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All Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Plexus Medical Journal

Teguh Prakosa, Teguh

Faculty Of Medicine, Universita Sebelas Maret / Department Of Obstetrics And Gynecology, Dr. Moewardi Hospital, Ir. Sutami 36 A, Kentingan Surakarta 57126 Telp. (0271) 662622

Author-ID : 548747

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Ekspresi p53 Mutan dan caspase 3 sebagai Faktor Prediksi terhadap Operabilitas Kanker Serviks IIB setelah Mendapat Kemoterapi Neoajuvan Prakosa, Teguh; Askandar, Brahmana; Fauziah, Dyah
Indonesian Journal of Cancer Vol 7, No 2 (2013): Apr - Jun 2013
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (689.197 KB)

Tujuan: untuk mengetahui ekspresiÂ caspaseÂ 3 dan p53 mutan dalam memprediksi respons operabilitas (pra-operatif) pada penderita kanker serviks IIB yang mendapatkan kemoterapi neoajuvanÂ paclitaxel-platinum.Metode: ekspresiÂ caspaseÂ 3 dan p53 mutan diperiksa dengan pengecatan immunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya mulai bulan Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita kanker serviks IIB yang mendapatkan rejimen kemoterapi neoajuvanÂ paclitaxel-platinumÂ (cisplatin 75 mg/m2 atau carboplatin AUC 5 âÂ paclitaxelÂ 175 mg/m2) sebanyak tiga seri berturut-turut 3 mingguan dan telah dilakukan evaluasi operabilitasnya pasca-kemoterapi neoajuvan yang dilakukan sebelum operasi, 3 minggu sampai 4 minggu setelah kemoterapi yang terakhir. Penelitian ini merupakan studi analitik dengan studi kasus kontrol.Hasil: hubungan antara ekspresi p53 mutan danÂ caspaseÂ 3 dengan operabilitas post kemoterapi neoajuvanpaclitaxel-platinumÂ dianalisis dengan uji regresi logistik sederhana. Dari penelitian ini didapatkan sejumlah 22 (55%) pasien kanker serviks IIB yang mendapat kemoterapi neoajuvan memberikan responsÂ inoperableÂ dan 18 (45%) pasien memberikan respons operabel. Ekspresi p53 mutan terbanyak menunjukkan hasil ekspresi negatif, dengan rentang skor 0-1, yaitu sebanyak 33 (82,5%) penderita. Ekspresi positif didapatkan pada 7 (17,5 %) penderita, dan tidak didapatkan perbedaan yang signifikan (p 0,48; OR: 0,55 (CI 95%:0,11-2,87)). Jumlah ekspresiÂ caspaseÂ 3 yang positif dan negatif menunjukkan jumlah yang sama besarnya baik pada luaran inoperabel maupun operabel, yaitu masing-masing 13 (72,2%) dan 11 (50,0%); dengan p=0,158, OR:2,60(CI 95%:0,69-9,81).Kesimpulan: ekspresiÂ caspaseÂ 3 dan p53 mutan tidak dapat memprediksi respons operabilitas pada pasien kanker serviks IIB yang mendapatkan kemoterapi neoajuvanÂ paclitaxel-platinum.Kata kunci: kanker serviks stadium IIB, kemoterapi neoajuvanÂ paclitaxel-platinum, operabilitas pascakemoterapi neoajuvan

Improved Understanding of IUD and Implant Family Planning Acceptors in Family Planning Services at Solo Peduli Clinic Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.944 KB)

Background: Family planning acceptor's understanding of intra uterine device (IUD) and implant contracep

