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All Journal bionature Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal Ilmiah Farmako Bahari Jurnal Mandala Pengabdian Masyarakat Kieraha Medical Journal Abdimas Indonesian Journal Journal Microbiology Science Jurnal Pengabdian Farmasi dan Sains MPSJ
Sitti Amirah
Fakultas Farmasi Universitas Muslim Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana Lam.) TERHADAP BAKTERI Salmonella typhi Fitriana, Fitriana; Amirah, Sitti; Rahman, Safriani; Fadilah, Nur; Jihadi, Athira; Polopadang, Arion Whaizer
Kieraha Medical Journal Vol 6, No 2 (2024): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v6i2.8650

Abstract

Daun bidara (Ziziphus mauritiana Lam.) merupakan tanaman yang bermanfaat dalam pengobatan penyakit infeksi pencernaan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) terhadap bakteri Salmonella typhi dengan metode difusi agar. Penelitian ini diawali dengan uji skrining menggunakan konsentrasi 0,1%, 0,5%, dan 1% kemudian dilanjutkan dengan uji Konsentrasi Hambat Minimum (KHM) dan uji Konsentrasi Bunuh Minimum (KBM) dengan konsentrasi 0,05 %, 1%, 2%, 4%, 6%, 8% dan 16% terhadap bakteri Salmonella thypi dan dilanjutkan uji aktivitas antibakteri dengan menggunakan metode difusi agar. Hasil uji skrining aktivitas antibakteri ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) memberikan aktivitas antibakteri terhadap Salmonella thypi pada konsentrasi 1%. Hasil uji KHM diperoleh pada konsentrasi 1% terhadap bakteri Salmonella thypi, sedangkan nilai KBM pada konsentrasi 0,05%. Hasil uji aktivitas antibakteri dengan metode difusi agar menggunakan konsentrasi 2,5%, 5%, dan 10% diperoleh diameter terbesar dalam menghambat bakteri pada konsentrasi 10%. Hasil uji statistik menunjukkan bahwa semua konsentrasi ekstrak memiliki kemampuan yang sama dalam menghambat pertumbuhan mikroba (p0,05). Kesimpulan yang didapatkan adalah ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) memiliki aktivitas antibakteri terhadap bakteri Salmonella typhi.
AKTIVITAS ANTIBAKTERI EKSTRAK FERMENTAT ISOLAT FUNGI ENDOFIT KODE IFAZ-6 DARI AKAR BIDARA (Ziziphus mauritiana Lam.) TERHADAP BAKTERI Streptococcus mutans Fitriana, Fitriana; Amirah, Sitti; Rahman, Safriani; Charawati, Nurul Mega
As-Syifaa Jurnal Farmasi Vol 17, No 1 (2025): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v17i1.1338

Abstract

Endophytic fungi are microorganisms that reside within plant tissues and are known to produce secondary metabolites with antibacterial potential. This study aimed to evaluate the antibacterial activity of the fermented extract of the endophytic fungal isolate IFAZ-6, derived from the roots of Ziziphus mauritiana Lam. (bidara), against Streptococcus mutans. The isolate was fermented for 21 days and extracted using ethyl acetate. The extract was tested for antibacterial activity using Minimum Inhibitory Concentration (MIC) at concentrations ranging from 0.2% to 25.6%, Minimum Bactericidal Concentration (MBC) from 3.2% to 25.6%, and agar diffusion assay at concentrations of 8%, 12%, and 16%. Inhibition zone diameters were analyzed statistically using the Kruskal–Wallis test followed by the Mann–Whitney post hoc test to assess differences between concentration groups. The results showed an MIC value of 3.2% and an MBC of 6.4%. The agar diffusion assay revealed a maximum inhibition zone diameter of 9.86 mm at 16% concentration, with statistically significant differences between concentrations (p < 0.05). These findings suggest that the fermented extract of IFAZ-6 possesses antibacterial activity against S. mutans, although its efficacy remains lower than that of the positive control, chloramphenicol
EDUKASI TENTANG KOLESTEROL PADA IBU PKK DESA PADDINGING KECAMATAN SANROBONE KABUPATEN TAKALAR Amirah, Sitti; Kosman, Rachmat; Fitriana; Rahman, Safriana; Rusli; Putra, Bayu; Nuryanti, Siska; Harly Nurung, Ayyub
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 1 No. 2 (2023): April 2023
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2023.v1.i2.16306

