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All Journal bionature Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal Ilmiah Farmako Bahari Jurnal Mandala Pengabdian Masyarakat Kieraha Medical Journal Abdimas Indonesian Journal Journal Microbiology Science Jurnal Pengabdian Farmasi dan Sains MPSJ
Sitti Amirah
Fakultas Farmasi Universitas Muslim Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus) Hendra Herman; Sitti Amirah; Triani Putri Ayu
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.585 KB) | DOI: 10.33096/jifa.v10i1.335

Abstract

Hepatoprotector is a liver protected-agent of hepatotoxic. This research was aimed to determine the hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus L.) and most effective dose as a hepatoprotector. The study using 20 male rats divided into 5 groups. Group I was given the Na-CMC 1%, group II was given a herbal supplement, and group III, IV, and V were given ethanol extract of the rhizome dringo (Acorus calamus L.) with a dose of 50 mg/100 mg, kgBB/kgBB, and 200 mg/kgBB orally for 7 days. At 5th day interval 2 hours after administering the test preparations were given a single dose of 2 g of paracetamol/kgBB in all groups except the Group I. Measurement of levels of SGPT is done before and after the treatment the animal test. From the results of a statistical analysis of Kruskal-Wallis’ test followed by Man-Whitney’s test that dringo Rhizome (Acorus calamus L.) ethanol extracts  has the effect of a hepatoprotector in rats. Extract 50 mg/kgBB dose has the same effect as statistically with herbal supplements’ group (˃ p 0.05).
UJI EFEK EPITELISASI EKSTRAK BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS Safriani Rahman; Rachmat Kosman; Sitti Amirah
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.792

Abstract

Wole woe is a native plant of Indonesia which is widely used by the people of Central Halmahera as a medicinal plant. Empirically this plant is widely used for wound treatment. This study aims to determine the effect of epithelialization of wole woe stem extract and determine the effective concentration and duration of wound healing in rats after administration of wole woe stem extract. This research was conducted experimentally in a laboratory using 25 rats which were divided into 5 groups consisting of 1 control group, 1 comparison group, and 3 treatment groups of wole woe stem extract. Wound induction was carried out using a 100 0C hot plate measuring 2x2 cm and affixed to the surface of the rat's back skin for 2 seconds. After a burn is formed, the extract is applied 2 times a day for 21 days. Observations on wound healing were carried out macroscopically and measuring the surface area of the wound. The results showed that the administration of wole woe bark extract influenced healing second-degree burns in rats. The results of statistical analysis showed that there was no difference between the comparison group and the extract test group (p>0.05). Based on the percent reduction in wound, the most effective concentration in wound healing was 5% (99.75%). Wound healing time in rats was 21 days.
AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERA TENGAH TERHADAP BAKTERI GRAM POSITIF Staphylococcus epidermidis DAN Staphylococcus aureus Fitriana Fitriana; Sitti Amirah; Safriani Rahman
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.793

Abstract

The wole woe plant is one of the plants empirically used by the Weda community in Central Halmahera district as a traditional medicine to treat various diseases such as breast cancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and gout. Therefore, a study was conducted on the antimicrobial activity of the ethanolic extract of wole woe stems against gram-positive bacteria S. epidermidis and S. aureus with the aim of determining the concentration that provides antimicrobial activity of the ethanolic extract of wole woe stems by using the agar diffusion method. The results obtained in the screening test gave activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained a MIC value of 1.6% for S. epidermidis bacteria and 0.8% for S. aureus bacteria, while the MBC value is 1.6% for both bacteria. The results of statistical tests on the diameter of the inhibition zone from the antimicrobial activity test against S. epidermidis and S. aureus, showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. In the ratio of the inhibitory ability of bacteria at a spesific concentration, the test results showed that S. epidermidis bacteria had different bacterial growth inhibition abilities with S. aureus bacteria. Based on the results obtained, the ethanol extract of wole woe stems has potential as an antimicrobial.
POTENSI ANTIBAKTERI EKSTRAK ETANOL BATANG WOLE WOE ASAL HALMAHERAH TENGAH TERHADAP BAKTERI Pseudomonas aeruginosa dan Bacillus subtilis MENGGUNAKAN METODE DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.904

