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All Journal Jurnal Ilmu Kesehatan Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) JMM (Jurnal Masyarakat Mandiri) Indonesian Journal of Cardiology Heart Science Journal Narra J Jurnal Neuroanestesi Indonesia Narra X Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Teuku Heriansyah, Teuku
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Other

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Ascorbic acid and calcitriol as alternative preventive strategies for myocardial damage in type 2 diabetes mellitus: an in vivo study using diabetic and atherosclerotic rat models Saputra, Jefri Dwi; Heriansyah, Teuku; Sofyan, Hamny; Dimiati, Herlina; Mudatsir, Mudatsir
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.14

Abstract

BACKGROUND: Type 2 diabetes mellitus can increase the production of reactive oxygen species (ROS) and genetic transcription factors, such as nuclear factor kappa beta (NF-κB). These phenomena may enhance the progression of atherosclerosis. Additionally, NF-κB can induce apoptosis of pancreatic beta cells and accelerate disease progression. OBJECTIVE: To investigate the role of calcitriol and ascorbic acid on NF-κβ expression in vivo in aortic and myocardial tissues of Wistar rats. METHODS: This randomized experimental study involved 24 male Wistar rats of the Rattus norvegicus strain, divided into four groups: NC (negative control), PC (positive control), AG (ascorbic acid group), and CG (calcitriol group). The study spanned 90 days, including a 30-day intervention period. Aortic and myocardial samples were processed into histological preparations and stained using immunohistochemical techniques. NF-κB expression was assessed using an intensity scoring method. RESULTS: The CG group demonstrated the lowest NF-κB immunoexpression in myocardial tissue (0.27 ± 0.08), followed by the AG (0.37 ± 0.05), NC (0.68 ± 0.08), and PC (1.13 ± 0.34) groups, with statistically significant 3sbetween the groups (p < 0.05). In aortic tissue, the CG group also exhibited the lowest NF-κB expression (0.30 ± 0.18), followed by the AG (0.50 ± 0.09), NC (0.97 ± 0.05), and PC (1.23 ± 0.38) groups, with statistically significant differences between the groups (p < 0.05).  Similar trends were observed in the immunohistochemical staining of the NF-κB antigen in myocardial and aortic tissue samples. Calcitriol administration was more effective than ascorbic acid in reducing NF-κB expression in both myocardial (p < 0.05) and aortic tissues (p < 0.05). CONCLUSION: Both ascorbic acid and calcitriol reduce NF-κB expression in the aorta and myocardium, with calcitriol showing greater effectiveness than ascorbic acid.
Association between admission blood sugar levels and length of stay among patients with acute heart failure: A cross-sectional study in Aceh, Indonesia Gusti, Naufal; Heriansyah, Teuku; Saputra, Irwan
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.75

Abstract

Heart failure persists to be a major health problem worldwide. Numerous factors associated with this condition have been studied to determine its prognosis. History of diabetes mellitus is one of the factors extensively studied, nonetheless, the correlation between acutely elevated admission blood glucose in critically ill patients or stress hyperglycemia towards the prognosis of heart failure remains inconclusive among previously reported studies. Therefore, the aim of this study was to investigate the correlation between admission blood glucose and the length of stay of acute heart failure patients. A cross-sectional study was conducted in Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia from July to August 2020. Patients’ data were retrieved from medical records documenting admission blood glucose and length of stay. Total sampling was employed, where eighty-five patients diagnosed as acute heart failure were included. The results showed that patients (n=85) had the general characteristics of being normoglycemic on admission (69.4%) and having 5–10 days length of stay (44.7%) with Killip 2 as the presiding Killip Class (50.6%). According to Gamma’s Correlation Coefficient, the p-value of this study is 0.012 (p< 0.05) with a correlation value of 0.454. Therefore, our study revealed the presence of a significant moderate-correlation between admission blood glucose and the length of stay among patients with acute heart failure.
PEMBERDAYAAN PEREMPUAN DESA MELALUI PEMBENTUKAN BUNDA LANSIA DAN PELATIHAN CAREGIVER LANSIA Kumboyono, Kumboyono; Kristianingrum, Niko Dima; Dewi, Elvira Sari; Dara, Yuliezar Perwira; Soenarti, Sri; Heriansyah, Teuku; Amanda, Febrina; Arifah, Medisa Roro Putri Nur; Jannah, Riska Raudhatul; Indriyani, Damayanti; Machfud, Savinka Salsabiela Iriana; Nursuhaida, Haffa Syafana; Marfuah, Marfuah; Nurhayati, Septi; Riswandha, Sofyan
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 2 (2025): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i2.27225