Abstract

Cholesterol is a lipid compound needed by the body as an essential component of cell membranes, hormone synthesis, energy sources and other needs. The body needs lipids in moderate amounts, the average adult's cholesterol requirement is around 1100 mg of cholesterol/day. About 25-40% of cholesterol needs are obtained from food and the rest is obtained from synthesis by the body. High cholesterol levels can trigger atherosclerosis, hardening and narrowing of the arteries which can lead to various diseases such as ischemia, stroke, heart attack. By looking at the daily life of the people in Paddinding village, kec. Sanrobone, where the majority of farmers are farmers, allows the public to ignore information about health, so education is needed to improve public health status. This activity is carried out using lecture and discucussion methods that are focused on providing understanding to the public about cholesterol, what is the role of cholesterol in the body, sources of cholesterol, how to prevent and deal with cholesterol disorders. Community service activities carried out are one of the means to increase public knowledge about how to prevent and treat cholesterol disorders.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Benalu Batu (Begonia medicinalis) Terhadap Bakteri Uji Penyebab Infeksi Saluran Pencernaan pratiwi, dita; Fitriana, Fitriana; Amirah, Sitti
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.70

Abstract

Benalu batu (Begonia medicinalis) mengandung senyawa sekunder seperti polifenol, saponin, flavonoid, dan tannin yang mempunyai aktivitas sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas antimikroba dari ekstrak etanol daun benalu batu terhadap bakteri penyebab infeksi saluran pencernaan. Hasil penelitian yang diperoleh pada uji skrining terhadap bakteri uji Escherichia coli, Salmonella typhi, Shigella dysenteriae, dan Vibrio chloreae memberikan aktivitas pada konsentrasi 6% untuk bakteri E. Coli, S. dysentriae V. Cholerae. Pengujian dilanjutkan dengan penentuan nilai KHM menggunakan metode dilusi cair dan KBM menggunakan metode dilusi padat. Hasil uji KHM yang diperoleh pada konsentrasi 18% terhadap bakteri uji. Hasil uji KBM yang diperoleh yaitu 18% untuk bakteri E. Coli, 12% untuk bakteri S.Dysentriae, dan 6% untuk bakteri V. Cholerae. Selanjutnya dilakukan pengujian aktivitas antimikroba menggunakan metode difusi agar dengan seri konsentrasi yaitu 18%, 24%, dan 30%. Hasil uji aktivitas antibakteri ekstrak etanol daun benalu batu diperoleh diameter zona hambatan terbesar pada konsentrasi 30%. Hasil uji statistik data diameter zona hambatan menunjukkan adanya perbedaan kemampuan penghambatan pertumbuhan bakteri antara konsentrasi 18% dan 24% serta 18% dan 30%, kemudian antara konsentrasi 24% dan 30% memiliki kemampuan yang sama dalam menghambat pertumbuhan bakteri. Berdasarkan penelitian, ekstrak etanol daun benalu batu memiliki potensi sebagai antibakteri.
Profil Pengelolaan Obat Golongan Narkotika, Psikotropika dan Prekursor di Apotek Rumah Sakit Stella Maris Makassar SAFITRI, INDAH DIAN; Hasrawati, Andi; Amirah, Sitti
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 4 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i4.117

