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All Journal Jurnal Penelitian Pendidikan Kimia Lantanida Journal SPEKTRA: Jurnal Kajian Pendidikan Sains Seminar Nasional Pendidikan IPA Martabe : Jurnal Pengabdian Kepada Masyarakat LAVOISIER: Chemistry Education Journal Jurnal Pengabdian West Science LAVOISIER: Chemistry Education Journal Jurnal Sains dan Kesehatan Jurnal Pendidikan MIPA
Andi Suharman, Andi
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Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Analysis of Chemistry Education Students' Perceptions Regarding the Use of ChatGPT for Organic Chemistry Learning Fikriya, Sakti Hidayati; Zulqurnain, Muhammad; Suharman, Andi; Ad’hiya, Eka
LAVOISIER: Chemistry Education Journal Vol 4, No 2 (2025): LAVOISIER: Chemistry Education Journal
Publisher : UIN Syekh Ali Hasan Ahmad Addary Padangsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/lavoisier.v4i2.17937

Abstract

Advances in artificial intelligence technologies, such as ChatGPT, provide new opportunities for learning Organic Chemistry, a subject noted for its abstract and complex concepts. The purpose of this study is to investigate students' impressions of using ChatGPT as a learning tool for mastering Organic Chemistry subjects. This descriptive quantitative study included 87 Chemistry Education Study Program students from Sriwijaya University's Faculty of Teacher Training and Education. A Likert-scale survey was used to obtain data on frequency of usage, perception of use, perception of utility, prompt effort, and ethical awareness when using ChatGPT. The results revealed that 98.9% had used ChatGPT to learn Organic Chemistry; 74% thought ChatGPT was successful in promoting understanding of the content; and 72% recognized the efficiency of learning time. Thematic study revealed that ChatGPT aided in the smooth exposition of difficult concepts such as stereochemistry and chemical processes. However, 59% believed that the explanations' accuracy required further scientific validation. Respondents acknowledged the possibility of conceptualization errors if ChatGPT was utilized without lecturer guidance or evaluation of scientific sources. These findings support ChatGPT's potential as an adaptable and relevant Organic Chemistry learning tool for achieving 21st-century demands such as critical thinking and problem solving. Additional study recommendations include integrating ChatGPT into organic chemistry learning models and media.
DESAIN DAN EVALUASI IN SILICO TURUNAN BARU PIRAZINAMIDA BERBASIS 1,2,4-TRIAZOL SEBAGAI KANDIDAT OBAT ANTITUBERKULOSIS Zulqurnain, Muhammad; Fikriya, Sakti Hidayati; Suharman, Andi
Seminar Nasional Pendidikan IPA Ke III Tahun 2025 Vol 3, No 1 (2025): Prosiding Seminar Pendidikan IPA
Publisher : Seminar Nasional Pendidikan IPA Ke III Tahun 2025

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Abstract

Tuberkulosis masih menjadi salah satu penyakit menular paling mematikan di dunia, sementara resistansi terhadap obat lini pertama seperti pirazinamida terus meningkat. Penelitian ini bertujuan untuk merancang dan mengevaluasi dua turunan pirazinamida yang disubstitusi dengan gugus 1,2,4-triazol sebagai kandidat antituberkulosis baru melalui pendekatan in silico. Senyawa yang dirancang meliputi N-(1-(4-hidroksibenzil)-1H-1,2,4-triazol-3-il)pirazin-2-karboksamida (D) dan 6-kloro-N-(1-(4-hidroksibenzil)-1H-1,2,4-triazol-3-il)pirazin-2-karboksamida (E), yang diuji sebagai inhibitor enzim enoyl-[acyl-carrier-protein] reductase (InhA) dari Mycobacterium tuberculosis. Evaluasi dilakukan melalui analisis sifat fisikokimia, farmakokinetika, dan penambatan molekul. Hasil analisis menunjukkan bahwa kedua senyawa memenuhi seluruh parameter kelayakan obat (drug-likeness) utama berdasarkan aturan Lipinski, Ghose, dan Veber, dengan profil absorpsi oral yang baik serta risiko interaksi obat yang rendah. Hasil penambatan molekul memperlihatkan bahwa senyawa (E) memiliki energi bebas pengikatan (ΔG) sebesar −9,55 kcal/mol dan membentuk interaksi hidrogen serta π–π penting dengan residu tirosin (TYR) A:158, treonin (THR) A:196, dan kofaktor nikotinamida adenin dinukleotida (NAD) A:500, menyerupai ligan referensi. Sementara itu, senyawa (D) juga menunjukkan interaksi stabil dan potensi penghambatan yang kompetitif. Dengan demikian, modifikasi struktur pirazinamida melalui penambahan gugus triazol dan hidroksifenil terbukti meningkatkan potensi penghambatan terhadap enzim InhA. Senyawa (E) menonjol sebagai kandidat inhibitor kompetitif yang potensial, sedangkan senyawa (D) tetap menjanjikan sebagai analog aktif untuk pengembangan obat antituberkulosis yang lebih spesifik dan efektif.
Co-Authors A. Rachman Ibrahim, A. Rachman Ad’hiya, Eka Ad’hiya, Eka D Desi, D Diah Kartika Sari Effendi Nawawi, Effendi Eka Ad’hiya Fakhili Gulo Fikriya, Sakti Hidayati Hadeli L, M Hadeli, Muhammad Haryani, Maefa Eka Karolin, Cindi KARTIKA SARI, DIAH L., Muhammad Hadeli Mulyono, Budi Rachman Ibrahim, Abdul Rananda Vinsiah, Rananda Sanjaya sanjaya Simbolon, Anita H. Sofia Sofia Sofia, Sofia Sukaryawan, Made syarani, meylina Tatang Suhery, Tatang W, K Anom Zulqurnain, Muhammad