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All Journal Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Plexus Medical Journal

Teguh Prakosa, Teguh

Faculty Of Medicine, Universita Sebelas Maret / Department Of Obstetrics And Gynecology, Dr. Moewardi Hospital, Ir. Sutami 36 A, Kentingan Surakarta 57126 Telp. (0271) 662622

Author-ID : 548747

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Ekspresi p53 Mutan dan caspase 3 sebagai Faktor Prediksi terhadap Operabilitas Kanker Serviks IIB setelah Mendapat Kemoterapi Neoajuvan Prakosa, Teguh; Askandar, Brahmana; Fauziah, Dyah
Indonesian Journal of Cancer Vol 7, No 2 (2013): Apr - Jun 2013
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (689.197 KB)

Tujuan: untuk mengetahui ekspresiÂ caspaseÂ 3 dan p53 mutan dalam memprediksi respons operabilitas (pra-operatif) pada penderita kanker serviks IIB yang mendapatkan kemoterapi neoajuvanÂ paclitaxel-platinum.Metode: ekspresiÂ caspaseÂ 3 dan p53 mutan diperiksa dengan pengecatan immunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya mulai bulan Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita kanker serviks IIB yang mendapatkan rejimen kemoterapi neoajuvanÂ paclitaxel-platinumÂ (cisplatin 75 mg/m2 atau carboplatin AUC 5 âÂ paclitaxelÂ 175 mg/m2) sebanyak tiga seri berturut-turut 3 mingguan dan telah dilakukan evaluasi operabilitasnya pasca-kemoterapi neoajuvan yang dilakukan sebelum operasi, 3 minggu sampai 4 minggu setelah kemoterapi yang terakhir. Penelitian ini merupakan studi analitik dengan studi kasus kontrol.Hasil: hubungan antara ekspresi p53 mutan danÂ caspaseÂ 3 dengan operabilitas post kemoterapi neoajuvanpaclitaxel-platinumÂ dianalisis dengan uji regresi logistik sederhana. Dari penelitian ini didapatkan sejumlah 22 (55%) pasien kanker serviks IIB yang mendapat kemoterapi neoajuvan memberikan responsÂ inoperableÂ dan 18 (45%) pasien memberikan respons operabel. Ekspresi p53 mutan terbanyak menunjukkan hasil ekspresi negatif, dengan rentang skor 0-1, yaitu sebanyak 33 (82,5%) penderita. Ekspresi positif didapatkan pada 7 (17,5 %) penderita, dan tidak didapatkan perbedaan yang signifikan (p 0,48; OR: 0,55 (CI 95%:0,11-2,87)). Jumlah ekspresiÂ caspaseÂ 3 yang positif dan negatif menunjukkan jumlah yang sama besarnya baik pada luaran inoperabel maupun operabel, yaitu masing-masing 13 (72,2%) dan 11 (50,0%); dengan p=0,158, OR:2,60(CI 95%:0,69-9,81).Kesimpulan: ekspresiÂ caspaseÂ 3 dan p53 mutan tidak dapat memprediksi respons operabilitas pada pasien kanker serviks IIB yang mendapatkan kemoterapi neoajuvanÂ paclitaxel-platinum.Kata kunci: kanker serviks stadium IIB, kemoterapi neoajuvanÂ paclitaxel-platinum, operabilitas pascakemoterapi neoajuvan

Improved Understanding of IUD and Implant Family Planning Acceptors in Family Planning Services at Solo Peduli Clinic Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.944 KB)

Background: Family planning acceptor's understanding of intra uterine device (IUD) and implant contracep

Peningkatan Pemahaman Akseptor KB terhadap Efek Samping IUD dan Implan dalam Pelayanan KB di Klinik Solo Peduli Uki Retno Budihastuti; Abdurahman Laqif; Eriana Melinawati; Teguh Prakosa; Hermawan Udiyanto; Heru Priyanto; Darto -; Affi Angelia Ratnasari; Asih Anggraeni
PLACENTUM: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 9, No 1 (2021): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v9i1.44306

