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Risk Factor Analysis of Residential Topography and Age on Prostate Cancer Incidence Nabilah, Aisyah; Kurniati, Yuni Prastyo
Journal of Agromedicine and Medical Sciences Vol 10 No 3 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i3.52261

Abstract

Prostate cancer is malignancy that originates from the luminal and basal epithelial acinar of prostate gland. Global Cancer Statistics in 2020 stated that prostate cancer is the third most common type of cancer in the world. The incidence and mortality of prostate cancer in Indonesia ranks 10th out of 32 Asian countries. Prostate cancer is multifactorial disease influenced by genetic mutations and inflammation. Research shows risk factors include increasing age and topographical factors of residence. Literature studies from various sources related to age and topography of residence in prostate cancer are still very limited. This study aims to analyze the effect of topographic profile factors of rice fields around the residence and age on the severity of prostate cancer An Observational analytic study was conducted with a case control design. Total of 177 samples using total sampling method. Age variable parameters are less than or more than 65 years. While the topography of residence uses a cut-off point of 39%. The results of the chi-square test found a significant influence between topographic profile of rice fields around the residence with prostate cancer incidence (p = 0.028, OR = 2.155). The results also found a significant influence between age factor with prostate cancer incidence (p=0.018, OR=2.187). The incidence of prostate cancer caused by the topographic profile of residence and age amounted to 7.2%. In conclusion shows that the topographic profile of the rice field area around the residence and age have a significant influence on prostate cancer severity. Keywords: age, pollutant, prostate cancer, residence, rice field
Analysis of The Incidence of Uterine Leiomyoma Based on Body Mass Index and Neutrophil-Lymphocyte Ratio Farma, Aufa Faza Fauzan; Kurniati, Yuni Prastyo
Journal La Medihealtico Vol. 5 No. 5 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i5.1609

Abstract

Leiomyoma is the most common benign uterine tumor in the female with an incidence rate of 70-80%. The cause of these tumors is still unknown, but one of the known causes is that they grow in response to hormonal stimulation. Lymphocytic infiltration in this disease has been identified as an unusual finding. This suggests a potential role for lymphocytes in the development of such tumors. A bibliometric analysis of various sources found minimal research on the Neutrophil-Lymphocyte Ratio (NLR) in uterine leiomyoma, especially in Indonesia. This study analyzed the incidence of uterine leiomyoma based on Body Mass Index (BMI) and Neutrophil-Lymphocyte Ratio (NLR). This study used an observational analytic method with a case-control design. The sampling technique used was consecutive sampling and 129 samples were obtained in the form of 65 uterine leiomyoma case groups and 64 adenomyosis control groups. BMI variable parameters were obesity (>25kg/m2) and not obese (≤25kg/m2), while NLR was at risk (>3.53) and not at risk (≤3.53). Data analysis consisted of univariate, bivariate with a Chi-Square test, and continued with multivariate using logistic regression analysis. There was a significant relationship between BMI and uterine leiomyoma incidence (p = 0.028). There was also a significant relationship between NLR and uterine leiomyoma (p = 0.017). NLR had a 3,688-fold more association with the incidence of uterine leiomyoma than BMI. In conclusion, a relationship exists between BMI and NLR in the incidence of uterine leiomyoma. NLR can be a predictor of uterine leiomyoma, especially in women of reproductive age.
The Influence of Age Factor and Industrial Area on The Malignancy Rate of Bone Tumours Devi, Namira Aisya; Kurniati, Yuni Prastyo
Journal La Medihealtico Vol. 5 No. 5 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i5.1616

