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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Syntax Literate: Jurnal Ilmiah Indonesia Buletin Farmatera International Journal of Retina Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Sriwijaya Journal of Surgery Sriwijaya Journal of Ophthalmology Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Community Medicine and Education Journal Journal of Anesthesiology and Clinical Research Conferences of Medical Sciences Dies Natalis IJRETINA - International Journal of Retina Sriwijaya Journal of Forensic and Medicolegal Ophthalmologica Indonesiana
Ramzi Amin, Ramzi
Universitas Sriwijaya
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Successful Visual Rehabilitation Following Pars Plana Vitrectomy and Endolaser in a Patient with Severe Vitreous Hemorrhage due to Proliferative Diabetic Retinopathy Ramzi Amin; Rafika
Archives of The Medicine and Case Reports Vol. 5 No. 3 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i3.742

Abstract

Proliferative diabetic retinopathy (PDR) represents an advanced stage of diabetic eye disease, frequently leading to severe visual impairment through complications such as vitreous hemorrhage (VH). Dense VH significantly obstructs vision and often requires surgical intervention. Pars plana vitrectomy (PPV) coupled with endolaser photocoagulation serves as a critical treatment modality, aiming to clear the hemorrhage, remove tractional elements, and manage the underlying ischemic drive of PDR. This report documents a case demonstrating significant visual recovery after this intervention. A 53-year-old male, diagnosed with type 2 diabetes mellitus 6 years prior and under medical control, presented with a one-month history of sudden, severe vision loss in his right eye (OD). His best-corrected visual acuity (BCVA) was profoundly reduced to 1/300 OD, while the left eye (OS) measured 6/15. Clinical examination revealed dense VH OD, preventing detailed funduscopic assessment. The fellow eye OS exhibited features consistent with high-risk PDR. The patient underwent a 23-gauge PPV, including core vitrectomy and extensive pan-retinal endolaser photocoagulation OD, performed under general anesthesia. Postoperatively, the vitreous clarity was restored, and a remarkable improvement in BCVA OD to 6/7.5 was achieved by the three-week follow-up visit. In conclusion, timely surgical management utilizing PPV with endolaser photocoagulation was effective in resolving dense VH secondary to PDR in this patient, culminating in substantial visual rehabilitation
Successful Management of Inferotemporal Rhegmatogenous Retinal Detachment with Scleral Buckle in High Myopia: A Case Report Ramzi Amin; Ririn Rahayu
Archives of The Medicine and Case Reports Vol. 4 No. 4 (2023): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v4i4.743

Abstract

Rhegmatogenous retinal detachment (RRD) represents a significant ophthalmic emergency, characterized by the separation of the neurosensory retina from the underlying retinal pigment epithelium (RPE) due to a full-thickness retinal break. High myopia is a major risk factor, particularly in younger individuals, owing to associated vitreoretinal changes and axial elongation. Surgical intervention is mandatory to prevent permanent vision loss. While pars plana vitrectomy (PPV) has gained popularity, conventional scleral buckling (SB) remains a highly effective and often preferred primary treatment, especially in young, phakic patients with peripheral breaks and uncomplicated detachments. This report details the successful management of an inferotemporal RRD using SB in a young female patient with high myopia. A 25-year-old female presented with a two-week history of progressively worsening blurred vision, preceded by floaters and photopsia in her left eye (OS). She had a history of high myopia (manifest refraction -7.50 D sphere OS) but no prior ocular surgery or trauma. Best-corrected visual acuity (BCVA) was counting fingers at 1 meter OS and 6/30 OD. Intraocular pressure (IOP) was 8.1 mmHg OS and 18.3 mmHg OD. Funduscopic examination OS revealed a bullous RRD involving the inferior and temporal quadrants, extending across approximately 6 clock hours, with the macula appearing clinically off. A single flap tear was identified in the inferotemporal quadrant at the 7 o'clock position, consistent with Lincoff's Rule 3. Optical Coherence Tomography (OCT) confirmed subretinal fluid involving the fovea. B-scan ultrasonography corroborated the presence of retinal detachment. The patient underwent conventional scleral buckling surgery with cryotherapy to the retinal break and subretinal fluid drainage under general anesthesia. Postoperatively, the retina achieved complete anatomical reattachment. BCVA OS improved slightly to counting fingers at 1 meter by day 12 post-operation, with expectations for further gradual improvement. In conclusion, conventional scleral buckling provided successful anatomical reattachment for an inferotemporal RRD secondary to a flap tear in this young, highly myopic patient. SB remains a crucial and effective surgical option for primary RRD, particularly in phakic eyes with peripheral breaks, offering excellent anatomical outcomes while avoiding the cataractogenic effects and potential intraocular manipulation risks associated with primary vitrectomy in this demographic. Careful case selection and meticulous surgical technique are paramount for success.
Impact of Glycemic Control on Amsler Grid Findings in Patients with Diabetic Retinopathy in Palembang, Indonesia Ramzi Amin; Ayu Aliyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1330