ABSTRAKLatar Belakang: Pemahaman akseptor KB (Keluarga Berencana) tentang KB IUD dan implan masih rendah, hal ini dikarenakan minimnya pengetahuan dan adanya persepsi negatif mengenai kontrasepsi IUD dan implan di masyarakat. Perlu adanya upaya peningkatan pemahaman akseptor KB untuk meningkatkan kualitas dalam pelayanan KB untuk mencapai kesehatan individu yang optimal dan menurunkan angka fertilitas melalui peningkatan pemakaian alat kontrasepsi.Tujuan: Mengetahui pengaruh perlakuan penyuluhan terhadap peningkatan pemahaman dan kesiapan akseptor KB terhadap efek samping alat kontrasepsi di Klinik Solo Peduli.Metode: Pengabdi memberikan penyuluhan kepada akseptor KB mengenai KB IUD dan implan. Kemudian, Akseptor KB dibagikan kuesioner meliputi pertanyaan tentang efek samping yang dirasakan, serta langkah yang dapat dilakukan ketika efek samping timbul.Hasil: Dari 60 responden, didapatkan mayoritas tingkat pengetahuan efek samping alat kontrasepsi akseptor KB sebanyak 65% adalah “baik”, 35% adalah “kurang”, dan terdapat 18 (30%) orang yang mengalami efek samping minimal, diantaranya: nyeri, ketidaknyamanan hubungan seksual, kenaikan berat badan, jerawat, siklus mentruasi berubah setelah pemasangan alat kontrasepsi.Kesimpulan: Terdapat peningkatan pengetahuan efek samping alat kontrasepsi setelah dilakukan penyuluhan dan efek samping yang relatif minimal.Kata Kunci: Akseptor KB, IUD, Implan, Pelayanan KB. ABSTRACTBackground: The understanding of family planning acceptors about IUD and implant contraception is still low, this is due to the lack of knowledge and negative perceptions about IUD contraception and implants in the community. There needs to be an effort to increase understanding of family planning acceptors to improve the quality of family planning services to achieve optimal individual health and to reduce fertility rates through increased use of contraceptives.Objective: To determine the effect of counseling treatment on increasing understanding and readiness of family planning acceptors on the side effects of contraceptives at the Solo Peduli Clinic.Methods: The service provider provides counseling to family planning acceptors about IUD and implant family planning. Then, family planning acceptors were distributed questionnaires covering questions about side effects that were felt, as well as steps that could be taken when side effects arose.Results: Of the 60 respondents, it was found that the majority of the level of knowledge about the side effects of contraceptives acceptors of family planning as much as 65% were "good", 35% were "less", and there were 18 (30%) people who experienced minimal side effects, including: pain, discomfort of sexual intercourse, weight gain, acne, menstrual cycles changed after the insertion of contraceptives.Conclusion: There is an increase in knowledge of the side effects of contraceptives after counseling and the relatively minimal side effects.Keywords: family planning acceptors, IUD, implants, family planning services.

