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All Journal Majalah Kedokteran Bandung Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) World Nutrition Journal PREPOTIF : Jurnal Kesehatan Masyarakat Cermin Dunia Kedokteran eJournal Kedokteran Indonesia Makara Journal of Health Research MEDICINUS Cermin Dunia Kedokteran
Rima Irwinda
Department Of Obstetric And Gynaecology, Faculty Of Medicine, Universitas Indonesia – Cipto Mangunkusumo General Hospital
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peran Kalsium dan Magnesium pada Kehamilan Irwinda, Rima
MEDICINUS Vol. 33 No. 1 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.631 KB) | DOI: 10.56951/medicinus.v33i1.1

Abstract

Mikronutrien memiliki peran penting dalam outcome kehamilan. Defisiensi mikronutrien berhubungan dengan outcome perinatal yang buruk serta berdampak pada kualitas kesehatan di masa yang akan datang. Di antara berbagai jenis mikronutrien, mineral kalsium dan magnesium diketahui bersifat esensial dalam masa kehamilan. Kalsium dan magnesium memiliki peran fisiologis yang luas, di antaranya berperan dalam proses pembentukan tulang, metabolisme energi, sekresi hormon, komunikasi antarsel, dan fungsi homeostasis lainnya. Beberapa penelitian menunjukkan adanya hubungan antara defisiensi kalsium dengan risiko preeklamsia yang lebih tinggi, oleh karena itu perlu diperhatikan kecukupan kalsium dalam masa kehamilan, serta komponen nutrisi lain yang dapat mengoptimalkan absorpsi kalsium, seperti magnesium dan vitamin D3.
Iron deficiency anemia in a woman’s life cycle and its impact Irwinda, Rima
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0003

Abstract

According to WHO, iron deficiency anemia is a condition where the body lacks iron, which is proven by signs of iron deficiency in the tissues and insufficient iron reserves in the body, accompanied by a decrease in hemoglobin levels of >2 standard deviations from the reference value in the same population. Iron deficiency anemia is one of the most common micronutrient deficiencies that occurs in a woman's life cycle due to menstruation (blood loss), pregnancy (needs for the mother and fetus), and bleeding during childbirth.aanemi
Linking minds and growth: maternal mental health and child stunting : A systematic review Pratiwi, Mayditania Intan Bunga; Qirani, Ida Ayu Devi; Anugrah, Pani Matin; Ocviyanti, Dwiana; Irwinda, Rima
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0032

Abstract

Maternal mental health during pregnancy has a significant impact on early childhood development, but its association with child growth outcomes, notably stunting, has received less attention, particularly in Indonesia.
Preeklamsia: Pencegahan hingga Pengelolaan Berbasis Bukti Raymond Surya; Rima Irwinda; Ali Sungkar
Cermin Dunia Kedokteran Vol 46 No 1 (2019): Obstetri-Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i1.525

Abstract

Mekanisme pasti preeklamsia masih tidak diketahui, sering dikaitkan dengan faktor imunologi, genetik, kerentanan terhadap sindrom metabolik, inflamasi/infeksi kronik, hipertensi sebelumnya, penyakit ginjal kronik. Uji prediksi preeklamsia dapat dilakukan dengan melihat faktor risiko demografi, penemuan biofisik, ataupun kombinasi keduanya. Pencegahan preeklamsia di antaranya aspirin dosis rendah pada populasi risiko tinggi dan suplementasi kalsium pada populasi rendah asupan kalsium. Penatalaksanaan preeklamsia yang baik terdiri dari antihipertensi, magnesium sulfat, kortikosteroid, penentuan saat terminasi kehamilan, hingga metode persalinan. The exact mechanism of preeclampsia is unknown; it is associated with immunological, genetic factor, susceptibility to metabolic syndrome, chronic inflammation/infection, history of previous hypertension, and chronic renal disease. Preeclampsia prediction test can be conducted through demographic risk factors, biophysical findings, or both. The prevention measures include low dose aspirin in high risk population and calcium supplementation in low calcium intake population. Good management of preeclampsia consists of antihypertensive, magnesium sulphate, corticosteroid, pregnancy termination, and delivery methods.
Feasibility Study For Birth Defect’s and Congenital Abnormalities’s Integrated Service In A Low-Middle Income Country Saroyo, Yudianto Budi; Firmansha Dilmy, Mohammad Adya; Salsabila Putri, Cut Tisya; Islamah, Rachelya Nurfirdausi; Budiman, Jenica Xaviera; Rumondang, Amanda; Purwosunu, Yuditiya; Irwinda, Rima; Rohsiswatmo, Rinawati
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2783

