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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Urology Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Kesehatan Andalas Medical Laboratory Technology Journal Journal of Medicine and Health Majalah Patologi Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Ilmu Faal Olahraga Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Ophthalmologica Indonesiana Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Journal of Medicine and Health

Hasrayati Agustina

Departemen Patologi Anatomik Fakultas Kedokteran Universitas Padjadjaran

Author-ID : 560416

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Validitas Pemeriksaan Imunositokimia HMGA2 dalam Penegakan Diagnosis Nodul Jinak dan Ganas Tiroidpada Sediaan Biopsi Aspirasi Jarum Halus Yenni Wisudarma; Hasrayati Agustina; Sri Suryanti; Bethy S. Hernowo
Majalah Patologi Indonesia Vol 26 No 1 (2017): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.373 KB)

Latar belakang Tindakan biopsi aspirasi jarum halus (BAJAH) merupakanpemeriksaan preoperatif baku yang sederhana dan relatif lebih murah dalam penegakan diagnosis karsinoma tiroid, tetapi diagnosis sitologi BAJAH tersebut tidak selalu mudah. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan imunositokimia HMGA2 dalam penegakan diagnosis sediaan BAJAH nodul tiroid jinak, ganas dan indeterminate. Metode Penelitian ini merupakan penelitian uji diagnostik yang dilakukan terhadap 62 kasus nodul tiroid yang terdiri dari 18 kasus karsinoma papiler,13 kasus nodul folikular jinak dan 31 kasus indeterminate (27 kasus follicular neoplasmdan 4 kasus suspicious for papillary carcinoma) yang didiagnosis tahun 2011-2014 dan telah dilakukan pemeriksaan histopatologi pasca operasi sebagai konfirmasi diagnosis. Pemeriksaan imunositokimia HMGA2 dilakukan terhadap semua kasus dengan metode cell transfer. Hasil Akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 dalam diagnosis nodul tiroid masing-masing adalah 85,5%, 79,4%, 92,8%, 93,1% dan 78,8%. Sedangkan untuk kasus indeterminate, akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 adalah 77,4%, 68,7%%, 86,7%, 84,6% dan 72,2%. Kesimpulan Pemeriksaan imunositokimia HMGA2 relatif spesifik dan sensitif dalam menegakkan diagnosis preoperatif nodul tiroid termasuk pada kasus indeterminate. Kata kunci : biopsi aspirasi jarum halus, HMGA2, indeterminate, nodultiroid.

Imunoekspresi CK-7 dan CK-20 pada Karsinoma Musinosum Ovarium Primer di RSUP Dr. Hasan Sadikin Bandung Lili Sumarni; Hasrayati Agustina; Afiati Afiati
Majalah Patologi Indonesia Vol 27 No 1 (2018): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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LatarbelakangKarsinoma musinosum ovarium (KMO) merupakan subtipe karsinoma ovarium, yang sering mempunyai prognosis buruk. Ada dua bentuk KMO yang sering ditemukan, yaitu bentuk primer (KMOP) dan sekunder atau metastasis (KMOS). Untuk membedakan terapi tumor primer (KMOP) dan sekunder/metastasis perlu dilakukan pemeriksaan menggunakan CK-7 dan CK-20. Penelitian ini bertujuan untuk menganalisis imunoekspresi CK-7 dan CK-20 pada KMO.MetodePenelitian ini menggunakan desain penelitian potong lintang dengan data deskriptif retrospektif pada kasus KMO yang secara klinis didiagnosis tumor primer ovarium di RSUP dr. Hasan Sadikin Bandung periode Januari 2013 sampai dengan Juni 2016. Pada seluruh kasus dilakukan pemeriksaan histopatologi dan imunohistokimia CK-7 dan CK-20 dan dilihat parameter klinis yaitu ukuran dan lateralitas. KMOP didiagnosis bila ukuran lebih dari dari 10 cm dan unilateral, sedangkan KMOS bila ukuran kurang dari 10 cm dan bilateral.HasilHasil penelitian ini menunjukkan dari 49 kasus KMO, sebanyak 17 kasus (34,7%) adalah karsinoma musinosum ovarium sekunder (KMOS) {CK-7(-), CK-20(+)} dan 32 kasus (65,3%) adalah KMOP {CK-7(+), CK-20(-)}. Seluruh kasus KMOP (100%) dan sebagian besar kasus KMOS (88,2%) berukuran lebih besar dari 10 cm. Tidak terdapat hubungan antara ukuran tumor (p=0,29 ) dan lateralitas (p=0,94) yang signifikan dengan KMOP dan KMOS.KesimpulanPulasan imunohistokimia (IHK) CK-7 dan CK-20 dapat digunakan untuk menegakkan diagnosis KMOP.

