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All Journal Tropical Medicine Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian MEDISAINS MEDIC MEdical Dedication JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Electronic Journal Scientific of Environmental Health And Diseases Journal of Medical Studies Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Ave Olivia Rahman

Program Studi Kedokteran, Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Jambi

Author-ID : 5750626

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Other

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ANTIBACTERIAL ACTIVITY OF ARECA NUT SOAP FORMULATION AGAINST STAPHYLOCOCCUS AUREUS Rahman, Ave Olivia; Purwakanthi, Anati
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 9 No. 1 (2021): Special Issues: JAMHESIC 2020
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

ABSTRACTBackground: Areca nuts are widely grown in Jambi and areca seeds have antibacterial activity, antioxidant, skinaging and cosmetics. It has the potential to be developed as antibacterial soap.Objective: This study was to compare the antibacterial effect of betel nut concentration powder and extract in oursoap formulation against Staphylococcus aureus using the in vitro test.Method: Soap formulation was made with 3 concentration of areca nut powder in soap, namely 1,5 grams/soap(soap 1); 2,3 grams/soap (soap 2) and 3 grams/soap (soap 3). also with extract of areca nut 1,2 grams/soap (soap4). The final weight of soap was obtained 50 grams. Antiseptic soap brand X and Y as a control. Antibacterialactivity test using Staphylococcus aureus ATCC 25923 with the well method.Results: The diameter of the clear zone produced by each areca nut soap was not much different (p>0,05). Theclear zone diameter of soap 1, 2, 3 and 4 were 24.28 ± 7,95 mm, 23,96 ± 6,41 mm, 23,87 ± 6,14 mm, and 23,08± 1,52 mm respectively. While, diameter of clear zone in brand X and Y were zero. Conclusion: The betel nutsoap formulation in this study has better antibacterial activity against Staphylococcus aureus ATCC 25923 thancontrol.Keywords: soap, areca nut, antibacterial, Staphylococcus aureusABSTRAKLatar Belakang: . Pohon pinang banyak ditanam di Jambi dan biji pinang memiliki aktivitas antibakteri, antioksidan,anti penuaan dan kosmetik. Biji pinang berpotensi untuk dikembangkan sebagai sabun antibakteri.Tujuan: Penelitian ini membandingkan efek antibakteri sabun pinang dengan bahan aktif dalam bentuk serbukdan eksktrak terhadap Staphylococcus aureus menggunakan uji in vitro.Metode: Formulasi sabun dibuat dengan 3 kadar serbuk pinang dalam sabun, yaitu 1,5 gram / sabun (sabun 1);2,3 gram / sabun (sabun 2) dan 3 gram / sabun (sabun 3), serta ekstrak biji pinang 1,2 gram/sabun. Berat akhirsabun diperoleh 50 gram. Sabun antiseptik merek X dan Y sebagai kontrol. Uji aktivitas antibakteri menggunakanStaphylococcus aureus ATCC 25923 dengan metode sumur.Hasil: Diameter zona bening yang dihasilkan masing-masing sabun pinang tidak jauh berbeda (p>0,05). Diameterzona bening sabun 1, 2 , 3 dan 4 masing-masing adalah 24.28 ± 7,95 mm, 23,96 ± 6,41 mm, 23,87 ± 6,14 mm,dan 23,08 ± 1,52 mm. Sedangkan diameter zona bening pada merek X dan Y adalah nol. Kesimpulan: Formulasisabun pinang pada penelitian ini memiliki aktivitas antibakteri yang lebih baik terhadap Staphylococcus aureusATCC 25923 daripada sabun control.Kata kunci: sabun, pinang, antibakteri, Staphylococcus aureus

AKTIVITAS ANTIBAKTERI MINYAK ESENSIAL KULIT KAYU MANIS (CINNAMOMUM ZEYLANICUM) IN VITRO Purwakanthi, Anati; Rahman, Ave Olivia
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 9 No. 3 (2021): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