Abstract

The wole woe plant empirically in the community in Central Halmaherah district is used to treat various diseases, such as breast anticancer, cysts, vaginal discharge, diabetes mellitus, wounds, dysentery, cholesterol, and uric acid, which is thought to have bioactive compounds, that is antibacterial compounds. Therefore, a study was conducted to determine the antibacterial potential of the ethanol extract of wole woe stems against Pseudomonas aeruginosa and Bacillus subtilis bacteria using the agar diffusion method. The results of the screening test showed activity at a concentration of 0.1% and the results of the minimum inhibitory concentration test (MIC) and the minimum killing concentration test (MBC) obtained 1.6% for Pseudomonas aeruginosa bacteria. For Bacillus subtilis bacteria, the MIC value is 0.2% and the MBC value is 3.2%. The statistical test results of the inhibition zone diameter data from the antibacterial activity test against Pseudomonas aeruginosa and Bacillus subtilis bacteria showed that there was a difference in the ability to inhibit bacterial growth between the positive control and the test concentration group of 2.5%, 5% and 10%. The results obtained from the ethanol extract of wole woe stems have potential as antibacterial.
AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL BATANG WOLE WOE TERHADAP MIKROBA PATOGEN MENGGUNAKAN DIFUSI AGAR Fitriana Fitriana; Sitti Amirah; Safriani Rahman; Sukmawati Sukmawati
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.967

Abstract

Infectious diseases can be caused by the entry of microorganisms such as bacteria, fungi, parasites, and viruses that can cause diseases in humans. One of the plants used empirically by the Weda community in Central Halmahera is the stem part of the wole woe plant. The aim of this study was to determine the antimicrobial activity of the ethanol extract of wole woe stems against pathogenic microbes such as Propionibacterium acnes, Escherichia coli, Salmonella thypi, Shigella dysentriae, Vibrio cholerae, and Candida albicans. This study used the agar diffusion method with various concentrations of 2.5%, 5%, and 10%, and positive controls for bacteria with chloramphenicol, positive controls for fungi with nystatin, and DMSO as a negative control. Based on the average diameter of the inhibition zone obtained, the test microbes were classified into the medium-strong category because they had an inhibition zone diameter ranging from 9 mm to 13 mm. The positive control for chloramphenicol for bacteria was classified into the very strong category because it had an inhibition zone diameter of >20 mm, while the positive control for nystatin for fungi was classified into the strong category because it had an inhibition zone diameter of >10 mm. Based on these tests, it can be concluded that the ethanol extract of wole woe stems has antimicrobial activity
AKTIVITAS ANTIINFLAMASII EKSTRAK ETANOL BATANG WOLE WOE PADA TIKUS DENGAN METODE RAT HIND PAW EDEMA Safriani Rahman; Sitti Amirah; Fitriana Fitriana; Bayu Putra
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.961

