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All Journal Current Biochemistry Journal of Natural Sciences and Mathematics Research Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biotek Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Jurnal Ners Jurnal Ilmiah Pharmacy Jurnal Pijar MIPA Jurnal Medical Laboratory Jurnal Ilmiah Pengabdian dan Inovasi Jurnal Multidisiplin Sahombu PCJN Pharmaceutical and Clinical Journal of Nusantara Darma Diksani: Jurnal Pengabdian Ilmu Pendidikan, Sosial, dan Humaniora BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Jurnal Sains dan Kesehatan Alamtana Indonesian Journal of Health Research Innovation Folia Medica Indonesiana
Kresnapati, I Nyoman Bagus Aji
Universitas Bumigora
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Hepatoprotector Edible Flower in Indonesia: A Review Kresnapati, I Nyoman Bagus Aji; Kurniawan, Salsabila Yunita; Novitarini, Novitarini; Pratiwi, Baiq Yulia Hasni
Jurnal Pijar Mipa Vol. 20 No. 3 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i3.8983

Abstract

Hepatotoxicity is an agent that causes damage to human liver function, and every year, cases of liver damage are increasing. Agents that cause liver damage, such as drugs (Paracetamol), chemicals, Carbon Tetrachloride (CCL4), cause liver damage, which is characterized by an increase in the liver enzymes Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Giving natural ingredients such as edible flower extracts (hepatoprotectors) can reduce SGOT and SGPT levels in liver damage (Hepatoxicity). Indonesia is a country rich in biodiversity, including edible flowers. Therefore, the purpose of this study was to analyze edible flowers that grow in Indonesia and have hepatoprotective activity. This research method is based on a Google Scholar search for the last 5 years (2024-2020) with a keyword search for herbal plants that grow in Indonesia, then selected edible flowers, and a search for edible flowers, then selected edible flowers that act as hepatoprotective. From the search results, edible flowers that act as hepatoprotectors were obtained, namely, Rosella Flower (Hibiscus sabdariffa), Pagoda Flower (Clerodendrum paniculatum L.), Water Hyacinth Flower (Eichhornia crassipes), French Marigold Flower (Tagetes Patula) and Butterfly Pea Flower (Clitoria ternatea), which grow abundantly in Indonesia. Based on the content of active edible compounds, namely flavonoids, anthocyanins, tannins, alkaloids, saponins, terpenoids, phenolic acids and carotenoids, with flavonoids being the most dominant found in all edible flowers. And among the 5 edible flowers as hepatoprotective, only 2 are the most familiar in Indonesia, namely Rosella Flower (Hibiscus sabdariffa) and Butterfly Pea Flower (Clitoria ternatea), so it can be concluded that the most familiar hepatoprotective edible flowers in Indonesia are Rosella Flower (Hibiscus sabdariffa) and Butterfly Pea Flower (Clitoria ternatea).
Gerakan Masyarakat Sehat: Sosialisasi Penggunaan Obat Yang Baik dan Benar Indriani, Nurul; Kresnapati, I Nyoman Bagus Aji; Qomaliyah, Eka Nurul; Pratiwi, Baiq Yulia Hasni; Ramandha, Muhammad Eka Putra; Muchsin, Lalu Busyairi
Jurnal Ilmiah Pengabdian dan Inovasi Vol. 1 No. 4 (2023): Jurnal Ilmiah Pengabdian dan Inovasi (Juni)
Publisher : Insan Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57248/jilpi.v1i4.211

Abstract

Self-medication activities are increasingly found in the community. Self-medication is the use of medicines without a prescription on their initiative. Thus, irrational treatment often occurs, and both the duration and dosage of treatment are inappropriate. Appropriate self-medication activities can be started with a healthy living community movement (GERMAS) in the form of socialization of proper drug use. This community service in the form of socializing the use of proper medicines coupled with health checks was carried out to the people of Bagik Polak Village, Labuapi District, West Lombok Regency. This service activity was carried out through direct socialization methods followed by interactive discussions. The implementation of this community service activity went smoothly. The community enthusiastically participated in socialization activities on drug use and a series of health checks.   The discussion session was carried out with a number of questions and answers about drugs, handling, storage, and duration and dosage of treatment.
Anemia Megaloblastik: Sebuah Tinjauan Pustaka Jayawardhana, I Ketut Wisnuaji; Kresnapati, I Nyoman Bagus Aji
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol. 1 No. 1 (2022): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v1i1.2422