Abstract

Background: Congenital abnormalities are anatomical and physiological abnormalities that are present in babies from birth. One of the main causes of high infant mortality and neonatal mortality in Indonesia is congenital abnormalities in babies. This study describes the prevalence of congenital abnormalities in Dr. Cipto Mangunkusumo Hospital, as a tertiary referral hospital in Indonesia, which requires integrated healthcare service to be treated well. Methods: Data obtained from 323 patients at Dr. Cipto Mangunkusumo General Hospital are collected in a year, to be further analyzed in retrospective cohort study. Collected data includes the patients’ age, birth date, reproductive history, gestational age, and congenital abnormalities of the baby. Results: The data shows that patients with the age group of 30-39 years old dominated the cases of pregnancy with congenital abnormalities. Cases are also more dominant in the gestational age of 13 – 28 weeks (second-trimester). Most cases of abnormalities are from the central nervous system with 159 cases and followed by cardiovascular system with 130 cases. Overall prevalence of congenital abnormalities are detected within patients during prenatal screening in Dr. Cipto Mangunkusumo General Hospital. Conclusion: This study highlights the importance in managing congenital abnormalities and birth defects by developing an integrated service in the healthcare system to lower infant and neonatal mortality. Keywords: birth defect, congenital abnormalities, prenatal screening
Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia Putri, Ruth Widhiati Raharjo; Prasmusinto, Damar; Wibowo, Noroyono; Irwinda, Rima; Purwosunu, Yuditiya; Saroyo, Yudianto Budi
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3256

Abstract

BACKGROUND: Preeclampsia is one of the common causes of maternal death in Indonesia. Many studies only focus on the diagnosis and pharmacological treatment of preeclampsia. However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. The imbalances of trace elements and fatty acids play an important role in preeclampsia. Therefore, this study was conducted to evaluate the status of trace elements and fatty acids in preeclampsia patients as predictors of preeclampsia.METHODS: A cross-sectional study was conducted in 3 hospitals, and involving 40 pregnant women classified into severe preeclampsia and normotensive groups. Trace elements and fatty acids were measured in serum and erythrocytes using Inductively Coupled Plasma and Gas Chromatography-Mass Spectrometry. Serum and erythrocytes fatty acid levels' cut-off value, sensitivity, and specificity were analyzed using Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) value.RESULTS: Serum selenium, manganese, and iron levels were significantly different in the preeclampsia group than in the controls (p<0.05). Of all the heavy metals, higher concentrations of cadmium, arsenic, lead, and mercury were found in preeclampsia groups compared to control. Linoleic acid showed the highest predictive value to increase severe preeclampsia with AUC of 0.8. The ratio of high omega-6/omega-3 increases the risk of preeclampsia.CONCLUSION: Selenium, manganese, iron, cadmium, arsenic, lead, and mercury levels are higher in the serum of preeclampsia patients. Almost all erythrocyte fatty acids were significantly higher in the control group compared to preeclampsia. Measurement of trace elements and fatty acids is needed as a predictor of preeclampsia. Erythrocyte fatty acids measurement is considered better than serum.KEYWORDS: trace elements, fatty acids, preeclampsia
Lower Ferrum, Selenium, and Cadmium; Higher Chromium and Lead Levels in Preeclampsia Patients’ Erythrocyte: A Cross-Sectional Study Sandhy Prayudhana; Damar Prasmusinto; Noroyono Wibowo; Rima Irwinda; Yuditiya Purwosunu; Yudianto Budi Saroyo
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3257

