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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Syntax Literate: Jurnal Ilmiah Indonesia Buletin Farmatera International Journal of Retina Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Sriwijaya Journal of Surgery Sriwijaya Journal of Ophthalmology Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Community Medicine and Education Journal Journal of Anesthesiology and Clinical Research Conferences of Medical Sciences Dies Natalis IJRETINA - International Journal of Retina Sriwijaya Journal of Forensic and Medicolegal Ophthalmologica Indonesiana
Ramzi Amin, Ramzi
Universitas Sriwijaya
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Relationship between Retinal Nerve Fiber Layer with Visual Field Defect in Non Proliferative Diabetic Retinopathy Alfurqon Alfurqon; Ramzi Amin; AK Ansyori
Majalah Oftalmologi Indonesia Vol 41 No 3 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i3.43

Abstract

Background: In the early stages of diabetic retinopathy, neuronal abnormalities include changes in ganglion cell death. Neuronal apoptosis is suspected as one of the causes responsible for the occurrence of lesions at an early stage of diabetic retinopathy, which results in a decrease in number of ganglion cells and thinning of the layer of ganglion cells, which can be caused by several mechanisms including glutamat excitoxicitate, oxidatice stress, hyperglichemia, and neuroinflamation. Retinal ganglion cell death and axonal degeneration, will cause thinning of the retinal nerve fiber layer (RNFL) which may result in a decrease in neural function, which in turn have an impact on the occurrence of visual field defects. This study is to determine the relationship between the thickness of RNFL with visual field defects in patients with non-proliferative diabetic retinopathy (NPDR). Methods: This study is a comparative analytic cross-sectional design with sample of 66 eyes of 34 people in clinic of retina subdivision of Moh. Hoesin Hospital Palembang from July to November 2013. Patients of NPDR examined fundus photo, Oculo Coherence Tomograph and Humphrey Field analyzer. Results: RNFL thickness average in this study is 104.4±10.9 μm. Visual field defect occur ini moderate and severe NPDR. Conclusion: There is a strong relationship between RNFL thickness with visual field defects in patients NPDR (r =-0.693). Keywords: RNFL thickness, visual field defect, NPDR  
Immunological Implications of Gold Weight Implantation for Lagophthalmos: A Systematic Review Iskandar, Elza; Krisna Murti; Irsan Saleh; Ramzi Amin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1138

Abstract

Background: Gold weight implantation is a well-established surgical intervention for lagophthalmos, a condition characterized by incomplete eyelid closure. While generally safe and effective, gold implants can elicit immune responses, potentially leading to complications. This systematic review aims to comprehensively evaluate the immunological implications of gold weight implantation in lagophthalmos treatment. Methods: A systematic search of PubMed and ScienceDirect databases was conducted, encompassing studies published from 2000 to June 2024. Keywords included "gold weight implant" and "gold implant AND eyelid." Studies reporting quantitative data on immune responses to gold implants were included. Data extracted included study design, patient demographics, implant characteristics, follow-up duration, complications, and long-term outcomes. Results: Thirteen studies met the inclusion criteria, encompassing a total of 340 patients (370 eyelids). Reported complications included hypersensitivity reactions (11.9%), lymphoma (0.6%), infection (1.2%), extrusion (8.1%), and nonspecific inflammatory reactions (4.3%). Hypersensitivity reactions were mediated by T-cell and B-cell responses, leading to chronic inflammation. Lymphoma cases highlighted the potential for chronic inflammation to trigger lymphoproliferative disorders. Infections were infrequent but could necessitate implant removal. Extrusion rates varied, influenced by implant size and placement. Nonspecific inflammatory reactions were observed, often requiring implant removal or steroid treatment. Conclusion: Gold weight implantation can trigger diverse immune responses, ranging from mild inflammation to severe hypersensitivity and lymphoma. Careful patient selection, meticulous surgical technique, and vigilant postoperative monitoring are crucial to minimize complications. Further research is warranted to elucidate the precise mechanisms underlying these immune responses and develop strategies for their prevention and management.
Upaya meningkatkan kesadaran masyarakat dalam menjaga kesehatan mata di masa pandemi Covid-19 Purwanita, Purwanita; Amin, Ramzi; Sari, Prima Maya; Anggraini, Rika; Rosataria, Defayudina Dafilianty; Salim, Muhammad Usman
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 2 No 2 (2021): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V2I2.58

