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Rachmawati Dwi Agustin
Fakultas Kedokteran Universitas Pattimura
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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PENGETAHUAN STROKE DAN FAKTOR RISIKONYA PADA PENDERITA HIPERTENSI-NON HIPERTENSI Asmin, Elpira; Mus, Rosdiana; Noya, Farah; Yunita, Melda; Latuheru, Grace; Warella, Juen Carla; Sulfiana, Sulfiana; Bandjar, Fitri Kardasih; Rahawarin, Halidah; Agustin, Rachmawati Dwi; de Lima, Filda V.I.
Molucca Medica Vol 17 (2024): VOLUME 17, NOVEMBER 2024 : EDISI KHUSUS PENELITIAN GAMBARAN POLA PENYAKIT MASYARAKAT
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/molmed.2024.v17.ik.20

Abstract

Seseorang yang mengalami hipertensi menyebabkan rusaknya dinding pembuluh darah sehingga pembuluh darah di otak tersumbat atau bahkan pecah. Faktor risiko stroke antara lain merokok, diabetes, kolesterol tinggi, obesitas, kurang aktivitas fisik, pola makan serta konsumsi alkohol yang berlebihan. Tujuan penelitian ini adalah untuk mengetahui gambaran faktor risiko dan pengetahuan stroke pada penderita hipertensi dan non hipertensi. Penelitian ini menggunakan desain studi potong lintang dengan sampelnya adalah penderita hipertensi dan non hipertensi berusia 18 tahun sampai usia 60 tahun yang berdomisili di Kota Tual. Sampel sebanyak 96 orang dengan menggunakan teknik simple random sampling. Hasil penelitian menunjukkan responden yang mengalami hipertensi (93,75%) lebih banyak dibandingkan yang tidak hipertensi. Responden yang mengalami hipertensi mengaku pernah mendengar stroke sebanyak 92,4%, sedangkan yang tidak pernah mendengar stroke lebih banyak yaitu 96,7%. Penderita hipertensi sebagian besar memiliki faktor risiko seperti rendahnya pengetahuan tentang stroke, mengonsumsi minuman beralkohol, merokok dan obesitas. Rekomendasi dari penelitian ini dapat menjadi informasi bagi masyarakat terkait faktor risiko stroke dan dapat termotivasi untuk menghindari rokok serta konsumsi alkohol yang berlebihan. Sosialisasi terkait stroke sangat diperlukan untuk peningkatan pengetahuan dan kesadaran masyarakat.
KAJIAN ETNOBOTANI DAN ETNOFARMAKOLOGI TANAMAN OBAT YANG DIMANFAATKAN MASYARAKAT PESISIR GUGUS KEPULAUAN KEI, KOTA TUAL, MALUKU Agustin, Rachmawati Dwi; Noya, Farah Christina; de Lima, Filda Vionita Irene; Asmin, Elpira; Rahawarin, Halidah; Sulfiana, Sulfiana; Bandjar, Fitri Kadarsih; Mus, Rosdiana; Latuheru, Grace; Warella, Juen Carla; Yunita, Melda
Molucca Medica Vol 17 (2024): VOLUME 17, NOVEMBER 2024 : EDISI KHUSUS PENELITIAN GAMBARAN POLA PENYAKIT MASYARAKAT
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/molmed.2024.v17.ik.27

