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All Journal Pharmaciana: Jurnal Kefarmasian Damianus Journal of Medicine Science and Technology Indonesia JFL : Jurnal Farmasi Lampung Jurnal Kreativitas PKM Jurnal Abdimas Mahakam MAHESA : Malahayati Health Student Journal Jurnal Pengabdian kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada Sciences and Clinical Pharmacy Research Journal Medical Sains : Jurnal Ilmiah Kefarmasian Health Care Media
Febriana Astuti
Politeknik Kesehatan TNI AU Adisujtipto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Penyuluhan Pencegahan Penyakit Tukak Lambung di Desa Pelem Baturetno Banguntapan Bantul Izzati, Unsa; Astuti, Febriana; Suryanto, Bambang
Jurnal Abdimas Mahakam Vol. 8 No. 01 (2024): Januari
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/jam.v8i01.2515

Abstract

Lambung adalah salah satu organ dalam sistem pencernaan pada manusia yang berfungsi untuk mencerna makan dan menyerap beberapa sari-sari makanan. Secara garis besar ada tiga faktor penyebab dari tukak lambung diantaranya Helicobacter pylori, penggunaan OAINS dan kerusakan mukosa yang berhubungan dengan stress. Kurangnya edukasi, informasi dan pelatihan mengenai cara pencegahan dan pengobatan gejala tukak lambung sering kali membuat masyarakat keliru dalam mencegah dan menggunakan atau mengkonsumsi obat tukak lambung. Penyuluhan ini dilaksanakan menggunakan metode edukasi dan sharing serta pemaparan materi dengan ceramah kesehatan. Materi yang disampaikan adalah pengertian dari penyakit tukak lambung, macam-macam penyakit pada lambung, prevalensi penyakit di Indonesia, gejala penyakit, pencegahan penyakit dan pengobatan penyakit berdasarkan obat dipasaran. Pengukuran tingkat pengetahuan masyarakat menggunakan kuesioner yang diberikan sebelum dan sesudah pemberian ceramah kesehatan. Kuesioner diberikan sebelum responden mendapatkan leaflet dan penyuluhan mengenai pencegahan serta pengobatan pada penyakit lambung khususnya tukak lambung (pre-test) dan sesudah selesai penyuluhan (Post-test). Setelah dilaksanakan edukasi dan ceramah serta pemberian kuesioner (post-test) tingkat kemampuan responden meningkat. Terjadinya peningkatan pengetahuan disebabkan adanya edukasi diberikan leaflet dan penyuluhan.
Peredaran Obat Secara Daring di Indonesia, Kemajuan atau Ancaman Goni, Nur; Astuti, Febriana; Abidin, Zainal; Purwanto, Gunawan
Sciences and Clinical Pharmacy Research Journal Vol. 2 No. 4 (2026): January
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/scpr.v2i4.5115

Abstract

Penelitian ini bertujuan untuk menganalisis fenomena peredaran obat secara daring di Indonesia dalam konteks kemajuan digital dan ancaman terhadap keamanan kesehatan masyarakat. Penelitian menggunakan pendekatan kualitatif deskriptif melalui studi pustaka dengan menelaah artikel ilmiah, laporan resmi, serta dokumen akademik terkini terkait kebijakan farmasi digital dan regulasi BPOM. Teknik pengumpulan data dilakukan melalui penelusuran literatur dan analisis dokumen, sementara analisis data menggunakan tahapan identifikasi tema, reduksi data, dan penarikan kesimpulan secara induktif. Hasil penelitian menunjukkan bahwa digitalisasi farmasi memberikan kemajuan signifikan dalam peningkatan akses, efisiensi, dan pemerataan layanan kesehatan, khususnya melalui platform e-pharmacy seperti GoApotik dan KlikDokter. Namun, di sisi lain, maraknya penjualan obat tanpa izin dan lemahnya pengawasan digital menimbulkan ancaman serius bagi keamanan konsumen dan integritas profesi farmasi. Implementasi Peraturan BPOM No. 8 Tahun 2020 masih menghadapi kendala karena keterbatasan sumber daya manusia, rendahnya literasi kesehatan masyarakat, serta minimnya tanggung jawab dari pihak e-commerce. Penelitian ini memberikan kontribusi teoretis terhadap pemahaman tentang Technology Acceptance Model dan governance gap theory dalam konteks farmasi digital, sekaligus menegaskan pentingnya kolaborasi antara pemerintah, pelaku usaha, dan akademisi untuk memperkuat tata kelola distribusi obat daring di Indonesia.
Flavonoid synergy in antioxidant optimization: a study of Apium graveolens and Orthosipon stamineus Astuti, Febriana; Akrom; Setianto, Arif Budi; Hidayati, Titiek; Mustofa; Anwar, Muslih; Sun, Suny
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30599