Abstract

BACKGROUND: Oxidative stress and trace elements in erythrocytes are linked to impaired nitric oxide that can lead to endothelial dysfunction in preeclampsia patients. The morphology of erythrocytes could also be affected by oxidative stress and trace elements. While the relationships between erythrocyte index, superoxide dismutase (SOD) activity, and oxidative stress in preeclampsia have been well established, less attention has been given to the erythrocyte trace elements and their role in disease progression. This study was performed to examine the erythrocyte trace element profile in women with preeclampsia, comparing it with controls. Additionally, it will explore the correlations between erythrocyte trace element levels, the erythrocyte index, and SOD activity.METHODS: A cross-sectional study was conducted involving 40 pregnant women consisting of those with severe preeclampsia and normotensive. Erythrocytes was isolated from blood samples, and analysis of erythrocyte SOD activity and trace elements were performed using the enzyme linked immunosorbent assay (ELISA) and inductively coupled plasma mass spectrometry (ICP-MS), respectively.RESULTS: Among 15 examined erythrocyte trace elements, the levels of ferrum (Fe), selenium (Se), and cadmium (Cd) were significantly lower, meanwhile, the levels of chromium (Cr) and lead (Pb) were significantly higher in preeclampsia subjects. Additionally, preeclampsia subjects exhibited smaller erythrocyte sizes compared to the normotensive subjects. The erythrocyte SOD activity was significantly elevated in the preeclampsia subjects than the normotensive subjects.CONCLUSION: Erythrocyte trace element levels of Fe, Se, Cd, Cr, and Pb were significantly altered in preeclampsia compared to normotensive controls. These findings suggest that these trace elements may serve as potential predictors for preeclampsia.KEYWORDS: preeclampsia, trace elements, antioxidant, oxidative stress, superoxide dismutase, erythrocyte index
Effect of High-Dose Vitamin D on Angiogenesis Markers in High-Risk Pregnant Women Nunki Febriastuti; Rima Irwinda; Noroyono Wibowo; Damar Prasmusinto; Yudi B. Saroyo; Yuditiya Purwosunu
Majalah Kedokteran Bandung Vol 58, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v58.4544

Abstract

Preeclampsia is characterized by impaired trophoblast invasion and angiogenesis. Recent evidence suggests that vitamin D supplementation may reduce the risk of preeclampsia by optimizing angiogenesis. This study aimed to evaluate the effect of high-dose vitamin D on angiogenesis markers in the first trimester by evaluating serum maternal placental growth factor (PlGF) and uterine artery pulsality index (UtA-PI) in pregnant women with a high risk for preeclampsia. A single-blind, randomized controlled trial was conducted on 80 pregnant women from April 2021 to April 2022 at Dr. Cipto Mangunkusumo National General Hospital and Koja District Hospital. Pregnant women at 7–11 weeks of gestation were divided into low-risk and high-risk preeclampsia groups. Each group was then randomized into a control group (multi-micronutrient supplementation/MMS) and an intervention group (MMS + vitamin D at 5,000 IU/day). Maternal serum 25(OH)D levels and PlGF levels, as well as Doppler UtA-PI, were measured at baseline and after one month of intervention. All participants had vitamin D deficiency at baseline. After one month, the increase in 25(OH)D level was significantly higher in the low-risk group (12.3±6.3 ng/mL vs 10.5±5.1 ng/, p<0.001). Mean UtA-PI was significantly reduced in both low-risk (-1.1±0.3) and high-risk (-0.43±0.26) intervention groups. PlGF level increasedwas significantly in both intervention groups (low-risk 107.9±32.0 vs. high-risk 70.5±18.3, p<0.001). High-dose vitamin D supplementation (5,000 IU/day) improves angiogenesis in the first trimester, suggesting potential benefits for improving pregnancy outcomes in women at risk for preeclampsia.
Association of dietary inflammatory index score with gestational weight gain in 22 to 28 weeks of pregnancy Riezki Amalia; Rima Irwinda; Okky Lupita Sari
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0031

Abstract

Maternal mental health during pregnancy has a significant impact on early childhood development, but its association with child growth outcomes, notably stunting, has received less attention, particularly in Indonesia.
Placental Vitamin D, Oxidative Stress, and Senescence Markers in Spontaneous Preterm Birth: A Comparative Cross-Sectional Study Yudianto Budi Saroyo; Noroyono Wibowo; Damar Prasmusinto; Yuditiya Purwosunu; Rima Irwinda; Mohammad Adya Firmansha Dilmy; Atikah Sayogo Putri; Arya Ivan Mahendra; Lysandra Olivia Prasanti Putri
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2928