Abstract

Masyarakat Kota Tual, Gugus Kepulauan Kei, Maluku merupakan salah satu kelompok masyarakat yang saat ini masih memanfaatkan tanaman sebagai bahan baku obat tradisional. Namun, pengetahuan lokal tersebut belum terdokumentasikan dengan baik hingga saat ini dan hanya bersifat empiris. Penelitian ini bertujuan untuk mengidentifikasi dan melaporkan tanaman obat yang digunakan sebagai pengobatan empiris di Kota Tual sehingga tanaman obat dapat digunakan sebagai bahan baku pengembangan obat tradisional yang diolah secara modern. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional. Pengambilan sampel dilakukan dengan menggunakan teknik probabilitas proporsional terhadap besarnya populasi. Penelitian dilakukan dengan cara wawancara dan penyajian data dengan cara kuantitatif yang dilakukan dengan mengukur persentase sitasi (FC). Data etnobotani diperoleh dari 64 informan lokal. Hasil menunjukkan diperoleh 14 spesies tanaman yang termasuk dalam 12 famili telah diidentifikasi. Famili yang paling banyak teridentifikasi adalah Apocynaceae, diikuti oleh Myrtaceae, dan Lamiaceae. Sebagian besar obat herbal dikonsumsi dalam bentuk rebusan. Daun (79,69%) merupakan bagian tanaman yang paling banyak digunakan, diikuti oleh batang (9,37%), akar (7,81%), dan buah (3,13%). Alstonia beatricis, Tinospora cordifolia, dan Orthosiphon aristatus memiliki nilai FC tertinggi. Sebagian besar tanaman digunakan untuk pengobatan diabetes, kolesterol, dan demam. Metode pengolahan yang paling sering digunakan adalah dengan merebus (67,18%). Berdasarkan hasil tersebut diperoleh kesimpulan bahwa terdapat beragam tanaman obat yang digunakan di masyarakat Kota Tual yang dapat berkontribusi pada pengembangan obat-obatan tanaman baru. Pengetahuan lokal tentang terapi herbal dapat digunakan sebagai pengobatan komplementer dan sebagai panduan untuk studi farmakologis di masa mendatang. Tanaman yang kurang dikenal dengan skor FC tinggi dapat diselidiki secara fitokimia dan farmakologis dalam penelitian di masa mendatang.
Aktivitas Antibakteri Gel Hand Sanitizer Minyak Biji Pala (Myristica fragrans Houtt.) dengan Variasi Gelling Agent RACHMAWATI DWI AGUSTIN; YUNIASIH MULYANI JUBELIENE TAIHUTTU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.479

Abstract

Hand hygiene is important because hands are one of the intermediary pathways for the entry of microbes into the body. Efforts to maintain cleanliness by diligently washing hands and using a practical way of using hand sanitizer. The alcohol content in hand sanitizers can have a long-term impact on skin health, for that alternative alcohol substitutes can use natural ingredients as the basic ingredients of antiseptic hand sanitizers. Nutmeg seed oil contains active compounds as antibacterial ingredients. This study aims to determine the correct formulation of nutmeg oil hand sanitizer gel preparation and test its effectiveness in inhibiting the growth of pathogenic bacteria, namely Escherichia coli and Pseudomonas aeruginosa. Gel preparations were made with variations of the gelling agent Carbopol and CMC-Na. The stability test of the physical properties of the gel preparation includes organoleptic test, homogeneity test, and pH test. Antibacterial activity test by disc diffusion method. The results showed that the gel preparation had a characteristic nutmeg odor, with a clear color for the CMC-Na base and white for the Carbopol base. The pH values obtained for all preparations ranged from 5.7-6.2. The results of the antibacterial activity test showed that the nutmeg oil hand sanitizer gel based on CMC-Na and Carbopol had the ability to inhibit Escherichia coli and Pseudomonas aeruginosa bacteria quite well. The conclusion of this study is that the formulation of CMC-Na-based nutmeg seed oil gel formulation is considered to be the optimal formulation in inhibiting the growth of pathogenic bacteria and has a consistent physical form.
Aktivitas Antibakteri Gel Hand SanitizerMinyak Biji Pala (MyristicafragransHoutt) Terhadap Bakteri Gram Positif dan Gram Negatif Agustin, Rachmawati Dwi; Taihuttu, Yuniasih Mulyani Jubeliene
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 2 (2024): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i2.4285