Abstract

Background: Diabetic retinopathy (DR) remains a principal cause of vision impairment globally, frequently affecting the macula and central vision. This study aimed to investigate the association between glycemic control status and the presence of Amsler grid abnormalities in patients diagnosed with diabetic retinopathy in Palembang. Methods: This cross-sectional study was conducted at the outpatient ophthalmology and internal medicine clinics of a tertiary referral hospital in Palembang between January 2023 and December 2024. Patients aged 18 years or older with a confirmed diagnosis of type 1 or type 2 diabetes mellitus and any stage of diabetic retinopathy, capable of performing Amsler grid testing, were included after providing informed consent. Patients with other significant ocular pathologies affecting the macula or media opacities precluding fundus examination were excluded. Data collected included demographics, diabetes history, comprehensive ophthalmic examination findings, standardized Amsler grid testing results, and recent HbA1c levels. Glycemic control was categorized as good (<7.0%), fair (7.0-9.0%), and poor (>9.0%). Statistical analysis involved descriptive statistics, chi-square tests, t-tests/Mann-Whitney U tests, and multivariable logistic regression to assess the association between HbA1c levels and abnormal Amsler grid findings, adjusting for potential confounders. Results: A total of 385 patients with DR (mean age 58.2 ± 9.5 years; 53.8% female) were included. The mean duration of diabetes was 12.4 ± 6.8 years, and the mean HbA1c was 8.9% ± 2.1%. Abnormal Amsler grid findings were reported by 161 participants (41.8%). Patients with abnormal Amsler grid findings had significantly higher mean HbA1c levels compared to those with normal findings (9.8% ± 1.9% vs. 8.3% ± 1.8%, p < 0.001). In the multivariable logistic regression analysis, after adjusting for age, diabetes duration, DR severity, and hypertension, poor glycemic control (HbA1c >9.0%) was independently associated with significantly higher odds of having abnormal Amsler grid findings compared to good glycemic control (HbA1c <7.0%) (Adjusted Odds Ratio [aOR] = 3.45, 95% CI: 1.98-6.01, p < 0.001). Fair glycemic control (HbA1c 7.0-9.0%) also showed increased odds, although to a lesser extent (aOR = 1.82, 95% CI: 1.05-3.15, p = 0.032). Each 1% increase in HbA1c was associated with a 35% increased odds of abnormal Amsler findings. Conclusion: This study demonstrated a significant association between poorer glycemic control, as indicated by higher HbA1c levels, and the presence of abnormal Amsler grid findings among diabetic retinopathy patients in Palembang. These findings underscore the critical role of meticulous glycemic management in preserving not only retinal structure but also central visual function detectable through simple psychophysical tests. The Amsler grid serves as a valuable, accessible tool for functional monitoring in this patient population.
Management Of Eales’ Disease Grade III B: A Rare Case Evasha, Agung Putra; Amin, Ramzi; Ansyori, A.K.
International Journal of Retina Vol 6 No 2 (2023): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2023.vol006.iss002.248

