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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Jurnal Pengabdian Magister Pendidikan IPA Heart Science Journal Anakes: Jurnal Ilmiah Analis Kesehatan Cardiovascular and Cardiometabolic Journal (CCJ) TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Jurnal Ilmiah STIKES Yarsi Mataram
Romi Ermawan, Romi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Predictors of right subclavian artery tortuosity in trans-radial coronary angiography access Ermawan, Romi; Pintaningrum, Yusra; Rahmat, Basuki; Putra, AASM Meiswaryasti; Indrayana, Yanna
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.13

Abstract

BACKGROUND: Trans-radial access has become the new standard and is increasingly in demand in coronary angiography. However, this method can fail due to tortuosity of the right subclavian artery. OBJECTIVES: This study aims to identify the predictors of right subclavian artery tortuosity. METHODS: This retrospective case-control study was conducted at two of the largest hospitals in West Nusa Tenggara, Indonesia. All research data were obtained from secondary sources, including video recordings of coronary angiographies, angiography reports, and patient medical records. Predictors included age, gender, smoking, height, body mass index, hypertension, diabetes mellitus, systolic and diastolic blood pressure, and random blood sugar. RESULTS: The study involved 80 subjects, divided into right subclavian artery tortuosity and normal group, with 40 subjects each. The prevalence of tortuosity was 8.1%, while the success rate of trans-radial access was 70.0%. Four significant predictors were identified: smoking (adjusted OR 0.26; p = 0.019), hypertension (adjusted OR 4.83; p = 0.020), diastolic blood pressure (adjusted OR 1.05; p = 0.044), and body mass index (adjusted OR 1.16; p = 0.035). The optimal cutoff points were determined to be a body mass index of ≥ 24.4 (sensitivity 60.0%; specificity 60.0%; p = 0.006; AUC = 0.665) and diastolic blood pressure of ≥ 78.5 mmHg (sensitivity 67.5%; specificity 67.5%; p = 0.002; AUC = 0.685). CONCLUSION: This study has identified smoking, hypertension, diastolic blood pressure, and body mass index as significant predictors of right subclavian artery tortuosity in trans-radial coronary angiography access. 
Quercetin Inhibits the Progression of Atherosclerosis by Enhancing the Activity of M2 Macrophages in Wistar Rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto
Journal of Tropical Life Science Vol. 15 No. 3
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.15.03.08

Abstract

Quercetin, widely acknowledged as an exceptionally potent antioxidant, is known for its diverse array of bioactive properties that confer numerous health benefits. However, the specific effect of quercetin on atherosclerosis progression remains unclear and warrants further investigation. This experimental study used Wistar rats with a post-test-only control-group design. It aimed to analyze the effect of quercetin in inhibiting the progression of atherosclerosis. Twelve adult male rats were selected and used to construct an experimental model that mimics atherosclerotic plaque formation. The model was achieved by administering a high-fat diet with a caloric value of 414 kcal per 100 grams and performing an endothelial injury procedure during the second week of the study. After six weeks, the rats were divided into two groups of six: the control group continued on the high-fat diet, while the quercetin group maintained the same diet and received 10 mg/kg of quercetin via gavage. At the end of week eight, the progression of atherosclerotic plaques was evaluated by measuring the activity of M1 and M2 macrophages, as well as the carotid artery intima-media thickness and the degree of carotid arterial stenosis. Quercetin administration significantly increased the activity of M2 macrophages (p=0.002, mean difference 10.66, 95% CI 5.90 - 15.41); in contrast, no significant effect was found on the activity of M1 macrophages (p=0.562), carotid artery intima-media thickness (p=0.407), and the degree of carotid arterial stenosis (p=0.734). This study emphasizes quercetin's role in inhibiting atherosclerosis progression by enhancing the activity of M2 macrophages. Additional studies are necessary to explore various quercetin doses involving more atherosclerosis parameters.
The endothelial injury technique using intravenous catheters: a new alternative method for developing atherosclerotic plaque models in Wistar rats Ermawan, Romi; Pikir, Budi Susetyo; Mulyanto, Mulyanto; Utomo, Budi; Widjiati , Widjiati; Oktaviono, Yudi Her
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.14

Abstract

Background: Developing an atherosclerotic plaque model is crucial in atherosclerosis research, as creating such a model remains a significant challenge. Objective: This study evaluates the endothelial injury technique using intravenous catheters as an alternative method for developing atherosclerotic plaque models in Wistar rats. Methods: This true experimental study employs a post-test-only control group design. Twenty-two adult male Wistar rats were randomly allocated into three groups: a control group, a treatment group that underwent a 6-week intervention, and another treatment group that underwent an 8-week intervention. The control group was fed a standard diet of 320 kcal per 100 grams, while both treatment groups received a high-fat diet of 414 kcal per 100 grams. In the second week, endothelial injury was induced in the left common carotid artery of both treatment groups using a 26G intravenous catheter. The parameters assessed in the atherosclerotic plaque model included matrix metalloprotease-9 expression, M1 macrophage activity, M2 macrophage activity, maximal intima thickness, and the degree of arterial stenosis. Result: The endothelial injury technique using intravenous catheters significantly impacted matrix metalloprotease-9 expression (p<0.001) in both the 6-week and 8-week treatment groups compared to the control group. In contrast, the treatment's effects on maximal intima thickness (p=0.003) and the degree of arterial stenosis (p=0.002) were statistically significant only after 8 weeks of intervention compared to the control group. Conclusion: The endothelial injury techniques using intravenous catheters can be considered an alternative method for developing atherosclerotic plaque models in Wistar rats. Although this new technique has several limitations, it holds promise for further development in future studies.
Co-Authors A.A.S.M. Meiswaryasti Putra Andi Annisa Amaliah Darman Aprilia, Kartika Baiq Nopria Dwi Cahyani Balqis, Fathinnisa Adillah Basuki Rahmat Basuki Rahmat Masdi Siduppa Budi Susetyo Pikir Budi Utomo Devi Rahmadhona Dewi, Komang Puspa Dian Puspita Sari Indrayana, Yanna Mulyanto Mulyanto Nimas Resti Nugraha, Gede Rama Hardy Pintaningrum, Yusra Putra, AASM Meiswaryasti Putu Diva Gayatri Jaya Putri Ragad, Putra Ramadhani, Dhea Asty Rizky, Muhammad Ilham Siti Jaisy Millah Hadaina Widjiati , Widjiati yanna indrayana Yudi Her Oktaviono, Yudi Her Yusra Pintaningrum Yusra Yusra Pintaningrum Yusuf Alfin Firmawan Zikriyya Melati Rahmany