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All Journal Indonesian Journal of Pharmaceutical Science and Technology Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia HERBAPHARMA : Journal of Herb Farmacological BERNAS: Jurnal Pengabdian Kepada Masyarakat journal of Basic Medical Veterinary Journal of Fundamental and Applied Pharmaceutical Science Journal Physical Health Recreation (JPHR) Jurnal Farmasi Sains dan Praktis Jurnal Keolahragaan Prosiding Seminar Nasional Dies Natalis Universitas Negeri Makassar Borneo Journal of Pharmacy Mammiri: Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacology and Therapy Journal of Social Sciences and Technology for Community Service
Chaerul Fadly Mochtar
Faculty Of Sport And Health Sciences, Universitas Negeri Makassar, Makassar, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Therapeutic Potential of Eugenol for Muscle Pain Management in Athletes: A Scoping Review Mochtar, Chaerul Fadly
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72552

Abstract

Muscle pain is a prevalent affliction experienced by athletes during training and competition. Eugenol, a natural compound found in cloves, exhibits considerable promise as a therapeutic agent for myalgia through multiple mechanisms of action. Eugenol has been shown to inhibit prostaglandin E2 production and reduce cyclooxygenase-2 (COX-2) expression, a process that plays a pivotal role in inflammation and pain. Furthermore, eugenol has been observed to interact with TRPV1, HVACC, and α2-adrenergic and opioidergic receptors, contributing to its analgesic effects. In addition, studies have demonstrated that eugenol possesses significant anti-inflammatory properties, as evidenced by its ability to reduce the expression of pro-inflammatory cytokines and augment the activity of antioxidant enzymes. In a preclinical context, eugenol-active topical formulations have demonstrated encouraging results, showing promise in the development of muscle pain relief preparations for athletes, with a superior safety profile compared to conventional drugs. However, further research is necessary to optimize the dosage, formulation, and the appropriate application method. This review underscores the potential of eugenol as a safe and effective muscle pain therapy for athletes, as well as opportunities for the development of innovative topical formulations.
Marine Sponge Petrosia sp. from Maratua Island: A Potential Source of Antibiofilm Agents Against Pathogenic Biofilms Mochtar, Chaerul Fadly; Hamzah, Hasyrul; Bakti, Muhammad Tursina; Rozak, Abdul
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72915

Abstract

Microbial biofilm-associated infections, particularly those caused by Pseudomonas aeruginosa and Candida albicans, have emerged as global challenges due to resistance to conventional antimicrobials. This study investigated the antibiofilm activity of ethanol extract from the sponge Petrosia sp., collected from the waters of Maratua Island, against both pathogens. Extraction was performed using 96% ethanol maceration, followed by in vitro biofilm inhibition and eradication assays using the broth microdilution method in microtiter plates. Biofilm density was quantified through crystal violet staining and absorbance measurement (OD₅₉₅ nm). The results demonstrated that the extract inhibited both intermediate-stage (24 hours) and mature-stage (48 hours) biofilm formation, with an MBIC₅₀ of 0.125% for both microorganisms. At a concentration of 1%, the inhibition percentages reached 73.86% for P. aeruginosa and 84.70% for C. albicans. The highest mature biofilm eradication activity was observed at 1% concentration, with MBEC₅₀ values of 51.98% for P. aeruginosa and 80.53% for C. albicans, approaching the effectiveness of positive controls (nystatin 82.04% and chloramphenicol 61.72%). The extract exhibited a dose-dependent pattern, with greater efficacy against C. albicans, possibly due to differences in biofilm matrix composition. These findings confirm the potential of Petrosia sp. as a source of multitarget antibiofilm compounds, particularly for fungal infections, and underscore the significance of Indonesia’s marine biodiversity as a basis for innovative therapeutic development.
Analysis of the Relationship between Anxiety Level and Smash Accuracy of Badminton Athletes Arimbi; Andi Ainun Zulkiah Surur; Poppy Elisano Arfanda; Wahyana Mujari Wahid; HarvinaMukrim; Chaerul Fadly Mochtar Luthfi
Journal Physical Health Recreation (JPHR) Vol 5 No 2 (2025): Journal Physical Health Recreation (JPHR)
Publisher : Program Studi Pendidikan Jasmani Kesehatan dan Rekreasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55081/jphr.v5i2.3966