Abstract

Introduction: Eales' disease is an idiopathic, bilateral, occlusive retinal vasculopathy that primarily affects young, predominately male patients. It seems to have multiple causes and is probably immunologic in nature. Recurrent vitreous hemorrhages, macular degeneration, and tractional or mixed retinal detachments involving the macula can all cause some patients to experience severe vision loss. Case Report: A 39-year-old male with vitreous hemorrhage caused by Eales Disease grade III Bwith an initial visual acuity 1/300 came to our department. Ultrasound imaging showed themembrane like lesion with 1/2 retinal reflectivity, after moderate movement and vitreoushemorrhage on both eyes. The photo-fundus showed there is decreased fovea reflex andperimacular exudate with visible contours of sclerotic blood vessels, visible cotton wall spot, andmacroaneurysm. There is also haze grade 3 on media, visible folds in the inferior part, visibleshadows of cotton wall spots. The patient underwent pars plana vitrectomy with endolaser tomanage the disease. Discussion: In this case, patient was diagnosed as vitreous hemorrhage caused by Eales Diseasegrade III B on both eyes but it getting worse on left eye further. We chose to perform PPV withendolaser on right eye. Based on improved visual acuity and less hemorrhage, the right eye'soutcome was favorable, while the left eye, which was not treated, had a worsening of thesituation. Only eyes with a non-resolving vitreous hemorrhage after three months should have avitrectomy.Conclusion: The treatment of this patient's case produced good anatomical and functionaloutcomes for the right eye, but the left eye, unfortunately, has a major issue. In order to furtherconfirm the results, longer follow-up is still required.
Pengaruh Estradiol Terhadap Sepsis Haloho, Agustina Br.; Amin, Ramzi; Saleh, Mgs. Irsan; Murti, Krisna
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.104-112

Abstract

Sepsis is an emergency condition as a result of host dysregulation systemic immune response to infection that is related to the end stage of organ dysfunction. Both sepsis and septic shock conditions are the main problems in ICU especially, those that affect millions of people in the whole world every year. Studies in line with immune-neuroendocrine related to sepsis get high attention about factors that play roles in sepsis pathogenesis and prognosis, like correlation to gender, hormones, and other factors. In this case, lots of experimental studies and clinical studies showed that sepsis has significant sexual dysmorphic. The female gender has proven protective against sepsis, meanwhile, males could have worse sepsis because of decreasing immunologic response that mediates cell and cardiovascular function. Estrogen is a hormone in women that plays important roles in not only reproductive function but also non-reproductive function. Physiological estrogen in women is divided into three forms: estrone (E1), estradiol (E2 or 17β- estradiol), and estriol (E3). Several experimental studies in animals showed that estradiol has a protective response when infection occurs. Estrogen generally stimulates cytokine release, induction of HO-1, and restoration of organ function due to sepsis. Potential pathogenesis for this condition is a specific expression of cytokine pro and anti-inflammation. This pathological inflammatory condition is related to gender that is found in surgical patients at the molecular level.
Efficacy of Sambiloto Extracts, Andrographis paniculate, (Burm. F) in Inhibiting Diabetic Retinopathy Progression: An in Vivo Study: Oral Presentation - Experimental Study - Resident Shariff, Muhammad Apriliandy; Amin, Ramzi; Ansyori, AK.
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/1ww79n21

Abstract

Introduction & ObjectivesDiabetic retinopathy (DR) is one of diabetes mellitus complication and occurred in retinalmicrovascular. This study was aimed to investigate the efficacy of Sambiloto, Andrographispaniculate (A. paniculata) extract on glycemic profile, antioxidant and inflammatory cytokineparameters in diabetic rats, and phytochemical analysis of A. paniculata. MethodsA. paniculata extract (APE) was carried out by maceration with ethanol. Diabetes mellitus in Wistarmale rats was induced with streptozotocin. Retinal vessel diameters were estimated using a methodby Vucetic. Inflammatory cytokine and antioxidant parameters were evaluated in retinal tissue. Thealkaloid and flavonoid contents in extract were analyzed using thin layer chromatography method. ResultsFunduscopic examination presented some changes in the diameter of the blood vessels. The vesseldiameter in the diabetic retinopathy group with APE in concentration of 100 and 200 mg/kg BWgroups was significantly lower than in the DR group (p<0.05). The administration of APE in dosagesof 100 and 200 mg/kg BW showed reduced glutathione, SOD, and catalase levels compared to theDR group (p<0.05). ConclusionA. paniculata extract doses of 100 and 200 mg/kg BW improved diabetic retinopathy in rats throughhypoglycemic effects, antioxidant effects, and anti-inflammatory mechanisms.
Anti-RAGE (Receptor Advanced Glycation End products) Antibody Improves Diabetic Retinopathy in Rats via Hypoglycemic and Anti-inflammatory Mechanism Indiarsih, Tiara Bunga; Amin, Ramzi; Ansyori, A.K.
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/xny05743