Abstract

Inflammation is the natural protective response of the body to tissue damage brought on by toxic chemicals, microbiological organisms, or physical trauma. The purpose of this investigation is to find out how active the ethanol extract of Wole woe stem is and how much of it is needed to get results. This anti-inflammatory study was conducted on 15 rats using the rat hind paw edema method. The rats were divided into 5 groups: group I served as a negative control (Na.CMC), group II served as a positive control (diclofenac sodium 0.9 mg/kgBW), groups III, IV, V received doses of Wole woe stem ethanol extract ranging from 100 mg/kgBW to 400 mg/kgBW, respectively. Oral administration was used for all the test materials, and after an hour, each test animal received a subplantar injection of 0.1 milliliters of 1% carrageenan solution. A plethysmometer was used to take readings every hour for a period of eight hours to get an accurate reading of the volume of the rat’s foot. The collected test results were subjected to statistical analysis, in which a one-way ANOVA and a post hoc LSD test were used. According to the findings of the research that was carried out, it was discovered that an ethanol extract of Wole woe stems possessed anti-inflammatory action, and the most effective dose was found to be 400 milligrams per kilogram of body weight (mg/kgBW).
PEMBUATAN COOKIES SEHAT UNTUK PENDERITA KOLESTEROL DI DESA PADDINGING KECAMATAN SANROBONE KABUPATEN TAKALAR Fitriana Fitriana; Safriani Rahman; Sitti Amirah; Ayyub Harly Nurung
Jurnal Mandala Pengabdian Masyarakat Vol. 4 No. 1 (2023): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v4i1.150

Abstract

Cookies merupakan makanan ringan yang rasanya enak dan renyah sehingga banyak dijadikan cemilan dan digemari masyarakat termasuk anak-anak, remaja, dan orang dewasa. Cookies sering dijadikan kudapan atau teman minum teh oleh masyarakat. Kandungan gula dan lemak yang tinggi menyebabkan cookies ini memiliki kalori yang tinggi. Selain itu, kandungan lemak dan gula tinggi dapat memicu obesitas jika sering di konsumsi. Tidak bisa dipungkiri bahwa kebiasaan makan camilan dengan kandungan kalori yang tinggi menjadi salah satu pemicu obesitas. Salah satu bahan yang berpotensi dan dapat digunakan sebagai bahan baku cookies adalah oat. Oat adalah biji-bijian yang bebas gluten dan merupakan sumber vitamin, mineral, serat, dan antioksidan. Kandungan antioksidannya dapat meningkatkan kolesterol baik di dalam tubuh dan dapat membantu menurunkan kolesterol total di dalam tubuh. Pada kegiatan pengabdian ini yang menjadi mitra adalah tim PKK di desa Paddinging, Kecamatan Sanrobone, Kabupaten Takalar. Desa ini merupakan salah satu desa mitra binaan Universitas Muslim Indonesia (UMI). Kegiatan pengabdian yang dilakukan untuk meningkatkan pengetahuan dan ketrampilan tentang pembuatan cookies sehat untuk penderita kolesterol dengan cara menjelaskan tentang cookies sehat dan pembuatan cookies yang menggunakan bahan utama yaitu oat. Hasil yang diperoleh dari kegiatan ini adalah meningkatnya pengetahuan dan ketrampilan dari tim PKK dapat dilihat dari pembuatan cookies yang dilakukan secara mandiri berdasarkan informasi yang diperoleh dari kegiatan pengbadian. Berdasarkan hal tersebut,  masyarakat di desa Paddinging, khususnya tim PKK telah mengetahui cara pembuatan cookies yang sehat untuk penderita kolesterol sebagai cemilan sehat.
POTENSI EKSTRAK ETANOL BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH SEBAGAI ANTIBAKTERI MENGGUNAKAN METODE KLT-BIOAUTOGRAFI Fitriana, Fitriana; Amirah, Sitti; Rahman, Safriani; Rusli, Rusli; Nurung, Ayyub Harly
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1066

Abstract

The development of natural materials both from plants and from other materials as traditional medicines can be done by taking habits from the community in utilizing natural materials empirically. The wole woe plant is one of the plants that comes from the forest and grows wildly and is empirically used as a traditional medicine by the Weda community in Central Halmahera Regency. This study aims to see the chromatogram of wole woe stem extract and the group of chemical components that have potential as antibacterial using KLT-Bioautography method. The results of the chromatogram of the ethanol extract of wole woe stem, obtained 6 spots and there are 2 spots with rf values of 0.65 and 0.09 which have activity against bacteria Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis and Pseudomonas aeruginosa. The results of the identification of chemical components using specific reagents, obtained chemical groups of anthraquinones, flavonoids, phenolics and alkaloids have potential as antibacterial, so that the ethanol extract of wole woe stem has potential as antibacterial.
PENGARUH PEMBERIAN EKSTRAK DAUN BIDARA (Zizipus mauritiana Lam.) TERHADAP FUNGSI HATI TIKUS DENGAN PARAMETER SGPT Amirah, Sitti; Rahman, Safriani; Fitriana, Fitriana; Wati, Aulia; Putra, Bayu; Rakhmat, Syahgita; Mustakim, Putri Dwiyanti Adha; Resvani, Syahyu; Hasbullah, Nurhijjah; Arini, Arini
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1127