Abstract

One of the media for spreading the bacteria the fastest in hand, so an antibacterial substance is needed. Hand sanitizers, which are more effective in killing bacteria, by quickly processing hands with airflow. However, most of the hand sanitizers' content is alcohol, which can repeatedly irritate the skin, so natural ingredients are needed to make hand sanitizers. Nutmeg is a tropical plant that is commonly found in Indonesia. Nutmeg contains active compounds as antibacterial agents. Research on the antibacterial activity test of the hand sanitizer gel formulation of nutmeg oil has been carried out. This study aimed to determine the antibacterial activity in the optimum formulation of the nutmeg oil hand sanitizer gel. Antibacterial activity test using the disc diffusion method showed that the nutmeg oil hand sanitizer gel had antibacterial activity against several pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Propionibacterium acne, and Pseudomonas aeruginosa, which were optimum concentration in nutmeg oil by 15% (F1), obtained the inhibition power of 1.42 mm; 1.35 mm; 0.56 mm; and 1.67 mm, respectively.
Pengaruh Pemberian Vitamin D Terhadap Kadar Malondialdehyde (MDA) Pada Mahasiswa Tahun Pertama Fakultas Kedokteran Universitas Pattimura Priyosahubawa, Suluh; Angkejaya, Ony W.; de Lima, Filda V.I; Sanaky, Marliyati; Abbas, Mutmainnah; Agustin, Rachmawati D
JURNAL NUTRISIA Vol 27 No 2 (2025): September 2025
Publisher : Poltekkes Kemenkes Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/jnutri.v27i2.419

Abstract

High levels of free radicals induce oxidative stress. In young adults, as students, the increase of free radicals is triggered by psychological stress, obesity, and lack of physical activity. Malondialdehyde (MDA) is the product of lipid peroxidation by free radicals, which can be used as a marker of oxidative stress. Free radicals can be neutralized by antioxidants such as vitamin D. This study aims to determine the effect of vitamin D supplementation on malondialdehyde (MDA) levels in first-year medical students at the Faculty of Medicine, Pattimura University. This is an experimental analytic study with a pretest-posttest control group design approach. The data used were primary data taken from 22 samples given vitamin D for 10 days and 22 control samples. Measurement of plasma MDA in this study was performed using the TBARS method. The result shows a decrease in plasma MDA levels in the intervention group with a significant p-value = 0.001. This indicates the potential of vitamin D to be used as an antioxidant. Further research is needed to determine the exact mechanisms related to this antioxidant effect..
The Effect of Galoba (Hornstedtia sp.) Fruit Extract on Malondialdehyde (MDA) Serum Level of Hyperglycemic Mice (Mus musculus) Streptozotocin-Induced Yuan Ivani Rumengan; Indrawanti Kusadhiani; Rachmawati Dwi Agustin
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42144