Abstract

Drug management is a major factor in supporting the patient's recovery rate. Drug management can run well if supported by the ability of existing resources, both in pharmacies, health centers, and hospitals. Narcotics, psychotropic drugs and precursors can affect the nervous system and legally their circulation has been regulated in legislation. Based on the Regulation of the Minister of Health of the Republic of Indonesia Number 3 of 2015, the management of narcotic drugs, psychotropic drugs and precursors consists of circulation, storage, destruction, and recording and reporting. This study aims to determine the drug management process at the Stella Maris Makassar Hospital Pharmacy. This study uses a qualitative method with a descriptive approach and data collection techniques through interviews and observations. The results of this study are in the process of circulation, destruction, and recording and reporting at the Stella Maris Makassar Hospital Pharmacy according to the guttman scale obtained a percentage of 100% with a very good scale. However, in the storage process there are still some discrepancies so that the percentage obtained is 85%. This has met the applicable regulatory standards in Indonesia and is in accordance with the Regulation of the Minister of Health of the Republic of Indonesia No. 3 of 2015.
UJI EFEK GASTROPROTEKTIF EKSTRAK ETANOL DAUN BIDARA PADA TIKUS ULKUS PEPTIKUM DENGAN PARAMETER pH safriani- rahman1; Sitti Amirah; Fitriana; Muh. Rayhan Fachreza
Kieraha Medical Journal Vol 8 No 1 (2026): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v8i1.12266

Abstract

Peptic ulcer suffered by many people and potentially to cause DRP (Drug Related Problems) and has many severe side effects. Bidara leaves (Ziziphus mauritana Lam.) contain saponins, flavonoids, alkaloids, and tannins that can potentially be an alternative treatment for peptic ulcers. This study aims to see the gastroprotective effect of bidara leaves extract on peptic ulcers in rats based on pH parameters. A total of 15 rats were divided into 5 groups consisting of 1 Normal group, 1 comparison group (Omeprazole 20 mg/kgBW) and 3 treatment groups of bidara leaves extract with doses of 50 mg/KgBW, 150 mg/KgBW, and 250 mg/kgBW. . Administration was carried out orally once a day for 14 days. On the 15th day all test animals were induced with 96% ethanol at a dose of 5 mL/kgBW. Next, all test animals were sacrificed and dissected to remove their stomach organs. The gastroprotective effect was then observed using gastric pH measurements. The results showed that administration of ethanol extract of bidara leaves at a dose of 250 mg/kgBW provided a better gastroprotective effect than other dosage variations and comparisons, as seen from the average gastric pH value of 5.96 ± 1.48.
Co-Authors A Hasrawati Adimi, Nurhikma Adriansyah, Muhammad Alani, Fitri Wasto Anak Agung Istri Sri Wiadnyani Andi Evi Wulandari Luspi Andi Maulana Kamri Andi Sulfika Annisa, Khusnul Arini Arini As’ad, Nur Asyirah Aulia Wati, Aulia Ayyub Harly Nurung Bayu Putra Bayu Putra Bayu Putra, Bayu Charawati, Nurul Mega Dita Pratiwi Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Franita Achmad Hasbullah, Nurhijjah Hendra Herman Heriyanto Beddu Hi Amin, Rahmatia S Irma Andriani Irma Santi Jamaluddin, Siti Nurlillah Janna, Nur Jihadi, Athira Kamri, Andi Khaedhir Mirawati Mirawati Muh. Rayhan Fachreza Mustakim, Putri Dwiyanti Adha NUR FADILAH Nurdayani, Sitti Nurung, Ayyub Harly Polopadang, Arion Whaizer R. Rusli Rachmat Kosman Rachmat Kosman, Rachmat Rahman, Safriana Rahmatia S Hi Amin Rakhmat, Syahgita Resvani, Syahyu Riany Novianti Y., Riany Rusli SAFITRI, INDAH DIAN Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman, Safriani safriani- rahman1 Sari, Andini Indah Permata Siska Nuryanti, Siska Triani Putri Ayu Zulkarnain MB, Iskandar