Ekspresi p53 Mutan dan caspase 3 sebagai Faktor Prediksi terhadap Operabilitas Kanker Serviks IIB setelah Mendapat Kemoterapi Neoajuvan Teguh Prakosa; Brahmana Askandar; Dyah Fauziah
Indonesian Journal of Cancer Vol 7, No 2 (2013): Apr - Jun 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Tujuan: untuk mengetahui ekspresicaspase3 dan p53 mutan dalam memprediksi respons operabilitas (pra-operatif) pada penderita kanker serviks IIB yang mendapatkan kemoterapi neoajuvanpaclitaxel-platinum.Metode: ekspresicaspase3 dan p53 mutan diperiksa dengan pengecatan immunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya mulai bulan Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita kanker serviks IIB yang mendapatkan rejimen kemoterapi neoajuvanpaclitaxel-platinum(cisplatin 75 mg/m2 atau carboplatin AUC 5 paclitaxel175 mg/m2) sebanyak tiga seri berturut-turut 3 mingguan dan telah dilakukan evaluasi operabilitasnya pasca-kemoterapi neoajuvan yang dilakukan sebelum operasi, 3 minggu sampai 4 minggu setelah kemoterapi yang terakhir. Penelitian ini merupakan studi analitik dengan studi kasus kontrol.Hasil: hubungan antara ekspresi p53 mutan dancaspase3 dengan operabilitas post kemoterapi neoajuvanpaclitaxel-platinumdianalisis dengan uji regresi logistik sederhana. Dari penelitian ini didapatkan sejumlah 22 (55%) pasien kanker serviks IIB yang mendapat kemoterapi neoajuvan memberikan responsinoperabledan 18 (45%) pasien memberikan respons operabel. Ekspresi p53 mutan terbanyak menunjukkan hasil ekspresi negatif, dengan rentang skor 0-1, yaitu sebanyak 33 (82,5%) penderita. Ekspresi positif didapatkan pada 7 (17,5 %) penderita, dan tidak didapatkan perbedaan yang signifikan (p 0,48; OR: 0,55 (CI 95%:0,11-2,87)). Jumlah ekspresicaspase3 yang positif dan negatif menunjukkan jumlah yang sama besarnya baik pada luaran inoperabel maupun operabel, yaitu masing-masing 13 (72,2%) dan 11 (50,0%); dengan p=0,158, OR:2,60(CI 95%:0,69-9,81).Kesimpulan: ekspresicaspase3 dan p53 mutan tidak dapat memprediksi respons operabilitas pada pasien kanker serviks IIB yang mendapatkan kemoterapi neoajuvanpaclitaxel-platinum.Kata kunci: kanker serviks stadium IIB, kemoterapi neoajuvanpaclitaxel-platinum, operabilitas pascakemoterapi neoajuvan

Integrative psychotherapy in stress management of cervical cancer patients at RSUD Dr. Moewardi Surakarta: A case study Jhonny Prambudi Batong; Gusti Ayu Maharatih; Debree Septiawan; Teguh Prakosa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 2, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss2.art8

Background: Worldwide, cervical cancer is the second highest cause of death after breast cancer. In Indonesia, cervical cancer is ranked second among all types of cancer. Psychological distress negatively affects the mortality rate of cancer patients, and there is no stress management treatment of standard integrative psychotherapy to be carried out in the process of individual therapy in cervical cancer.Objective: To treat psychological distress in cases of cervical cancer using an integrative psychotherapy approach, create a model of factors that influence psychopathology related to psychological distress, and an integrative psychotherapy model as the basis for making modules and standard operation procedures of stress management in cervical cancer patients.Methods: This is an integrated case study with descriptive, exploratory, and exploratory qualitative approaches in two women with cervical cancer who were given integrative psychotherapy (integrative psychoeducation combined with integrative guided imagery and music), data analysis using the constant comparative method. Presentation of data using tables and graphs.Results: Two models were illustrated, a model of factors that influence psychopathology related to psychological distress and an integrative psychotherapy model in stress management of cervical cancer patients. Evaluation of decreased distress and improved related physical symptoms (pain and sleep quality).Conclusion: A model of factors that influence psychopathology related to psychological distress and an integrative psychotherapy model that can be implemented in stress management of cervical cancer patients were obtained, with sessions and types tailored to the patient’s needs.