Maternal Characteristics and Histopathological Features of Placenta Accreta Spectrum in Dr. Hasan Sadikin General Hospital Bandung, Period 2015–2020 Yuktiana Kharisma; Hasrayati Agustina; Sri Suryanti; Birgitta Maria Dewayani; Bethy Suryawati Hernowo
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2631

Background: The placenta accreta spectrum (PAS) incidence has inclined today. The PAS is divided into three histopathological classifications, including accreta, increta, and percreta, associated with maternal, fetal morbidity, and mortality. This study aimed to explore the maternal characteristics and histopathological features in PAS at Dr. Hasan Sadikin General Hospital Bandung.Methods: This descriptive observational study involved 135 cases from January 2015–December 2020 at Dr. Hasan Sadikin General Hospital that met the inclusion criteria. The PAS histopathological classification was evaluated based on maternal characteristics such as age, parity, cesarean section (CS), and miscarriage. Results: The incidence of placenta accreta from 2015 to 2020 was 37.0%, whereas increta was 43.4%, followed by percreta at 19.3%. The maternal age of placenta accreta and increta mainly occurred at the age of 30–34 years with the prevalence of 40% and 46%, respectively, whereas percreta was aged 35–39 yo (27%). Most parities in placenta accreta, increta, percreta were three. Interestingly, 93% of cases had a CS history. Furthermore, the miscarriage history for accreta was 18%, increta 29% and percreta 38%. Conclusion: The highest incidence of PAS in Dr. Hasan Sadikin General Hospital is placenta increta, which mainly occurs at the age of 30–34 years. Almost all PAS patients have a history of CS; however, most of the patients do not have a miscarriage history.

Characteristics of Thyroiditis Patients in Dr. Hasan Sadikin General Hospital in 2009–2013 Sri Maryanti; Hasrayati Agustina; Mifatuhrachman Mifatuhrachman
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.231 KB)

Background: It is reported that thyroid diseases affect around 200 milion people in the world. One of them is thyroiditis that may cause the risk of cancer. Moreover, thyroiditis can also cause hormonal disorders, such as hypothyroid and hyperthyroid. It is assumed that thyroiditis has distinctive clinical characteristics. The aim of this study was to evaluate the characteristics of thyroiditis based on age, gender, location, and clinical features of the patient.Methods: The study was conducted using descriptive-retrospective method. The data were collected from patients’ medical records through total sampling from January 2009 to Desember 2013 in Dr. Hasan Sadikin General Hospital, Bandung.Results: It was found 35 cases of thyroiditis. Based on the histopathological type, the most frequently found thyroiditis was Hashimoto’s thyroiditis. Based on age, thyroiditis mostly affected people at age 41–60 years old. Based on the gender, thyroiditis mostly affected female and the location of lesions were bilateral. The majority clinical features of patients were hypothyroid in Hashimoto’s thyroiditis, hyperthyroid in acute thyroiditis, and normothyroid in sub-acute granulomatous thyroiditis.Conclusions: Based on age, gender, and the location, the majority type of thyroiditis did not show specific characteristics. However, thyroiditis showed specific characteristics based on the clinical features of patient. [AMJ.2016;3(1):49–53]DOI: 10.15850/amj.v3n1.701