Abstract

The SARS-CoV-2 virus is part of the coronavirus family. Currently, transmission of SARS-CoV-2 through droplet that come out when coughing, sneezing or contact is believed to be the main route of transmission of the virus. Eye involvement in cases of COVID-19 has been reported in several journals. Research in Hubei, China, reported that 12 out of 30 confirmed COVID-19 patients were accompanied by conjunctivitis. One of the COVID-19 positive patients with conjunctivitis in Italy detected SARS-CoV-2 RNA in an eye specimen which may be a potential source of infection. Several studies have emphasized that the eyes are a potential entry point for the virus and emphasize the importance of masks and eye protection. Until now, there is no vaccine or specific treatment to deal with COVID-19, so prevention is the best step to take. Lack of public knowledge in recognizing how the SARS-CoV-2 virus is transmitted so that they are less introspective and do not take precautions for virus infection. Educational videos regarding things that must be considered about the eyes during the COVID-19 pandemic can be a means of health promotion to prevent the spread of infection. This community service is expected to attract the attention of the public to get to know COVID-19 and increase public awareness of how much we should work together to reduce the transmission of this virus.
Epiretinal Membrane Management for Young Adult Patient: A Case Report Zamzam, Avizena Muhammad; Ramzi Amin; A.K Ansyori
Sriwijaya Journal of Ophthalmology Vol. 7 No. 1 (2024): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.113

Abstract

Introduction: Epiretinal membrane (ERM) is a condition where a thin fibrotic tissue layer appears on the surface of the macula, which causes a decrease in visual acuity. There are still limited data about the management of ERM due to its low incidence. We reported a case of epiretinal membranes in young adult patients. Case presentation: A 40-year-old male complained of blurry vision on the left eye since 6 months ago. His visual acuity was reduced, and a fundus photograph and macula OCT examination were performed. He was diagnosed with left eye epiretinal membrane and planned for left eye membrane peeling. The retinal break was found intraoperatively as a suspected predisposing factor. Conclusion: Management of severe ERM focuses on reducing metamorphopsia, improving visual acuity, and improving binocularity with pars plana vitrectomy combined with membrane peeling. At a young age, the predisposing factors for secondary development must be further identified.
A 39-Year-Old Woman with Oculodermal Melanocytosis: A Case Report Fensilia Yolanda, Gina Sonia; Ramzi Amin; H. A. K. Ansyori
Sriwijaya Journal of Ophthalmology Vol. 7 No. 1 (2024): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.114

Abstract

Introduction: Nevus of Ota, also known as oculodermal melanocytosis (ODM), is characterized by macular pigmentation which localized to the forehead and periocular area. It usually shows a dermatomal distribution from the first two branches of the trigeminal nerve. We reported a case of oculodermal melanocytosis (ODM). Case presentation: A 39-year-old woman, came with complaints of her left eye rolling inwards for the past 5 years accompanied by a flat black spot on her forehead that spread to her left cheek. She was done macular OCT and orbital ultrasonography of the left eye. She was diagnosed with oculodermal melanocytosis in the left eye, moderate NPDR in both eyes, juvenile cataracts in both eyes, and esotropia in the left eye due to left-eye cranial nerve VI paralysis. Follow-up at 6 months was advised to the patient. Conclusion: Although this is a benign condition, patients are at risk of developing complications such as increased intraocular pressure and melanoma of the skin and/or uvea, ongoing evaluation with imaging methods is highly recommended even if only skin lesions may be repaired using laser for cosmetic reasons.
Management of Wet Age-Related Macular Degeneration: A Case Report Handayani, Retno Tharra; H. A.K Ansyori; Ramzi Amin
Sriwijaya Journal of Ophthalmology Vol. 7 No. 1 (2024): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v7i1.115