ABSTRACT Background: Cinnamon bark has long been used as a traditional medicine. Cinnamon is also used as an aromatic spice and a flavoring additive in many cuisines around the world. Cinnamon contains cinnamaldehyde which is known to have antibacterial activity The aim of the study: to test the antibacterial effect of Cinnamon bark essential oil invitro. Methods: The antibacterial activity test was carried out in vitro using the disc diffusion method (Kirby-Bauer), with six concentrations of cinnamon bark essential oil, namely 1, 2, 4, 8, 16, and 32πl / ml. The bacteria used were Escherichia coli ATCC 25922, Streptococcus pneumoniae ATCC 49619 and Pseudomonas aeruginosa ATCC 27853 Results: The diameter of the clear zone formed was different at each concentration (p<0.05), both for E. coli S. pneumoniae or P. aeruginosa bacteria. Conclusion: Cinnamon bark essential oil have antibacterial activity against E.coli, S. Pneumoniae and P. Aeruginosa bacteria Keyword: Cinnamon bark, Essential oil, Antibacterial activity ABSTRAK Latar Belakang: Kulit kayu manis sudah sejak lama digunakan sebagai obat tradisional. Kayu manis juga digunakan sebagai bumbu aromatik dan aditif penyedap dalam berbagai masakan hampir di seluruh dunia. Kayu manis memiliki kandungan cinnamaldehyde yang diketahui memiliki aktivitas antibakteri. Tujuan penelitian: Menguji efek antibakteri minyak esensial kulit kayu manis secara invitro. Metode: Uji aktivitas antibakteri dilakukan secara in vitro menggunakan metode difusi cakram (Kirby-Bauer), dengan enam konsentrasi minyak esensial kulit kayu manis yaitu 1, 2, 4, 8, 16, dan 32πl / ml. Bakteri yang digunakan adalah Escherichia coli ATCC 25922, Streptococcus pneumoniae ATCC 49619 dan Pseudomonas aeruginosa ATCC 27853 Hasil: Diameter zona bening yang terbentuk berbeda pada masing-masing konsentrasi (p<0,05), baik pada bakteri E. coli S. Pneumoniae ataupun P. Aeruginosa . Kesimpulan: Minyak esensial kulit kayu manis memiliki aktivitas antibakteri terhadap bakteri E. coli S. Pneumoniae dan P. Aeruginosa Kata kunci: Kulit kayu manis, Minyak esensial, Aktivitas antibakteri

EFEKTIVITAS ANTIBAKTERI EKSTRAK KULIT KULIT NANAS (Ananas Comosus) N-HEKSANA TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS ATCC 25923 Nadilla Sitepu; Ave Olivia Rahman; Anggelia Puspasari
Journal of Medical Studies Vol. 2 No. 1 (2022): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v2i1.18093

ABSTRACT Background: Infectious diseases are generally treated using antibiotics and chloramphenicol is one of the main choice. However, it causes several side effects. Pineapple skin is thought to contain alkaloids, tannins, and terpenoids which are believed to have antibacterial activity. Objectives: This study aims to determine the effect of n-hexane exctract of pineapple peel on antibacterial activity of Staphylococcus aureus. Methods: In this study, we used fresh Pineapple skin that dried, powdered and macerated with n-hexane with ratio 1:10 ml extract were dried by rotary evaporator. A paper disc size 6 mm were soaked in the extract for 15 minutes, then ready to tested. Chloramphenicol as a positive control and n-hexane as a negative control. Antibacterial activity of extract against Staphylococcus aureus were tested by disk-diffussion method. Results: The results of the qualitative phytochemical test of pineapple peel extract of n-hexane showed positive for alkaloids and tannins, and negatif for terpenoid. There were no antibacterial activity of 100% n-hexane extract of pineapple skin against Staphylococcus aureus. While the positive control using chloramphenicol obtained an average clear zone diameter of 22.63 mm which is included in the very strong category. Conclusions: It concluded n-hexane extract of pineapple peel have no antibacterial activity against Staphylococcus aureus. Keywords: pineapple peels extract, Staphylococcus aureus, N-hexane ABSTRAK Latar Belakang: Penyakit infeksi umumnya diobati dengan antibiotik dan kloramfenikol merupakan salah satu pilihan utama. Namun, hal tersebut menyebabkan beberapa efek samping. Kulit nanas diduga mengandung alkaloid, tanin, dan terpenoid yang dipercaya memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak n-heksana kulit nanas terhadap aktivitas antibakteri Staphylococcus aureus. Metode: Pada penelitian ini menggunakan kulit nanas segar yang dikeringkan, diserbukkan dan dimaserasi dengan n-heksana dengan perbandingan ekstrak 1:10 yang dikeringkan dengan rotary evaporator. Kertas cakram ukuran 6 mm direndam dalam ekstrak selama 15 menit, kemudian siap untuk diuji. Menggunakan kloramfenikol sebagai kontrol positif dan n-heksana sebagai kontrol negatif. Aktivitas antibakteri ekstrak terhadap Staphylococcus aureus diuji dengan metode difusi cakram. Hasil: Hasil uji fitokimia kualitatif ekstrak kulit nanas n-heksana menunjukkan positif alkaloid dan tanin, dan negatif untuk terpenoid. Tidak ada aktivitas antibakteri ekstrak n-heksana 100% kulit nanas terhadap Staphylococcus aureus. Sedangkan kontrol positif menggunakan kloramfenikol diperoleh rata-rata diameter zona bening sebesar 22,63 mm yang termasuk dalam kategori sangat kuat. Kesimpulan: Disimpulkan ekstrak n-heksana kulit nanas tidak memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Kata kunci: Ekstrak kulit nanas, Staphylococcus aureus, N-heksana