Abstract

Bone tumour is a term for a group of tumours located in the bones. World Health Organization data in 2020 stated that the incidence rate of bone sarcoma in the Americas and Europe was 0.8 per 100,000 population. Industrial development, especially in areas with high population density, has environmental impacts such as air pollution and contamination of water sources. This has been associated with an increase in the prevalence of bone tumours in children. However, studies on this matter are still limited. This study aims to analyze the effect of industrial areas and age factors on the level of bone tumour malignancy. This study used observational analytics with a case-control design. Osteosarcoma as the case variable and GCT as the control variable. The sample used was 106, consisting of 53 osteosarcoma tumours and 53 GCT tumours. Age classification is divided into 0-18 years and 319 years. Industrial area classification is divided into <2.5 km and 32.5 km. Bivariate analysis using the chi square test. Has obtained approval from the Health Research Ethics Commission (KEPK) of RSUD dr. Moewardi with Number: 1.557/VI/HREC/2024. Results found no significant effect of age factor on the level of bone tumour malignancy (p-value=0.204). Meanwhile, an insignificant effect was also found between the proximity of residence to industrial areas on the level of bone tumour malignancy (p-value=0.121). This study shows that age factor and proximity of residence to industrial areas do not affect the level of bone tumour malignancy.
Edukasi Literasi Kesehatan Reproduksi tentang Manajemen Preventif Leukorhea pada Santriwati: Reproductive Health Literacy Education about Preventive Management of Leukorrhea in Female Students Kurniati, Yuni Prastyo; Romadhon, Yusuf Alam; Futana, Ninda Pradani; Rosyita, Fadhilla Jihan; Farma, Aufa Faza Fauzan; Latifah, Lisanul
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 5 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i5.6688

Abstract

Teenager is an age group that is in a transitional period of human development. The transition period is the process of biological maturation into adults who can reproduce sexually and has the potential for all the consequences of sexual activity. Vaginal discharge is a problem that is often encountered after women experience puberty and may indicate a normal phenomenon, an infection, or other conditions. Healthy, clean-living behavior related to reproductive health in teenagers has a significant correlation with the level of knowledge and daily behavior of teenagers that affect leukorrhea. To increase the awareness of female students at the Modern Assalam Islamic Boarding School regarding clean and healthy living behavior in the field of healthy female reproduction system with support from health professionals and preventive education on leucorrhoea. This service activity was conducted with a total of 60 participants who were involved in filling out the pretest and post-test. The activity phase included initial studies through student-teacher discussions, preparation of learning materials and evaluation methods, and implementation of learning activities and evaluations. A total of 60 female students who took part in this reproductive health education activity got a preventive education knowledge, proved by comparing the pretest scores before the health education activity was carried out and the post-test after the educational activity. A significant increase was obtained with a rate of 93%. Activities related to leucorrhoea in female students show the effectiveness of significant improvement in the knowledge and enthusiasm of the participants.
The Influence of Agricultural Environment on Inflammation and Breast Cancer: A Systematic Review Abdussalam, Arrizqi Hafidh; Permatasari, Happy Kurnia; Sutrisna, EM.; Romadhon, Yusuf Alam; Kurniati, Yuni Prastyo
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5493

Abstract

Purpose: Analyzing the influence of agricultural environment on inflammation and breast cancer. Methodology: PECOS by mentioning terms in MeSH as search keywords. Inclusion criteria include: observational cohort, cross sectional or case control study design. Exclusion criteria included various forms of reviews, experimental design studies, RCTs and in animals, in-vitro studies and in-silico studies. Results: Google Scholar platform search obtained 112 articles and 177 articles from the Scopus database. After identification and screening using PRISMA-P, 6 articles were obtained. Benign and malignant breast lesions were significantly associated with exposure to environmental estrogens including polychlorinated biphenyls (PCBs) and organochlorines. There was an increase in inflammatory biomarkers, namely NF-κB, PPAR-γ, IL-12 dan TNF-α levels in breast lesions from areas with high pesticide spending. Applications: The agricultural environment is a risk factor for breast cancer mediated by inflammatory factors.
Relationship between Obesity and Location of Residence with The Incidence of Fibroadenoma Mammae Povitasari, P; Kurniati, Yuni Prastyo; Lestari, Nining; Mahmudah, Nur
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5531