Abstract

Background: Receptor advanced glycation end products (RAGE) activation plays an essential role in diabetic retinopathy (DR) progression. This study was aimed to explore the role of anti-RAGE antibodies (RAGE antagonists) in inhibiting DR progression through their hypoglycemic and anti- inflammatory mechanism in diabetic retinopathy induced rats. Methods: A total of 30 male Wistar rats were randomly divided into five group. The group was consisted of normal control group, DR group without treatment, DR group with anti-RAGE 1 g/kg BW, 10 g/kg BW, and 100 g/kg BW. To assess the diabetic retinopathy, fundus photographs were taken every week using a camera with 16x magnification placed in front of the rat's eyes. Blood glucose was checked by the glucose oxidase-peroxidase method. Retinal TNF-? levels and VEGF were examined using an enzyme-linked immunosorbent assay (ELISA) kit. Results: The finding of this study showed that anti-RAGE treatment at dose of 10 and 100 g/kg BW, HbA1c levels were significantly higher (p< 0.05) compared to the normal control group but significantly lower (p< 0.05) than in the diabetes group. The mean blood vessel diameter in the DR+anti-RAGE 10 and 100 g/kg BW groups was significantly lower than in the diabetic retinopathy group (p< 0.05). The administration of anti-RAGE 10 and 100 g/kg BW showed the ability to significantly reduce VEGF levels compared to the DR group (p< 0.05). Conclusions: This study revealed at doses of 10 and 100 g/kg BW, anti-RAGE antibodies improved diabetic retinopathy in Wistar rats through hypoglycemic effects and anti-inflammatory mechanisms.
DIAGNOSTIC TEST OF POSTERIOR SEGMENT OCULAR EXAMINATION ON THE SEVERITY OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG Putra, Chani Sinaro; Amin, Ramzi; Sari, Dian Puspita; Theodorus
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/axmc2035

Abstract

Background: Acute lymphoblastic leukemia (ALL) is one of the highest incidence of all cancers in children. Ocular involvement can diagnose the development of the disease. Patients with ALL often have ocular manifestations either resulting from direct infiltration or indirect causes of neoplastic cells. The aim of this study to diagnose from posterior segment findings on disease severity in pediatric patients with acute lymphoblastic leukemia (ALL) at Muhammad Hoesin Hospital Palembang Methods: A diagnostic test to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of posterior segment findings in disease severity diagnostic of pediatric patients with ALL from November 2021 to May 2022. Posterior segment findings that were evaluated included retinal hemorrhages, roth spots, exudate and papilledema. Disease severity of pediatric ALL is divided into high risk and standard risk. All data were analyzed using SPPS version 22.0 Results: There were 68 patients who selected by inclusion criteria. A total of 30 (44.1%) subjects with high risk and 38 (55.9%) with standard risk. in this study there is no patient have papilledema and only one patient (1.5%) has retinal hemorrhage, roth spot and exudate. From statistical analysis, it was found that the three posterior findings had a sensitivity of 0% and a specificity of 97.4%. Conclusion: The results of this study show that the findings of the posterior eye segment can be used as a screening tool for the severity of acute lymphoblastic leukemia, because only one component of sensitivity and specificity has a value of > 80%.
Management of Central Serous Chorioretinopathy (CSC) with Focal Laser Photocoagulation: Poster Presentation - Case Report - Resident Aziztama, Rezandi; Amin, Ramzi; Ansyori, AK
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/17saar34

Abstract

Introduction : Central Serous Chorioretinopathy (CSC) is an idiopathic retinal disease, characterized by focal leakage from the choroidal vessels due to RPE changes resulted in serous detachment of the neurosensory retina. CSC is suspected to be a multifactorial disease. Treatment of CSC is indicated for cases with SRF persisting for more than 4 months, decreased visual acuity, history of recurrence or history of previous CSC in other side with poor visual outcome. Case Illustration : A 41-year-old man complained sudden blurry vision on left eye since 3 months ago, accompanied by decreased ability to see in the middle field. In the left eye there was decrease fovea reflex. Fundus Fluorescein Angiography showed Central Serous Chorioretinopathy (CSC). Laser Focal Photocoagulation was performed for a patient in this case. Discussion : Conclusion : Patient was treated with Laser Focal Photocoagulation and pharmacological acetazolamide with the aim of closing the leak in the RPE and increasing SRF absorption.
MANAGEMENT EALES’ DISEASE GRADE III B: A RARE CASE: Poster Presentation - Case Report - Resident Evasha, Agung Putra; Amin, Ramzi; Ansyori, AK
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/92cbvg28