Abstract

  Background: Hyperglycemia or increased blood sugar levels is a sign of diabetes mellitus. In hyperglycemia, there will be an increase in Reactive Oxygen Species (ROS) in the body so that it will lead to a state of oxidative stress characterized by an increase in malondialdehyde (MDA) levels. Galoba fruit is an endemic fruit in Maluku Province that contains antioxidants. Antioxidants contained in galoba fruit can help endogenous antioxidants to overcome oxidative stress. Objective: This study aims to determine the effect of galoba fruit extract on serum MDA levels of hyperglycemia mice induced by streptozotocin. Methods: This study is an experimental study with post-test only control group design and random sampling. The sample consisted of 24 mice divided into 6 groups, namely normal control (KN), negative control (K-), positive control (K+), treatment 1 (P1), treatment 2 (P2), and treatment 3 (P3). The KN group was only given a standard diet, the K- group was only induced streptozotocin, the K+ group was induced streptozotocin and treated with metformin for 21 days, and the P1, P2, and P3 groups were induced streptozotocin and given galoba fruit extract concentrations of 100%, 75%, and 50% for 21 days. After treatment, the mice were dissected to collect blood serum from the heart of the mice to measure MDA levels. Serum MDA levels were measured by the TBARS method. Results: The average serum MDA levels of the KN, K-, K+, P1, P2, and P3 groups were 358.75 nmol/mg, 1278.75 nmol/mg, 522.08 nmol/mg, 526.16 nmol/mg, 442.66 nmol/mg, and 432.41 nmol/mg. MDA data obtained was then tested with one way ANOVA and obtained a value of p=0.00 (<0.05). Conclusion: Based on the Tukey test, both P1, P2, and P3 have the same effect on reducing serum MDA levels of mice after being induced by streptozotocin with P3 providing the greatest decrease.
Effectiveness of Providing Galoba (Hornstedtia sp.) Fruit Tea on Glutathione Peroxidase (Gsh-Px) Enzyme Activity in the Serum of Hyperglycemic Mice (Mus Musculus) Tuahena, Abdul; Agustin, Rachmawati Dwi; Qisthi, Dian
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Hyperglycemia is a pathological condition characterized by fasting blood glucose levels exceeding 100 mg/dL, leading to increased production of free radicals and reduced activity of endogenous antioxidant enzymes such as glutathione peroxidase (GSH-Px). Oxidative stress plays a crucial role in the progression of diabetes complications. Galoba fruit (Hornstedtia sp.) is a traditional herbal plant rich in flavonoids, recognized for its antioxidant properties. These characteristics mark the potential of the plant as a complementary therapy in reducing oxidative stress in hyperglycemia. Objective: This study aimed to evaluate the effect of galoba fruit tea on GSH-Px enzyme activity in the serum of hyperglycemic mice. Materials and Methods: This study used post-test-only control group design. As many as 24 male Balb/C mice were divided into six groups: KN (normal control), K− (negative control), K+ (positive control, receiving metformin 1.3 mg/kg BW), and three treatment groups receiving galoba fruit tea at doses of 100 mg/kg BW (P1), 200 mg/kg BW (P2), and 300 mg/kg BW (P3). Hyperglycemia was induced with multiple low doses of streptozotocin (40 mg/kg BW) for 5 days. We collected serum on day 22, and measured GSH-Px activity using a UV–Vis Spectrophotometer at 412 nm. Results: Administration of galoba fruit tea increased GSH-Px activity, with the highest mean value observed in the P1 group (38.08 U/mL), followed by P2 (36.11 U/mL) and P3 (20.74 U/mL). However, these differences were not statistically significant (p > 0.05). Conclusion: Galoba fruit tea exhibits potential in enhancing GSH-Px enzyme activity in hyperglycemic mice, particularly at lower doses (100 mg/kg BW). This potential has demonstrated that galoba fruit tea can support endogenous antioxidant defense mechanisms as a complementary strategy to manage hyperglycemia. Therefore, this study suggests optimizing dosage and evaluating long-term effects of the galoba fruit tea for further studies.
Hypolipidemic Effect of Galoba Fruit (Hornstedtia sp.) Extract on LDL-Cholesterol in Hypercholesterolemic Mice Rahmah, Nadia Fathiyatur; Agustin, Rachmawati; Latief, Rahmi; Sanaky, Marliyati; Latuconsina, Vina Zakiah; Sulfiana
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.289