PERBANDINGAN DAYA HAMBAT MINYAK ATSIRI GREEN TEA DAN TEA TREE TERHADAP BAKTERI Staphylococcus Aureus Dea Manda Fredella; Ave Olivia Rahman; Miftahurrahmah Miftahurrahmah
Journal of Medical Studies Vol. 2 No. 1 (2022): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v2i1.18094

ABSTRACT Background: Infectious diseases are a problem that is still a global concern. Staphylococcus aureus is a bacterium that is the most common cause of infection in the world. Treatment of infectious diseases is generally with antibiotics. One of the antibiotics that can be used to treat Staphylococcus aureus bacterial infection is chloramphenicol. An alternative that can be developed to reduce the problem of Staphylococcus aureus infection and resistance to antibiotics is the use of herbal plants or medicinal plants. The herbal plants that can be used are green tea leaf essential oil and tea tree essential oil. Methods: The type of research used is True Experimental with Posttest Only With Control Group Design. In this study, the materials to be tested were green tea essential oil and tea tree essential oil against Staphylococcus aureus bacteria with chloramphenicol as a positive control and aquadest as a negative control. Results: The average diameter of the inhibition zone on green tea essential oil was 11.45 mm, tea tree essential oil was 16.22 mm, positive control was 25.58 mm, while the negative control had no inhibition zone. and Green tea and tea tree essential oils are positive for alkaloids, tannins and terpenoids.Conclusions: There is a difference in the inhibitory power of green tea essential oil with tea tree. Keywords: Essential Oil, Green Tea, Tea Tree, Bacteria ABSTRAK Latar Belakang: Penyakit infeksi merupakan masalah yang masih menjadi perhatian dunia. Bakteri Staphylococcus aureus adalah bakteri yang merupakan penyebab infeksi tersering didunia. Pengobatan penyakit infeksi umumnya dengan pemberian antibiotik. Salah satu antibiotik yang dapat digunakan dalam mengobati infeksi bakteri Staphylococcus aureus adalah kloramfenikol. Alternatif yang dapat dikembangkan untuk mengurangi permasalahan infeksi bakteri Staphylococcus aureus dan resisten terhadap antibiotik adalah penggunaan tanaman herbal atau tanaman obat. Adapun tanaman herbal yang dapat digunakan adalah minyak atsiri daun teh hijau (green tea) dan minyak atsiri tea tree. Metode: Jenis penelitian yang digunakan adalah True Eksperimental dengan Posttest Only With Control Group Design. Pada penelitian ini bahan yang akan diuji adalah minyak atsiri green tea dan minyak atsiri tea tree terhadap bakteri Staphylococcus aureus dengan antibiotik kloramfenikol sebagai kontrol positif dan aquadest sebagai kontrol negatif. Hasil: Diperoleh rerata diameter zona hambat pada minyak atsiri green tea sebesar 11,45 mm, pada minyak atsiri tea tree sebesar 16,22 mm, kontrol positif sebesar 25,58 mm, sedangkan kontrol negatif tidak memiliki zona hambat dan Minyak atsiri Green tea dan tea tree positif mengandung senyawa alkaloid, tanin dan terpenoid. Kesimpulan: Terdapat perbedaan daya hambat minyak atsiri green tea dengan tea tree. Kata Kunci: Minyak Atsiri, Green Tea, Tea Tree, Bakteri

