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All Journal bionature Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Jurnal Ilmiah Farmako Bahari Jurnal Mandala Pengabdian Masyarakat Kieraha Medical Journal Abdimas Indonesian Journal Journal Microbiology Science Jurnal Pengabdian Farmasi dan Sains MPSJ
Sitti Amirah
Fakultas Farmasi Universitas Muslim Indonesia
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Potential of Endophyctic Fungi Isolates IFAZ-6 from Bidara Root (Ziziphus mauritiana Lam.) as Antibacterials Againts Digestive Tract Infection janna, Nur; Fitriana, Fitriana; Amirah, Sitti
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.995

Abstract

Bidara root (Ziziphus mauritiana Lam.) has activity as an antibacterial against digestive tract infections. This study aims to determine the antibacterial activity of isolate IFAZ-6 endophytic fungi of bidara root against bacteria that cause digestive tract infections using the TLC-Bioautography method. Purification was conducted on the active isolate IFAZ-6 to obtain a pure endophytic fungi isolate. Subsequently, macroscopic and microscopic observations were carried out. Then, fermentation was performed in MYB (Maltose Yeast Broth) medium for 21 days. Screening and evaporation were conducted to produce an extract. The obtained extract was subjected to TLC analysis using a chloroform: methanol eluent (7:1). The TLC-Bioautography test was conducted against Escherichia coli, Salmonella typhi, Shigella dysentriae, and Vibrio cholerae bacteria. The TLC identification results showed one spot with an Rf value of 0.80 for the IFAZ-6 isolate. The chromatogram profile obtained from the TLC-Bioautography method for the IFAZ-6 isolate demonstrated antibacterial activity against bacteria that cause digestive tract infections.
Antibacterial Activity of Endophytic Fungi Isolated from Bidara Roots (Ziziphus mauritiana Lam.) Against Bacteria That Cause Skin Infections Using TLC-Bioutography Sari, Andini Indah Permata; Fitriana, Fitriana; Amirah, Sitti
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.996

Abstract

One common disease found in tropical countries is skin infection. Inappropriate use of antibiotics to treat skin infections can lead to bacterial resistance, making it necessary to explore the source of bioactive compounds in natural materials. The Bidara plant (Ziziphus mauritiana Lam.) is known to have antibacterial properties. This research aimed to determine the antibacterial activity of endophytic fungal isolated from the parts of the Bidara plant against bacteria that cause skin infections using the TLC-Bioautography method. In this research, the isolate with the code IFAZ-6 was purified to obtain a pure endophytic fungal isolate, and macroscopic and microscopic examinations were conducted on that isolate. The obtained isolate was fermented for 21 days at room temperature using MYB (Maltose Yeast Broth) medium. The fermentation products were extracted using ethyl acetate (1:1). The obtained extract was further tested using TLC with a chloroform: methanol eluent (7:1). The TLC-Bioautography results showed Rf values of 0.81 and 0.58 indicating antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Propionibacterium acnes bacteria. The identification of chemical components in the endophytic fungal isolate from the Bidara plant confirmed the presence of flavonoids, alkaloids, and anthraquinones. The extract from the endophytic fungal isolate with the code IFAZ-6 indicated antibacterial activity.
Antibacterial Activity of Endophytic Fungi from Bidara Roots Against Bacteria that Cause Skin Infections Nurdayani, Sitti; Fitriana, Fitriana; Amirah, Sitti
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.1001

Abstract

Endophytic fungi are fungi that grow and colonize plant tissues and are capable of producing bioactive compounds similar to those produced by their host. This study aims to determine the concentration of endophytic fungal isolates from Bidara roots (Ziziphus mauritiana Lam) that have antibacterial activity against bacteria that cause skin infections using the agar diffusion method. The research method begins with the rejuvenation of IFAZ-6 isolates, and microscopic and macroscopic observations are carried out. The isolates were fermented using Maltose Yeast Broth medium at 200 rpm for 21 days. The fermentate was extracted with an ethyl acetate solvent to obtain a thick extract. The tests carried out were minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and antibacterial activity tests carried out using the agar diffusion method. The results of the antibacterial activity test showed that the IFAZ-6 isolate extract at a concentration of 800 ppm showed antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Propionibacterium acnes. The statistical analysis results showed that the extract of isolate IFAZ-6 against Staphylococcus aureus and Staphylococcus epidermidis at concentrations of 800-1600 ppm and 1600–3200 ppm exhibited the same antibacterial activity. The bacterium Pseudomonas aeruginosa showed the same antibacterial activity at all tested concentrations, and the bacterium Propionibacterium acnes at concentrations of 1600–3200 ppm also exhibited the same antibacterial activity.
Optimization Time for Antibacterial Production of Endophytic Fungi Isolated from Bidara Root (Ziziphus mauritiana Lam.) Annisa, Khusnul; Fitriana, Fitriana; Amirah, Sitti
Journal Microbiology Science Vol 4, No 1 (2024)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v4i1.997