Ekspresi p53 Mutan dan caspase 3 sebagai Faktor Prediksi terhadap Operabilitas Kanker Serviks IIB setelah Mendapat Kemoterapi Neoajuvan Teguh Prakosa; Brahmana Askandar; Dyah Fauziah
Indonesian Journal of Cancer Vol 7, No 2 (2013): Apr - Jun 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Tujuan: untuk mengetahui ekspresicaspase3 dan p53 mutan dalam memprediksi respons operabilitas (pra-operatif) pada penderita kanker serviks IIB yang mendapatkan kemoterapi neoajuvanpaclitaxel-platinum.Metode: ekspresicaspase3 dan p53 mutan diperiksa dengan pengecatan immunohistokimia pada 40 potongan biopsi jaringan pasien kanker serviks IIB yang memenuhi kriteria inklusi, yang melakukan pengobatan di RSUD dr. Soetomo, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Airlangga, Surabaya mulai bulan Desember 2006 hingga Juli 2011. Kriteria inklusi meliputi penderita kanker serviks IIB yang mendapatkan rejimen kemoterapi neoajuvanpaclitaxel-platinum(cisplatin 75 mg/m2 atau carboplatin AUC 5 paclitaxel175 mg/m2) sebanyak tiga seri berturut-turut 3 mingguan dan telah dilakukan evaluasi operabilitasnya pasca-kemoterapi neoajuvan yang dilakukan sebelum operasi, 3 minggu sampai 4 minggu setelah kemoterapi yang terakhir. Penelitian ini merupakan studi analitik dengan studi kasus kontrol.Hasil: hubungan antara ekspresi p53 mutan dancaspase3 dengan operabilitas post kemoterapi neoajuvanpaclitaxel-platinumdianalisis dengan uji regresi logistik sederhana. Dari penelitian ini didapatkan sejumlah 22 (55%) pasien kanker serviks IIB yang mendapat kemoterapi neoajuvan memberikan responsinoperabledan 18 (45%) pasien memberikan respons operabel. Ekspresi p53 mutan terbanyak menunjukkan hasil ekspresi negatif, dengan rentang skor 0-1, yaitu sebanyak 33 (82,5%) penderita. Ekspresi positif didapatkan pada 7 (17,5 %) penderita, dan tidak didapatkan perbedaan yang signifikan (p 0,48; OR: 0,55 (CI 95%:0,11-2,87)). Jumlah ekspresicaspase3 yang positif dan negatif menunjukkan jumlah yang sama besarnya baik pada luaran inoperabel maupun operabel, yaitu masing-masing 13 (72,2%) dan 11 (50,0%); dengan p=0,158, OR:2,60(CI 95%:0,69-9,81).Kesimpulan: ekspresicaspase3 dan p53 mutan tidak dapat memprediksi respons operabilitas pada pasien kanker serviks IIB yang mendapatkan kemoterapi neoajuvanpaclitaxel-platinum.Kata kunci: kanker serviks stadium IIB, kemoterapi neoajuvanpaclitaxel-platinum, operabilitas pascakemoterapi neoajuvan

Integrative psychotherapy in stress management of cervical cancer patients at RSUD Dr. Moewardi Surakarta: A case study Jhonny Prambudi Batong; Gusti Ayu Maharatih; Debree Septiawan; Teguh Prakosa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 2, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss2.art8

Background: Worldwide, cervical cancer is the second highest cause of death after breast cancer. In Indonesia, cervical cancer is ranked second among all types of cancer. Psychological distress negatively affects the mortality rate of cancer patients, and there is no stress management treatment of standard integrative psychotherapy to be carried out in the process of individual therapy in cervical cancer.Objective: To treat psychological distress in cases of cervical cancer using an integrative psychotherapy approach, create a model of factors that influence psychopathology related to psychological distress, and an integrative psychotherapy model as the basis for making modules and standard operation procedures of stress management in cervical cancer patients.Methods: This is an integrated case study with descriptive, exploratory, and exploratory qualitative approaches in two women with cervical cancer who were given integrative psychotherapy (integrative psychoeducation combined with integrative guided imagery and music), data analysis using the constant comparative method. Presentation of data using tables and graphs.Results: Two models were illustrated, a model of factors that influence psychopathology related to psychological distress and an integrative psychotherapy model in stress management of cervical cancer patients. Evaluation of decreased distress and improved related physical symptoms (pain and sleep quality).Conclusion: A model of factors that influence psychopathology related to psychological distress and an integrative psychotherapy model that can be implemented in stress management of cervical cancer patients were obtained, with sessions and types tailored to the patient’s needs.

Education on Assisted Reproductive Technology Program with Low Cost Uki Retno Budihastuti; Abdurahman Laqif; Eriana Melinawati; Teguh Prakosa; Hermawan Udiyanto; Heru Priyanto; Darto .; Affi Angelia Ratnasari; Asih Anggraeni; Agung Sari Wijayanti
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 1 (2023): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i1.64796

Background: Assisted reproductive technology (ART) programs have proven to be a solution to help infertility couples to conceive. However, most couples face a financial crisis related to the relatively expensive cost of ART treatment. This service aims to educate about ART's meaning, direction, and procedures. Thus, couples want children to be able to understand the ART program at an affordable cost (low-cost) and undergo the ART program without any concerns about costs.Method: Seminar participants be given socialization in person and online through zoom software by the service provider. It is in two stages, in-person and online, so participants who cannot attend in person can follow this service program. In addition, participants are given a pre-test and post-test questions to assess their understanding of the ART program at an affordable cost.Result: The pre-test and post-test results were analyzed using Wilcoxon, which showed that after providing education about the ART program, the post-test results were significantly better than the pre-test results. Down value: 5.5%, fixed value: 15.2%, value rise: 79.3% with significance p<0.001.Conclusion: There are significant differences in the pre-test and post-test scores, which means that the participants understood the explanation the servicer gave.