UMPAN BALIK PENERAPAN METODE CASE-BASED TEACHING PADA PERKULIAHAN FARMAKOLOGI BLOK KELAINAN SISTEM RESPIRASI MAHASISWA KEDOKTERAN UNIVERSITAS JAMBI Ave Olivia Rahman; Nindya Aryanty
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 4 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Background: In the medical program of Jambi University, Lectures on pharmacology use conventional methods. Teaching-learning with the case-method can improve critical reasoning and problem-solving analysis. Objective: to develop pharmacology lectures with the case-method and receive feedback from students and lecturer. Methods: The questionnaire contains several statements with answer choices using a 5-point Linkert scale, strongly agree-strongly disagree. The post-test assessment uses vignette questions, while the CBT test scores come from study program data. Results: Most of the students accepted the application of the case-method in pharmacology lectures. Some of the benefits that are felt by students include increasing understanding of pharmacology material, helping exam preparation, and the knowledges integration in learning. There is a significant relationship between post test scores and CBT test scores (p<0.05). Conclusion: There is good acceptance of students in pharmacology lectures using the case-method. Keywords: pharmacology, medical program student, block system curiculum, case-method, case-based teaching.

Effect of essential oil on hypertrophic scars Rahman, Ave Olivia; Humaryanto, Humaryanto; Purwakanthi, Anati; Simanjuntak, Charles Apul
MEDISAINS Vol 19, No 1 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i1.10192

Background: Hypertrophic scars are abnormal scars resulted from a disrupted wound healing process. Hypertrophic scars can affect the body aesthetic of the sufferers, but, on the other hand, conventional therapy has not been optimally effective. The application of essential oil combinations as an alternative therapy for hypertrophic scars has not been scientifically proven.Purposes: This study was to determine the effectiveness of the essential oil as a hypertrophic scar therapy.Methods: This study used a pre and post-test design. As many as 24 subjects aged 17-25 years with hypertrophic scars were given essential oil combinations every morning and evening for six months. Assessment of hypertrophic scars was done using the POSAS (Patient and Observer Scar Assessment Scale).Results: The results showed that the POSAS score decreased after the essential oil combination administration for six months, 14.40±6.08 vs. 22.67±8.31 (p<0.001).Conclusion: the combination of essential oil oils used in this study reduces hypertrophic scars based on the POSAS assessment.

Antifertility effect of betel nut (Areca catechu L) in male rat Rahman, Ave Olivia; Purwakanthi, Anati; Dewi, Hasna
MEDISAINS Vol 18, No 2 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i2.7588

Background: Betel nut (Areca catechu L) are traditional beverages in Jambi. Betel nut high dose has a cytotoxic effect on testis and other organs—limited data about the effect of betel nut as male antifertility.Purposes: This study aimed to determine the effect of infertility on betel nut use at a dose of 50 mg/kg body weight (BW) in male rats. Methods: Ten male Sprague Dawney rats that had passed the fertility test, aged 2-3 months and weighing 150-200 grams ware used in this study. The rat was grouped into two groups randomly. Group 1, as the negative control, were received aqua dest, and group 2 was treated by betel nut with dose 50 mg/kg BW for 35 days. When terminated, testis weight weighed using micro scales. Blood collected for measuring testosterone levels. Histopathology assessment of testis used Hematoxylin Eosin Staining and sperm counting from cauda epididymis.Results: The weight of testis in the group received betel nut was lower than the control group. The histopathology of testis showed shrunk, reduced the diameter of seminiferous tubules, and like cytolytic lesions in the germinal layer—the total sperm number and progressive sperms also lower than the control group (p<0.05). There was no abnormality in Leydig cell and interstitium tissue. Male rats after treatment could not impregnate the female rats.Conclusion: Betel nut at dose 50 mg/kg BW have antifertility activity in male rats.

Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Sebagai Antiinflamasi Metode Carrageenan-Induced Air Pouch: The Effect of Administering Ethanolic Extract Gel from Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Leaves as an Anti-Inflammation Carrageenan-Induced Air Pouch Method Fathnur Sani K; Kristin Simamora; Havizur Rahman; Ave Olivia Rahman; Yuliawati Yuliawati
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1707

The ethanol extract ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) has been studied as an anti-inflammatory agent. This study aims to formulate a topical preparation of ekor naga leavesextract gel so that it can be a futher step from previous research as a product development effort. The research method used is experimental design. The treatment group was divided into five groups: positive control (Hydrocortisone), Formula 0 (Gel Base), Formula 1 (10% Extract Concentration), Formula 2 (15% Extract Concentration), and Formula 3 (20% Extract Concentration). The test animals used in each treatment group were 5 animals. The data obtained were analyzed using one way ANOVA with a 95% confidence level. The results showed that the more extracts, the better the anti-inflammatory effect. However, based on preparation evaluation data in previous studies regarding gel formulations, it was concluded that formula 2 was the best formula with an effect that was statistically almost the same as formula 3 and had good gel stability in the formulation. Keywords: Ekor Naga Leaves, Gel, Inflammation, Air Pouch Abstrak Ekstrak etanol daun ekor naga (Rhaphidophora pinnata (L.f) Schott) telah diteliti memiliki efek sebagai agen antiinflamasi. Penenlitian ini bertujuan untuk memformulasi sediaan topikal gel ekstrak daun ekor naga sehingga dapat menjadi menjadi langkah lanjut dari penelitian sebelumnya sebagai upaya pengembangan produk. Metode penelitian yang digunakan adalah experimental design. Kelompok perlakuan dibagi menjadi lima kelompok yaitu: Kontrol positif (Hidrokortisone), Formula 0 (Basis Gel), Formula 1 (Konsentrasi Ekstrak 10%), Formula 2 (Konsentrasi Ekstrak 15%), dan Formula 3 (Konsentrasi Ekstrak 20%). Hewan uji yang digunakan masing-masing kelompok perlakuan 5 ekor. Data yang didapat dianalisis menggunakan ANOVA satu arah dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa semakin banyak ekstrak maka semakin baik efek antiinflamasinya. Namun berdasarkan data evaluasi sediaan pada penelitian sebelumnya tentang formulasi gel maka disimpulkan bahwa formula 2 merupakan formula terbaik dengan efek yang secara statistic hampir sama dengan formula 3 serta memiliki stabilitas gel yang baik dalam formulasi. Kata Kunci: Daun Ekor Naga, Gel, Inflamasi, Air Pouch

Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats Kasmadi, Fathnur Sani; Rahman, Ave Olivia; Rahman, Havizur; Yuliawati, Yuliawati; Samudra, Agung Giri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.7525

Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf extract nanoparticle gel. Previous research from our group highlighted the significant wound-healing potential of a conventional R. pinnata gel. This present study aimed to evaluate the wound-healing efficacy of a novel R. pinnata nanoparticle gel in male Wistar rats, specifically investigating the impact of nanotechnology application. Nanoparticles were successfully formulated via the ionic gelation method, utilizing 0.250 g of R. pinnata extract, 0.1% chitosan, 0.2% sodium tripolyphosphate, and 0.5% Tween 80. Characterization revealed an average nanoparticle size of 165.70±42.76 nm with a zeta potential of 22.0±1.83 mV. The wound-healing efficacy was assessed across five treatment groups: a positive control (Bioplasenton®), a plain gel base (Formula 0), and nanoparticle gels at 0.5% (Formula I), 1% (Formula II), and 1.5% (Formula III) extract concentrations. Statistical analysis using one-way ANOVA (p <0.05) demonstrated a significant difference in incision wound healing across the groups. Formula III, containing 1.5% R. pinnata nanoparticle extract, exhibited the most superior wound-healing effect, achieving 100% inhibition by day 14, elevated hydroxyproline levels (59 µg/mL), and histologically confirmed excellent skin tissue repair. Formulas II and I followed in efficacy. These compelling findings underscore the significant potential of utilizing nanotechnology in the development of topical preparations for accelerated and effective wound healing.