Abstract

AbstractObjective: To evaluate the associations between vitamin D metabolism markers and biomarkers of oxidative stress and placental senescence among women with spontaneous preterm labor compared with those with term labor. Methods: We conducted a comparative cross-sectional study between 2017 and 2019 in two hospitals in Jakarta, Indonesia. Maternal serum and placental samples were collected from women with term labor and spontaneous preterm labor. Markers of the vitamin D pathway 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D? (1,25[OH]?D?), vitamin D receptor (VDR), and CYP27B1 along with oxidative stress (8-hydroxy-2--deoxyguanosine [8-OHdG]) and placental senescence markers (GLB1 and HMGB), were measured using ELISA, LC–MS/MS, and ICP–MS. Between-group comparisons were performed using parametric or nonparametric tests, as appropriate, and correlations were assessed using Pearson’s or Spearman’s correlation coefficients. Results: A total of 67 women were included (term labor, n = 34; spontaneous preterm labor, n = 33), and both groups were vitamin D deficient. Placental 1,25(OH)?D? levels were significantly lower in the preterm group than in the term group (4.58 ± 2.90 vs 5.57 ± 3.50 pg/ng, p = 0.037). Placental VDR levels also differed significantly between groups {21.70 (6.06–73.40) vs 16.48 (1.87–74.67), p = 0.041}. Across all participants, 8-OHdG and placental senescence markers were negatively correlated with placental 25(OH)D and 1,25(OH)?D? levels and positively correlated with placental CYP27B1 and VDR expression. Conclusion: In this comparative cross-sectional cohort, placental vitamin D metabolites were associated with lower levels of oxidative stress and placental senescence biomarkers, whereas VDR and CYP27B1 showed positive associations with these biomarkers. These patterns may reflect compensatory regulatory mechanisms in the context of maternal vitamin D deficiency. These findings are hypothesis-generating and warrant confirmation in prospective studies and mechanistic investigations. Keywords: oxidative stress, placental senescence, spontaneous preterm labor, vitamin D.
Co-Authors Adly N.A. Fattah Ali Sungkar Ali Sungkar Ali Sungkar Andrew Pratama Kurniawan Angela Rowan Anugrah, Pani Matin Arya Ivan Mahendra Atikah Sayogo Putri Bangun T. Purwaka, Bangun T. Berguna, Jimmy S.N. Budi I. Santoso Budi Iman Santoso Budiman, Jenica Xaviera Damar Prasmusinto Dian Novita Chandra Dilmy, Mohammad Adya Firmansha Dwiana Ocviyanti Farah Asyuri Yasmin Febriansyah Darus Guinto, Valerie Tiempo Herman Kristanto Islamah, Rachelya Nurfirdausi James Dekker Jimmy S. N. Berguna Jimmy Sakti Johanes C. Mose Jun Zhang Juneke J. Kaeng Karina N. Pratiwi, Karina N. Kindy Agustin Luciana Budiati Sutanto Lysandra Olivia Prasanti Putri Made K. Karkata, Made K. Maisuri T. Chalid, Maisuri T. Makmur Sitepu, Makmur Mayditania Intan Bunga Pratiwi Mohammad Azmi Nadia Nurfauziah Nembo, Lidia F. Nembo, Lidia Firmiaty Noroyono Wibowo Nunki Febriastuti Nuswil Bernolian Okky Lupita Sari Okky Lupita Sari Peby Maulina Prameswari, Natasya Pratiwi, Mayditania Intan Bunga Putri, Atikah S. Putri, Ruth Widhiati Raharjo Qirani, Ida Ayu Devi Raymond Surya Raymond Surya Raymond Surya Raymond Surya Rebecca Cannan Riezki Amalia Rinawati Rohsiswatmo Rumondang, Amanda Salsabila Putri, Cut Tisya Sandhy Prayudhana Saptawati Bardosono Saptawati Bardosono Saroyo, Yudianto Budi Sulaeman A. Susilo, Sulaeman A. Syafitri, Inayah Tazkia Putri Kagami Yudi B. Saroyo Yuditiya Purwosunu Yusrawati Yusrawati Yuyun Lisnawati