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All Journal Pharmaciana: Jurnal Kefarmasian Current Biochemistry BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan MATRIK : Jurnal Manajemen, Teknik Informatika, dan Rekayasa Komputer Chemistry Education Practice Jurnal Kolaboratif Sains Jurnal Pijar MIPA Jurnal Pengabdian Masyarakat Bhinneka Jurnal Ilmiah Pengabdian dan Inovasi BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Asian Journal of Environmental Research

Eka Nurul Qomaliyah

Department Of Pharmacy, Bumigora University, Jl. Ismail Marzuki No.22, Mataram 83127, Indonesia

Author-ID : 2818370

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Antibacterial Activity of Lemongrass (Cymbopogon nardus) Ethanolic Extract Waras Nurcholis; Mira Takene; Ratna Puspita; Lisnawati Tumanggor; Eka Nurul Qomaliyah; Muhammad Maftuchin Sholeh
Current Biochemistry Vol. 6 No. 2 (2019)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.6.2.4

Infectious diseases are a disease caused by bacteria such as Escherichia coli and Staphylococcus aureus. One way to overcome the disease by using antibiotics. However, wise use can lead to antibiotic resistance, so many bacteria are resistant to antibiotics. Therefore it is necessary to search the natural compounds as antibacterials, one of them by using lemongrass (Cymbopogon nardus). This study aims to determine the effectiveness of leaf extracts, stems, and roots lemongrass as antibacterial. The method used in this research is the disc method. Bacteria used are E. coli and S. aureus. The results show extracts of roots, stems, and leaf has activity against S. aureus, while E. coli shows no activity as antibacterial, it can be possible because of the different properties of the bacteria. Keywords: anti-bacteria, lemongrass, Escherichia coli, Staphylococcus aureus

Antiproliferation activity of water and ethyl acetate red yeast rice fraction against MCM-B2 tumor cells Hasim Hasim; Surya Pangidoan Nasution; Bambang Pontjo Priosoeryanto; Eka Nurul Qomaliyah
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Red yeast rice (RYR), commonly known as angkak, is a functional food fermented by rice using Monascus mushrooms. It has a pigment and flavonoid content that is useful as an antioxidant and plays a role in preventing cancer or tumors. This analysis aims to test the antiproliferation activity of commercial RYR fractions of water and ethyl acetate against Miyazaki Canine Mammary Gland Tumor-Bambang 2 (MCM-B2) breast tumor cells. Research on RYR antiproliferation of cancer-sustaining MCM-B2 cells has not been previously released. In the preliminary study, the antiproliferation bioactivity was measured using the brine shrimp lethality test. The outcome of the brine shrimp lethality test showed that ethyl acetate and water fraction cytotoxicity were more than 1000 ppm and 337.07 ppm, respectively, at a lethal concentration of 50. Antiproliferative activity analyses were performed using direct hemocytometer counting. The antiproliferation activity data collected were analyzed using one-way ANOVA and Duncan continuous testing. The outcome showed that the water and ethyl acetate RYR antiproliferation activity against MCM B2 cancer cells correlated positively with the increasing concentration of each fraction. Ethyl acetate and water fractions at concentrations of 350 ppm may inhibit the growth of MCM-B2 cancer cells in vitro, reaching 42.63 percent and 39.84 percent, respectively, not significantly different (P < 0.05) with a positive doxorubicin control of 41.24 percent. In conclusion, the ethyl acetate and water fraction of RYR have potent antiproliferation activity against MCM-B2 breast tumor cells.

PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBASIS LITERASI SAINS TERHADAP HASIL BELAJAR MATERI POKOK LARUTAN PENYANGGA Eka Nurul Qomaliyah; Sukib Sukib; I Nyoman Loka
Jurnal Pijar Mipa Vol. 11 No. 2 (2016): SEPTEMBER
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram

Abstrak.ÃÂ Penelitian ini bertujuan untuk mengetahui pengaruh model inkuiri terbimbing berbasis literasi sains terhadap hasil belajar materi pokok larutan penyangga pada siswa kelas XI SMAN 1 Gunungsari. Desain penelitian yang digunakan adalah quasi experimental dengan rancangan nonequivalent control group design. Populasi penelitian yaitu seluruh siswa kelas XI IPA SMAN 1 Gunungsari yang terdiri dari empatÃÂ kelas, dengan jumlah total 98 siswa. Teknik pengambilan sampel dalam penelitian ini adalah purposive sampling. Sampel terpilih yaitu kelas XI IPA 1 sebagai kelas eksperimen yang diberi perlakuan model inkuiri terbimbing berbasis literasi sains dan kelas XI IPA 2 sebagai kelas kontrol yang diberi perlakuan model konvensional, yaitu ceramah dan tanya jawab. Hasil uji hipotesis dengan uji Anakova satu jalur dengan satu kovariabel didapatkan Fhitung sebesar 13,91, sedangkan nilai Ftabel dengan probabilita 0,05 sebesar 4,05, maka Fhitung>Ftabel (13,91>4,05) yang menunjukkan ada pengaruh model pembelajaran inkuiri terbimbing berbasis literasi sains terhadap hasil belajar. Nilai rata-rata kelas dan ketuntasan klasikal yang lebih besar pada kelas eksperimen dibandingkan kelas kontrol menunjukkan pembelajaran dengan model inkuiri terbimbing berbasis literasi sains lebih baik dibandingkan dengan pembelajaran konvensional dikaitkan dengan hasil belajar.Kata Kunci: Hasil belajar, Inkuiri Terbimbing, Larutan Penyangga, Literasi Sains Abstract.ÃÂ This research aimed to investigate the influence of guided inquiry model based on science literacy to the learning outcomes of the subject matter of the buffer solution of second year student in SMAN 1 Gunungsari. The research used quasi-experimental method with nonequivalent control group design. The population of the research were 98 students of second year science of SMAN 1 Gunungsari, which were divided into four classes. The sampling technique in this research used purposive sampling. XI science-1 class was selected as the experimental class which used guided inquiry model based on science literacy and XI science-2 class was selected as the control class which used conventional models through lectures and question-answer. Hypothesis test results through the Ancova one lane with one covariates test obtained Fcount equal to 13.91, while the value ofÃÂ Ftable with probability 0,05 equal to 4,05, then Fcount > Ftable (13.91 > 4.05), the results show that there is an influence of guided inquiry learning model. The average and classical completeness value of experimental class greater than the control class shows that guided inquiry based on science literacy learning is better than the conventional learning related to learning outcomes.Key words: Learning Outcomes, Guided Inquiry, Buffer Solution, Science Literacy