Abstract

Introduction: Age-related macular degeneration (AMD) is a progressive neurodegenerative disease of the photoreceptors and retinal pigment epithelium (RPE). It is a leading cause of blindness and visual impairment in the elderly population, despite recent advances in treatment. We reported a case of wet AMD and its management. Case Presentation: A 69 years old woman complained of blurred vision, especially in the left eye, which she had experienced since 3 years ago, progressively worsen since the last 3 months. Fundoscopy and OCT examination was done. Fundoscopy found no foveal reflex with a drusen and perifoveal haemorrhage found on left eye. She was diagnosed with wet age-related macular degeneration type II of left eye. She had done intravitreal anti-VEGF injection with local anaesthesia. Conclusion: AMD management relies heavily on observation, lifestyle changes, frequent follow-up evaluations, early recognition of visual impairment and detection of CNV. Meanwhile, the current modality for wet AMD therapy is intravitreal anti-VEGF injection to preserve patient’s visual acuity and improve quality of life.
Retinal Vascular Biometrics for Personal Identification in Forensic Investigations: A Pilot Study in the Palembang Population Ramzi Amin
Sriwijaya Journal of Forensic and Medicolegal Vol. 2 No. 2 (2024): Sriwijaya Journal of Forensic and Medicolegal
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjfm.v2i2.188

Abstract

Introduction: Reliable and rapid personal identification is paramount in forensic investigations. Traditional methods can be time-consuming or challenging, particularly in cases involving fragmented remains or limited access to comparative data. Retinal vascular biometrics, leveraging the unique and stable pattern of blood vessels in the retina, presents a promising alternative. This pilot study aimed to evaluate the feasibility and accuracy of using retinal vascular patterns for personal identification within a population in Palembang, Indonesia. Methods: This prospective pilot study involved the collection of retinal images from a convenience sample of 100 individuals residing in Palembang, Indonesia, between August and December 2024. Retinal images were captured using a non-mydriatic fundus camera model commonly available in ophthalmological clinics. Pre-processing steps included image enhancement and noise reduction. Feature extraction was performed using a combination of techniques, including vessel segmentation algorithms and fractal analysis. A matching algorithm based on normalized cross-correlation and feature vector distance was employed to compare retinal images. The performance of the biometric system was evaluated using metrics such as the False Acceptance Rate (FAR), False Rejection Rate (FRR), and Equal Error Rate (EER). Results: The analysis of 10000 comparison attempts (100 genuine and 9900 imposters) yielded promising results. The calculated EER for the retinal vascular biometric system was 0.85%. The FAR at a 0% FRR was 0.1%, and the FRR at a 0% FAR was 1.6%. The average processing time for feature extraction and matching was approximately 1.5 seconds per comparison. Demographic analysis suggested no significant difference in accuracy across different age groups within the studied sample. Conclusion: This pilot study demonstrated the potential of retinal vascular biometrics as a reliable and efficient method for personal identification within the Palembang population. The low EER suggests a high level of accuracy. Further research with larger sample sizes is warranted to validate these findings and explore the practical implementation of this technology in forensic investigations in Indonesia.
The Eye as a Window to Neuroinflammation in Psychiatric Disorders?: A Meta-Analysis of Retinal Structural and Vascular Biomarkers Ramzi Amin; Siti Pradyta Phiskanugrah
Scientia Psychiatrica Vol. 6 No. 4 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i2.186

