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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal SOLMA Biosel: Biologi Science and Education Journal of Parasite Science Jurnal HPT (Hama Penyakit Tumbuhan) MASALIQ: Jurnal Pendidikan dan Sains Biocaster : Jurnal Kajian Biologi Jurnal Biologi
Febry Rahmadhani Hasibuan
UIN Sumatera Utara Medan
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Energy Environmental Science Immunology & microbiology Social Sciences Veterinary Other

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Journal : Biocaster : Jurnal Kajian Biologi

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Ethnobotanical, Phytochemical, and Pharmacologies Aspect of Kaempferia rotunda L. as a Local Herbal Plant with Global Potential: A Review Pujiyanti, Aloysia Sri; Kusuma, Ratna; Ilmi, Annisa Nurul; Hasibuan, Febry Rahmadhani
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.462

Abstract

Kaempferia rotunda L., also known as kunci pepet, is a local herbal plant with global potential traditionally used in various medicinal practices across Southeast Asia. This review summarizes the ethnobotanical, phytochemical, and pharmacological aspects of Kaempferia rotunda L., to explore its applications in modern medicine. Ethnobotanically, its rhizome has been widely utilized for treating digestive disorders, inflammation, and wound healing. Phytochemical studies reveal that Kaempferia rotunda L., contains flavonoids, alkaloids, phenols, and terpenoids, contributing to its biological activities. Several studies have demonstrated significant anti-inflammatory, antibacterial, antioxidant, and anticancer properties. With the increasing demand for natural-based therapies, further exploration of their active compounds and mechanisms of action is highly relevant. This review aims to provide a broader insight into the pharmaceutical potential of Kaempferia rotunda L., and encourage further research for the development of evidence-based herbal medicine.
Immunomodulatory and Antidiabetic Potential of Kratom (Mitragyna speciosa) on Animal Models: Potentials and Future Research Ilmi, Annisa Nurul; Hasibuan, Febry Rahmadhani; Pujiyanti, Aloysia Sri; Kurniati, Reni
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.463

Abstract

Kratom (Mitragyna speciosa) has been traditionally used for its analgesic and stimulant properties. Recent preclinical studies suggesting its potential as an anti-inflammatory and antidiabetic agent. A comprehensive search of PubMed, ScienceDirect, and Google Scholar (2010-2024) using keywords “Kratom”, “inflammation”, and “diabetes” identified 82 studies. After applying inclusion criteria (original research, English/Bahasa Indonesia, in vivo animal models investigating anti-inflammatory/antidiabetic effects) and excluding reviews, in vitro studies, and conference abstracts, 14 studies comprising 9 key articles on the pharmacological activities of Kratom were analyzed. Dosages ranged from 0,5 mg/g to 500 mg/kg across various extraction methods and treatment durations. Studies show that Kratom extracts can inhibit pro-inflammatory cytokines (IL-1β, TNF-α) via NF-κB, COX-2, and MAPK/ERK pathways. In diabetic models, Kratom reduced blood glucose levels by 15-45%, improved glucose tolerance, and enhanced antioxidant status. Aqueous and ethanolic extracts showed comparable efficacy, with optimal effects observed at 100-200 mg/kg doses. Despite these findings, safety concerns remain regarding toxicity, dependence, and drug interactions. Further toxicological studies and clinical trials are essential to validate its therapeutic potential. This review highlights the need for comprehensive research and regulatory evaluation to support the safe medicinal use of Kratom.
Co-Authors Achyari, Putri Rizq Adinda Madhuri Hakim Afdan, Rifqi Khoir Afrianti, Billah Amalia, Qoyum Amelia, Suhaila Anafi, Salshabilla Wahyu Anggraini, Ade Sekar Arwira, Putri Agustina Anggraini Aulia, Ayu Riski Br Hasibuan, Fitri Elizabeth Br Hasibuan Budiman Butar, Marentina Kirana Butar Dewi Ratna Sari Fatmawati Patang Fitri Elizabrth Hasibuan Hafizhah, Kayla Nur Handayani, Fitriya Hariyanti, Mutina Ilmi, Annisa Nurul Ismail, Ahmad Yasin Jawa, Maria Elisabeth Khairuddin, Faritz Khatimah, Ardhiatul Khotizah, Laraz Nur Kinanti Rambe, Diva Raya Kinanti, Aulia Andin Kurniati, Reni Lubis, Febrianti Putri Lubis, Isnaini Rahmah Marthina Marwi, Adyla Syukhraini Mawaddah, Hanifa Mawla Lubis, Muhammad Fazil Munthe, Ratna Dewi Musdalifah, Yuni Nahombang, Syntia Zeyrani Nanda, Annisa Aulia Nasution, Aziz Husein Nayla Nova Hariani Pujiyanti, Aloysia Sri Pulungan, Raini Dahriana Putri, Rania Sakanti Arindra Ramadhani, Widiyanto Ratna Kusuma, Ratna Rifdha, Rifdha Saragih, Fany Erlangga Sinurat, Yulianti Syahfitri, Dini Indah Syahfitri, Widya Tsaabitahusnaa Tsany, Alisha Umaroh, Izza Yani Veraresa, Ray Herry wardana purba, Balqis putri Widya Syahfitri Yuliatin, Ervinda