Ekstrak Angkak dan Bekatul untuk Mencegah Peroksidasi Lipid Tikus Spague-Dawley Hiperglikemik Hasim Hasim; Moh Asroriy Nuris; Agus Setyono; Eka Nurul Qomaliyah; Didah Nur Faridah
Jurnal Aplikasi Teknologi Pangan Vol 9, No 2 (2020): Mei 2020
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Angkak dan bekatul merupakan pangan fungsional yang berpotensi sebagai agen terapi untuk mengendalikan gula darah, dikarenakan kandungan antioksidan alaminya. Tujuan penelitian adalah untuk mengevaluasi pengaruh campuran ekstrak angkak dan bekatul dalam menghambat peroksidasi lipid serta efeknya terhadap organ pankreas, hati dan ginjal tikus hiperglikemik secara histopatologi. Tikus dibagi ke dalam 7 kelompok yaitu kelompok kontrol normal, kontrol negatif, kontrol positif, formulasi ekstrak angkak bekatul kelompok I, II, III dan IV (20:1400, 40:700, 30:1050, dan 60:2100 mg/kg BB). Parameter pengujian yang dilakukan adalah konsentrasi malondialdehid (MDA) dan aktivitas enzim aminotransferase (ALT/AST) serum darah tikus dan histopatologi organ pankreas, hati dan ginjal. Campuran terbaik dalam menghambat pembentukan MDA dan peningkatan enzim ALT/AST adalah kelompok III dengan konsentrasi MDA (3,.31±0,.53 nmol/ml) dan aktivitas enzim ALT (35,.80±5,.63 U/l) tidak berbeda nyata dengan kontrol normal (4,.85±2,.32 nmol/ml) dan (27,.85±8,.13), sementara aktivitas enzim AST (67,.221±16,.05) mengalami penurunan namun berbeda nyata dengan kontrol normal (4,.365±0,.00). Kondisi histopatologi organ pankreas, hati, dan ginjal tikus semua kelompok perlakuan menunjukkan kemampuan dalam memperbaiki kerusakan organ. Kesimpulannya, campuran angkak dan bekatul 30:1050 mg/kg BB memiliki kemampuan terbaik dalam meghambat peroksidan lipid.Angkak and Rice Bran Extract to Prevent Lipid Peroxidation in Spague-Dawley Rats HyperglycemicAbstractAngkak and rice bran is a functional food that has potential as a therapeutic agent to control blood sugar. This potential is due to the content of natural antioxidants in red yeast rice and rice bran. The objective of this research was to evaluate the effect of angkak and rice bran extract as lipid peroxidation inhibition. The effect on the pancreatic, liver and kidney organs in hyperglycemic rats by histopatological study was also analyzed. Rats were divided into 7 groups namely normal control group, negative control, positive control, rice bran extract formulation on gorup I, II, III, IV (20: 1400, 40: 700, 30: 1050, and 60: 2100 mg/kg BW). The analysis parameters carried out were the concentration of malondialdehyde (MDA), the activity of the serum alanine/aspartat aminotransferase (ALT/AST) enzymes and rat histopathology of pancreatic, liver and kidney organs. The best mixture of angkak and rice bran to inhibit the formation of MDA and increase the ALT/AST enzyme was group III with MDA concentration (3,.31±0.,53 nmol/ml) and ALT enzyme activity (35.,80±5,.63 U/l) was not significantly different from normal control (4,.85±2,.32 nmol/ml) and (27.,85±8,.13), while the enzyme activity of AST (67,221±16,.05) decreased but was significantly different from normal controls (4,365±0,.00). Histopathological conditions of pancreatic, liver, and kidney organs of rats in all treatment groups showed the ability to repair damaged organs. In conclusion, the mixture of red yeast rice and rice bran 30:1050 mg/kg BW had the best ability to inhibit lipid antioxidants.

Pancreatic Lipase Inhibition Activity in Lipid Absorption Using Traditional Plants: A Systematic Review and Meta-Analysis Hasim Hasim; Didah Nur Faridah; Eka Nurul Qomaliyah; Frendy Ahmad Afandi
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76873

Obesity is a complex and multifactorial disease resulting from excessive accumulation of fat. With a significant annual increase, it has become a health concern across the globe in the last decades. To tackle this problem, an exploration of traditional medicinal plants (TMP) functioning as anti-obesity drugs using an ethnopharmacology approach has been carried out. Research on the drug development of obesity treatment was directed at how to inhibit pancreatic lipase as the enzyme accounted for lipid absorption. Using a systematic review and meta-analysis, this current study investigated TMP anti-obesity from the articles published in 6 scientific databases, i.e., Scopus, Science Direct, Proquest, Cengage Library, Ebsco, and Emerald, using particular keywords. The review resulted in 19 articles containing 91 eligible data based on inclusive and exclusive criteria. Meta-analysis extracted data as follows: IC50, number of replications, and standard error, regarding the anti-obesity effects of medicinal plants and orlistat as a positive control. The results showed 8 medicinal plants showing anti-obesity via inhibition of pancreatic lipase, including Solenostemma argel, Garcinia vilersiana, Phyllanthus chamaepeuce, Cassia auriculata, Moringa oleifera, Ficus carica, Ocimum gratissimum, and Adiantum capillus-veneris.

Etnofarmakologi dan Potensi Bioaktivitas Daun dan Buah Sirsak (Annona Muricata): Artikel Review Eka Nurul Qomaliyah
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 1 No 1 (2022): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v1i1.2488

The leaves and fruit of soursop or Annona muracita have been used extensively as medicinal plants by people in various ethnic groups in Indonesia. Soursop leaves and fruit are believed to prevent and treat diabetes, obesity, and hypertension. Various scientific studies have proven the potential activity of soursop leaves and fruit to have antidiabetic, antioxidant, antiobesity, cytotoxic, anticancer, antihypertensive, antibacterial, anti-inflammatory, antirheumatic, and hepatoprotective effects. Based on literature studies related to phytochemicals sourced from Scopus, Science direct, PubMed, ProQuest reports that at least 54 secondary metabolites have been isolated and identified. These compounds include a group of alkaloids, phenols, and acetogenins. This article presents a brief overview that seeks to compile all information regarding the phytochemistry, ethnopharmacology, and bioactivity of soursop leaves and fruit.