Abstract

Abstrak: Peningkatan jumlah lanjut usia (lansia) dapat memicu beragam masalah kesehatan yang membutuhkan perhatian khusus dari masyarakat. Salah satu upaya yang dapat dilakukan adalah pemberdayaan masyarakat, khususnya perempuan desa, dalam perawatan lansia. Kegiatan ini bertujuan untuk membentuk Bunda Lansia serta meningkatkan pengetahuan dan keterampilan perempuan desa dalam merawat lansia. Metode kegiatan mencakup pembentukan Bunda Lansia, penyuluhan, dan pelatihan perawatan lansia, bekerja sama dengan Dinas Kesehatan, Pengendalian Penduduk, dan Keluarga Berencana Kabupaten Lumajang. Kegiatan ini melibatkan 75 perempuan dari Desa Kraton, Desa Yosowilangun Lor, dan Desa Yosowilangun Kidul. Evaluasi dilakukan melalui pre-test dan post-test, observasi praktik, skala penilaian keterampilan, umpan balik peserta, serta tindak lanjut untuk menilai penerapan keterampilan dalam kehidupan sehari-hari. Hasil kegiatan menunjukkan bahwa 75 Bunda Lansia telah dilantik, dengan peningkatan pengetahuan dari rata-rata 77,5 menjadi 92 (18,7%), serta peningkatan keterampilan dalam perawatan lansia dari rata-rata 72,5 menjadi 85 (17,2%). Kesimpulannya, kegiatan ini efektif dalam meningkatkan pengetahuan dan keterampilan perempuan desa dalam perawatan lansia.Abstract: The increasing number of elderly individuals can lead to various health issues that require special attention from the community. One possible approach to address this is through community empowerment, particularly of rural women, in elderly giver. This initiative aims to establish “Bunda Lansia” (Elderly Care Mothers) and to enhance the knowledge and skills of rural women in elderly care. The methods include the formation of Bunda Lansia, education sessions, and elderly care training, in collaboration with the Department of Health, Population Control, and Family Planning of Lumajang Regency. This activity involved 75 women from Kraton Village, Yosowilangun Lor Village, and Yosowilangun Kidul Village. The evaluation was conducted through pre-tests and post-tests, practice observations, skill rating scales, participant feedback, and follow-up assessments to evaluate the application of skills in daily life. The results indicate that 75 Bunda Lansia were inaugurated, with an increase in knowledge from an average of 77.5 to 92 (18.7%) and an improvement in elderly care skills from an average of 72.5 to 85 (17.2%). In conclusion, this initiative effectively enhances the knowledge and skills of rural women in elderly care.
Dyslipidemia management among patients with high and very high cardiovascular risk in Indonesia: a multi-center registry Ng, Sunanto; Santoso, Anwar; Sukmawan, Renan; Erwinanto, Erwinanto; Adam, Erika; Desandri, Dwita Rian; Zahra, Rita; Wicaksono, Sony Hilal; Putra, Magma Purnawan; Heriansyah, Teuku; Tiksnadi, Badai Bhatara; Pintaningrum, Yusra
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1880

Abstract

Background Indonesia, the world's largest archipelago, faces significant challenges in equitable healthcare delivery due to its geographical and infrastructural disparities. Atherosclerotic Cardiovascular Disease (ASCVD) remains the leading cause of mortality, with over 659,000 deaths recorded in 2019. Effective dyslipidemia management is crucial for preventing adverse ASCVD events. Unfortunately, the lack of implementation of an updated national lipid management registry might hinder optimal strategy for the adverse events. This study evaluated dyslipidemia cholesterol management practices among high- and very high-risk patients across the country. Methods The study recruited 322 patients from eight centers across six provinces in Indonesia between May 2022 and March 2023. Patients were stratified based on the ASCVD risk and followed over three visits. Baseline clinical characteristics, lipid profiles, and treatment regimens were analyzed. Descriptive statistics summarized continuous and categorical variables, and low-density lipoprotein cholesterol (LDL-C) achievement was assessed. Results Of the 322 patients, 98.8% were very high-risk, with only 4.9% achieving <55 mg/dL and 21.2% achieving <70 mg/dL. Moderate-intensity statins were the most prescribed (51.2%), followed by high-intensity (36.6%). LDL-C reduction was most pronounced in private insurance patients, achieving a mean LDL-C of 69.8 mg/dL at the third visit compared to 98.9 mg/dL in National Health Insurance (Jaminan Kesehatan Nasional/JKN) participants. Missed visit rates increased over time, with 57.5% of patients missing the third visit, predominantly among JKN participants and low-income groups. Conclusion Majority of the population failed to achieve the recommended target of LDL-C levels. Dyslipidemia management in Indonesia remains suboptimal, with disparities driven by socioeconomic factors. Improved policies addressing medication availability, national lipid registry establishment, and equitable healthcare access are essential to enhance lipid management and reduce the burden of ASCVD in Indonesia.
Relationship between the Left Atrial Volume Index and Left Ventricular Geometry and the Incidence of Atrial Fibrillation in Hypertensive Patients with Cardiovascular Complications Djeni, Chairatu Sadrina; Heriansyah, Teuku; Mudatsir; Novita; Munirwan, Haris
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12031