Biopsychosocial Analysis of Factors on COVID-19 Screening Awareness of Infertile Couples in Assisted Reproductive Technology Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru Priyanto; Darto, Darto; Rantasari, Affi Angelia; Wasyanto, Trisulo; Anggraeni, Asih; Wijayanti, Agung Sari
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: The development of screening methods for infertility patients during the Coronavirus-2019 (COVID-19) pandemic provides new challenges in the adaptation of children's want programs in the era of the COVID-19pandemic. Several screening methods have been developed but various factors affect the awareness of couples to want to do COVID-19 screening. This study aimed to analyze biopsychosocial factors associated with awareness of COVID-19 screening in infertile couples. Subjects and Method: A cross-sectional study conducted at The Sekar Polyclinic of Dr. Moewardi Regional General Hospital during the COVID-19 pandemic. A number of 60 infertile couple of reproductive age who underwent the ART program was selected by random sampling. The dependent variable was awareness for COVID-19 screening. The independent variables were anxiety, knowledge, age, and length of infertility. The data were obtained from medical record and questionnaire and analyzed by a multiple logistic regression. Results: Anxiety (OR= 26; 95% CI; p<0.001) and above-average knowledge levels (OR=16; 95% CI; p<0.001) affected awareness for COVID-19 screening. While the age and length of infertility do not affect awareness for COVID-19 screening (p >0.05). Conclusion: Anxiety and above-average knowledge levels affect awareness for COVID-19 screening.

The success rate of intrauterine insemination in sperm preparation swim-up method at room temperature compared to the incubator temperature Eriana Melinawati; Uki Retno Budihastuti; Mulyoto Pangestu; Teguh Prakosa; Affi Angelia Ratnasari; Abdurahman Laqif; Darto; Cahyono Hadi; Lunardhi Susanto; Metanolia Sukmawati; Rakano Kautsar Dwiyana; Alfi Marita Tristiarti; Abida Zuhra Jatiningtyas
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.11-16

HIGHLIGHTS There were no significant differences in TMSC, sperm motility, sperm morphology, and DFI in sperm preparation using the swim-up method at 27°C and 37°C. However, this study provided an overview of the average improvement of DFI at 27°C compared to 37°C. There was no significant difference in the pregnancy rate of IUI in sperm preparation using the swim-up method at 27°C and 37°C. ABSTRACT Objective: This study aimed to determine the effect of temperature during sperm preparation on total sperm motile count (TMSC), sperm motility, sperm morphology, DNA fragmentation index (DFI), and pregnancy rate. Materials and Methods: A quasi-experimental laboratory study with pre- and post-test control group was conducted at Sekar Fertility Clinic, Dr. Moewardi General Hospital, Surakarta, Indonesia. A total of 20 sperm samples from infertile patients were prepared using the swim-up method at 27°C (group 1) and 37°C (group 2). TMSC, motility, morphology, and DFI examinations were performed. In addition, IUI was performed to confirm pregnancy rate. Sperm DNA fragmentation was determined using Sperm Chromatin Dispersion/SpermFunc DNAf test. Sperm DNA fragmentation was characterized by a halo <30% of the volume of the sperm head. Results: Group 1 had mean TMSC of 13.77 ± 9.30, while group 2 had 14.82 ± 8.82; p=0.218. Group 1 had a motility value 82.25+12.77 and group 2 had 82.55 ± 11.69; p=0.968. The morphological value for group 1 was 11.25 ± 5.15 and group 2 was 11.6 ± 5.34; p=0.626. The mean DFI for group 1 was 17.79 ± 10.88 and group 2 was 18.18 ± 12.95; p=0.765. Pregnancy rate in group 1 was 10% and group 2 was 20%; p=1.000. Conclusion: There were no significant differences in TMSC, sperm motility, sperm morphology, DFI, and pregnancy rate in sperm preparation using the swim-up method at 27°C and 37°C.

