Garuda - Garba Rujukan Digital

Ascorbic acid and calcitriol as alternative preventive strategies for myocardial damage in type 2 diabetes mellitus: an in vivo study using diabetic and atherosclerotic rat models Saputra, Jefri Dwi; Heriansyah, Teuku; Sofyan, Hamny; Dimiati, Herlina; Mudatsir, Mudatsir
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.14

BACKGROUND: Type 2 diabetes mellitus can increase the production of reactive oxygen species (ROS) and genetic transcription factors, such as nuclear factor kappa beta (NF-κB). These phenomena may enhance the progression of atherosclerosis. Additionally, NF-κB can induce apoptosis of pancreatic beta cells and accelerate disease progression. OBJECTIVE: To investigate the role of calcitriol and ascorbic acid on NF-κβ expression in vivo in aortic and myocardial tissues of Wistar rats. METHODS: This randomized experimental study involved 24 male Wistar rats of the Rattus norvegicus strain, divided into four groups: NC (negative control), PC (positive control), AG (ascorbic acid group), and CG (calcitriol group). The study spanned 90 days, including a 30-day intervention period. Aortic and myocardial samples were processed into histological preparations and stained using immunohistochemical techniques. NF-κB expression was assessed using an intensity scoring method. RESULTS: The CG group demonstrated the lowest NF-κB immunoexpression in myocardial tissue (0.27 ± 0.08), followed by the AG (0.37 ± 0.05), NC (0.68 ± 0.08), and PC (1.13 ± 0.34) groups, with statistically significant 3sbetween the groups (p < 0.05). In aortic tissue, the CG group also exhibited the lowest NF-κB expression (0.30 ± 0.18), followed by the AG (0.50 ± 0.09), NC (0.97 ± 0.05), and PC (1.23 ± 0.38) groups, with statistically significant differences between the groups (p < 0.05). Similar trends were observed in the immunohistochemical staining of the NF-κB antigen in myocardial and aortic tissue samples. Calcitriol administration was more effective than ascorbic acid in reducing NF-κB expression in both myocardial (p < 0.05) and aortic tissues (p < 0.05). CONCLUSION: Both ascorbic acid and calcitriol reduce NF-κB expression in the aorta and myocardium, with calcitriol showing greater effectiveness than ascorbic acid.

Association between admission blood sugar levels and length of stay among patients with acute heart failure: A cross-sectional study in Aceh, Indonesia Gusti, Naufal; Heriansyah, Teuku; Saputra, Irwan
Narra X Vol. 1 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v1i2.75

Heart failure persists to be a major health problem worldwide. Numerous factors associated with this condition have been studied to determine its prognosis. History of diabetes mellitus is one of the factors extensively studied, nonetheless, the correlation between acutely elevated admission blood glucose in critically ill patients or stress hyperglycemia towards the prognosis of heart failure remains inconclusive among previously reported studies. Therefore, the aim of this study was to investigate the correlation between admission blood glucose and the length of stay of acute heart failure patients. A cross-sectional study was conducted in Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia from July to August 2020. Patients’ data were retrieved from medical records documenting admission blood glucose and length of stay. Total sampling was employed, where eighty-five patients diagnosed as acute heart failure were included. The results showed that patients (n=85) had the general characteristics of being normoglycemic on admission (69.4%) and having 5–10 days length of stay (44.7%) with Killip 2 as the presiding Killip Class (50.6%). According to Gamma’s Correlation Coefficient, the p-value of this study is 0.012 (p< 0.05) with a correlation value of 0.454. Therefore, our study revealed the presence of a significant moderate-correlation between admission blood glucose and the length of stay among patients with acute heart failure.

Dyslipidemia management among patients with high and very high cardiovascular risk in Indonesia: a multi-center registry Ng, Sunanto; Santoso, Anwar; Sukmawan, Renan; Erwinanto, Erwinanto; Adam, Erika; Desandri, Dwita Rian; Zahra, Rita; Wicaksono, Sony Hilal; Putra, Magma Purnawan; Heriansyah, Teuku; Tiksnadi, Badai Bhatara; Pintaningrum, Yusra
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1880