Abstract

Purpose: Fibroadenoma mammae (FAM) is a common benign breast tumor predominantly affecting young women. While obesity and location of residence are thought to influence the risk of FAM, evidence remains inconclusive. The aim to analyze the relationship between obesity, location of residence, and the incidence of FAM in Central Java, Indonesia. Methodology: This observational analytical study employed a case-control design using retrospective medical record data. The study included patients with breast tumors who underwent surgery and histopathological examination. Patients were categorized into the FAM group (cases) and non-FAM group (controls). Data on body mass index (BMI) and location of residence (urban or rural) were analyzed to determine their relationship with FAM. Results: The study revealed that FAM patients had a significantly younger median age compared to non-FAM patients (30 vs. 36 years; p = 0.015). Obesity was significantly less common in FAM patients than non-FAM patients (p = 0.001), with obese individuals having a 0.2 times lower risk of developing FAM (OR = 0.2). There was no significant association between location of residence and FAM incidence (p = 1.000; OR = 1.0). Applications/Originality/Value: There is a relationship between obesity status and the incidence of FAM. Obese women have a 0.2 times lower risk of experiencing FAM than non-obese study subjects, it can be considered that obesity is a protective factor against the occurrence of FAM. There is no relationship between location of residence and the incidence of FAM.
An An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor: An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor Dilla, Natasya Salsa; Wirayudha, Yan; Kurniati, Yuni Prastyo; Soekiswati, Siti
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53711

Abstract

Indonesia ranks fourth in Southeast Asia with a 2.3% prevalence of sensorineural hearing loss, a condition that may result from various risk factors including diabetes mellitus (DM) and obesity. DM can impair cochlear vascularization, while obesity significantly affects vascular function, potentially impacting the auditory system. This study aims to analyze the relationship between type 2 DM and obesity with sensorineural hearing loss. An observational analytic study with a cross-sectional approach was conducted on 64 participants aged 18–60 years, selected via purposive sampling. Type 2 DM was diagnosed by internal medicine consultants, and obesity was assessed using waist-to-hip ratio measurements. Data analysis employed Fisher's exact test and logistic regression. The study was ethically approved by the Health Ethics Committee of RS PKU Muhammadiyah Surakarta (No. 05/KEPK/RS.PKU/X/2024). Results showed a significant correlation between type 2 DM and sensorineural hearing loss (p=0.037) and between obesity and sensorineural hearing loss (p=0.001). The odds ratio for type 2 DM was 12.031, while for obesity it was 58.059, indicating that obesity poses a substantially higher risk. In conclusion, type 2 DM and obesity are significantly associated with the occurrence of sensorineural hearing loss, suggesting that addressing these risk factors may help reduce its prevalence. Keywords: Diabetes Melitus Tipe 2, Obesitas, Gangguan Pendengaran Sensorineural, Faktor Risiko.
Peningkatan Pengetahuan tentang Pengelolaan Scabies pada Santriwati Pondok Pesantren Modern: Increased Knowledge about the Management of Scabies in Female Students of Modern Islamic Boarding School Romadhon, Yusuf Alam; Kurniati, Yuni Prastyo; Farma, Aufa Faza Fauzan; Yunandar, Rio; Tuanaya, Muhammad Rizqy Noer
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i2.5770