Abstract

Introduction. Elevated low-density lipoprotein cholesterol (LDL-C), particularly in its oxidized form, contributes to atherosclerosis and increases the risk of cardiovascular disease. Galoba fruit (Hornstedtia sp.) contains antioxidant phytochemicals that may support lipid regulation. This study evaluated the hypolipidemic effect of Hornstedtia sp. extract in hypercholesterolemic mice. Methods. Twenty-five male mice were randomly assigned to five groups: normal control (KN), negative control (K–, high-fat diet only), positive control (K+, simvastatin 10 mg/kg BW), and two treatment groups receiving Galoba fruit extract at doses of 200 mg/kg BW (P1) and 400 mg/kg BW (P2). Hypercholesterolemia was induced with a high-fat diet, and the extract was prepared by ethanol maceration. Because of limited serum volume, LDL-C levels were estimated indirectly using the Anandaraja equation based on total cholesterol and triglyceride concentrations. Results. LDL-C levels decreased in the extract-treated groups compared with the negative control. The Kruskal–Wallis test showed significant differences among groups (p < 0.05; overall p = 0.000). The greatest reduction was observed in P1 (11.90 mg/dL), followed by P2 (16.60 mg/dL), although neither exceeded the effect of K+ (7.90 mg/dL). Conclusion. Hornstedtia sp. extract demonstrated potential in lowering LDL-C in hypercholesterolemic mice, suggesting its role as a natural adjunct for lipid control. However, the use of indirect LDL-C estimation and the small sample size warrant cautious interpretation. Further studies with direct lipid profiling and mechanistic exploration are recommended before translational application.
Comparison of the Castelli-II Index Between Normal Weight Obesity and Obese Medical Students Alimbran, Fadhilah Adawiyyah; de Lima, Filda Vionita Irene; Latuconsina, Vina Zakiah; Agustin, Rachmawati Dwi; Latief, Rahmi R.; Irwan
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.309

Abstract

Introduction. Cardiovascular disease remains the leading cause of mortality in Indonesia, with obesity recognized as a major risk factor. Excess body weight not only contributes to obesity but also alters lipid metabolism, thereby accelerating atherosclerosis. Interestingly, not all individuals with metabolic risk exhibit excess weight. This condition, termed normal weight obesity (NWO), describes individuals with a normal BMI (18.5-24.9 kg/m2) but an elevated body fat percentage (men >25%, women >30%). One of the important predictors of cardiovascular risk is the Castelli-II Index, defined as the LDL/HDL ratio, which reflects the balance between atherogenic and protective lipoproteins. This study aimed to evaluate the Castelli-II Index as a predictor of cardiovascular disease in individuals with NWO and obesity among medical students at the Faculty of Medicine, Universitas Pattimura. Methods. An analytic observational design with a cross-sectional approach was employed. A total of 52 respondents were recruited, comprising 26 individuals with NWO and 26 with obesity. BMI and body fat composition were assessed using a bioelectrical impedance analyzer (BIA), while LDL and HDL levels were determined through direct enzymatic testing. Results. Bivariate analysis using the chi-square test demonstrated no statistically significant difference in the Castelli-II Index between the NWO and obesity groups (p = 0.235). Conclusion. In conclusion, despite differences in body composition, the Castelli-II Index did not significantly differ between students with NWO and those with obesity. Further studies with larger and more diverse samples are recommended to validate the role of the Castelli-II Index in predicting cardiovascular risk among young adults.
Co-Authors Abbas, Mutmainnah Alessandra Saija Alimbran, Fadhilah Adawiyyah Amanda Gracia Manuputty Angkejaya, Ony W. Anwar, Rofila Asjad Aulanni'am, Aulanni'am Bandjar, Fitri Kadarsih Bandjar, Fitri Kardasih Bension, Johan B Chanif Mahdi de Lima, Filda V.I de Lima, Filda V.I. de Lima, Filda Vionita Irene Dian Qisthi, Dian Elpira Asmin F Saija, Alessandra Farah Christina Noya Filda de Lima Huliselan, Isabela Huwae, Laura BS Indrawanti Kusadhiani Irwan Irwan Irwan Johan Bruif Bension Laratmasse, Reny Aksamina Latief, Rahmi Latief, Rahmi R. Latief, Rahmi Rifany Latuconsina, Vina Zakiah Latuheru, Grace Masaoy, Epo MR Matinahoru, Marissa Melda Yunita Mus, Rosdiana Priyosahubawa, Suluh Rahawarin, Halidah Rahmah, Nadia Fathiyatur Sanaky, Marliyati Siahaya, Presli Glovrig Soumena, Rifah Zafarani Sulfiana SULFIANA, SULFIANA Taihuttu, Yuniasih MJ Taihuttu, Yuniasih Mulyani Jubeliene Tuahena, Abdul Warella, Juen Carla Yuan Ivani Rumengan Yuniasih Mulyani Jubeliene Taihuttu