Background Indonesia, the world's largest archipelago, faces significant challenges in equitable healthcare delivery due to its geographical and infrastructural disparities. Atherosclerotic Cardiovascular Disease (ASCVD) remains the leading cause of mortality, with over 659,000 deaths recorded in 2019. Effective dyslipidemia management is crucial for preventing adverse ASCVD events. Unfortunately, the lack of implementation of an updated national lipid management registry might hinder optimal strategy for the adverse events. This study evaluated dyslipidemia cholesterol management practices among high- and very high-risk patients across the country. Methods The study recruited 322 patients from eight centers across six provinces in Indonesia between May 2022 and March 2023. Patients were stratified based on the ASCVD risk and followed over three visits. Baseline clinical characteristics, lipid profiles, and treatment regimens were analyzed. Descriptive statistics summarized continuous and categorical variables, and low-density lipoprotein cholesterol (LDL-C) achievement was assessed. Results Of the 322 patients, 98.8% were very high-risk, with only 4.9% achieving <55 mg/dL and 21.2% achieving <70 mg/dL. Moderate-intensity statins were the most prescribed (51.2%), followed by high-intensity (36.6%). LDL-C reduction was most pronounced in private insurance patients, achieving a mean LDL-C of 69.8 mg/dL at the third visit compared to 98.9 mg/dL in National Health Insurance (Jaminan Kesehatan Nasional/JKN) participants. Missed visit rates increased over time, with 57.5% of patients missing the third visit, predominantly among JKN participants and low-income groups. Conclusion Majority of the population failed to achieve the recommended target of LDL-C levels. Dyslipidemia management in Indonesia remains suboptimal, with disparities driven by socioeconomic factors. Improved policies addressing medication availability, national lipid registry establishment, and equitable healthcare access are essential to enhance lipid management and reduce the burden of ASCVD in Indonesia.

Ascorbic acid and calcitriol as alternative preventive strategies for myocardial damage in type 2 diabetes mellitus: an in vivo study using diabetic and atherosclerotic rat models Saputra, Jefri Dwi; Heriansyah, Teuku; Sofyan, Hamny; Dimiati, Herlina; Mudatsir, Mudatsir
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.14

BACKGROUND: Type 2 diabetes mellitus can increase the production of reactive oxygen species (ROS) and genetic transcription factors, such as nuclear factor kappa beta (NF-κB). These phenomena may enhance the progression of atherosclerosis. Additionally, NF-κB can induce apoptosis of pancreatic beta cells and accelerate disease progression. OBJECTIVE: To investigate the role of calcitriol and ascorbic acid on NF-κβ expression in vivo in aortic and myocardial tissues of Wistar rats. METHODS: This randomized experimental study involved 24 male Wistar rats of the Rattus norvegicus strain, divided into four groups: NC (negative control), PC (positive control), AG (ascorbic acid group), and CG (calcitriol group). The study spanned 90 days, including a 30-day intervention period. Aortic and myocardial samples were processed into histological preparations and stained using immunohistochemical techniques. NF-κB expression was assessed using an intensity scoring method. RESULTS: The CG group demonstrated the lowest NF-κB immunoexpression in myocardial tissue (0.27 ± 0.08), followed by the AG (0.37 ± 0.05), NC (0.68 ± 0.08), and PC (1.13 ± 0.34) groups, with statistically significant 3sbetween the groups (p < 0.05). In aortic tissue, the CG group also exhibited the lowest NF-κB expression (0.30 ± 0.18), followed by the AG (0.50 ± 0.09), NC (0.97 ± 0.05), and PC (1.23 ± 0.38) groups, with statistically significant differences between the groups (p < 0.05). Similar trends were observed in the immunohistochemical staining of the NF-κB antigen in myocardial and aortic tissue samples. Calcitriol administration was more effective than ascorbic acid in reducing NF-κB expression in both myocardial (p < 0.05) and aortic tissues (p < 0.05). CONCLUSION: Both ascorbic acid and calcitriol reduce NF-κB expression in the aorta and myocardium, with calcitriol showing greater effectiveness than ascorbic acid.