Biopsychosocial Analysis of Factors on COVID-19 Screening Awareness of Infertile Couples in Assisted Reproductive Technology Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru Priyanto; Darto, Darto; Rantasari, Affi Angelia; Wasyanto, Trisulo; Anggraeni, Asih; Wijayanti, Agung Sari
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: The development of screening methods for infertility patients during the Coronavirus-2019 (COVID-19) pandemic provides new challenges in the adaptation of children's want programs in the era of the COVID-19pandemic. Several screening methods have been developed but various factors affect the awareness of couples to want to do COVID-19 screening. This study aimed to analyze biopsychosocial factors associated with awareness of COVID-19 screening in infertile couples. Subjects and Method: A cross-sectional study conducted at The Sekar Polyclinic of Dr. Moewardi Regional General Hospital during the COVID-19 pandemic. A number of 60 infertile couple of reproductive age who underwent the ART program was selected by random sampling. The dependent variable was awareness for COVID-19 screening. The independent variables were anxiety, knowledge, age, and length of infertility. The data were obtained from medical record and questionnaire and analyzed by a multiple logistic regression. Results: Anxiety (OR= 26; 95% CI; p<0.001) and above-average knowledge levels (OR=16; 95% CI; p<0.001) affected awareness for COVID-19 screening. While the age and length of infertility do not affect awareness for COVID-19 screening (p >0.05). Conclusion: Anxiety and above-average knowledge levels affect awareness for COVID-19 screening.

The success rate of intrauterine insemination in sperm preparation swim-up method at room temperature compared to the incubator temperature Eriana Melinawati; Uki Retno Budihastuti; Mulyoto Pangestu; Teguh Prakosa; Affi Angelia Ratnasari; Abdurahman Laqif; Darto; Cahyono Hadi; Lunardhi Susanto; Metanolia Sukmawati; Rakano Kautsar Dwiyana; Alfi Marita Tristiarti; Abida Zuhra Jatiningtyas
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.11-16

HIGHLIGHTS There were no significant differences in TMSC, sperm motility, sperm morphology, and DFI in sperm preparation using the swim-up method at 27°C and 37°C. However, this study provided an overview of the average improvement of DFI at 27°C compared to 37°C. There was no significant difference in the pregnancy rate of IUI in sperm preparation using the swim-up method at 27°C and 37°C. ABSTRACT Objective: This study aimed to determine the effect of temperature during sperm preparation on total sperm motile count (TMSC), sperm motility, sperm morphology, DNA fragmentation index (DFI), and pregnancy rate. Materials and Methods: A quasi-experimental laboratory study with pre- and post-test control group was conducted at Sekar Fertility Clinic, Dr. Moewardi General Hospital, Surakarta, Indonesia. A total of 20 sperm samples from infertile patients were prepared using the swim-up method at 27°C (group 1) and 37°C (group 2). TMSC, motility, morphology, and DFI examinations were performed. In addition, IUI was performed to confirm pregnancy rate. Sperm DNA fragmentation was determined using Sperm Chromatin Dispersion/SpermFunc DNAf test. Sperm DNA fragmentation was characterized by a halo <30% of the volume of the sperm head. Results: Group 1 had mean TMSC of 13.77 ± 9.30, while group 2 had 14.82 ± 8.82; p=0.218. Group 1 had a motility value 82.25+12.77 and group 2 had 82.55 ± 11.69; p=0.968. The morphological value for group 1 was 11.25 ± 5.15 and group 2 was 11.6 ± 5.34; p=0.626. The mean DFI for group 1 was 17.79 ± 10.88 and group 2 was 18.18 ± 12.95; p=0.765. Pregnancy rate in group 1 was 10% and group 2 was 20%; p=1.000. Conclusion: There were no significant differences in TMSC, sperm motility, sperm morphology, DFI, and pregnancy rate in sperm preparation using the swim-up method at 27°C and 37°C.