Optimizing Treatment of Herbal Plant Using SOPHERBAL Android Application Fordward Chaining Method Muhamad Azwar; Eka Nurul Qomaliyah; Nurul Indriani
MATRIK : Jurnal Manajemen, Teknik Informatika dan Rekayasa Komputer Vol 23 No 2 (2024)
Publisher : LPPM Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/matrik.v23i2.3371

The utilization of traditional herbal medicine among the inhabitants of Lombok is notably prevalent yet frequently hindered by a lack of comprehension regarding the efficacy of herbal remedies for specific ailments. Addressing this challenge, this study proposes the development of an Android application called ”sopherbal,” aimed at delivering personalized herbal plant recommendations via easily accessible mobile devices. Employing forward chaining methodology, the application identifies optimal herbal remedies based on ailment type, processing techniques, usage instructions, and recommended dosage and treatment duration. Notably, while effective in this context, the forward chaining approach entails certain trade-offs and hurdles. Previous research indicates that forward chaining facilitatesaccurate recommendation generation, and it may be constrained by its reliance on predefined rules and limited adaptability to complex, evolving scenarios. Despite these challenges, the ”sopherbal” application, featuring 50 Sasak medicinal plants curated for 15 common ailments, achieved an 86% validation rate, affirming its efficacy in bridging the gap between traditional herbal knowledge and modern healthcare needs.

DIVERSITY OF PISCES IN THE LEMBAH TUMPANG Murti, Aisyah Andhina; Ayu, Fatma Aisyah; Nisa, Hafidzah Ra'iyatun; Mukti, Nuril Chasanah; Maudina, Rahma Ursula; Fardani, Indra; Qomaliyah, Eka Nurul
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.13660

The objective of this study was to determine the diversity of fish species found in Tumpang Valley, Tumpang Sub-district, Malang Regency, East Java as an effort to preserve fish species. The method used in this research is observation in various ponds by using the help of reflection book and google lens to identify the types of fish found. Based on the results of research conducted by researchers on the diversity of fish species in Tumpang Resort Valley Area, Tumpang District, Malang Regency, the results indiccate that there are 5 species, namely koi fish, Javanese wader fish (tawes), tilapia fish, citul fish, and goldfish. There are various types of koi fish with different genetic variations, but there are 8 koi fish that can be identified by researchers, namely platinum koi fish, orenji ogon koi fish, karasugoi koi fish, kigoi koi fish, yamato nishiki koi fish, nezu ogon koi fish, silver koi fish, and sanke koi fish. The result of the fish diversity index obtained is 1.173 (in the low category).

DIVERSITY OF MOSS PLANTS (BRYOPHYTA) IN COBAN TALUN, BATU CITY Royana, Dhita Fitri; Shofi, Fifi Maziyatus; Damayanti, Lisa Kurnia Anggraeni; Zulfa, Naila; Kurniawati, Nika Fitri; Fardhani, Indra; Qomaliyah, Eka Nurul
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.13666

Mosses (Bryophyta) are lower plants that lack the vascular tissue, roots, stems and true leaves of higher plants. Lichens can grow in a variety of habitats, including in extreme environments. This study aims to identify the diversity of moss plants in Coban Talun, Batu City, East Java. The sampling technique applied in this study involved dividing the area into 10 plots, with each plot having a size of 3m x 3m. The results obtained from ten plots in the Coban Talun waterfall area showed the presence of 9 species of lichens growing in the location, namely Anoectangium aestivum, Anomodon attenuatus, Campylopus introflexus, Marchantia polymorpha, L. cruciata, Pogonatum inflexum, Andreaea sp., Leucobryum glaucum, and Conocephalum conicum. Moss diversity is strongly influenced by environmental conditions such as temperature, air humidity, and light intensity. At low temperatures (around 25°C) moss diversity is higher than at higher temperatures (around 29°C). At humidity close to 72%, liverwort diversity is more dominant, while at humidity around 62%, leafwort diversity is more dominant.