Abstract

Research on optimization time for antibacterial production of endophytic fungal isolated from bidara root (Ziziphus mauritiana Lam.) has been conducted, with the aim of determining the optimum production time for antibacterial compounds. Endophytic fungi are a group of fungi that live within plant tissues without causing harm to their host plants. In this research, the roots of bidara were isolated and purified using PDA media, isolates were followed by screening endophytic fungi isolates against test bacteria. The results of the endophytic fungal isolation from the bidara roots yielded 10 endophytic fungal isolates. The screening test against the test bacteria showed the largest inhibitory zone for IFAZ-6. Subsequently, the growth curve of these isolates was determined through fermentation using MYB media using a shaker speed of 200 rpm at a temperature of 25-28°C for 27 days. Then, mycelia and supernatant were collected on days 11, 13, 15, 17, 19, 21, 23, 25, and 27 with a 48-hour interval. The mycelia were weighed until a constant weight was obtained, while the supernatant was used to test the activity against the test bacteria using MHA media. The growth curve results indicated a stationary phase on day 21. The antibacterial activity test showed that Isolate IFAZ-6 reached optimum activity on day 27 with an inhibitory zone of 12.33 mm against Salmonella thypi.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana Lam.) TERHADAP BAKTERI Salmonella typhi Fitriana, Fitriana; Amirah, Sitti; Rahman, Safriani; Fadilah, Nur; Jihadi, Athira; Polopadang, Arion Whaizer
Kieraha Medical Journal Vol 6, No 2 (2024): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v6i2.8650

Abstract

Daun bidara (Ziziphus mauritiana Lam.) merupakan tanaman yang bermanfaat dalam pengobatan penyakit infeksi pencernaan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) terhadap bakteri Salmonella typhi dengan metode difusi agar. Penelitian ini diawali dengan uji skrining menggunakan konsentrasi 0,1%, 0,5%, dan 1% kemudian dilanjutkan dengan uji Konsentrasi Hambat Minimum (KHM) dan uji Konsentrasi Bunuh Minimum (KBM) dengan konsentrasi 0,05 %, 1%, 2%, 4%, 6%, 8% dan 16% terhadap bakteri Salmonella thypi dan dilanjutkan uji aktivitas antibakteri dengan menggunakan metode difusi agar. Hasil uji skrining aktivitas antibakteri ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) memberikan aktivitas antibakteri terhadap Salmonella thypi pada konsentrasi 1%. Hasil uji KHM diperoleh pada konsentrasi 1% terhadap bakteri Salmonella thypi, sedangkan nilai KBM pada konsentrasi 0,05%. Hasil uji aktivitas antibakteri dengan metode difusi agar menggunakan konsentrasi 2,5%, 5%, dan 10% diperoleh diameter terbesar dalam menghambat bakteri pada konsentrasi 10%. Hasil uji statistik menunjukkan bahwa semua konsentrasi ekstrak memiliki kemampuan yang sama dalam menghambat pertumbuhan mikroba (p0,05). Kesimpulan yang didapatkan adalah ekstrak etanol daun bidara (Ziziphus mauritiana Lam.) memiliki aktivitas antibakteri terhadap bakteri Salmonella typhi.
Development of Mie-Diabet as a Healthy Food Option For Millennials in Maros Regency Pentol.in Maulana, Andi; Amirah, Sitti; Mirawati, Mirawati; As’ad, Nur Asyirah; Adimi, Nurhikma; Kamri, Andi Khaedhir
Abdimas Indonesian Journal Vol. 4 No. 2 (2024)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.v4i2.544

Abstract

Mie-Diabet is a culinary concept that emphasises the utilisation of balanced and nutritious ingredients to produce noodles that can improve health and quality of life. In contemporary society, a balanced and nutritious diet is essential for sustaining physical health, particularly for the younger population that favours inexpensive food options. Mie-Diabet enhances quality of life by supplying essential nourishment and mitigating the risk of sugar-related ailments. Mie-Diabet embodies the principle of nutritious cuisine that can be appreciated by individuals of all ages, serving as an accompaniment to various dishes, including meatballs, which are particularly favoured by the Indonesian populace. Pento.in is an UMKM in Maros Regency that has popularity among the young and is a favoured snack among the populace. Pento.in has been operational for nearly a year but has not yet obtained a PIRT permission. Consequently, the UMI professor team identifies a chance to present Mie-Diabet to the Maros community through partnership with Pento.in, while simultaneously promoting UMKMs to secure PIRT and Halal certification in the future. Furthermore, Mie-Diabet will assist in preserving physical condition by substituting high-sugar meals, such as other harmful instant noodles. The education delivered has demonstrated efficacy in enhancing the UMKM community's comprehension of the Mie-Diabet product. The substantial rise in average scores post-education clearly indicates that the observed difference is statistically significant and not attributable to chance. These instructional initiatives can significantly aid UMKMs in comprehending and integrating innovative items that enhance public health.
UJI TOKSISITAS SUB KRONIK EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritana L) TERHADAP GINJAL TIKUS Amirah, Sitti; Rahman, Safriani; Fitriana, Fitriana; Rakhmat, Syahgita; Mustakim, Putri Dwiyanti Adha
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.3491