PEMBERDAYAAN PEREMPUAN DESA MELALUI PEMBENTUKAN BUNDA LANSIA DAN PELATIHAN CAREGIVER LANSIA Kumboyono, Kumboyono; Kristianingrum, Niko Dima; Dewi, Elvira Sari; Dara, Yuliezar Perwira; Soenarti, Sri; Heriansyah, Teuku; Amanda, Febrina; Arifah, Medisa Roro Putri Nur; Jannah, Riska Raudhatul; Indriyani, Damayanti; Machfud, Savinka Salsabiela Iriana; Nursuhaida, Haffa Syafana; Marfuah, Marfuah; Nurhayati, Septi; Riswandha, Sofyan
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 2 (2025): April
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i2.27225

Abstrak: Peningkatan jumlah lanjut usia (lansia) dapat memicu beragam masalah kesehatan yang membutuhkan perhatian khusus dari masyarakat. Salah satu upaya yang dapat dilakukan adalah pemberdayaan masyarakat, khususnya perempuan desa, dalam perawatan lansia. Kegiatan ini bertujuan untuk membentuk Bunda Lansia serta meningkatkan pengetahuan dan keterampilan perempuan desa dalam merawat lansia. Metode kegiatan mencakup pembentukan Bunda Lansia, penyuluhan, dan pelatihan perawatan lansia, bekerja sama dengan Dinas Kesehatan, Pengendalian Penduduk, dan Keluarga Berencana Kabupaten Lumajang. Kegiatan ini melibatkan 75 perempuan dari Desa Kraton, Desa Yosowilangun Lor, dan Desa Yosowilangun Kidul. Evaluasi dilakukan melalui pre-test dan post-test, observasi praktik, skala penilaian keterampilan, umpan balik peserta, serta tindak lanjut untuk menilai penerapan keterampilan dalam kehidupan sehari-hari. Hasil kegiatan menunjukkan bahwa 75 Bunda Lansia telah dilantik, dengan peningkatan pengetahuan dari rata-rata 77,5 menjadi 92 (18,7%), serta peningkatan keterampilan dalam perawatan lansia dari rata-rata 72,5 menjadi 85 (17,2%). Kesimpulannya, kegiatan ini efektif dalam meningkatkan pengetahuan dan keterampilan perempuan desa dalam perawatan lansia.Abstract: The increasing number of elderly individuals can lead to various health issues that require special attention from the community. One possible approach to address this is through community empowerment, particularly of rural women, in elderly giver. This initiative aims to establish “Bunda Lansia” (Elderly Care Mothers) and to enhance the knowledge and skills of rural women in elderly care. The methods include the formation of Bunda Lansia, education sessions, and elderly care training, in collaboration with the Department of Health, Population Control, and Family Planning of Lumajang Regency. This activity involved 75 women from Kraton Village, Yosowilangun Lor Village, and Yosowilangun Kidul Village. The evaluation was conducted through pre-tests and post-tests, practice observations, skill rating scales, participant feedback, and follow-up assessments to evaluate the application of skills in daily life. The results indicate that 75 Bunda Lansia were inaugurated, with an increase in knowledge from an average of 77.5 to 92 (18.7%) and an improvement in elderly care skills from an average of 72.5 to 85 (17.2%). In conclusion, this initiative effectively enhances the knowledge and skills of rural women in elderly care.

Renal function and potassium changes in HFrEF patients treated with ACEI vs. ARNI: A prospective cohort study among Acehnese, Indonesia Munawarah, Iffah; Heriansyah, Teuku; Syukri, Maimun; Purnawarman, Adi; Buchari
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.10

Background: Renin-Angiotensin-Aldosterone System (RAAS) acceleration commonly occur in Heart Failure (HF). Drugs such as Angiotensin-Converting Enzyme Inhibitors (ACEI) and Angiotensin Receptor-Neprilysin Inhibitors (ARNI) become essential part of HF treatment. Long-term consumption may impair kidney function and potassium imbalance, which could potentially limit the therapy, therefore we conducted this study to assess the effects of ACEI and ARNI on renal function and potassium level in Indonesian patients with heart failure with reduced ejection fraction (HFrEF), as no local studies exist. Method: A prospective cohort was performed in Banda Aceh, which comprise of 40 ACEI and 40 ARNI patients on standard therapy. Left ventricular ejection fraction (LVEF), serum creatinine level then converted into estimated Glomerular Filtration Rate (eGFR), and serum potassium level were measured at baseline and after 3 months into the therapy. Independent t-test was applied to compare groups. Result: Both ARNI and ACEI groups showed significant improvement in eGFR (p < 0.005). The intergroup difference was 11 mg/dL (p = 0.038) showed that ACEI had a better outcome in eGFR improvement compare with ARNI. Potassium rose slightly in both groups, with an intergroup difference of 0.082 mmol/L (p = 0.623), indicating no meaningful difference. Conclusion: Both ACEI and ARNI improved eGFR after 3 months, with a modest potassium increase.