Abstract

This study aims to analyse the relationship between anxiety level and smash accuracy in badminton athletes. Anxiety is one of the psychological factors that can affect athlete performance, especially in sports that require concentration and accuracy such as badminton. This study uses a quantitative approach with a correlational design. Data were collected through anxiety questionnaire and smash accuracy measurement through validated skill test. The results of the analysis show that there is a significant relationship between anxiety levels and athletes' smash accuracy. The higher the level of anxiety experienced by athletes, the lower the smash accuracy displayed, and vice versa. This finding indicates the importance of managing psychological aspects in athlete training to improve technical performance on the field.
Pemberdayaan Masyarakat Melalui Inovasi Pembuatan Sabun Padat Bajakah Tampala (Spatholobus littoralis Hassk) pada Masyarakat Kampung Ketupat Samarinda: Community Empowerment Through Innovation in Making Bajakah Tampala Solid Soap (Patholobus littoralis Hassk) in the Community of Ketupat Village, Samarinda Hamzah, Hasyrul; Luthfi M, Chaerul Fadly Mochtar; Faldi, Faldi; Pradana, Anugrah Riska; Febriani, Riska; Aris, Risna; Mardatilah, Suci; Rani, Frederika Erwina
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 6 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i6.6323

Abstract

Bajakah tampala is a plant native to Kalimantan that can be found in forests in the interior of Kalimantan. The use of Bajakah Tampala wood is not widely known by most people. One of the uses of Bajakah Tampala wood is that it can be used as an economically valuable product. This community service takes the form of an empowerment program for PKK and Dasawisma women to provide training in making bajakah solid soap. However, before that, education or outreach was carried out regarding solid soap. Of all participants, 22.2% answered that they knew the process of making solid soap, 44.4% knew about solid soap which has a steel composition, and 20% had an understanding of making solid soap. The results of community service activities showed an increase in the total understanding of participants to 100% answered that they knew the process of making solid soap, 100% answered that they knew about solid soap which has a steel composition, and 100% answered that they understood the process of making solid soap. This activity concludes that all participants can better understand the process of making solid soap products and can feel the benefits of Bajakah solid soap.
Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats Mochtar, Chaerul Fadly; Bakhtiar, Muh Irham; Hamzah, Hasyrul; Pratama, Aldo; Rasyidah, Jamiatur; Indriyani, Juniar Rakhmatia; Alfiannur, Muhammad Rizky; Amalia, Nadhifah Suci; Putri, Nur Octaviany; Damis, Nur Lutfiah
Indonesian Journal of Pharmacology and Therapy Vol 5 No 1 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11510

Abstract

A wound is a disorder of skin integrity caused by physical trauma or disease. Wound healing is a natural restorative response to tissue injury. It is a complex dynamic physiological process involving several overlapping phases. Although wound management has been applied, however, some time it is associated withmajor drawbak including invasiveness, antibiotic resistance, and high costs. Natural medicines are being developed for wound management to resolve the drawback. Commensal Staphylococcus epidermidis was proven to play a role in natural wound healing process. This study aimed to investigate the wound healingactivity of a topical gel preparation containing S. epidermidis isolate extract on an incision wound model in rats. The methanol extract of S. epidermidis isolate was prepared by maceration and used as an active ingredient of the topical gel using NaCMC as a gelling agent. A physical stability test was carried out by assessingorganoleptic properties, pH value, homogeneity, dispersion, and viscosity of the gel preparation. The gel preparation was then topically applied once-daily for 11 d on incision wound model of male white rats (Rattus norvegicus). The wound healing was observed daily and calculated using Morton’s formula. Nosignificant change in the physical stability parameters of the gel preparation was observed during observation on day 1, 7, and 14 (p>0.05). A significant increase in wound healing after the application of the gel preparation compared to negative control was observed (p<0.05). In contrast, no significant difference inwound healing between the gel preparation and the positive control group was observed (p>0.05). In conclusion, the topical gel preparation from S. epidermidis isolate extract accelerates healing on incision wound models in rats.
Essential Oils as Modulators of TRPV1: A Scoping Review of Mechanisms and Preclinical Evidence for Natural Analgesics Chaerul Fadly Mochtar; Andini Febriyanda; Andi Ainun Zulkiah Surur; Andi Sri Dewi Anggraeni; Ulfah Widyastuti Arsal; Nana Aulia Massakuta; Nita Magfirah Ilyas; Suriati
Journal of Basic Medical Veterinary Vol. 15 No. 1 (2026): Journal of Basic Medical Veterinary, June 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v15i1.82224

