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All Journal HAYATI Journal of Biosciences Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Pharmaceutical Science and Technology Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Kultivasi Jurnal Biodjati Chimica et Natura Acta Indonesian Journal of Chemistry Jurnal Mikologi Indonesia Biosaintifika: Journal of Biology & Biology Education JURNAL SELULOSA 3BIO: Journal of Biological Science, Technology and Management Proceeding Biology Education Conference Indonesian Journal of Medical Sciences and Public Health Jurnal Sylva Lestari Makara Journal of Science Journal of Fibers and Polymer Composites Molekul: Jurnal Ilmiah Kimia
Asri Peni Wulandari
Laboratorium Mikrobiologi, Departemen Biologi, FMIPA, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : Makara Journal of Science

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Diketopiperazine Cyclo-(S-Pro-R-Leu) Produced by Periconia pseudobyssoides K5 Isolated from Toona sureni (Meliaceae) and its Heme Polymerization Inhibition Activity Azhari, Azmi; Harneti, Desi; Wulandari, Asri Peni; Mulyani, Yeni; Purbaya, Sari; Sari, Aprilia Permata; Pratama, Galih Bayu; Supratman, Unang; Shiono, Yoshihito
Makara Journal of Science Vol. 27, No. 1
Publisher : UI Scholars Hub

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Abstract

Fungi endophytes are living microorganisms colonizing inside the internal tissue of a plant and provide ecological benefits for their host. Endophytes provide various metabolites for plant adaptation toward biotic and abiotic stresses and have tremendous pharmacological activities. Toona sureni (T. sureni) (Meliaceae) belongs to the Toona genera and is reported to have antimalarial activity. To determine the compounds produced by the endophytic fungus from this plant, we isolated a compound from Periconia pseudobyssoides (P. pseudobyssoides) K5 endophytes from the stem bark of T. sureni. Diketopiperazine cyclo-(S-Pro-R-Leu), a non-ribosomal peptide, was isolated from brown rice fermented at 28 ± 2 ℃ for 30 days. The structure was determined by spectroscopic methods including fourier-transform infrared spectroscopy, mass spectrometry, and 1D and 2D nuclear magnetic resonance techniques. This compound was evaluated for heme polymerization inhibition activity (HPIA) with an IC50 value of 9.89 ± 0.24 mmol/L compared with positive control chloroquine phosphate with an IC50 value of 3.08 ± 0.58 mmol/L. This compound has been categorized as having low activity three times lower than positive control chloroquine phosphate. This information provides new leads about the compound diketopiperazine cyclo-(S-Pro-R-Leu) produced by P. pseudobyssoides K5 endophytes having low activity in inhibiting heme polymerization. In the future, to explore the potency of this compound as antimalarial agent, the other antimalarial test such as lactate dehydrogenase assay might be useful.
Co-Authors Abdul Rohmat Ade Zuhrotun Afina Yusradinan Annas Nursyahid Anne Nuraini Annisa Abdiwijaya Qaromah Annisa Handayani Dewi Aprilia Permata Sari Ayu Wandira Azmi Azhari Azmi Azhari, Azmi Baghya Nugraha Betty Mayawatie Marzuki, Betty Mayawatie Danni Ramdani Desi Harneti Putri Huspa Dewi, Annisa Handayani Dewi, Maranti Dwi Margiati Dwi Ramadhani Sukmana Elisabeth, Pauline Ema Wulandini Eva Aprilia Fadillah, Muhammad Nugraha Faizatul Falah Faizatul FALAH Fajar Fauzi Abdullah Fatih Awliya, Meuthia Felicia Fiandisty Fitri Widiantini Galih Bayu Pratama Heli Siti Halimatul Hutajulu, Esther Christy Natasya Ida Indrawati Ida Indrawati Ida Indrawati Inneke Andita Putri Laoli Irfan Zidni Ismayati, Maya Karen Kezia Lolowang Kartika Sari Kindi Farabi Kusumah, Sukma Surya Laksana, Raden Permana Budi Laoli, Inneke Andita Putri Lubis, Muhammad Adly Rahandi Manggar Arum Aristri Maya Ismayati Michelle Azista N. Casandra Mohamad Nurzaman Muhammad Adly Rahandi Lubis Muhammad Rasyidur Ridho Muhammadiyah, Muhammadiyah Murgayanti Murgayanti Nia Rossiana Nidia Primastia Ningsih, Nur Hasna Nurindah Nurindah Nurindah Oktaviani, Anti Poniah Andayaningsih Pratama, Galih Bayu Purbaya, Sari Rachmawati, Ulyaa Raden Permana Budi Laksana Rahayuningsih, Sri Redjeki Rusky Intan Pratama Sari Purbaya Sari, Aprilia Permata Shiono, Yoshihito Sukmana, Dwi Ramadhani Syifa Nabila, Devina Tati Herlina Ulyaa Rachmawati Unang Supratman Victor Handoko Vira Kusuma Dewi Wahyu Syafriansyah Widya Fatriasari Widya FATRIASARI Widya, Shafira Nurul Windra Yuniarsih Yeni Mulyani Yoshihito Shiono Yuli Andriani Yuniarsih, Windra