Dyslipidemia management among patients with high and very high cardiovascular risk in Indonesia: a multi-center registry Ng, Sunanto; Santoso, Anwar; Sukmawan, Renan; Erwinanto, Erwinanto; Adam, Erika; Desandri, Dwita; Zahara, Rita; Wicaksono, Sony; Putra, Magma Purnawan; Heriansyah, Teuku; Tiksnadi, Badai Bhatara; Pintaningrum, Yusra
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2232

In “Dyslipidemia management among patients with high and very high cardiovascular risk in Indonesia: a multi-center registry” (Indonesian Journal of Cardiology, 46(2), 51-63. https://doi.org/10.30701/ijc.1880), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1880. The error occurs only in the PDF; the DOI listed in the article metadata is already correct. The publisher apologizes for any inconvenience caused by this error. DOI of original article: https://doi.org/10.30701/ijc.1880

Perbandingan Program Rehabilitasi Jantung Terpusat (Tersupervisi) dengan Rehab Jantung Mandiri Terhadap Kapasitas Fungsional ada Penderita Penyakit Jantung Koroner Pasca Intervensi Koroner Per Kutan Heriansyah, Teuku; Fithriany; Lestari, Inda; Suciana
Journal of Medical Science Vol 7 No 1 (2026): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v7i1.281

Penyakit jantung koroner (PJK) termasuk salah satu penyebab utama kematian di seluruh dunia dengan angka morbiditas dan mortalitas yang tinggi. Intervensi koroner per kutan (IKP) merupakan prosedur untuk melebarkan arteri yang menyempit sehingga aliran darah ke jantung dapat normal kembali. Prosedur ini merupakan terapi definitif untuk mengatasi PJK. Namun setelah menjalani IKP pasien mengalami penurunan dalam aktivitas fisik dan stamina. Program rehabilitasi jantung yang terstruktur membantu pasien untuk secara bertahap meningkatkan aktivitas fisik mereka melalui latihan yang aman dan efektif, sehingga dapat memperbaiki fungsi kardio-pulmonal, daya tahan tubuh serta meningkatkan kapasitas fungsional dan kualitas hidup. Rehabilitasi jantung dapat dilakukan secara terpusat dengan pengawasan profesional kesehatan atau secara mandiri oleh pasien yang dilakukan di rumah. Untuk membandingkan efektivitas program rehabilitasi jantung terpusat dengan program rehabilitasi jantung mandiri terhadap kapasitas fungsional pasien pasca IKP. Penelitian ini menggunakan desain penelitian quasi-eksperimental. Subjek penelitian dibagi dalam dua kelompok, yaitu satu kelompok menjalani program rehabilitasi jantung terpusat yang dilaksanakan di unit rehabilitasi jantung RSUDZA dan kelompok lainnya melakukan rehabilitasi jantung mandiri di rumah. Subjek penelitian terdiri dari pasien yang telah menjalani intervensi koroner per kutan dan memenuhi kriteria inklusi. Uji paired samples t-test menunjukkan peningkatan kapasitas fungsional yang signifikan pada kedua kelompok dengan nilai rata-rata 6MWT akhir lebih tinggi daripada 6MWT awal dengan p value <0.0001 (<0.05), menandakan bahwa program rehabilitasi jantung baik terpusat maupun mandiri efektif meningkatkan kapasitas fungsional pasien. Selain itu, hasil uji menunjukkan tidak terdapat perbedaan yang signifikan secara statistik dalam peningkatan kapasitas fungsional pasien pada kelompok rehabilitasi jantung terpusat (tersupervisi) dengan kelompok rehabilitasi jantung mandiri dengan p value 0.058. Penelitian ini menyimpulkan bahwa kedua modalitas rehabilitasi jantung memberikan manfaat yang serupa dalam perbaikan kapasitas fungsional pada pasien PJK pasca IKP, memberikan fleksibilitas dalam pilihan program rehabilitasi berdasarkan preferensi dan kesediaan pasien, sehingga memudahkan pasien yang ingin menjalani rehabilitasi jantung.

Title

Found 18 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 18 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 18 Documents
Search