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All Journal HAYATI Journal of Biosciences Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Obat Tradisional Indonesian Journal of Cardiology Jurnal Kesehatan Islam : Islamic Health Journal JFIOnline Biomolecular and Health Science Journal Medica Arteriana (Med-Art) CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Jurnal Pengabdian Masyarakat Medika
Meddy Setiawan
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Extract of Purple Sweet Potato Against Heat-Shock Protein 70 Expression in White Male Rat of Atherosclerosis Model Meddy Setiawan; Fitriana Yulanda
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66254

Abstract

Shock protein 70 (Hsp-70) molecule is pro-inflammatory mediator cytokine that trigger atherosclerosis. The purple sweet potato has many natural antioxidants such as flavonoids (anthocyanins) and is valuable for reducing Hsp-70 expression due to its antioxidant content.This study aims to determine the effect of purple sweet potato (Ipoema batatas L.) extract in reducing the Hsp-70 levels in the white male rat atherosclerosis model.This study was a posttest-only control group design with normality, homogeneity, ANOVA, post hoc test, correlation, and regression tests. There were five groups in this study. Groups 1 (negative control) and 2 (positive control) were given 2 ml/day of high-cholesterol diet for eight weeks, and the other three groups were given purple sweet potato extract at 24, 48, and 96 mg/kg doses weight per day for eight weeks. Results: The purple sweet potato extract affected the Hsp-70 levels in Wistar strain rats (p < 0.05). There was a significant difference in the Hsp-70 level between the positive control group and the group with purple sweet potato extract. The highest Hsp-70 level reduction was seen in the group with a 96 mg/day dose of purple sweet potato extract. In conclusion, theadministration of purple sweet potato extract (I. batatas L.) reduced the Hsp-70 levels. The dose of 96 mg/kg BW/day had the highest effect on decreasing Hsp-70 levels in the male rat atherosclerosis model.
Pengaruh Ekstrak Kulit Manggis (Garcinia Mangostana Linn) Sebagai Antioksidan Terhadap Tikus Model Aterosklerotik Muhammad Dicky Hafisalevi; Meddy Setiawan; Djanggan Sargowo
Jurnal Kardiologi Indonesia Vol. 33, No. 2 April - Juni 2012
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v33i2.55

Abstract

Backgrounds: Atherosclerosis defined by accumulation of Low density Lipoprotein (LDL) and inflammatory cells in tunica intima triggered by oxi-dative stress. Oxidative stress increase the level of Malondialdehid(MDA) which its activity inhibited by superokside dismutase (SOD) as endogenous antioxidant. Extract from pericaps of mangosteen has antioxidants activity that can inhibit the release of free radicals through reactive oxygen species (ROS) are characterized by increased levels of SOD and decrease levels of MDA rats serum. Objectives: aim of this research is to evaluate effect of extract from pericarp of mangosteen (Garcianna mangostana Linn) as antioxidants in rats models of atherosclerosis.Methods: The subjects of the research were 30 white rats (Rattus novergi-cus Strain wistar), divided into 5 groups (negative control, positive control, administration of extract  from pericarp of mangosteen 200, 400, and 800 mg/kg, p.o for 90 days) exploying True Experimental with The Post Test Only Control Group Design.The parameters used in this study is the SOD and MBA are read using spectrophotometry and analyzed by test of ANOVA, BNT1% test, using correlation and regression test.Results and discussion: Based on the statistic analysis, the value of MDA is MDA (r= -0,809; Sig = 0,000 < 0,01 and 2=0,655) and SOD(r = 0,565; Sig= 0,000 < 0,01 and 2=0,391). Whereas oral administration (800 mg/kg) dose of extract from pericap of mangosteen has a good result by increasing the level of SOD and decreasing the level of MDA.Conclusion: This research suggests that extract from pericarp of mangosteen may be potent antioxidant.
The Potential Effect Of Sweet Potato (Ipomoea batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus norvegicus) Meddy Setiawan; Dzikrulloh Abdi; S Khanza Zatalini; Kevin Muliawan Soetanto
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31689

Abstract

Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL. Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day. Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels. Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.
Pengaruh Ekstrak Buah Labu Siam (Sechium edule) terhadap Ketebalan Dinding Aorta Tikus Putih (Rattus norvegicus strain wistar) Model Aterosklerosis Desy Andari; Aulia Wiraldi Putra; Meddy Setiawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol 11, No 1 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i1.16079