Abstract

Oxidative stress, which arises by an imbalance among the formation of free radicals and the body's antioxidant defenses, is a pivotal factor in the pathogenesis of numerous degenerative abnormalities, comprising cardiovascular abnormality. Flavonoids, that are natural chemicals by antioxidant capabilities, have been identified as potential agents for protection against the adverse impacts of oxidative stress. The objective of this study was to ascertain the flavonoid substance of Apium graveolens and Orthosipon stamineus extracts and their antioxidant activity. The technique comprising qualitative and quantitative phytochemical tests to decide the flavonoid substance of the extracts. In addition, bioactive compounds were screened utilizing LC-HRMS, and antioxidant activity was evaluated utilizing the DPPH technique. The outcomes of this study drawn the presence of flavonoid compounds, alkaloids, tannins, and saponins in the Apium graveolens and Orthosipon stamineus extracts. The Orthosipon stamineus extract was found to contain steroid compounds. The screening of flavonoids compounds utilizing LC-HRMS has drawn the presence of the greatest diversity of flavonoid compounds in the Apium graveolens extract. The antioxidant activity assay employed quercetin as the standard, possessing an IC₅₀ value of 3.95 μg/mL. Apium graveolens extract exhibited an IC₅₀ value of 58.86±0.44μg/mL, Orthosiphon stamineus extract drawn an IC₅₀ value of 61.69±0.21 μg/mL, whereas the combined extract yielded an IC₅₀ value of 46.32±0.34 μg/mL. The outcomes indicate that the extract combination shows superior free radical scavenging ability compared to the individual extracts, suggesting its potential to enhance the antioxidant efficacy of bioactive compounds derived by herbal plants.
Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Program Penyuluhan tentang Pemanfaatan Pelayanan Kesehatan di Pengungsian Gempa Bumi Cianjur 2022 Iskardyani, Delfi; Astuti, Febriana; Arifin, Novi Riza
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 4 (2026): Volume 9 Nomor 4 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i4.13177

Abstract

ABSTRAK Gempa bumi Cianjur menimbulkan kerusakan infrastruktur dalam skala besar termasuk fasilitas layanan kesehatan. Adanya pengungsian yang diakibatkan oleh bencana, berakibat pada timbulnya masalah kesehatan seperti, campak, batuk, demam, malaria, luka, kurang gizi, sakit kulit serta adanya komplikasi pada bayi. Kegiatan ini bertujuan untuk memberikan pengetahuan tentang pemanfaatan pelayanan kesehatan di pengungsian. Penyuluhan dilakukan menggunakan leaflet dengan mendatangi tenda pengungsian secara langsung serta serta melibatkan tim Dukungan Kesehatan dari RSAU dr. M. Salamun Bandung untuk pemeriksaan Kesehatan. Kegiatan dilaksanakan sesuai dengan yang ada di pedoman promosi kesehatan, yaitu memberikan informasi 5 jenis layanan kesehatan yang dapat diperoleh pada lokasi pengungsian. Pemeriksaan tersebut terdiri dari: a) Pemeriksaan kehamilan; b) Pemeriksaan kesehatan bayi balita; c) Pemeriksaan kesehatan umum; d) Pemeriksaan kesehatan pada orang yang cacat dan pada lansia; e) Pelayanan kesehatan mental. Dilakukannya penyuluhan ini dapat meningkatkan pengetahuan serta kesadaran dari pengungsi terhadap pemanfaatan layanan kesehatan pada lokasi pengungsian yang dibuktikan dengan antusiasme pengungsi untuk langsung mengikuti pemeriksaan kesehatan. Kata Kunci: Gempa Bumi, Pelayanan Kesehatan, Pengungsian. ABSTRACT The Cianjur earthquake caused large-scale damage to infrastructure, including health service facilities. Displacement caused by disasters results in health problems such as measles, coughs, fever, malaria, wounds, malnutrition, skin diseases, and complications in babies.  This activity aims to provide knowledge about the use of health services in refugee camps. Counseling was carried out using leaflets by visiting refugee tents directly and involving the Health Support team from RSAU dr. M. Salamun Bandung for a health check.  Activities are carried out in accordance with the health promotion guidelines, namely providing information on five types of health services that can be obtained at refugee camps. The examination consists of: a) Pregnancy examination; b) Health checks for babies and toddlers; c) General health examination; d) Health checks on disabled people and the elderly, e) Mental health services.  Carrying out this outreach can increase the knowledge and awareness of refugees regarding the use of health services at refugee locations, as evidenced by the enthusiasm of refugees to attend health checks immediately. Keywords: Earthquake, Health Service, Shelter.
Co-Authors Akrom Akrom, Akrom Andhika Nor Hendryawan Angela Angela Anggoro Wicaksono Anggrek Anggrek Anisa Utami Anna L Yusuf Anna Lesmanasari Yusuf Anwar, Muslih Apriyani, Herlinan Dwi Arif Budi Setianto Arifin, Novi Riza Arifin, Novi Rizal Asnaya Ayysy Rahmadhani Azhima, Adelia Azzahra, Fara Azzahra, Faza Bambang Suryanto Bita Bita Capritasari, Rafiastiana Citra Farah Diana Simatupang Davit Nugraha Delfi Iskardyani Delfi Iskardyani Delfi Iskardyani Devi Febriella Dona Suzana Erfanuzan Erfanuzan Fara Azzahra Farah Nur Rahadatul Aisy Goni, Nur Hasna, Elly Rosita Herlina Herlina Ilham Alifiar Iskardyani, Delfi Izzati, Unsa Jarot Styapurnomo Karabu, Ince Rambu Kharisma Dani Iswati Kurnia Ageng Miracle Gumilang Kusmini Kusmini Lalu Muhammad Irham M. Sofyan Marisa Elfina Marius Agung S.J Masrifan Masrifan Mintoro Sumego Monik Krisnawati Muhammad Irham Mustofa Mustofa Mutiara Laila Azizah Nadhifa Rizq Raissa Puteri Nur Absul Goni Pristina Adi Rachmawati Purwanto, Gunawan Putri, Meilisa Putri, Viona Melinda Rafiastiana Capritasari Rafiastiana Capritasari Rafiastiana Capritasari Rafiastiana Capritasari Rahmadani Tirta Ningrum Redha Okta Silfina Rizky Amanda Salvito Salvito Sumego, Mintoro Sun, Suny Taufiq Rahmadi Temu Eko Hardjanto Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tiyas Putri Nurgraheni Unsa Izzati Wicaksono, Herlambang Zahraini Nur Devrinda Putri Zainal Abidin Zulkifli Halid