Abstract

Anemia megaloblastik merupakan anemia yang ditandai dengan membesarnya eritroblast di sumsum tulang sehingga menganggu pematangan inti sel dan pembelahan sel eritrosit. Kelainan utamanya disebabakan karena defisiensi vitamin B-12 dan asam folat sehingga sintesis DNA terganggu. Diagnosis anemia megaloblastik dilakukan melalui anamnesis, pemeriksaan fisik, dan pemeriksaan penunjang. Pengobatannya dilakukan berdasarkan etiologi yang mendasari. Semakin cepat didiagnosis, prognosisnya akan semakin baik. Penting untuk mengenali, mencegah, dan mengobati anemia megaloblastik.
Evaluasi Tingkat Kepatuhan Penggunaan Obat Antiepilepsi (OAE) terhadap Fungsi Kognitif Anak Anida, Rizki Putri Ayu Dwi; Kresnapati, I Nyoman Bagus Aji; Pratiwi, Baiq Yulia Hasni
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol. 3 No. 1 (2024): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v3i1.4366

Abstract

Epilepsy is a chronic brain disorder with various causes characterized by recurrent attacks. Epilepsy can affect all ages, including children, which affects around 40%-50%. Epilepsy can have an impact on memory disorders, either caused by symptoms of epilepsy itself, antiepileptic drugs (AEDs), psychosocial factors, or comorbidities. Patients with epilepsy are generally advised to consume AEDs for more than 3 months. This antiepileptic treatment takes a long time, so it is very susceptible to causing patient non-compliance in taking AEDs. Therefore, this study aims to determine the level of compliance of pediatric epilepsy patients and whether there is a relationship between compliance and the cognitive function of pediatric patients. In this study, 54 respondents were used from the Mataram City Hospital polyclinic. Compliance was measured using the Morisky Medication Adherence Scale 8 item (MMAS-8) questionnaire and cognitive function measure using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). The result based on the MMAS-8 shows that  7.4% of respondents had high compliance, 61.1% had moderate compliance, and 31.5% had low compliance. Data analysis used the Chi-Square test with α = 0.01 and obtained a significance value (p-value = 0.329). Based on these results, it can be concluded that the level of compliance is moderate, and there is no relationship between compliance and cognitive function.
Effectiveness Test of Ketapang Leaf Extract (Terminalia Catappa L.) as a Hepatoprotective Agent in Mice (Mus musculus) Induced by Acetaminophen Anjani, Desak Sri Ayu; Indriani, Nurul; Kresnapati, I Nyoman Bagus Aji
Jurnal Multidisiplin Sahombu Vol. 5 No. 5 (2025): Jurnal Multidisiplin Sahombu, July - August (2025)
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Drug-induced liver injury (DILI) is a leading cause of acute liver failure, with acetaminophen being the most frequent etiological agent. Overdose induces formation of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI), resulting in glutathione depletion, oxidative stress, and hepatocellular necrosis. This study aimed to evaluate the hepatoprotective effect of ethanolic extract of Terminalia catappa L. leaves in male mice (Mus musculus) with acetaminophen-induced acute liver injury. A post-test only control group design was employed using 20 mice divided into five groups: negative control (Na-CMC), positive control (N-acetylcysteine), and three treatment groups receiving T. catappa extract at doses of 200, 400, and 600 mg/kg BW. Acetaminophen was administered intraperitoneally at 500 mg/kg BW. Serum SGPT and SGOT levels were quantified spectrophotometrically, and phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, tannins, and terpenoids. Extract administration significantly (p < 0.05) reduced SGPT and SGOT levels compared to the negative control, with a clear dose-dependent trend; the 600 mg/kg BW group achieved biochemical parameters approaching those of the N-acetylcysteine group. The hepatoprotective effect is likely mediated by flavonoid-driven antioxidant and anti-inflammatory mechanisms. These findings indicate that T. catappa extract is a promising, safe, and cost-effective plant-based hepatoprotective agent, meriting further investigation toward clinical application as an adjunct therapy for drug-induced hepatotoxicity
PERBANDINGAN EFEK ANTIBAKTERI KULIT BATANG GAMAL (Gliricidia sepium) PADA BAKTERI GRAM POSITIF Bacillus sp. DAN GRAM NEGATIF Pseudomonas aeruginosa Maharani, Reyna; Kresnapati, I Nyoman Bagus Aji; Pratiwi, Baiq Yulia Hasni
Jurnal Ilmiah Pharmacy Vol 12, No 2 (2025)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v12i2.751