Abstract

Background: Atheroslerosis is a disease that formed due to cumulation of the fibrous tissues in vascular wall and gradually become thrombus. Chayote contains antioxidants such flavonoid, saponin, and ascorbic acid that could prevent the thickening of the vascular wall. Objective: To determine the effect of chayote extract on aortic vascular wall thickness in white rats with atherosclerosis model. Methods: True experimental with post-test only controlled group design. Sixteen white male rats divided into 4 groups: positive control group and 3 treatment groups that given chayote extract at different doses (20 mg/day, 40 mg/day, 80 mg/day). The H&E stained aortic preparate were observed with 400x magnification used optical microscope and vascular thickness were measured with optilab software. Data analized with one way ANOVA, post hoc, pearson and linear regression test. Result: There was significant effect of chayote extract to the aortic arch vascular wall thickness (ANOVA p=0,001) and the dose that started giving effect was 40 mg/day (Post Hoc test). There was very strong, significant, and reciprocally correlation between chayote extract and aortic wall thickness (R=-0,896). Chayote extract affected aortic wall thickness with the value of 80,4%. Conclusion: Chayote extract could prevent the thickening of aortic wall in atherosclerotic rats.
Pengaruh Ekstrak Ubi Jalar Ungu (Ipomoea Batatas L.) Terhadap Kadar Superoksida Dismutase (Sod) Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar Model Aterosklerosis Meddy Setiawan; E F Rahadi
Medica Arteriana (Med-Art) Vol 1, No 2 (2019): Desember 2019
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.529 KB) | DOI: 10.26714/medart.1.2.2019.15-20

Abstract

Latar Belakang: Penyakit jantung koroner (PJK) merupakan penyakit jantung yang terutama disebabkan karena penyempitan arteri koronaria akibat proses aterosklerosis. Faktor yang berpengaruh terhadap pembentukan plak aterosklerosis  adalah radikal bebas. Ekstrak ubi jalar ungu memliki kandungan antosianin, beta glukan dan assam askorbat  sebagai antioksidan, diharapkan dapat menghambat radikal bebas sehingga plak aterosklerosis tidak terbentuk. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak ubi jalar ungu (Ipomoea batatas L.) terhadap kadar superoksida dismutase SOD tikus jantan putih (Rattus norvegicus) galur wistar model aterosklerosis.Metode: Metode yang digunakan dalam penelitian ini true experimental, post-test only control group design dengan kelompok kontrol negatif, kontrol positif, serta 3 kelompok perlakuan ekstrak ubi jalar ungu yaitu dosis 24mg/hari, 48mg/hari, 96mg/hari.Hasil: Hasil uji one way anova adalah p=0,001 (p<0,05), yakni terdapat perbedaan signifikan. Hasil uji post-hoc didapatkan konotasi berbeda antar kelompok. Hasil uji korelasi terdapat hubungan yang kuat yaitu p=0,000 (p<0,05). Pada uji regresi linier didapatkan R2=0.65. Berdasarkan hasil uji yang dilakukan menunjukkan semakin tinggi dosis ekstrak yang diberikan, semakin tinggi kadar SOD.Kesimpulan: Terdapat pengaruh antara pemberian ekstrak ubi jalar ungu (Ipoema batatas L.) terhadap peningkatan kadar superoksida dismutase (SOD) tikus jantan putih (Rattus norvegicus) galur wistar model aterosklerosis.
Analisis Faktor Stress, Keteraturan Pola Makan dan Konsumsi Bahan Pangan Iritatif Terhadap Kejadian Dyspepsia A. Dedi Rusmanto; Fara Nindya Maharani; Meddy Setiawan; Annisa Nurul Arofah
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 2 (2022): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i2.99

Abstract

Stress, regular diet, and consumption of irritating food are some of the risk factors for dyspepsia. Medical students at the first level undergo a fairly high density of activities, where this requires an adaptation process that can cause stress. In stressful conditions, the regularity of eating patterns is disrupted. There are also many incidents of students consuming irritating foodstuffs.Aims of researchto analyze stress factors, regularity of eating patterns and consumption of irritating foodstuffs onthe incidence of dyspepsia in first-year medical faculty students.This research is an analytic observational study with a cross sectional study approach. The research activity was carried out at UMM Medical Faculty in November 2019 involving 60 students of the 2019 class. The sampling technique used was simple random sampling. The data analysis was carried out by the ichi-square test which was then carried out by the logistic regression test.This research shown76.7% of students suffer from dyspepsia, 65%experience stress, 61.7% have irregular eating patterns and 40% of students consume irritating foodstuffs. Stress and regularity in eating patterns affected the incidence of dyspepsia (p=0.022 and p=0.006), while irritative foods had no effect on dyspepsia (p=0.998).Stress and regularity of eating patterns affect the incidence of dyspepsia.
Tatalaksana Komprehensif Gangguan Ginjal pada Pekerja Industri Gula Badrul Munir; Meddy Setiawan; Febri Endra Budi Setyawan; Feny Tunjungsari
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 2 (2022): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i2.108