Abstract

Repeated administration of traditional medicines can be potentially poisonous and damage vital organs such as the heart, lungs, liver and kidneys. Tests of safety need to be carried out. Bidara leaves are used traditionally used as antimicrobial, analgesic, antipyretic, anti-inflammatory, anti-diabetic. This study aims to determine safety of ethanol extract of bidara leaves on liver function. This research used wistar rats as test animals which were divided into 4 groups. Test animals were given ethanol extract of bidara leaves at a dose of 50 mg/kgBW, 500 mg/kgBW and 2000 mg/kgBW given orally for 14 days. SGPT rate checks are carried out before and after administering the extract. The results showed that giving ethanol extract of bidara leaves for 14 days did not have a significant effect on rat SGPT levels (p<0.05).
Molecular Identification of Endophytic Fungi Isolated from Bidara Root (Ziziphus mauritiana Lam.) Using Polymerase Chain Reaction (Pcr) Jamaluddin, Siti Nurlillah; Fitriana, Fitriana; Amirah, Sitti
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.994

Abstract

The roots of the bidara plant have the potential as antibacterial agents. The antibacterial compounds in the roots of the bidara plant originate from secondary metabolites produced by endophytic compounds known as endophytic fungi. The purpose of this research is to identify the types of endophytic fungi in bidara roots. The identification of microorganisms can be done through morphology or molecular methods. However, morphological identification alone is unable to depict the morphospecies to the phylogenetic level of a microorganism, thus molecular identification using the Polymerase Chain Reaction (PCR) method is required. This study utilized root isolates from the bidara plant with the sample code IFAZ-6, which, after sequencing, yielded a pair of base pairs measuring 558bp. The results of BLAST and phylogenetic analysis revealed that the IFAZ-6 isolate has a close relationship with the species Clonostachys rosea., which has been recorded in the database with a 100% identity level.
Co-Authors A Hasrawati Adimi, Nurhikma Adriansyah, Muhammad Alani, Fitri Wasto Anak Agung Istri Sri Wiadnyani Andi Evi Wulandari Luspi Andi Maulana Kamri Andi Sulfika Annisa, Khusnul Arini Arini As’ad, Nur Asyirah Aulia Wati, Aulia Ayyub Harly Nurung Bayu Putra Bayu Putra Bayu Putra, Bayu Charawati, Nurul Mega Dita Pratiwi Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Franita Achmad Hasbullah, Nurhijjah Hendra Herman Heriyanto Beddu Hi Amin, Rahmatia S Irma Andriani Irma Santi Jamaluddin, Siti Nurlillah Janna, Nur Jihadi, Athira Kamri, Andi Khaedhir Mirawati Mirawati Mustakim, Putri Dwiyanti Adha NUR FADILAH Nurdayani, Sitti Nurung, Ayyub Harly Polopadang, Arion Whaizer R. Rusli Rachmat Kosman Rachmat Kosman, Rachmat Rahman, Safriana Rahmatia S Hi Amin Rakhmat, Syahgita Resvani, Syahyu Riany Novianti Y., Riany Rusli SAFITRI, INDAH DIAN Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman, Safriani Sari, Andini Indah Permata Siska Nuryanti, Siska Triani Putri Ayu Zulkarnain MB, Iskandar