Abstract

Introduction : Eales' disease is an idiopathic occlusive retinal vasculopathy that mostly affects the peripheral retina bilaterally in young, predominately male patients. A hallmark of eales disease is recurrent vitreous hemorrage can all cause some patients to experience severe vision loss Case Illustration : A 39-year-old male with vitreous hemorrhage caused by Eales Disease grade III B with initial visual acuity 1/300. Ultrasound imaging showed the membrane like lesion with 1/2 retinal reflectivity, after moderate movement and vitreous hemorrhage on both eyes. The photo-fundus showed there is decreased fovea reflex and perimacular exudate with visible contours of sclerotic blood vessels, visible cotton wall spot, and macroaneurysm. There is also haze grade 3 on media, visible folds in the inferior part, visible shadows of cotton wall spots. The patient was managed with pars plana vitrectomy with endolaser Discussion : In this case, patient was diagnosed as vitreous hemorrhage caused by Eales Disease grade III B on both eyes but it getting worse on left eye further. We chose to perform PPV with endolaser on right eye. The outcome was good on right eye based on better visual acuity and decreased hemorrhage, but in the left eye, which not treated, worsen outcome occurred Conclusion : The management of this patient’s case showed good results in both anatomic and functional outcomes for right eye, but unfortunately left eye is on serious problem
Co-Authors A.A. Ketut Agung Cahyawan W A.K Ansyori Ahmad Ghiffari Alfin Radhian Alfurqon Alfurqon Ammar Fardhana Ansyori, A.K. Ansyori, AK Ansyori, AK. Anwar, Chairil Ashita Hulwah A Ayu Aliyah Aziztama, Rezandi Budi Santoso Chairil Anwar Chairil Anwar Charil Anwar Cicilia, Monica Putri Cindy Kesty Defayudina Dafilianty Rosataria Devi Eryanti Devi Eryanti Dezca Nindita Dian Ariani Dian Puspita Sari Dina Fatwa Dio Asgira Rizky Dita Mintardi Dwiana Ocviyanti Dyah Rahayu Utami Elisa Taurisia Elza Iskandar, Elza Evasha, Agung Putra Faika Novadianaz Faiz Muhammad Ikhsan Faneisha Febrina Art Fensilia Yolanda, Gina Sonia Ferry Yusrizal Fidalia Galuh Ismayanti Ginda Chitra H. A. K. Ansyori H. A.K Ansyori Haloho, Agustina Br. Hamzah Hasyim Handayani, Retno Tharra Hartati Hartati Herdana, Nova Indiarsih, Tiara Bunga Indri Seta Septadina Irsan Saleh Kms Yusuf Effendi Krisna Murti Laksono Trisnantoro Linda Tri Wulandari M. Usman Salim Mandy Putriyudi Maria Ulfa Maya Ija Maya Sari, prima Mgs. Irsan Saleh, Mgs. Irsan Mistur Rozian Mufida Muzakkie Muhammad Baqir MUHAMMAD FAHMI Muhammad Irsan Saleh mulyati mulyati Mutiara, Ria Nailul Authoriyah Naufallah Dinda Harumi Nova Herdana Nur Farida Rahmawati Nyayu Fauziah Zen Oliffa Salma Atthahiroh Petty Purwanita Prima Maya Sari Purwanita, Purwanita Putra, Chani Sinaro Putri, Dwi Octaverina Radiyati Umi Partan Rafika Rafika Novianti Rahmah, Meidina Rajendra Ekki Maulana Reny Violeta Rika Anggraini Rika Anggraini Ririn Rahayu Ririn Rahayu MS Rizma Adlia Syakurah Roland Iqbal Rosataria, Defayudina Dafilianty Salim, Muhammad Usman Shaelva Lassa Sabatini Shariff, Muhammad Apriliandy Silvia Rahmi Siti Pradyta Phiskanugrah Sukmono, Nafila Mahida Syarif Husin Theodorus Tiara Mayasari Tribowo, Anang Vicela Patricia Virgyna Widya Wira Putri Yuanita Windusari Yuanita Windusari Zamzam, Avizena Muhammad Zen Hafy