Efforts to Increase Understanding of COVID-19 Screening in Assisted Reproductive Technology Services Uki Retno Budihastuti; Abdurahman Laqif; Eriana Melinawati; Teguh Prakosa; Hermawan Udiyanto; Heru Priyanto; Darto .; Affi Angelia Ratnasari; Asih Anggraeni
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 11, No 2 (2023): August
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v11i2.74618

Background: The assisted reproductive technology (ART) program for examining infertile couples requires face-to-face with a doctor. This face-to-face examination for the ART program has a risk for the transmission of COVID-19 to all medical personnel and infertile couples who want to undergo the ART program. This study aims to understand pre- and post-test education about COVID-19 screening on ART services.Methods: A total of 50 infertile couples in the ART program are given education online. The use of online methods using the Zoom application due to the COVID-19 pandemic. Evaluation of the level of understanding using pre and post-test providing education. Data analysis was carried out using the SPSS 23 application.Results: Analysis of the level of understanding of pre-test and post-test education using the Wilcoxon test. Pre-test results were 69.90±12.05, post-test 73.00±10.83 with significance values p<0.001. Chi-Square test analysis results obtained p<0.001 and OR = 15.68.Conclusion: There was a significant increase in understanding of COVID-19 screening in the post-test education ART service via the Zoom application compared to pre-test education.

Perbedaan Kadar D-dimer antara Persalinan Pervaginam dan C-section pada Ibu Hamil COVID-19 Garwita Anindya Restisa; Teguh Prakosa; Eric Edwin Yuliantara; Hermawan Udiyanto
Plexus Medical Journal Vol. 1 No. 5 (2022): Oktober
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v1i5.400

Pendahuluan: COVID-19 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2 yang sebagian besar menyerang sistem pernapasan dan bersifat menular. COVID-19 memiliki jumlah kasus dan tingkat mortalitas yang tinggi. Bahkan, ibu hamil pun rentan tertular penyakit COVID-19. D-dimer merupakan produk akhir degenerasi cross-linked fibrin oleh aktivitas kerja plasmin dalam sistem fibrinolitik. D-dimer dapat menjadi biomarker aktivitas koagulasi dan alat prognosis pasien COVID-19. D-dimer meningkat pada kehamilan, persalinan, dan infeksi COVID-19. Penelitian ini dilakukan untuk mengetahui perbedaan kadar D-dimer antara persalinan pervaginam dan C-section pada ibu hamil COVID-19, sehingga mengetahui apakah riwayat persalinan memengaruhi kadar D-dimer. Metode: Penelitian dilakukan di RSUD Dr. Moewardi Surakarta dengan pendekatan cross sectional. Penelitian menggunakan 67 sampel yang tercatat pada rekam medis sejak Maret 2020 hingga Maret 2022. Analisis data menggunakan uji Mann-Whitney pada software SPSS. Hasil: Hasil uji Mann-Whitney pada 26 subjek dengan persalinan pervaginam dan 41 subjek dengan C-section didapatkan P-Value 0,031 (P<0,05) yang menunjukkan terdapat perbedaan kadar D-dimer yang bermakna antara persalinan pervaginam (mean 40,44) dan C-section (mean 29,91). Kesimpulan: Terdapat perbedaan kadar D-dimer antara persalinan pervaginam dan C-section pada ibu hamil COVID-19, kadar D-dimer lebih tinggi pada persalinan pervaginam dibandingkan dengan C-section.

Co-Authors ., Darto Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Agung Sari Wijayanti Alfi Marita Tristiarti Alifa, Rosita Angelia Ratnasari, Affi Anggraeni, Asih Anggriyani Widya Pramuni Asih Anggraeni Askandar Tjokroprawiro Cahyono Hadi Darto Darto - Darto . Darto . Darto Darto Debree Septiawan DYAH FAUZIAH, DYAH Eriana Melinawati Eric Edwin Yuliantara Farras Wahdan, Arib Garwita Anindya Restisa Gusti Ayu Maharatih Hermawan Udiyanto Heru Priyanto Heru Priyanto Jhonny Prambudi Batong Laqif, Abdurahman Lunardhi Susanto Metanolia Sukmawati Mulyoto Pangestu Ngudi Insan Ksyatria, Yudhistira Prisasanti, Dympna Prameilita Rachma, Dhea Fitria Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratnasari, Affi Angelia Sania Ainin Nuzula Sigit Setyawan Uki Retno Budihastuti Wasyanto, Trisulo Wijayanti, Agung Sari

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