PENGARUH LATIHAN FISIK AEROBIK DENGAN INTENSITAS SEDANG TERHADAP KONDISI MAKROSKOPIK DAN GAMBARAN HISTOPATOLOGI MIOKARD MENCIT BALB/C Niswan Helja Batubara; Nova Sylviana; Hasrayati Agustina; Hadaral Hudanul Qolbi
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 2, No 1 (2019)
Publisher : PAIFORI

Cardiovascular diseases is one of the non-communicable diseases that has been the leading cause of death compared to other causes. Actually, cardiovascular diseases can be prevented with avoiding the risk factors and lifestyle improvements such as doing physical exercise. Useful physical exercise according to according to The American College of Cardiology/American Heart Association (ACC/AHA) is a moderate intensity aerobic exercise conducted 30 minutes in time for 5 days a week. This research aims to study the effects of moderate intensity aerobic exercise on macroscopic conditions, histopathologic features of the myocardium of mice. This research using 35 male balb/c mice devided to 3 groups (control, physical activity, exercise). Variables in this research included duration of physical activity and exercise, macroscopic conditions, histopathologic features of the myocardium of balb/c mice. After 10 and 28 days of exposure, the heart were harvested. The macroscopic conditions, histopathologic features of the myocardium were examined. The weight of heart in physical activity group was greater than control group (p=0.009). Similarly, the weight of heart exercise group was also greater compared to control group (p=0.013). The histopathologic features in physical activity and physical exercise groups showed pathological features of myocardial infarction (p=0.242). While in the control group did not show pathological features. Aerobic physical activity moderate intensity increase the risk of pathological condition of heart in the form of myocardial infarct through the macroscopic conditions and histological features of myocardium. Meanwhile, exercise with moderate intensity affect the physiological hypertrophy of the myocardium.

PENGARUH PENDIDIKAN KESEHATAN TERHADAP PENGETAHUAN MASYARAKAT AWAM DI RSUP DR. HASAN SADIKIN TENTANG KANKER BULI Sri Suryanti; Hasrayati Agustina; Sri Mulyati
Dharmakarya Vol 9, No 1 (2020): Maret, 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v9i1.19521

Kanker buli adalah masalah kesehatan masyarakat internasional dan peringkat ke lima keganaan terbanyak dan penyebab kematian tertinggi kedua karena keganasan di saluran kemih di negara-negara maju. Keterlambatan dalam diagnosis kasus kanker buli sering terjadi. Salah satu penyebab keterlambatan dalam diagnosis kanker buli adalah interval waktu ketika pasien pertama kali mengetahui gejala penyakit yang terjadi dengan saat pertama berkonsultasi tentang keluhannya kepada tenaga medis. Salah satu upaya untuk meningkatkan kesadaran individu terhadap kondisi tertentu adalah melalui upaya meningkatkan pengetahuan dalam bentuk penyuluhan kesehatan tentang kanker buli. Tujuan dari penelitian ini adalah untuk menentukan perubahan tingkat pengetahuan masyarakat awam tentang kanker buli melalui penyuluhan kesehatan. Penelitian ini menggunakan metode penelitian kuasi-eksperimental dengan desain "satu kelompok pretest-postest". Sebelum penyuluhan, mayoritas responden, 56,7%, memiliki pengetahuan kurang sementara setelah penyuluhan, pengetahuan meningkat secara signifikan.

