is calculated with an interval of 5 minutes for 1 hour. The suspension of ethanol extract of Plantago major L. was given at a dose of 500, 1000 and 2000 mg / kg BW, 2% methampyron suspension as a positive control and 0.5% CMC suspension as a negative control. Pharmacological test results based on ANOVA test found that the amount of stretching between treatment groups was significantly different (p <0.05). The results of the analgesic effectiveness percentage obtained that the EEPM (Ethanol Extract of Plantago Major L.) suspension dose 500, 1000 and 2000 mg / kg BW had the highest analgesic power at a dose of 2000 mg / kg BW of 85.84%, EEPM suspension group 1000 mg / kg BW of 74.96 % and in the EETDS suspension group 500 mg / kg BW 62.37%.
Co-Authors Annisa Humaira Arrosty, Muflizah Ayunda Mayyona Chairunnisa Anggi Cut Yulvizar Dikki Miswanda Dinda Sari Utami Dinda Sasmita Dini Maghfirah Gabena Indrayani Dalimunthe Haris Munandar Nasution Hartini, Putri Tri Hasibuan, Zulfiana Ramadhani Isma Oktadiana Isma Oktadiana Karo-Karo, Sry Ulina Kiki Rawitri Lubis, Minda Sari maghfirah, Suci Misrahanum Misrahanum Muhammad Agus Muljanto Muhammad Andry Mukti, Ridho Munandar, Verissa Ningtias, Anggita Ningtias, Anggitha Nomi Noviani Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Panny Chintya Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rawitri, Kiki Rena Meutia Rena Meutia Ridwanto Ridwanto Rizki, Vitri Dea Sari, Syilvi Rinda Sari, Sylvi Rinda Simahate, Sadjnah Siska Novita Sari Siti Fatimah Sultan Sri Wahyuni Uswatun Nisa Zela Oktavia Ziza Putri Aisyia Fauzi Zulmai Rani