Abstract

Sugarcane workers have a higher risk of being exposed to pesticides where pesticides have high toxicity. One of the most common diseases is kidney disorders, including acute kidney injury and chronic kidney disease of unknown disease or known as mesoamerican nephropathy. This study is a literature review to determine the comprehensive management of kidney disorders in sugar industry workers. A comprehensive review was conducted by searching for national and international journals in the last 6 years which were identified according to the topic. Kidney disease in sugarcane workers can take the form of acute kidney injury in the acute phase and become chronic if the risk factors cannot be overcome. Risk factors for kidney disease in sugarcane workers are dehydration, pesticides, heat stress, strenuous physical activity, exposure to sugarcane burning smoke. Preventive steps that can be taken include providing good fluid intake, providing good rest areas, setting working hours, modifying special backpacks for water bottles, procuring appropriate personal protective equipment and using bagasse to reduce cadmium ions in pesticides. If kidney disease has occurred, monitoring and treatment is carried out according to the level of the disease so that it does not get worse. Sugar industry workers have various risks for the occurrence of kidney disease. Management that includes promotive, preventive, curative and rehabilitative can be done to provide comprehensive services for kidney disorders in sugarcane workers.
Profile of Drug-Resistant Tuberculosis Patients at the Haji Regional Hospital, East Java Province in 2019-2022 Setiawan, Meddy; Surianata, Raditya Widya; Yustikasari, Yolla Gitamaya; Permana, Ridho A'bid; Hakiki, Nurani; Ornadi, Annisa Brilian
Saintika Medika Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.33708

Abstract

Objective: To determine the profile of TB cases that are resistant to antibiotics and the resistance pattern of Mycobacterium tuberculosis in patients at Haji Regional Hospital, East Java Province  Method: The type of research is descriptive-retrospective based on primary data from patient medical records and laboratories in the 2019-2022 period  Results: The results show that the incidence of drug resistance based on the most OAT in Tuberculosis Drug Resistant Patients at the Haji Hospital of East Java Province in 2019-2022 is a combination of R+H as many as 69 patients (46%) and the origin of the most infection is relapse / recurrence of 73 patients (48.7%)  Conclusion: According to the characteristics, the majority of drug-resistant tuberculosis patients at Haji Hospital in East Java Province from 2019-2022 were male patients aged 19-59 years. According to the resistance pattern of M. tuberculosis bacteria, the most common type of drug resistance was MDR-TB (Multi-Drug Resistant Tuberculosis), and the most previous TB history was relapsed patients.   
Hubungan Kesadaran Diri (Self Awareness) Pasien Terhadap Kualitas Hidup Pada Pasien Penyakit Ginjal Kronis Yang Menjalani Hemodialisis Di RSUD Mardi Waluyo Kota Blitar fila, fila; Setiawan, Meddy; Hasanah, Annisa’
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 2 (2024): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v5i2.237