Effectiveness of Xylene and Mineral Oil in DNA Extraction from Formalin-fixed Paraffin-embedded Diffuse Astrocytic Tumor Edward Jaya Hadi; Hasrayati Agustina; Hermin Aminah Usman
Medical Laboratory Technology Journal Vol. 8 No. 1 (2022): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Formalin-fixed paraffin-embedded (FFPE) tissue is an important source of material for molecular analysis. In the anatomical pathology field, molecular testing is needed in certain tumors, such as astrocytic tumors, to confirm the diagnosis. Extracting DNA from FFPE material is still challenging. The first important step in the extraction process is deparaffinization. This study aims to compare two types of deparaffinization methods. The first method used xylene, and the second one used mineral oil. The results of this study can be used to develop a reliable protocol for DNA extraction from FFPE tissue. DNA from 28 FFPE diffuse astrocytic tumor tissue blocks was extracted. The quantity and A260/A280 ratio of the DNA was measured by spectrophotometer. PCR assays were performed to assess the suitability of extracted DNA for molecular analysis. The results showed that the xylene group has significantly higher DNA concentrations than the mineral oil group (p<0.01). In both groups, average and median A260/A280 scores were between 1.8-2.0. In PCR assay, both groups show a similar result (27 of 28 samples were successfully amplified). In conclusion, xylene and mineral oil can be used effectively as deparaffinization agents. Both methods generated good quality extracted DNA. The advantage of mineral oil is that it is non-toxic and has shorter hands-on time. Xylene is preferable for a small-sized sample because it produces a higher DNA yield.

Hubungan Imunoekspresi CD44 dengan Metastasis Karsinoma Papilari Tiroid Yasni Iryani Widiasih; Herry Yulianti; Hasrayati Agustina; Bethy S Hernowo
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2202

Karsinoma tiroid (KT) merupakan keganasan endokrin yang paling sering terjadi dan karsinoma papilari tiroid (KPT) adalah tipe histopatologis terbanyak mencapai 80%. KPT mempunyai perangai yang baik dengan pertumbuhan yang lambat. Namun ditemukan KPT dengan perangai yang agresif, ditandai dengan metastasis ke KGB lebih dari 50% kasus. Cluster of Differentiation 44 (CD44) merupakan penanda imunohistokimia yang berperan dalam memprediksi sifat agresif tumor ganas payudara. Namun peran CD44 pada KPT belum diketahui dengan pasti. Tujuan penelitian ini adalah mengetahui hubungan antara imunoekspresi CD44 dengan metastasis pada KPT.Penelitian ini merupakan penelitian cross sectional terhadap kasus KPT yang didiagnosis secara histopatologis di Departemen Patologi Anatomi RSUP Dr Hasan Sadikin Bandung tahun 2012-2017. Jumlah sampel sebanyak 60 sampel yang terdiri dari 30 kasus KPT non metastasis dan 30 kasus KPT metastasis, keseluruhan sampel dilakukan pulasan imunohistokimia CD44 .Imunoekspresi CD44 pada kelompok metastasis terekspresi lemah pada 6 kasus (20,0%) dan terekspresi kuat pada 24 kasus (80,0%), sedangkan pada kelompok non metastasis terekspresi lemah pada 13 kasus (43,3%) dan terekspresi kuat pada 17 kasus (56,7%) dengan nilai p value 0,052. Hasil dari penelitian ini adalah tidak terdapat hubungan yang signifikan secara statistik antara imunoekspresi CD44 terhadap metastasis. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa CD44 tidak berperan di dalam metastasis dan tidak dapat dijadikan penanda untuk memprediksi metastasis pada kasus KPT serta diperlukan penelitian lanjutan dengan pemilihan penanda yang lebih selektif.Kata Kunci : agresif, CD44, KPT, metastasis

Diagnostic challenge in parathyroid carcinoma with multiple pathological bone fracture: A case report Hermin Aminah Usman; Hasrayati Agustina; Zahra Nurusshofa; Siska Dwiyantie Wahyuni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art14

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It often presents with unspecified clinical manifestation that leads to misdiagnosis. We report a case of a 36-year-old woman who suffered from multiple bone tumours and recurrent bone fracture for 3 years ago, and misdiagnosis as only a giant cell tumours of the bone. Then, the patient continued to develop another mass in the neck that kept growing and the mass move on swallowing. The clinician diagnosed her as a colloid goitre based on cytological examination from fine-needle aspiration biopsy. Elevated parathyroid hormone level, hypercalcemia, and suspected parathyroid adenoma in the Sestamibi Parathyroid scan led the clinician to perform a frozen section in this patient with subsequent histopathological of diagnosis as parathyroid carcinoma. The diagnosis of parathyroid carcinoma continues to be a challenge. Understanding the pathogenesis and multidisciplinary collaboration is important to define an accurate diagnosis and treatment.