Abstract

Essential oils contain diverse bioactive constituents capable of modulating ion channels involved in nociception, including the transient receptor potential vanilloid 1 (TRPV1) channel. Increasing evidence suggests that these volatile compounds may exert analgesic effects through TRPV1-mediated mechanisms; however, findings remain scattered across heterogeneous preclinical studies. This scoping review aimed to systematically map the current evidence on how essential oils and their isolated constituents interact with TRPV1 in the context of pain modulation. A comprehensive search of PubMed, Scopus, and Web of Science (up to October 2025) was conducted using predefined keywords related to essential oils, TRPV1, and pain. Eligible studies included in vitro or in vivo experiments evaluating the activation, inhibition, or modulation of TRPV1 alongside pain-related outcomes. Twenty studies met the inclusion criteria and were extracted for authorship, experimental models, compound types, TRPV1-specific findings, and nociceptive effects. Results demonstrated three dominant mechanisms of TRPV1 modulation: (i) direct inhibition of TRPV1 activity by compounds such as linalyl acetate and α-humulene; (ii) agonist-induced activation followed by desensitisation, as observed with myrcene, carvone, and citral; and (iii) multi-target modulation in which TRPV1 interacts with additional TRP channels and inflammatory pathways. Across models of acute, inflammatory, and neuropathic pain, these mechanisms consistently produced significant antinociceptive effects. Overall, essential oils show strong potential as natural TRPV1-targeted analgesic candidates. However, methodological heterogeneity, limited mechanistic depth, and the lack of clinical validation remain key limitations.
Penguatan Minat Belajar Sains melalui Pembelajaran Interaktif pada Siswa SDN 106 Barru Nita Magfirah Ilyas; Chaerul Fadly Mochtar; Chaerul Mundzir; Mochtar Luthfi M
MAMMIRI: JURNAL PENGABDIAN MASYARAKAT Vol. 3 No. 2 (2026): Juni 2026
Publisher : Education and Talent Development Center Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/mammiri.v3i2.5196

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan minat dan keterlibatan siswa dalam pembelajaran ilmu alam di SDN 106 Barru, Desa Ajakkang, Kecamatan Soppeng Riaja, Kabupaten Barru. Permasalahan yang dihadapi meliputi rendahnya keterlibatan siswa selama proses belajar, terbatasnya variasi metode mengajar, dan kurang optimalnya penerapan kegiatan belajar yang menarik. Program dilaksanakan selama Februari 2023 melalui kegiatan belajar mengajar rutin selama empat hari setiap pekan dengan menerapkan ice-breaking, permainan edukatif, diskusi sederhana, dan aktivitas belajar aktif yang melibatkan siswa secara langsung. Hasil observasi menunjukkan adanya peningkatan partisipasi siswa yang ditandai dengan bertambahnya jumlah siswa yang mengajukan pertanyaan, menjawab pertanyaan guru, serta terlibat dalam diskusi dan aktivitas kelas. Selain itu, suasana belajar menjadi lebih kondusif dan respons siswa terhadap materi pelajaran lebih positif. Guru dan pihak sekolah juga memberikan tanggapan yang baik terhadap program ini karena dinilai mampu menciptakan proses belajar yang lebih menarik dan efektif. Temuan ini menunjukkan bahwa penerapan metode belajar aktif dapat menjadi strategi yang efektif untuk meningkatkan keterlibatan siswa sekolah dasar dalam pembelajaran ilmu alam.
Bioactivity-Guided Evaluation of Tabernaemontana divaricata Leaf Fractions Reveals Promising Anti-Inflammatory, Antipyretic, and Analgesic Effects in Mice Chaerul Fadly Mochtar
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.80895