Edukasi Skrining COVID-19 pada Program Teknologi Reproduksi Berbantu di Era Pandemi COVID-19 Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih
Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Vol 5, No 2 (2023): Juli-Desember
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/baktiku.v5i2.7064

In the era of the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 screening education is essential for the general public, especially for those who undergo assisted reproductive technology (ART) programs. Understanding the preventive measures and precautions of COVID-19 during the treatment process is necessary. Health care staff must also understand the importance of proper COVID-19 screening and control measures. This educational activity is in the form of a YouTube live streaming program that can be followed by the general public, including infertile couples who want to know about infertility, examination procedures, COVID-19 screening guidelines, and the TRB program. Education about COVID-19 screening can minimize stigma and enhance public confidence in the screening procedures. The results of this educational delivery make the general public, especially couples who will undergo the ART program, ready and have the ability to undergo COVID-19 testing, services, and screening. In addition, by providing education and implementing effective screening, we can work together to combat the COVID-19 pandemic and ensure that people receive quality and safe health services.

Hubungan Kadar D-dimer pada Ibu Hamil COVID-19 terhadap Kejadian Ketuban Pecah Dini di RSUD Dr. Moewardi Anggriyani Widya Pramuni; Prakosa, Teguh; Setyawan, Sigit; Ratnasari, Affi Angelia
Plexus Medical Journal Vol. 3 No. 3 (2024): Juni
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i3.1218

Pendahuluan: Salah satu komplikasi COVID-19 pada ibu hamil yaitu terjadinya ketuban pecah dini. Infeksi SARS-CoV-2 mengaktivasi sitokin-sitokin inflamasi yang berkontribusi terhadap suatu kondisi hiperkoagulabilitas dengan mengaktivasi trombin yang memicu terjadinya ketuban pecah dini. Salah satu marker dari koagulasi yang dapat menentukan prognosis pasien COVID-19 adalah kadar D-dimer. Dibandingkan dengan wanita hamil yang tidak mengalami COVID-19, peningkatan kadar D-dimer yang lebih tinggi didapatkan pada wanita hamil yang mengalami COVID-19. Penelitian ini diharapkan dapat menunjukkan apakah terdapat hubungan antara kadar D-dimer pada ibu hamil yang mengalami COVID-19 terhadap kejadian ketuban pecah dini. Metode: Penelitian dilakukan melalui pendekatan cross-sectional di RSUD Dr. Moewardi, Surakarta dengan total 67 sampel yang tercatat di rekam medis pada periode Maret 2020 hingga Maret 2023. Setelah data diperoleh, analisis kemudian dilakukan pada software SPSS dengan uji Chi-Square. Hasil: Hasil analisis menunjukkan hubungan yang signifikan antara kadar D-dimer dengan kejadian KPD pada ibu hamil COVID-19 (p=0,014). Ibu hamil dengan KPD memiliki kadar D-dimer yang lebih tinggi dibandingkan dengan yang tidak mengalami KPD. Nilai Odds Ratio sebesar 0,261 menunjukkan bahwa ibu hamil dengan kadar D-dimer tinggi memiliki risiko lebih rendah untuk mengalami KPD. Kesimpulan: Terdapat hubungan yang signifikan antara kadar D-dimer pada ibu hamil COVID-19 dengan kejadian KPD. Peningkatan kadar D-dimer dapat menjadi indikator potensial untuk mengidentifikasi ibu hamil yang berisiko mengalami KPD.