Breast Cancer in West Java: Where Do We Stand and Go? Yohana Azhar; Hasrayati Agustina; Maman Abdurahman; Dimyati Achmad
Indonesian Journal of Cancer Vol 14, No 3 (2020): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Breast cancer is the most common cancer in Indonesia, a low-middle income country in Southeast Asia. We provide a regional hospital-based cancer registry of the central hospital in West Java, Indonesia. This study aims to characterize the presentation, diagnosis, evaluation, and management of breast cancer; to develop a regional breast cancer registry in West Java to monitor cancer care patterns; to evaluate cancer treatment outcomes.Methods: The data were collected from the medical records deposited in the Hasan Sadikin General Hospital Information System. The team has been contracted to operate the registry & organize an advisory board to standardize definitions of coding terminology of the registry’s reporting system and to monitor the cancer care pattern. Data validation was conducted by a team in the cancer registry, consisting of health officers, pathologists, and registrars. Data management and analysis were conducted by the cancer registry team.Results: A total of 913 women diagnosed with breast cancer, from January 2014 until December 2018, were studied. The median age was 49.5 years old. The initial diagnosis was at the age of 42.4 years old on average. About 64.5% were diagnosed with stage-3 and -4 cancers, and 75.1% had undergone a mastectomy, of which 47.3% of the intent was palliative. Of those who have hormonal receptors, only 26.9% were positive, and 36.5% were not assessed for immunohistochemistry evaluation. Inappropriate surgical management of breast cancer was common at the community level, which included indiscriminate diagnostic lumpectomy (21.9%), incomplete mastectomy and omission, or suboptimal lymph node axillary clearance (47.4%). Only 3.0% of patients received breast-conserving surgery and were treated with mastectomy and reconstruction. Conclusions: Breast cancer in West Java is often recognized at the late stage. Treatment was suboptimal, leading to poor survival. A more aggressive approach to early detection and treatment needs to be developed to improve the outcomes of this potentially curable disease.

Co-Authors Abdul H. Hassan Abdul H. Hassan, Abdul H. Abdul Hadi Hassan, Abdul Hadi Afiati Afiati Aminah Usman, Hermin Andika Prahasta Azhar, Yohana Bethy S Hernowo Bethy S Hernowo, Bethy S Bethy S. Hernowo Bethy S. Hernowo Bethy Suryawathy Hernowo Bethy Suryawati Hernowo Bethy Suryawati Hernowo Birgitta Maria Dewayani Dewayani, Birgitta Maria Dewi, Yussy A Dimyati Achmad Djajakusumah, Teguh M Dwi Putri, Riska Edward Jaya Hadi Elsa Gustianty Giovani, Octavianus Hadaral Hudanul Qolbi Hermin Aminah Usman Herry Yulianti Hidayat, Peri Hikmat Permana Inas Susanti Kiki Akhmad Rizki, Kiki Akhmad Kusumawati, Maya Lili Sumarni Maman Abdurahman Maretha Amrayni Maula Rifada Mifatuhrachman Mifatuhrachman Mifatuhrachman, Mifatuhrachman Muhammad Iman Pratama Putra Nanny Natalia Mulyani Soetedjo Naomi, Sonya M Niswan Helja Batubara Nita Novita Nova Sylviana Octavianus Giovani Odilia Dos Reis, Odilia Dos Raden Erwin Affandi Soeriadi Koesoemah Ris Kristiana Ris Kristiana, Ris Ritonga, Ervita Siska Dwiyantie Wahyuni Sitanggang, Rupita Sari Endangena Sri Maryanti Sri Mulyati Sri Mulyati Sri Suryanti Susi Heryati Teguh M Djajakusumah Teguh Marfen Djajakusumah, Teguh Marfen Tutik Nur Ayni Yasni Iryani Widiasih Yenni Wisudarma Yenni Wisudarma Yenni Wisudarma, Yenni Yohana Azhar Yohana Azhar Yuktiana Kharisma Zahra Nurusshofa

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