Abstract

Pemberian obat tradisional secara berulang dapat berpotensi toksik dan merusak organ-organ vital seperti jantung, paru-paru, hati, dan ginjal. Daun bidara digunakan secara tradisional oleh masyarakat sebagai antimikroba, analgesik, antipiretik, antiinflamasi, antidiabetes. Penelitian ini bertujuan untuk mengetahui tingkat keamanan ekstrak etanol daun bidara terhadap ginjal tikus. Penelitian menggunakan tikus wistar yang terdiri atas 4 kelompok. Kelompok 1 diberi NaCMC sebagai kontrol, kelompok 2, 3 dan 4 diberikan masing-masing ekstrak etanol daun bidara dosis 50 mg/kgBB, 500 mg/kgBB dan 2000 mg/kgBB secara oral sekali sehari selama 14 hari. Pengukuran kadar kreatinin dilakukan sebelum dan setelah pemberian ekstrak kemudian dilakukan analisa statistik untuk mengetahui adanya perbedaan pada tiap kelompok uji. Setelah itu, dilakukan pembedahan untuk pemeriksaan histopatologi ginjal. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun bidara selama 14 hari tidak memberikan pengaruh nyata terhadap kadar kreatinin tikus (p<0,05). Hasil pemeriksaan histopatologi memperlihatkan adanya kerusakan seperti peradangan, degenerasi, kongesti dan nekrosis yang berbeda pada masing-masing kelompok dengan kerusakan terbesar pada dosis 2000 mg/kgBB. Pemberian berulang ekstrak etanol daun bidara secara oral tidak memberikan pengaruh yang signifikan terhadap kadar kreatinin tikus tetapi secara histopatologi menunjukkan adanya beberapa kerusakan terutama pada dosis 2000 mg/kgBB.
UJI WAKTU KOAGULASI DARAH SECARA IN VITRO DARI SEDIAN MINYAK AYAM (Gallus domesticus) Amirah, Sitti; Zulkarnain MB, Iskandar; Adriansyah, Muhammad
Kieraha Medical Journal Vol 7, No 1 (2025): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v7i1.9582

Abstract

Minyak ayam (Gallus domesticus) memiliki . Asam linolenat (omega-3) dan asam oleat (omega-9) yang berperan dalam proses penyembuhan luka, penelitian ini bertujuan melakukan uji aktivitas minyak ayam (Gallus Domesticus) sebagai koagulan secara in vitro, pengamatan koagulasi dilihat secara visual darah darah diambil dari 4 relawan dibagi menjadi 7 kelompok: kelompok kontro negatif (darah saja), kelompok positif (asam traneksamat), setiap kelompok diisi darah 1ml setiap tabung, setiap 10 detik tabung dimiringkan untuk dilakukan pengamatan secara visual terjadinya koagulasi. Hasil penelitian ini menunjukan bahwa minyak ayam (Gallus domesticus) memiliki efek koagulasi pada konsentrasi 50 µL dan 75 µL dengan waktu 2,03 dan 3,10 menit            
Pemberdayaan Kelompok PKK Desa Pitusunggu Kecamatan Ma’rang Kabupaten Pangkep Dalam Pemanfaatan Tepung Pisang Kepok Untuk pembuatan Cookies Sehat Rendah Kalori Sitti Amirah; Fitriana, Fitriana; Asmaliani, Ira; Rahman, Safriani
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 1 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i1.517