Kolaborasi Tenaga Medis dan Masyarakat dalam Mendukung Layanan Infertilitas Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; ., Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Wijayanti, Agung Sari
Jurnal Abdidas Vol. 5 No. 6 (2024): Desember
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v5i6.1066

Kolaborasi antara tenaga medis dan masyarakat memiliki peran penting dalam mendukung penanganan infertilitas, sebuah kondisi yang sering menyebabkan kecemasan, stres, dan dampak negatif lainnya pada kesehatan mental. Tenaga medis berperan dalam diagnosis, perencanaan pengobatan, dan mendukung pasien mencapai tujuan mereka untuk memiliki anak, sementara masyarakat dapat memberikan dukungan emosional yang membantu mengurangi isolasi dan depresi pasien. Kegiatan pengabdian ini berfokus pada edukasi dan pemberdayaan tenaga medis serta masyarakat untuk meningkatkan pemahaman dan kapasitas mereka dalam mendukung individu dengan infertilitas. Evaluasi menggunakan pre-test dan post-test menunjukkan bahwa 25% peserta mengalami peningkatan pengetahuan setelah kegiatan, sementara 72% telah memiliki pemahaman yang memadai sebelumnya. Hasil ini menggambarkan efektivitas program dalam meningkatkan pemahaman terkait infertilitas. Selain itu, kegiatan ini berhasil menyebarkan informasi akurat dan memerangi mitos yang beredar di komunitas, sehingga meningkatkan kesadaran dan mengurangi stigma terhadap individu dengan infertilitas. Kesimpulannya, program ini efektif dalam meningkatkan dukungan sosial dan kapasitas tenaga medis untuk memberikan perawatan holistik yang lebih baik bagi pasien infertilitas, serta berkontribusi pada pengurangan dampak psikologis dan sosial yang dialami pasien.

Unraveling Of Urinary Disorders to Adenomyosis and Dysmenorrhea darto, darto; Anggraeni, Asih; Ngudi Insan Ksyatria, Yudhistira; Alifa, Rosita; Farras Wahdan, Arib; Retno Budihastuti, Uki; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Angelia Ratnasari, Affi
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2203

Objective : This study aims to explore the relationship between micturition disorders and adenomyosis and dysmenorrhea and provide insight into the factors associated with the severity of LUTS symptoms in these conditions. Methods : This study was a descriptive qualitative study. We retrospectively collected medical record data from the Obstetrics Gynecology Outpatient Ward of Dr. Moewardi Surakarta General Hospital in the period January 2021 to May 2023. The results of this study analyzed using Pearson correlation analysis if normally distributed and using Mann-Whitney if not normally distributed, thus, statistically analyzed. Results: There is a significant relationship between adenomyosis and dysmenorrhea on urinary disorders (p value of 0.016) where urinary disorders are found to be more severe in adenomyosis patients with dysmenorrhea. Conclusion : Lower urinary tract symptoms are common in symptomatic adenomyosis patients and greatly affect the patient's quality of life. Dysmenorrhea can be a potential risk factor that increases the occurrence of moderate to severe LUTS. Keywords: adenomyosis; dysmenorrhea; urinary disturbance.

Co-Authors ., Darto Abdurahman Laqif Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Alfi Marita Tristiarti Alifa, Rosita Angelia Ratnasari, Affi Anggraeni, Asih Anggriyani Widya Pramuni Asih Anggraeni Askandar Tjokroprawiro Cahyono Hadi Darto Darto - Darto Darto Debree Septiawan Dihade, Ajeng DYAH FAUZIAH, DYAH Eriana Melinawati Eric Edwin Yuliantara Farras Wahdan, Arib Garwita Anindya Restisa Gusti Ayu Maharatih Hermawan Udiyanto Heru Priyanto Heru Priyanto Jhonny Prambudi Batong Laqif, Abdurahman Lunardhi Susanto Metanolia Sukmawati Mulyoto Pangestu Ngudi Insan Ksyatria, Yudhistira Prisasanti, Dympna Prameilita Rachma, Dhea Fitria Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratnasari, Affi Angelia Sania Ainin Nuzula Uki Retno Budihastuti Wasyanto, Trisulo Wijayanti, Agung Sari

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