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All Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Narra J Biocaster : Jurnal Kajian Biologi
Risya Cilmiaty, Risya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Correlation between Milk Chocolate Consumption Habit and Chronotype with Gingivitis in Children with Mixed Tooth Period Fahmi, Muhammad Izzul Widad; Cilmiaty, Risya; Nurwati, Ida
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.387 KB) | DOI: 10.30604/jika.v8i2.1759

Abstract

Children in the mixed dentition period are prone to oral health problems. This can be caused by the frequent consumption of milk chocolate and the child's chronotype being the night type. This study aims to determine the relationship between milk chocolate consumption habits and chronotype with gingivitis in children with mixed dentition. The study used a survey method with a cross-sectional approach. The population of this study were Madrasah Ibtidaiyah (MI) students in the Situbondo district aged 6-12 years with 100 students from 9 MI subjects. Determination of schools using multistage random sampling and selecting subjects using proportional random sampling. The questionnaires used were the Children Chronotype and Semi-Quantitative Food Frequency Questionnaire. Gingival index examination is performed by a dentist. Data analysis used the Pearson statistical test at a significant level a= 0.05. The results showed that 49% of children had a moderate gingival index and 5.8% had a severe gingival index. As many as 23% of children often consume milk chocolate and 13% of children are included in the evening chronotype category. Statistical test results showed a positive correlation between milk chocolate consumption habits and gingivitis (p-value 0.021) and a positive relationship between chronotype and gingivitis (p-value 0.015). In conclusion, there is a correlation between milk chocolate consumption habits and gingivitis and there is a relationship between chronotype and gingivitis in mixed dentition children. Abstrak: Anak yang memasuki periode gigi bercampur rentan mengalami masalah kesehatan rongga mulut. Hal ini dapat disebabkan karena seringnya konsumsi cokelat susu dan beralihnya kronotipe anak menjadi tipe malam. Penelitian ini bertujuan untuk mengetahui keterkaitan antara kebiasaan konsumsi cokelat susu dan kronotipe dengan gingivitis pada anak periode gigi bercampur. Penelitian menggunakan metode survei dengan pendekatan cross sectional. Populasi penelitian ini adalah siswa Madrasah Ibtidaiyah (MI) di kabupaten Situbondo yang berusia 6-12 tahun dengan subjek sebanyak 100 siswa dari 9 MI. Penentuan sekolah menggunakan multistage random sampling dan pemilihan subjek menggunakan proportional random sampling. Kuesioner yang digunakan adalah Children Chronotype Questionare dan Semi Quantitative Food Frequency Questionare. Pemeriksaan indeks gingiva dilakukan oleh dokter gigi. Analisis data menggunakan uji statistik Pearson pada taraf signifikan a= 0,05. Hasil penelitian menunjukan bahwa 49% anak memiliki indeks gingiva sedang dan 5,8% parah. Sebanyak 23% anak sering mengkonsumsi cokelat susu dan sebanyak 13% anak termasuk kategori kronotipe malam. Hasil uji statistik menunjukkan bahwa ada korelasi positif antara kebiasaan konsumsi cokelat susu dengan gingivitis (p-value 0,021) dan ada hubungan positif kronotipe dengan gingivitis (p-value 0,015). Kesimpulannya terdapat korelasi antara kebiasaan konsumsi cokelat susu dengan gingivitis dan ada hubungan antara kronotipe dengan gingivitis pada anak periode gigi bercampur.
Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial Pasa, Chusairil; Pamungkasari, Eti P.; Doewes, Muchsin; Purwanto, Bambang; Hartono, Hartono; Cilmiaty, Risya; Dirgahayu, Paramasari
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1321

Abstract

Osteoporosis increases fracture risk and reduces quality of life in menopausal women. Although physical activity, such as walking and bone joint exercise, is known to help maintain bone health, its effectiveness needs further examination. The aim of this study was to analyze the effects of physical activity, in particular walking and bone joint exercise, on enhancing bone remodeling in menopausal women. A randomized controlled trial was conducted among menopausal women and allocated into three groups: walking, bone joint exercise, and control groups. The intervention was provided for eight weeks, with the outcomes measured before and after the intervention. The study assessed five bone remodeling biomarkers: estrogen, parathyroid hormone (PTH), receptor activator of nuclear factor kappa-β ligand (RANKL), tumor necrosis factor-alpha (TNF-α), and bone mineral density (BMD). The paired sample student t-test and ANOVA were used to assess the effects of the interventions. The results indicated that, compared to pre-intervention, both walking and bone joint exercise significantly increased the estrogen (p=0.026 and p=0.023, respectively), decreased RANKL (p=0.019 and p=0.002, respectively), decreased PTH levels (p=0.022 and p=0.048, respectively) and increased the BMD scores (p=0.001 and p<0.001, respectively). In the control group, none of the remodeling biomarkers significantly changed except the mean level of TNF-α, which was increased significantly (p=0.001). This study highlights that structured exercise, such as walking and bone joint exercise, can significantly enhance bone remodeling markers in menopausal women. Therefore, implementing such physical activities into management may provide benefits to menopausal women.
Effect of clove flower extract (Syzygium aromaticum) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study Ningrum, Tyas Sari Ratna; Doewes, Muchsin; Indarto, Dono; Cilmiaty, Risya; Kristiyanto, Agus; Widyaningsih, Vitri
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1680

Abstract

Eccentric exercise often leads to oxidative stress, inflammation, and muscle damage that impair athletic performance. To counter these adverse effects, clove flower extract (Syzygium aromaticum) offers promising potential as a natural remedy to promote muscle repair with its potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of clove flower extract administration timing on oxidative stress and inflammatory responses in skeletal muscle damage induced by acute eccentric exercise in mice. This study used a post-test-only control group design, involving 35 male mice (Mus musculus, Balb/c) randomly divided into five groups: a healthy control group (HC) with no exercise and no treatment, a negative control group (NC) with exercise but no treatment, and three treatment groups: T1, T2, and T3 (clove flower extract 24 hours before exercise, immediately after exercise, and 24 hours after exercise, respectively). The treatment groups received a single dose of clove flower extract (500 mg/kg body weight). The skeletal muscle damage of mice was collected for the NADPH oxidase (NOX) and superoxide dismutase (SOD) activities using spectrophotometry, and toll-like receptor 4 (TLR4) and interleukin-8 (IL-8) measurements using enzyme-linked immunosorbent assay (ELISA). Moreover, the skeletal muscle damage was analyzed through the histopathological method. Data were analyzed using one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) tests as a post hoc test. The result showed that clove flower extract significantly reduced NOX activity (p=0.049) and IL-8 levels (p=0.032), and increased SOD activity (p=0.001) while not significantly affecting the TLR4 levels (p=0.532). Moreover, the results showed a significant reduction in muscle damage (p=0.001). The study highlights that the administration of clove flower extract (500mg/kg bw) can be given 24 hours before, immediately after exercise, or 24 hours after exercise to prevent muscle damage.
The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
Co-Authors Adi Magna, Adi Agus Kristiyanto Bambang Purwanto Brian Wasita Christanto, Antonius Dono Indarto Eti Poncorini Pamungkasari Fahmi, Muhammad Izzul Widad Frienty Sherlla Mareta Lubis, Frienty Sherlla Mareta Harsono Salimo Hartono Hartono Ida Nurwati Muchsin Doewes NINGRUM, TYAS SARI RATNA Pamungkasari, Eti P. Paramasari Dirgahayu pasa, chusairil Rahmah Rahmah Setiamika, Made Soetrisno Soetrisno Vitri Widyaningsih Yudhani, Ratih Dewi Yusup Subagio