GAMBARAN AMBANG NYERI TRIGGER POINT PADA PASIEN TENSION-TYPE HEADACHE DI KOTA JAMBI Iskandar, MIrna Marhami; Rahman, Ave Olivia; Gading, Patrick William
Scientific Of Environmental Health and Diseases Vol. 1 No. 2 (2021): Scientific of Envitonmental Health And Diseases
Publisher : LPPM Universitas Jambi

ABSTRACT Introduction: The pathogenesis of tension-type headache (TTH) is unclear; however, studies report a correlation between lowered pain thresholds at myofascial trigger points (MTrP) as a cause of cervical spasm, that can develop further into TTH. The MTrP pain threshold among TTH patients in the city of Jambi has never been described. Method: Adult patients diagnosed with TTH in Jambi city are measured for their pain thresholds at the muscles of four known MTrPs: the trapezius, sternocleidomastoid, temporalis, and sub-occipital muscles. Results are then analyzed. Results: Fifty-three subjects were obtained (53 female, 18 male) with the largest age group between 26-40 years old, and most frequent profession to be government worker and housewife. Based on the average pain thresholds of the four MTrPs, the lowest to highest average measurements are on the temporalis muscle (1.93 kg/cm2), m. sternocleidomastoid (2.48 kg/cm2), m. sub-occipital (2.50 kg/cm2) dan trapezius (2.63 kg/cm2). Conclusion: MTrP pain threshold measurements can be considered as a routine examination among TTH patients, as MTrP plays a significant role in the pathogenesis of TTH and potentially as a target of multimodal therapy. Keywords: tension-type headache, myofascial trigger points, pain threshold ABSTRAK Latar belakang: Patogenesis dari tension-type headache (TTH) belum diketahui secara jelas, namun laporan dari beberapa studi menunjukkan bahwa rendahnya ambang nyeri pada beberapa trigger point di otot-otot servikal memiliki korelasi dengan TTH. Nilai ambang nyeri pada trigger point di antara pasien-pasien (TTH) di kota Jambi belum pernah digambarkan. Metode: Pasien-pasien dewasa dengan diagnosis (TTH) di rumah sakit di kota Jambi menjalani pengukuran ambang nyeri dengan algometer pada myofascial trigger point (MTrP) di beberapa titik, yaitu musculus trapezius, sternocleidomastoid, temporalis, dan sub-occipitalis bilateral. Hasil pengukuran kemudian dianalisis. Hasil: Subyek yang didapat yaitu sebanyak 53 pasien (35 perempuan, 18 laki-laki), dengan golongan usai terbanyak yaitu 26-40 tahun. Pekerjaan yang terbanyak yaitu pegawai negeri sipil dan ibu rumah tangga. Dari keempat MTrP, rata-rata ambang nyeri yang terendah hingga tertinggi yaitu m. temporalis (1.93 kg/cm2), m. sternocleidomastoid (2.48 kg/cm2), m. sub-occipital (2.50 kg/cm2) dan m. trapezius (2.63 kg/cm2). Kesimpulan: Pengukuran ambang nyeri pada MTrP dapat dipertimbangkan sebagai suatu pemeriksaan rutin pada pasien dengan TTH, agar dapat dipertimbangkan perannya dalam patogenesis TTH dan sebagai target dalam terapi multimodal. Kata kunci: tension-type headache, myofascial trigger point, ambang nyeri

Co-Authors Adrian, Adek Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Ahmad Syauqy Ahmad Syauqy Ameria Paramita Anati Purwakanthi Anati Purwakanthi Anati Purwakanthi, Anati Anggelia Puspasari Armaidi Darmawan Ayu Syahla Nadia Billi Brian Geniro Cassa de Floris Daffa Akrama Yudha Dea Manda Fredella dewi, hasna Dhea Hana Ismi Nabilah Easti Vishiara Amdely Erny Kusdiyah Esa Indah Ayu, Esa Indah Fenisenda, Angeline Gading, Patrick William Harissa, Nuri Putri Hasna Dewi Havizur Rahman Havizur Rahman Herlambang Humaryanto, Humaryanto Humaryanto, Humaryanto Irawan Anasta Putra, Irawan Anasta Iskandar, Mirna Marhami Jarir At Thobari Kristin Simamora La Ode Reskiaddin Maria, Ima Maulidia Imastary Tan Miftahurrahma, Miftahurrahma Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhaimin Muhaimin Mustofa Mustofa Nadilla Sitepu Nadrizal Nadrizal Nindya Aryanty Nyimas Natasha Ayu Shafira Rahman, Havizur Sani K, Fathnur Simanjuntak, Charles Apul Suzan, Raihanah Tia Wida Ekaputri Wahyu Indah Dewi Aurora Yuliawati Yuliawati Yuliawati

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