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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Abdi Insani Journal of Classroom Action Research Jurnal Kesmas Untika Luwuk: Public Health Journal Jurnal Mandala Pengabdian Masyarakat KESANS : International Journal of Health and Science Pustaka Katulistiwa : Karya Tulis Ilmiah Keperawatan Jurnal Ilmiah Kesmas-IJ (Indonesia Jaya) Journal of Public Health and Pharmacy
Nani Astria Polontalo
Akademi Farmasi Bina Farmasi
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Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats Niluh Puspita Dewi; Komang Dewik; Syafika Alaydrus; Athia Kurnia Kasim; Nani Astria Polontalo; Wayan Wirawan; Dian Andini; Irma Irma; Imelda Synthia Fatu
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14172

Abstract

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.
Study of Treatment in Heart Disease Patients Installation in Undata Hospital, Central Sulawesi Niluh Puspita Dewi; Indah Kurnia Utami; Al'vira Gunawan; Muh. Thamrin Tahir; Syafika Alaydrus; Nani Astria Polontalo
Journal of Public Health and Pharmacy Vol. 4 No. 1 (2024)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i1.4951

Abstract

Introduction: Heart diseasesis a disorder of heart functionsdue to lack of bloods in the heart muscles due to narrowingsof the coronary artery. The purposesof this study was to describe t he characteristics and use of heart disease drugs based on parameters of rationality of drug use in Undata Hospital, Central Sulawesi Province including gender, age, heart drug class, complementary drug class, length of hospitalization, laboratory data, comorbidities , appropriate indications, the right drugs and the right dose. Methods: This researchsis a non-experimental type of research conducted prospectively during February-April 2022. The sampling technique in this study was purposive sampling, namely sampling based on established criteria. All samples that met the requirements who came to the hospital were used as research samples according to the required sample size of 40 respondents and based on the available data collection time. Results: The results of the study were 40 patients with hearts disease, the most heart disease sufferers were male with a percentage of 67.5%, in the age range of 56-65 years 32.5%, the most commonly used companion drug was Alprazolam as much as 17%, the most length of hospitalization was 4-6 days (55%), the most laboratory results were Hemoglobin/HGB examination as many as 21 patients (14.38%), the most comorbidities namely Hypertension with a percentage of 60% Conclusion: Appropriate use of heart disease drugs based on drug rational parameters in hospitals Undata of the right indication 100%, the right drug selection 100% and the right dose 100%. Recommendedsfor further researchersscan conduct research on cardiac drug interactions.
Co-Authors Al'vira Gunawan Alaydrus, Syafika Athia Kurnia Kasim Desak Eka Susianawati Dian Andini Febrita, Veny Fitri Arni HR HR Imelda Kantohe Imelda Synthia Fatu Indah Kurnia Utami insani, fadilah Insani, Fadillah Irma Irma Joni Tandi, Joni Komang Dewik Lestari, Widya Ayu Lexy Kareba Lidia Lidia, Lidia Magfirah, Magfirah Marlina, Ni Ketut Muh. Thamrin Tahir Nadila Nadila Nadila, Nadila Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Nuraisya, Nuraisya Parmi Parmi Puspita Dewi, Niluh Rakanita, Yasinta Rita Oktaviani Rosmini Saiful Ambodalle Sartika Kasiala Sujati, Ni Wayan Syafika Alaydrus Syafika Alaydrus Syafika Alaydrus Tuldjanah, Muthmainah Utami, Indah Kurnia Viani Anggi Wahyu Wawan Krismanto Wayan Wirawan wirawan, Wayan Yulia Yulia