Abstract

Infeksi nosokomial masih menjadi masalah serius di fasilitas kesehatan, mendorong pencarian senyawa antibakteri alami. Gamal merupakan tanaman yang berpotensi. Penelitian ini mengevaluasi aktivitas antibakteri ekstrak etanol kulit batang gamal terhadap Bacillus sp. (gram positif) dan Pseudomonas aeruginosa (gram negatif). Metode yang digunakan adalah difusi cakram dengan konsentrasi ekstrak 50%, 60%, 70%, dan 100%. Ekstrak diperoleh melalui maserasi etanol 96%, lalu diuji fitokimia dan antibakteri. Ciprofloxacin digunakan sebagai kontrol positif. Hasil skrining menunjukkan adanya alkaloid dan saponin, tetapi tidak flavonoid. Ekstrak mampu menghambat Bacillus sp. di semua konsentrasi, dengan zona hambat tertinggi 11,7 mm (100%). Namun, tidak ada penghambatan terhadap P. aeruginosa. Analisis statistik (Kruskal-Wallis) menunjukkan perbedaan signifikan antar kelompok (p = 0,017 untuk Bacillus sp.; p = 0,005 untuk P. aeruginosa). Uji Mann-Whitney membuktikan perbedaan antara ekstrak dan kontrol positif, tetapi tidak ada perbedaan antar konsentrasi. Hasil menunjukkan bahwa ekstrak lebih efektif terhadap bakteri gram positif.
ANTIHIPERGLIKEMIA REBUSAN AIR DAUN SALAM (Syzygium polyanthum) TERHADAP PROFIL PEKERJA DI DESA PAOK MOTONG, KECAMATAN MASBAGIK, LOMBOK TIMUR Kresnapati, I Nyoman Bagus Aji; Ramandha, Muhammad Eka Putra; Sofya, Sri Winarni
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 1 (2024): Volume 11 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i1.12963