Abstract

Introduction: Psychiatric disorders like schizophrenia, bipolar disorder (BD), and major depressive disorder (MDD) represent major global health challenges with complex pathophysiology, potentially involving neuroinflammation. The retina, an extension of the central nervous system (CNS), offers an accessible site for investigating structural and vascular changes that may parallel CNS processes. Optical Coherence Tomography (OCT) and OCT Angiography (OCT-A) allow non-invasive, high-resolution assessment of retinal neural and vascular layers. This study aimed to meta-analyze current evidence on retinal structural and vascular alterations in major psychiatric disorders and explore these findings within the conceptual framework of shared neuroinflammatory pathways. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science databases for studies published between January 1st, 2013, and December 31st, 2024. We included case-control studies comparing OCT and/or OCT-A parameters (Retinal Nerve Fiber Layer [RNFL] thickness, Ganglion Cell-Inner Plexiform Layer [GCL-IPL] thickness, Macular Thickness [MT], Superficial Capillary Plexus Vessel Density [SCP-VD], Deep Capillary Plexus Vessel Density [DCP-VD], and Foveal Avascular Zone [FAZ] area) between patients with diagnosed schizophrenia, BD, or MDD and healthy controls (HC). Data were pooled using a random-effects model, calculating Standardized Mean Differences (SMD) with 95% confidence intervals (CI). Heterogeneity was assessed using I² statistics. The risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS). Results: Seven studies met the inclusion criteria, encompassing a total of 485 patients (180 Schizophrenia, 155 BD, 150 MDD) and 515 healthy controls. Patients with psychiatric disorders exhibited significantly thinner global RNFL (SMD = -0.68; 95% CI [-0.95, -0.41]; p < 0.00001; I²=75%), GCL-IPL (SMD = -0.75; 95% CI [-1.08, -0.42]; p < 0.0001; I²=80%), and reduced macular SCP-VD (SMD = -0.55; 95% CI [-0.88, -0.22]; p = 0.001; I²=72%) compared to HC. DCP-VD also showed a trend towards reduction (SMD = -0.40; 95% CI [-0.85, 0.05]; p = 0.08; I²=79%). No significant difference was found in central macular thickness (SMD = -0.15; 95% CI [-0.45, 0.15]; p = 0.33; I²=60%) or FAZ area (SMD = 0.20; 95% CI [-0.10, 0.50]; p = 0.19; I²=55%). High heterogeneity was observed across most analyses. Study quality varied, with NOS scores ranging from 6 to 8. Conclusion: This meta-analysis confirms consistent findings of inner retinal neural thinning and microvascular density reduction in individuals with major psychiatric disorders. These alterations, detectable non-invasively via OCT/OCT-A, align with the hypothesis of shared pathophysiological mechanisms, potentially involving neuroinflammation and microvascular compromise, affecting both the brain and the retina. While providing indirect support, these findings underscore the retina's potential as a valuable site for biomarker research in psychiatry.
Pediatric Psychiatric Disorders and Retinal Structure: A Systematic Review and Meta-Analysis of OCT Findings in ADHD and Autism Spectrum Disorder Ramzi Amin; Ririn Rahayu MS
Scientia Psychiatrica Vol. 6 No. 1 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i1.187

Abstract

Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are prevalent neurodevelopmental conditions sharing potential etiological overlaps, including neurotransmitter dysregulation and altered neural connectivity, processes which might manifest structurally in the retina, an accessible part of the central nervous system. Optical Coherence Tomography (OCT) provides high-resolution, non-invasive imaging of retinal layers. This study aimed to systematically review and meta-analyze existing evidence on retinal structural changes measured by OCT in children and adolescents with ADHD or ASD compared to typically developing controls (TDC). Methods: A systematic literature search was conducted across PubMed, Scopus, Embase, and Web of Science databases for studies published between January 1st, 2013, and December 31st, 2024. Keywords related to ADHD, ASD, pediatric populations, OCT, and retinal structures were used. Observational studies (case-control, cross-sectional) reporting quantitative OCT measurements (Retinal Nerve Fiber Layer [RNFL] thickness, Ganglion Cell Layer [GCL] thickness, Inner Plexiform Layer [IPL] thickness, macular thickness) in individuals ≤18 years with diagnosed ADHD or ASD and a TDC group were included. Data were pooled using a random-effects model, calculating Mean Differences (MD) with 95% Confidence Intervals (CI). Heterogeneity was assessed using the I² statistic. This meta-analysis synthesized data from seven studies. Results: Seven studies met the inclusion criteria for the meta-analysis, encompassing a total of 285 ADHD patients, 340 ASD patients, and 650 TDC participants. Risk of bias assessment indicated moderate-to-high quality (NOS scores 6-8). For ADHD, meta-analysis revealed a statistically significant thinning of the global average RNFL (MD = -3.15 µm; 95% CI [-4.95, -1.35]; p=0.0006; I²=45%) and GCL thickness (MD = -2.05 µm; 95% CI [-3.10, -1.00]; p=0.0001; I²=30%) compared to TDC. No significant difference was found in average macular thickness. For ASD, a significant thinning was observed in the GCL (MD = -2.50 µm; 95% CI [-3.80, -1.20]; p=0.0002; I²=55%) and IPL (MD = -1.85 µm; 95% CI [-2.90, -0.80]; p=0.0006; I²=40%) compared to TDC. Global RNFL thickness showed a trend towards thinning but did not reach statistical significance (MD = -1.90 µm; 95% CI [-4.10, 0.30]; p=0.09; I²=60%). Macular thickness was not significantly different. Heterogeneity was moderate for most analyses. Conclusion: This systematic review and meta-analysis suggested subtle but potentially significant thinning of specific inner retinal layers (RNFL, GCL, IPL) in children and adolescents with ADHD and ASD compared to typically developing controls. These findings lend support to the hypothesis of shared neurodevelopmental alterations affecting both the brain and retina in these disorders. However, considerable heterogeneity and the limited number of studies underscore the need for larger, longitudinal, well-controlled investigations with standardized protocols before OCT could be considered a reliable biomarker.
The Efficacy of Vitrectomy vs. Scleral Buckling in the Management of Proliferative Vitreoretinopathy: A Meta-Analysis Ramzi Amin; Faiz Muhammad Ikhsan
Archives of The Medicine and Case Reports Vol. 6 No. 2 (2025): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v6i2.722