Abstract

Inflammation, pain, and fever are major physiological responses to tissue injury or infection that often require pharmacological intervention. However, prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs) may cause gastrointestinal and hepatic toxicity, encouraging the search for safer natural alternatives. Tabernaemontana divaricata has been traditionally used to treat inflammatory and febrile conditions, yet limited studies have evaluated the pharmacological properties of its solvent fractions. This study aimed to assess the anti-inflammatory, antipyretic, and analgesic activities of the hexane (HeFrTD) and butanol (BuFrTD) fractions derived from the ethyl acetate extract of T. divaricata leaves in male mice. The fractions were obtained through liquid–liquid partitioning and administered orally at doses of 62.5, 125, and 250 mg/kg body weight. Anti-inflammatory, antipyretic, and analgesic effects were evaluated using carrageenan-induced paw edema, peptone-induced pyrexia, and hot plate assays, respectively. Statistical analysis was conducted using one-way ANOVA followed by Bonferroni’s post hoc test. Both fractions significantly (p < 0.05) reduced inflammation, pyrexia, and pain in a dose-dependent manner. The 250 mg/kg dose produced strong anti-inflammatory and antipyretic responses, with no statistically significant difference from diclofenac and paracetamol within the experimental model. Analgesic activity suggested possible involvement of central pathways commonly associated with opioid receptor modulation. In conclusion, the fractions of T. divaricata exhibit notable multi-target pharmacological effects, supporting their traditional use and potential for development as natural anti-inflammatory, antipyretic, and analgesic agents.
Transformasi Digital UMKM melalui Google My Business: Studi Pengabdian Masyarakat di Kecamatan Tamalanrea Kota Makassar Mochtar Luthfi; Chaerul Fadly Mochtar; Roni Canra; Nur Aulia Reskyta; Bintang Ali Marwan; Sarmila; Finarni Mahandian
Journal Social Science And Technology For Community Service Vol. 6 No. 2 (2025): Volume 6, Nomor 2, September 2025
Publisher : Universitas Teknokrat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33365/jsstcs.v6i2.663

Abstract

Usaha Mikro, Kecil, dan Menengah (UMKM) memiliki peran vital dalam ekonomi lokal, namun masih banyak yang menghadapi kendala dalam pemasaran, khususnya dalam pemanfaatan teknologi digital. Kegiatan pengabdian masyarakat ini bertujuan untuk menjawab permasalahan rendahnya visibilitas daring UMKM di Kecamatan Tamalanrea, Kota Makassar, dengan memberikan sosialisasi dan pelatihan penggunaan Google My Business (GMB) sebagai media pemasaran digital. Metode yang digunakan mencakup perencanaan, pelaksanaan, observasi lapangan, wawancara, dan dokumentasi. Hasil kegiatan menunjukkan peningkatan signifikan dalam omzet UMKM: barbershop naik 200%, bisnis hijab meningkat 400%, dan salon mobil naik 133% setelah mengadopsi GMB. Grafik perubahan pendapatan menunjukkan tren pertumbuhan positif yang konsisten pada ketiga UMKM. Adopsi GMB terbukti meningkatkan visibilitas usaha, memperluas jangkauan pasar, serta membangun kepercayaan pelanggan melalui ulasan dan informasi yang akurat. Kegiatan ini berhasil memberdayakan pelaku usaha agar lebih mandiri dalam memanfaatkan platform digital untuk pemasaran dan memberikan model pemberdayaan yang dapat direplikasi di daerah lain. Dengan demikian, intervensi ini memberikan kontribusi nyata dalam mendukung transformasi digital UMKM dan meningkatkan daya saing di era industri.
Digitalisasi Pembelajaran Alat Praktikum Fisioterapi melalui Pengenalan Website Physio.Learn Chaerul Fadly Mochtar; Arimbi; Sarifin; Rusli; Mochtar Luthfi; Rahmat Hidayat Abbas; Abhista Ibnu Fauzan; Sri Wahyuni; Nur Rahma; Alifiah Aisyah Biyni; Syavira Hafis
Journal Social Science And Technology For Community Service Vol. 6 No. 2 (2025): Volume 6, Nomor 2, September 2025
Publisher : Universitas Teknokrat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33365/jsstcs.v6i2.806