Penyuluhan Kefarmasian dan Pemeriksaan Kesehatan di Desa Gegelang, Lombok Barat Indriani, Nurul; Qomaliyah, Eka Nurul; Ramandha, Muhammad Eka Putra; Kresnapati, I Nyoman Bagus Aji; Ramadhani, Muhammad Wisda Pradja; Mudawil Qulub
Jurnal Ilmiah Pengabdian dan Inovasi Vol. 1 No. 3 (2023): Jurnal Ilmiah Pengabdian dan Inovasi (Maret)
Publisher : Insan Kreasi Media

The incidence of degenerative diseases is increasing every year. Degenerative diseases are caused by decreased organ function not only due to age but also due to lifestyle factors such as eating patterns, stress levels, and a history of other diseases. This community service is carried out in Gegelang Village, West Lombok, Indonesia. The aims of this community service are to detect degenerative diseases early and to provide an understanding of prevention to management as a preventive measure for several degenerative diseases. Methods used in these activities include providing free health checks, followed by health education training. Gegelang village received health education training on the causes and treatment of degenerative diseases specifically obesity, diabetes mellitus, hypertension, and uric acid. Health checks specifically that included measuring body mass index, checking blood pressure, blood sugar levels, and uric acid level. Of the 68 villagers who took part in the body mass index examination, the percentages of underweight, normal, overweight, and obesity types 1 and 2 were 5.89%, 23.53%, 22.06%, 29.41%, and 19.11%, respectively. Meanwhile, systolic blood pressure greater than 140 mmHg was 22.06%, and diastolic blood pressure greater than 90 mmHg was 11.27%. Examination of blood sugar during normal classification, high blood sugar levels at risk, and indications of diabetes in 58%, 23%, and 11%. The amount of uric acid included in the high classification is only 11%. Improving the quality of health, early detection, and management of degenerative diseases is urgently needed.

Co-Authors Abraham Tiandno Witjaksono Afandi, Frendy Ahmad Agus Setyono Ainul Yaqin Aji Kresnapati, Bagus Arifin, Achmad Saiful Asyaun Niqris, Adelliana Aulia Azahra, Rahmania Ayu, Fatma Aisyah Baiq Yulia Hasni Pratiwi Bambang Pontjo Priosoeryanto Chairani Fatimah, Nina Damayanti, Lisa Kurnia Anggraeni Dian Nugraheni Fardani, Indra Fardhani, Indra Habiddin Hanandya Rahma Dinda Destriani Hasim - Hasim Hasim Hasim Hasim I Gusti Nyoman Hari Satwika I Made Kawi Widana I Nyoman loka Islamiyati, Ricka Kresnapati, I Nyoman Bagus Aji Kurniawati, Nika Fitri Lisnawati Tumanggor Maudina, Rahma Ursula Mira Takene Moh Asroriy Nuris Muchsin, Lalu Busyairi Mudawil Qulub Muhamad Azwar Muhamad Azwar, Muhamad Muhammad Eka Putra Ramandha Muhammad Maftuchin Sholeh Muhsin, Lalu Busyairi Mukti, Nuril Chasanah Murti, Aisyah Andhina Nadia, Intan Naila Zulfa Nina Chairani Fatimah Nisa, Hafidzah Ra'iyatun Nurul Indriani Nyoman Bagus Aji K Prabowo, Himawan Ganjar Praptawati, Atika Ramadhani, Muhammad Wisda Pradja Ratna Puspita Relia Fitrah, Aura Rini Anggi Arista Riyanto, Obaja Eden Santosa Rohma, Atika Rosita Assyifa Purba Royana, Dhita Fitri Santosa, Khalis Nadhira Setyoningrum, Nadia Shofi, Fifi Maziyatus Sofya, Sri Winarni Sri Winarni Sofya Sri Winarni Sofya Sukib Sukib Surya Pangidoan Nasution Syamsuddin, Imam Waras Nurcholis Widowati, Tamara Rahma

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