Abstract

Scabies is a skin disease caused by an infestation of the ectoparasite Sarcoptes scabiei var hominis, which creates tunnels that cause clinical manifestations of itching at night. Health promotion through health hygiene literacy for scabies prevention is essential in various literature. Education is the delivery of health information and an effort to increase motivation/enthusiasm, skills, and confidence in carrying out health actions related to scabies management. According to the author, this comprehensive solution, besides increasing the literacy of individual students and teachers, also increases sustainability in a more comprehensive management of scabies in the future. A total of 60 people, consisting of 56 female students and 4 ustadzah, voluntarily participated in this activity to completion. An indicator of the effectiveness of implementing this activity is improving management knowledge as measured by the participants' pre vs post-test scores. There is a significant average increase in knowledge of scabies management. If we look at the proportion of participants who experienced an increase in their knowledge of scabies management, it was found that 95 percent of the participants had an increase in their knowledge, indicating the effectiveness and sustainability of this educational program. Education that aims to increase knowledge of scabies management as a whole runs effectively and shows the sustainability of this program in the future. These results are expected to increase independence in managing scabies effectively in modern Islamic boarding schools.
Karsinoma Sel Skuamous In Situ dari Kista Epidermoid Kavum Uterus Kurniati, Yuni Prastyo
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kelainan kistik pada organ pelvis wanita seringterjadi. Paling banyak kelainan ini berasal dari ovarium, dengangambaran yang sangat bervariasi, mulai dari kista fungsional hinggasuatu malignant. Kista epidermoid biasanya berlokasi pada daerahkulit sekitar wajah dan leher, sangat jarang ditemukan pada uterus.Perubahan keganasan pada kista epidermoid sendiri, hanya sekitar2,2% dengan jenis yang tersering adalah karsinoma selskuamous.Tujuan : Melaporkan kasus yang sangat jarang tentangkarsinoma sel skuamous in situ yang tumbuh dari kista epidermoidkavum uterus. Metode : Pelaporan kasus ini menggunakan pendekatanstudi pustaka ditinjau dari bidang Patologi Anatomi. Hasil : Seorangwanita usia 74 tahun, multipara, datang dengan diagnosa klinikkistoma ovarii. Durante operasi didapatkan uterus berbentuk kistikberisi masa keratin dan cairan mukous. Pada pemeriksaanhistopatologi tampak uterus dengan kavum dilapisi epitel skuamouskompleks. Rongga kavum berisi masa keratin disertai fokuskarsinoma in situ. Pada dinding uterus terdapat atrofi endometriumdan penipisan serabut myometrium. Sedangkan komponen ovariumdan tuba falopii dalam batas normal. Kesimpulan : Kista epidermoiduteri ini merupakan komplikasi dari inflamasi kronik endoserviks yangmeluas ke endometrium dengan epitel pelapisnya mengalamiperubahan keganasan.
Neurothekeoma: Tumor Neuronal Kulit Kurniati, Yuni Prastyo
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Neurothekeoma, (Dermal Nerve Sheath Mixoma),merupakan tumor kulit yang tidak jelas histogenesisnya dan jarangterjadi. Tumor ini biasanya muncul pada ekstremitas atas, regiokepala dan leher.Neurothekeoma sering keliru secara klinis denganepidermal inclusion cysts, intradermal nevi, lipomas, pilomatrixomas,atau dermatofibroma.Tujuan: Melaporkan kasus tentang Neurothekeomayang jarang dimasukkan sebagai diagnosa banding oleh klinisisehingga sering miss diagnosed dengan tumor kulit lainnya. Metode:Pelaporan kasus ini menggunakan pendekatan studi pustaka ditinjaudari bidang Patologi Anatomi.Hasil:Perempuan, 22 tahun dengankeluhan benjolan pada punggung sebelah kiri dengan suspek softtissue tumor. Pemeriksaan makroskopik berupa jaringan berkulitukuran 3 x 1,5 x 2 cm, warna kecoklatan,kenyal. Sedangkanmikroskopik mendapatkan kelompok sel tumor membentuk strukturmultilobular dengan inti sel bulat, oval, spindle hingga stellate,pleomorfik, normokromatin, terapung dalam massa mucin,diantaranya terdapat gambaran plexiform,. Kemudin dilakukanpemeriksaan imunohistokimia dengan hasil S100 dan CK negatif.Hasilini menguatkan diagnosis bahwa sediaan pasien tersebut sesuaidengan Neurothekeoma tipe “cellular”.Kesimpulan :Benjolan padapunggung perempuan, 22 tahun dengan suspek soft tisue tumor.Berdasarkan gambaran makroskopis,mikroskopis, dan imunohistokimia,diagnosis pasien ini sesuai dengan neurothekeoma tipe“cellular”.