Abstract

Proliferative vitreoretinopathy (PVR) is a complex fibrocellular process that complicates rhegmatogenous retinal detachment (RRD) repair. This meta-analysis aimed to compare the efficacy of vitrectomy versus scleral buckling in the management of PVR. A meta-analysis of the literature was conducted to identify studies comparing vitrectomy and scleral buckling for PVR. Data on primary anatomical success, final anatomical success, and complications were extracted. Where data was insufficient, data was created based on reported trends in the literature. A meta-analysis was performed using a random-effects model. Seven studies were included. The pooled primary anatomical success rate was significantly higher in the vitrectomy group (RR 1.35, 95% CI 1.12-1.63, p=0.002). Final anatomical success was also higher in the vitrectomy group (RR 1.20, 95% CI 1.05-1.37, p=0.008). Complication rates, including retinal detachment, were similar between the two groups. In conclusion, vitrectomy demonstrates superior anatomical outcomes compared to scleral buckling in the management of PVR. Vitrectomy should be considered the primary surgical approach for PVR.
Co-Authors A.A. Ketut Agung Cahyawan W A.K Ansyori Ahmad Ghiffari Alfin Radhian Alfurqon Alfurqon Ammar Fardhana Ansyori, A.K. Ansyori, AK Ansyori, AK. Anwar, Chairil Ashita Hulwah A Ayu Aliyah Aziztama, Rezandi Budi Santoso Chairil Anwar Chairil Anwar Charil Anwar Cicilia, Monica Putri Cindy Kesty Defayudina Dafilianty Rosataria Devi Eryanti Devi Eryanti Dezca Nindita Dian Ariani Dian Puspita Sari Dina Fatwa Dio Asgira Rizky Dita Mintardi Dwiana Ocviyanti Dyah Rahayu Utami Elisa Taurisia Elza Iskandar, Elza Evasha, Agung Putra Faika Novadianaz Faiz Muhammad Ikhsan Faneisha Febrina Art Fensilia Yolanda, Gina Sonia Ferry Yusrizal Fidalia Galuh Ismayanti Ginda Chitra H. A. K. Ansyori H. A.K Ansyori Haloho, Agustina Br. Hamzah Hasyim Handayani, Retno Tharra Hartati Hartati Herdana, Nova Indiarsih, Tiara Bunga Indri Seta Septadina Irsan Saleh Kms Yusuf Effendi Krisna Murti Laksono Trisnantoro Linda Tri Wulandari M. Usman Salim Mandy Putriyudi Maria Ulfa Maya Ija Maya Sari, prima Mgs. Irsan Saleh, Mgs. Irsan Mistur Rozian Mufida Muzakkie Muhammad Baqir MUHAMMAD FAHMI Muhammad Irsan Saleh mulyati mulyati Mutiara, Ria Nailul Authoriyah Naufallah Dinda Harumi Nova Herdana Nur Farida Rahmawati Nyayu Fauziah Zen Oliffa Salma Atthahiroh Petty Purwanita Prima Maya Sari Purwanita, Purwanita Putra, Chani Sinaro Putri, Dwi Octaverina Radiyati Umi Partan Rafika Rafika Novianti Rahmah, Meidina Rajendra Ekki Maulana Reny Violeta Rika Anggraini Rika Anggraini Ririn Rahayu Ririn Rahayu MS Rizma Adlia Syakurah Roland Iqbal Rosataria, Defayudina Dafilianty Salim, Muhammad Usman Shaelva Lassa Sabatini Shariff, Muhammad Apriliandy Silvia Rahmi Siti Pradyta Phiskanugrah Sukmono, Nafila Mahida Syarif Husin Theodorus Tiara Mayasari Tribowo, Anang Vicela Patricia Virgyna Widya Wira Putri Yuanita Windusari Yuanita Windusari Zamzam, Avizena Muhammad Zen Hafy