Abstract

Abstrak: Antihiperglikemia Rebusan Air Daun Salam (Syzygium Polyanthum) Terhadap Profil Pekerja Di Desa Paok Motong, Kecamatan Masbagik, Lombok Timur. Diabetes Mellitus (DM) merupakan penyakit kronis yang ditandai peningkatan kadar gula darah secara terus menerus akibat pankreas secara tidak efektif mensekresi hormon insulin. Daun salam (Syzygium Polyanthum) berperan sebagai obat pada berbagai penyakit seperti lambung, wasir, anti diare, diabetes mellitus, anti hiperkolesterol serta anti hipertensi. Tujuan penelitian ini untuk mengetahui antihiperglikemia rebusan air daun salam (Syzygium Polyanthum) berdasarkan profil pekerja. Sebanyak 41 responden di Desa Paok Motong Barat, Lombok Timur di ukur kadar Gula Darah Sewaktu (GDS) sebelum (pre-test) dan sesudah (post-test) pemberian air rebusan daun salam. Analisis Statisktik Paired Test digunakan untuk mengetahui perbedaan kadar glukosa darah pre-test dan post-test pemberian air rebusan daun salam. Hasil penelitian menunjukkan terjadi penurunan kadar gula darah secara signifikan (p= 0,001) setelah pemberian rebusan daun salam. Berdasarkan karakteristik pekerjaan, rerata penurunan kadar gula tertinggi yaitu berprofesi ibu rumah tangga (IRT) sebesar 20,42 mg/dL, pegawai 18 mg/dL, pedagang 16,67 mg/dL dan terendah petani sebesar 13,79 mg/dL. Terdapat efektivitas secara signifikan (p=0,001) pemberian rebusan daun salam terhadap penurunan kadar glukosa darah dan semua profesi yang ada di Desa Paok Motong. 
Effectiveness of Bay Leaf Decoction (Syzygium polyanthum) on Reducing Blood Glucose Levels in Paok Motong, Masbagik, East Lombok Kurniawan, Nadi; Rozikin; I Putu Bayu Agus Saputra; Sabariah; I Nyoman Bagus Aji Kresnapati
Current Biochemistry Vol. 10 No. 2 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.2.2

Abstract

One disease that correlates with blood glucose levels is diabetes mellitus (DM). According to Basic Health Research (RISKESDAS), in Indonesia by 2030 there will be an increase of up to 21.3 million people suffering from diabetes mellitus. However, nowadays most people are afraid of the side effects of using the drugs they consume and are turning to herbal therapy to lower blood glucose levels. Bay leaves have the benefit of treating diabetes mellitus, hypercholesterolemia, hypertension, diarrhea and gastritis. Phytochemical analysis shows that bay leaves contain essential oils, tannins, flavonoids and terpenoids. The aim of the research was to determine the effect of bay leaf boiled water on reducing blood glucose levels. The research was an experimental One Group Pretest Post-test Design, namely the research subjects had their blood glucose levels measured before (pre-test) and after being given bay leaf boiled water (post-test). 41 respondents in Paok Motong Barat village, Masbagik District, East Lombok Regency had their Blood Glucose Levels (GDS) measured before (pre-test) and after (post-test) giving 300 mL of bay leaf boiled water. Paired Test Statistical Analysis was used to determine the difference in pretest and posttest blood glucose levels given bay leaf boiled water. The results of the study showed that there was a significant decrease in blood glucose levels (p= 0.001) by 15.22 mg/dL to 179.27 mg/dL before administering bay leaf decoction amounting to 194.49 mg/dL. The conclusion is that there is a significant effect (p=0.001) of giving boiled bay leaves on reducing blood glucose levels. The suggestion for this research is to increase the number of respondents in the research as well as examination variables such as fasting blood glucose
The Correlation Between Smoking Behavior and The Use of “Used Cooking Oil” with Hypertension Incidences at Malimbu Coastal Area Adnyana, I Gede Angga; Kresnapati, I Nyoman Bagus Aji; Saputra, I Putu Bayu Agus; Diarti, Maruni Wiwin; Jiwintarum, Yunan
Jurnal Keperawatan Terpadu (Integrated Nursing Journal) Vol. 5 No. 2 (2023): OKTOBER
Publisher : Jurusan Keperawatan, Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jkt.v5i2.518