Abstract

Pisang merupakan salah satu buah yang banyak dikonsumsi oleh semua kalangan masyarakat. Selama ini konsumsi dan pengolahan pisang terbatas pada pengolahan pisang yang matang. Permasalahan yang muncul adalah pisang segar matang setelah dipanen cepat rusak sehingga akan mengurangi kualitas mutu pisang. Salah satu upaya yang ditawarkan adalah inovasi pengolahan pisang menjadi produk olahan setengah jadi dalam bentuk tepung. Tepung pisang mengandung pati dan memiliki kandungan gizi berupa karbohidrat, lemak, protein, vitamin B dan mineral seperti kalium, klor, natrium, magnesiuam dan fosfor. Kandungan serat dan gizi yang tinggi menjadikan tepung pisang dapat digunakan sebagai bahan baku dalam pembuatan cemilan sehat seperti cookies. Mitra pada kegiatan ini adalah tim PKK di Desa Pitusunggu, Kecamatan Ma`rang, Kabupaten Pangkep. Kegiatan ini bertujuan untuk meningkatkan pengetahuan masyarakat mengenai inovasi tepung pisang dan pemnfaatannya serta meningkatkan keterampilan ibu-ibu PKK dalam mengolah tepung pisang kepok menjadi cookies yang sehat dan rendah kalori. Melalui kegiatan ini, tim pengabdi memperkenalkan inovasi pengolahan pisang menjadi tepung yang bisa digunakan sebagai salah satu bahan dasar dalam pembuatan berbagai macam kudapan yang bernilai gizi tinggi. Pada pelaksanaanya, dilakukan pengisian kuisioner sebelum dan setelah kegiatan untuk mengetahui tingkat pemahaman peserta. Hasil dari kegiatan ini menunjukkan adanya peningkatan pemahaman peserta sebelum dan setelah kegiatan  berlangsung sebesar 12,05%. Hasil penilaian produk yang dilakukan pada akhir kegiatan menunjukkan bahwa cookies sehat yang dihasilkan 100% peserta menyatakan bahwa rasanya enak dan layak untuk diproduksi.
Aktivitas Ekstrak Daun Salam (Syzygium polyanthum) sebagai Antirheumatoid Artritis pada Tikus yang Diinduksi Complete Freund’s Adjuvants (CFA): Antirheumatoid Arthritis Activity of Salam (Syzygium polyanthum) Leaf Extract to Mice Induced by Complete Freund’s Adjuvants (CFA) Amirah, Sitti; Wati, Aulia; Putra, Bayu; Alani, Fitri Wasto
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.259 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14581

Abstract

Rheumatoid arthritis is an chronic autoimmune disease, which is characterized by inflammation and degradation of the joints and cartilages. Rheumatoid therapy is currently using immunosuppressant drugs, nonsteroidal anti-inflammatory drugs and corticosteroids. Treatment of chronic rheumatoid can trigger side effects. Syzygium polyanthum leaves contain alkaloid compounds, flavonoids, saponins, tannins and essential oils consist of citral and eugenol which are thought to be potential as antirheumatoid. This study aims to determine the effect antirheumatoid arthritis and effective dose of ethanol extracts of Syzygium polyanthum leaf. This study used 15 male rats. Treatment started by measuring foot volume using a pletismometer and then inducting CFA intraplantary as much as 0,1 mL on day 1 and left until day 16th. On the day 17th a foot volume and arthritis index was measured and then treated until the day 30th. The animals were divided into 5 groups: negative control (Na. CMC 1%), positive control (methylprednisolone dose 1.646 mg / kg BW), ethanol extractof Syzygium polyanthum leaf at a dose of 75 mg / kg, 150 mg / kg and 300 mg / kg. On the day 31st, foot volume and arthritis index measurements were taken again. The results showed a decrease in foot volume and arthritis index after given of the extract. Foot volume difference data were analyzed using the One Way Anova test followed by the Post Hoc LSD test. The difference between the arthritis index data was analyzed using Kruskal-Wallis followed by the Mann-Whitney test. Statistical results show that positive control has the same effect as extract (P> 0.05). Based on the results of statistical analysis of inflammation of the foot volume and the arthritis index shows that the ethanol extract of Syzygium polyanthum leaf had an effect as an antirheumatoid arthritis
Co-Authors A Hasrawati Adimi, Nurhikma Adriansyah, Muhammad Alani, Fitri Wasto Anak Agung Istri Sri Wiadnyani Andi Evi Wulandari Luspi Andi Maulana Kamri Andi Sulfika Annisa, Khusnul Arini Arini As’ad, Nur Asyirah Aulia Wati, Aulia Ayyub Harly Nurung Bayu Putra Bayu Putra Bayu Putra, Bayu Charawati, Nurul Mega Dita Pratiwi Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Fitriana Franita Achmad Hasbullah, Nurhijjah Hendra Herman Heriyanto Beddu Hi Amin, Rahmatia S Irma Andriani Irma Santi Jamaluddin, Siti Nurlillah Janna, Nur Jihadi, Athira Kamri, Andi Khaedhir Mirawati Mirawati Mustakim, Putri Dwiyanti Adha NUR FADILAH Nurdayani, Sitti Nurung, Ayyub Harly Polopadang, Arion Whaizer R. Rusli Rachmat Kosman Rachmat Kosman, Rachmat Rahman, Safriana Rahmatia S Hi Amin Rakhmat, Syahgita Resvani, Syahyu Riany Novianti Y., Riany Rusli SAFITRI, INDAH DIAN Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman Safriani Rahman, Safriani Sari, Andini Indah Permata Siska Nuryanti, Siska Triani Putri Ayu Zulkarnain MB, Iskandar