Abstract

This study aimed to evaluate the relationships of the left atrial volume index (LAVI) and left ventricular geometry with the incidence of AF in hypertensive patients with cardiovascular complications such as heart failure or coronary arterial disease.  This study employed a retrospective observational cohort design. A total of 202 subjects met the inclusion and exclusion criteria for the study. The subjects were selected from hypertensive patients with cardiovascular complications treated at Dr. Zainoel Abidin General Hospital Banda Aceh, a tertiary referral center in Indonesia, between July and December 2024. 12At the end of the study, the participants were divided into two groups: those with newly diagnosed atrial fibrillation (n=37) and those without atrial fibrillation (n=165). The diagnosis of new-onset atrial fibrillation was based on medical records obtained during hospitalization and continued through a three-month follow-up after discharge via outpatient clinic visits and 12-lead ECG monitoring. The study revealed a significant association between increased LAVI and AF incidence (p < 0.01). The mean LAVI in the AF group was 49.9 ± 19.2 ml/m², whereas it was 33.34 ± 15.6 ml/m² in the non-AF group. Additionally, changes in left ventricular geometry were correlated with increased AF incidence (p value = 0.03), with eccentric hypertrophy showing the highest AF incidence (29.5%). A strong association was also found between increased LAVI and left ventricular geometric changes, with eccentric hypertrophy resulting in the highest mean LAVI (43.2 ± 16.9 ml/m²). The odds ratio (OR) analysis demonstrated that patients with LAVI above the threshold had a significantly greater risk of developing AF (OR: 5.2; 95% CI: 2.475–11.161). Similarly, patients with normal ventricular geometry had a significantly lower risk of AF compared to those with eccentric hypertrophy (OR: 0.148; 95% CI: 0.049–0.449). Increased LAVI and left ventricular geometry changes, particularly eccentric hypertrophy, are significant risk factors for AF in hypertensive patients with cardiovascular complications such as heart failure and coronary arterial disease. Clinical practice should incorporate echocardiographic monitoring of left ventricular geometry and LAVI to prevent the progression of AF and detect risk early
Co-Authors Achdiat Agoes Adam, Erika Adi Purnawarman, Adi Aldri Frinaldi Amanda, Febrina Ambari, Ade Meidian Anwar Santoso Aria Kekalih Arifah, Medisa Roro Putri Nur Badai Bhatara Tiksnadi Bambang Budi Siswanto Bashori, Ahmad A. Basuni Radi Desandri, Dwita Rian Djanggan Sargowo Djeni, Chairatu Sadrina Dwiputra, Bambang Ekawati, Wahyu Elvira Sari Dewi Enitan, Seyi S. Erwinanto, Erwinanto Gusti, Naufal Hadi, Tjut F. Hamny Sofyan Harahap, Alida R. Harahap, Alida Rosita Herlina Dimiati, Herlina Indriyani, Damayanti Jannah, Riska Raudhatul Jasa, Zafrullah Kany Kamarlis, Reno K. Katsukawa, Hajime Kristianingrum, Niko Dima Kumboyono Kumboyono Kurniawan, Ferry D. Lestari, Nova D. Liza Salawati, Liza Machfud, Savinka Salsabiela Iriana Marfuah Marfuah Mudatsir Mudatsir Mudatsir Muhammad Ridwan Muhammad Riyan Munawarah, Iffah Munirwan, Haris Nina Widasari novia, rizki Novita Nurjani Nursuhaida, Haffa Syafana Pintaningrum, Yusra Putra, Magma Purnawan Putri, Cut JE. Renan Sukmawan Riswandha, Sofyan Saputra, Irwan Saputra, Jefri Dwi Sari, Indah P. Satuman Satuman Septi Nurhayati Sri Soenarti Subkhan, Muhammad Sunanto Ng Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Taufiks, Nasyaruddin H. Taufiqurrahman Taufiqurrahman Titin A Wihastuti, Titin A Triangto, Kevin Wicaksono, Sony Hilal Yanti, Budi Yuliezar Perwira Dara, Yuliezar Perwira Yuvhendmindo, Shahcoga L. ZAHRA, RITA