Abstract

Hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure and stroke, which is the highest cause of death in the world. One area with high risk of hypertension is the coastal area. The famous coastal area in the Lombok is Malimbu, located in North Lombok, West Nusa Tenggara Province. This research is an analytical observational study with a cross sectional design. This study aims to determine the correlation between smoking behavior and use of “used cooking oil” and the incidence of hypertension. Samples in this study were 70 people (n=70), and was taken using accidental sampling technique. Data were analyzed using chi-square. The results showed that the incidence of hypertension was 48% of the 70 respondents. Most of the respondents (70%), had no history of hypertension in their family. This research shows that there is no correlation between smoking behavior and the incidence of hypertension (p=0.807) with PR=1.156 (0.354 - 3.797). The use of “used cooking oil” was also found to be not correlated with the incidence of hypertension (p=0.632) with PR=1.275 (0.486 - 3.345). Although several previous studies showed that the smoking behavior and the use of used cooking oil correlate to hypertension, but this study result shows different data. This can be caused by other factors. Future research needs to examine the characteristics of smokers that may be related to the incidence of hypertension
ANALISIS TINGKAT PENGETAHUAN PENANGANAN ASI SERET MENGGUNAKAN OBAT TANAMAN KELUARGA PADA IBU MENYUSUI DI DESA MESANGGOK KECAMATAN GERUNG Muhammad Khairul Anam; Nurul Indriani; I Nyoman Bagus Aji Kresnapati
Indonesian Journal of Health Research Innovation Vol. 1 No. 4 (2024): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/50904812

Abstract

Penggunaan tanaman obat keluarga (TOGA) sebagai solusi alami untuk masalah laktasi semakin diperhatikan, terutama di daerah pedesaan. Pengetahuan ibu menyusui mengenai ASI eksklusif dan pemanfaatan TOGA untuk mengatasi ASI seret sangat penting untuk keberhasilan menyusui. Penelitian ini bertujuan untuk mengevaluasi karakteristik demografis dan tingkat pengetahuan ibu menyusui tentang ASI eksklusif serta penanganan ASI seret menggunakan TOGA di Desa Mesanggok. Desain penelitian ini adalah deskriptif kuantitatif. Data dikumpulkan melalui kuesioner yang didistribusikan kepada 52 responden. Validitas data diuji menggunakan perangkat SPSS versi 27. Hasil analisis menunjukkan bahwa mayoritas responden berusia 20-30 tahun (63,46%), diikuti oleh kelompok usia 31-40 tahun (32,70%), dan usia 41-47 tahun (3,84%). Dari segi pendidikan, 9,6% responden memiliki tingkat pendidikan SD, 21,2% SMP, 51,9% SMA, dan 17,3% perguruan tinggi. Tingkat pengetahuan responden tentang ASI eksklusif dan penggunaan TOGA untuk mengatasi ASI seret tergolong baik, dengan 61,54% responden memiliki pengetahuan tinggi, 21,15% sedang, dan 17,31% rendah. Hasil ini menunjukkan bahwa sebagian besar ibu menyusui memiliki pemahaman yang baik tentang pentingnya ASI eksklusif dan manfaat TOGA dalam penanganan ASI seret. Penelitian ini menegaskan pentingnya edukasi berkelanjutan untuk meningkatkan pengetahuan ibu menyusui tentang praktik kesehatan alami yang aman dan efektif.
Co-Authors Akmi, Alfarizi Muzaifa Amalia, Aini Ana Rahmatyar Anam, M Khairul Anida, Rizki Putri Ayu Dwi Anjani, Desak Sri Ayu Aryani , R . Ayu Ida Baiq Dinda Puspita Ayu Baiq Yulia Hasni Pratiwi Eka Nurul Qomaliyah Hairul Hairul I Gede Angga Adnyana I Ketut Wisnuaji Jayawardhana I Putu Bayu Agus Saputra Indri Safitri Indri Safitri, Indri Jayawardhana, I Ketut Wisnuaji Khaerunnisa, Siti Kurniawan, Nadi Maharani, Reyna Maruni Wiwin Diarti Maruni Wiwin Diarti Muchsin, Lalu Busyairi Mudawil Qulub Muhammad Eka Putra Ramandha Muhammad Haris Nasri Muhsin, Lalu Busyairi Nikendra, Ni Nengah Naia Novitarini Nurul Indriani Ramadhani, Muhammad Wisda Pradja Rasyid, M. Gazali Abdul Rozikin Sabariah Salsabila Yunita Kurniawan Saputri, Syarifa Anita Siti Khaerunnisa Sofya, Sri Winarni Sri Winarni Sofya Yunan Jiwintarum Yunan Jiwintarum