Abstract

PGK (Penyakit Ginjal Kronis) merupakan urutan penyakit katastropik keempat di Indonesia. Salah satu terapi yang sering digunakan pada PGK stadium akhir adalah terapi hemodialisis. Terapi hemdodialisis dilakukan oleh pasien secara berkelanjutan, sehingga bisa memicu timbulnya rasa bosan. Di samping itu, pasien PGK bisa memiliki gangguan hormon kortisol. Oleh karena itu, mereka membutuhkan kesadaran diri (Self awareness) untuk menjaga kesehatannya dan senantiasa menjadi seseorang yang berarti di kehidupannya. Seseorang yang memiliki dampak positif bagi lingkungan sekitarnya tentunya akan memiliki kualitas hidup yang lebih baik. Dokter dan perawat hanya bisa memantau kondisi pasien saat memberikan proses terapi dan mengevaluasi berdasarkan hasil laboratorium seperti ureum dan kreatinin. Saat di rumah, mereka sendirilah yang memutuskan untuk memantau dan menjaga kondisi kesehatannya. Mengetahui hubungan kesadaran diri (self awareness) terhadap kualitas hidup pada pasien penyakit ginjal kronis yang menjalani hemodialisis di RSUD Mardi Waluyo Kota Blitar. Desain penelitian ini menggunakan metode penelitian observasional analitik dengan pendekatan cross sectional. Alat pengambilan data pada penelitian ini yaitu lembar kuesioner. Pengamatan dilakukan secara langsung dan membagikan kuesioner kepada para pasien hemodialisis di RSUD Mardi Waluyo Kota Blitar sebagai responden. Analisis data dilakukan menggunakan uji SEM-PLS. Uji SEM-PLS menunjukkan hasil 2,815 yang berarti terdapat hubungan antara kesadaran diri (self awareness) pasien terhadap kualitas hidup pada pasien penyakit ginjal kronis yang menjalani hemodialisis di RSUD Mardi Waluyo Kota Blitar. Terdapat hubungan antara kesadaran diri (self awareness) pasien terhadap kualitas hidup pada pasien penyakit ginjal kronis yang menjalani hemodialisis di RSUD Mardi Waluyo Kota Blitar
Evaluation of the 90-Day Administration of Cyperus rotundus Tubers on Nrf2, SOD, and MDA Profiles by Flow Cytometry Setiawan, Meddy; Lestari, Noviana Dwi; Agustini, Sulistyo Mulyo
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.1025-1032

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2), superoxide dismutase (SOD), and malondialdehyde (MDA) are components involved in the antioxidant system and the body's response to oxidative stress. The bioactive compounds of Cyperus rotundus tuber (CRT) have pharmacological effects as antioxidants and anti-inflammatory. This study aimed to evaluate the impact of CRT administration for 90 days on the profiles of Nrf2, SOD, and MDA. 24 male Wistar rats were used in this study and divided into 4 treatment groups: Control, dose 1 (300 mg/kg BW), dose 2 (600 mg/kg BW), and dose 3 (900 mg/kg BW). Oral administration of CRT was carried out for 90 days. On day 91, liver isolation was performed to determine the profiles of Nrf2, SOD, and MDA using Flow Cytometry. Statistical analysis using One-Way ANOVA with P<0.05 was conducted using SPSS. The administration of CRT to Wistar rats for 90 days did not induce toxic or harmful effects. The Nrf2 and MDA profiles did not show excessive activation with CRT administration. The SOD profile increased with D1 administration compared to the control and other doses. The administration of CRT for 90 days has the potential to be used as a natural alternative to address diseases related to oxidative stress.
Co-Authors A. Dedi Rusmanto Aleq Sander, Moch Anisa Hasanah Annisa Nurul Arofah Aulia Wiraldi Putra Aziza, Nurita Badrul Munir Clara Yosinta Djoka, Madona Desy Andari Dian Yuliarta Djanggan Sargowo Dzikrulloh Abdi E F Rahadi Fara Nindya Maharani Febri Endra Budi Setyawan Feny Tunjungsari fila, fila Fitriana Yulanda Gani, Rima January Putri Ridwan Hakiki, Nurani Harum, Zahrotul Hasanah Harum, Zahrotul Hasanah Hasanah, Anisa Hasanah, Annisa’ Heriyanto, Mochammad Junaidy Inassani, Lustyafa Inassani, Lustyafa Kevin Muliawan Soetanto Kusuma Hati Kusuma Hati, Kusuma Lestari, Noviana Dwi M. Mansyur Romi Madona Clara Yosinta Djoka Malik, Ibnu Malik, Ibnu Mandiricha, Tara Mitayani Purwoko, Mitayani Moch Aleq Sander Muhammad Dicky Hafisalevi Muhammad Perdana Airlangga, Muhammad Perdana Novitasari, Erlina Krisdianita Nur Aisyah Ornadi, Annisa Brilian Pandhita, Gea Permana, Ridho A'bid Prakoso, Denny Anggoro Putra, Chendra Perdana Rudiyanto, Waluyo S Khanza Zatalini Sriningsih, Solikah Sukarno, Rizky Triutami SULISTIYANI SULISTIYANI Sulistyo Mulyo Agustini Surianata, Raditya Widya Tubarad, Gladys Dwiani Tinovella Yanuarita Tursinawati, Yanuarita Yuliarta, Dian Yustikasari, Yolla Gitamaya