Abstract

Physiotherapy education required optimal mastery of psychomotor skills, yet conventional learning was often hampered by limitations in time, access, and practical equipment demonstration. This activity aimed to improve students’ literacy and skills in using physiotherapy equipment through the socialization of the Physio.Learn website, which featured educational videos. The implementation method employed an educational-participatory approach conducted online, consisting of material preparation, socialization via Zoom, website demonstration, interactive discussion, and feedback evaluation. A total of 139 Physiotherapy students from Universitas Negeri Makassar participated in this activity. Survey results indicated that 72.1% of participants rated the video explanations as “clear” to “very clear,” 83% found the visualizations highly helpful, and 92.4% perceived the videos as beneficial in enhancing understanding. Ease of access and website design were also positively rated by the majority of respondents. These findings reinforced evidence that the integration of digital media based on educational videos effectively improved students’ understanding and skills in using physiotherapy equipment, while promoting more flexible and participatory independent learning. The development of interactive features and improvement of content quality were recommended for future platform optimization.
Co-Authors A. Nurfitriani Abdul Rozak Abhista Ibnu Fauzan Aisyiyah, Novia Misnawati Aji Firda Lia F Alfiannur, Muhammad Rizky Alfin Syahrian Dwi Nugraha Alifiah Aisyah Biyni Amalia, Nadhifah Suci Andi Ainun Zulkiah Surur Andi Ainun Zulkiah Surur Andi Ainun Zulkiah Surur Andi Sri Dewi Anggraeni Andini Febriyanda Andini Nur Amilia Anshari, Rahman Anugrah Riska Pradana Arimbi Arimbi Arimbi Aris, Risna Aulan Syahala Ayu Faradillah Ayu Faradillah Ayu Faradillah Badrani Abbas Al Fajri Bakti, Muhammad Tursina Bambang Setiaji Bintang Ali Marwan Christina Debomar Damis, Nur Lutfiah Dedi Setiawan Devi, Reni Selviana Diana Indri Sulistia Dwi Lestari Elva Elva Hafidzah Elva Hafidzah Endang Setyowati Eva Mardiana Evi Lutfia Sari FAHRIZAL Faldi Faldi Faldi, Faldi Faradillah, Ayu Fathiah Putri Varizza Fathiah Putri Varizza Fathiah Putri Varizza Febriani, Riska Fhirda Azhari Finarni Mahandian Fitri Fitri Fredy Dian Kurniawan Hafidzah, Elva Hamzah, Hasyrul HarvinaMukrim Hasanah Hasanah Helda Rahma Hendra Wahyudi Husna, Qur'anni Akhwatun Husna, Qur’anni Akhwatun Indra Yudhawan Indriyani, Juniar Rakhmatia Irfan Muris Setiawan Irfan Yunus Irzani, Elza Fadia Jati Pratiwi Jati Pratiwi Kurnita Puji Lestari Luthfi M, Mochtar Luthfiyyah Kahirun Nisa Lysa Oktaviani Saleh Lysa Oktaviani Saleh Mardatilah, Suci Muh Irham Bakhtiar Mundzir, Chaerul Nadia Chusnul Fiqriah Nana Aulia Massakuta Nila Fajrianti Nita Magfirah Ilyas Nita Magfirah Ilyas Nita Magfirah Ilyas Noor Aida Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Novia Misnawati Aisyiyah Nur Aulia Reskyta Nur Ismi Aulia Shifa Nur Lutfiah Damis Nur Lutfiah Damis Nur Lutfiah Damis Nur Lutfiah Damis Nur Lutfiah Damis Nur Rahma Nurmila Sari Paula Mariana Kustiawan Poppy Elisano Arfanda Pradana, Anugrah Riska Pratama, Aldo Putri, Nur Octaviany Qur’anni Akhwatun Husna Qur’anni Akhwatun Husna Qur’anni Akhwatun Husna Rabiatul Adawiyah Rahmat Hidayat Abbas Rani, Frederika Erwina Rasyidah, Jamiatur Reni Selviana Devi Reni Selviana Devi Reni Selviana Devi Risna Aris Riza Maulana Rizky Kurniawan Roni Canra Rusli Safitri Indah Lestari Salsabila Azzahra Sarifin Sarifin Sarifin Sarmila Sekar Ayu Kumara Shella Carlina Tasya Shella Putri Sinta Ratna Dewi Sinta Ratna Dewi Sri Wahyuni Suriati Suriati Suriati Suriati Suriati Suwoko Suwoko Syavira Hafis Tania Nazelilla Tomi Perdani Ulfah Widyastuti Arsal Ulfah Widyastuti Arsal Varizza, Fathiah Putri Virgiawan Yoga Pratama Virgiawan Yoga Pratama Vyona Ruli Paradhea Wahyana Mujari Wahid Wirnawati Wirnawati Wiyuniarta Syarifuddin