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All Journal The Journal of Pure and Applied Chemistry Research JURNAL MUQODDIMAH : Jurnal Ilmu Sosial, Politik dan Hummaniora Walisongo Journal of Chemistry Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Journal of Appropriate Technology for Community Services JURNAL BIOSHELL Jurnal Abdimas Kartika Wijayakusuma COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Indonesia Sosial Teknologi Gunung Djati Conference Series Nanggroe: Journal Of Scholarly Service Nanggroe: Journal of Scholarly Service Bohr: Jurnal Cendekia Kimia
Sari, Meiyanti Ratna Kumala
Universitas Palangka Raya, Kalimantan Tengah, Indonesia
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Journal : The Journal of Pure and Applied Chemistry Research

 1 
Antioxidant Potential of Secondary Metabolite from Kelakai (Stenochlaena palustris) as a Natural Growth Promoter Through Inhibition of Inducible Nitrite Oxide Synthase (iNOS) Irmawan, Muhammad; Kumalasari, Meiyanti Ratna; Sandriya, Ardi; Fariz Noorrahman, Nabil; Ysrafil, Ysrafil; Tesalonika, Lidya
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.6534

Abstract

Kelakai (Stenochlaena palustris), a plant native to Central Kalimantan, is recognized for its potent antioxidant properties. This study aimed to investigate the preparation, extraction, phytochemical composition, antioxidant potential, and molecular interactions of secondary metabolites derived from Kelakai, emphasizing its health-promoting benefits and possible use as a natural growth enhancer. The findings revealed that the Kelakai extract contained various secondary metabolites, including alkaloids (8.868%), flavonoids (5.3%), saponins (10.76%), phenolics (1.246%), tannins (0.067%), and triterpenes (30.7%). The extract demonstrated a powerful antioxidant effect, with an IC50 value of 44.81 μg/mL. Molecular docking analysis identified chlorogenic acid and eucalyptol as essential compounds contributing to the extract's antioxidant activity. These compounds effectively inhibit the iNOS protein, with binding free energy (ΔGbinding) values of -10.3044 kcal/mol and -6.0872 kcal/mol, respectively. These findings suggest that kelakai extract possesses significant antioxidant potential and may offer valuable applications as a natural growth promoter for broiler chickens.
Co-Authors Adiwijaya, Saputra Anasthasya Isaura Silalahi Annisa Istiqomah, Annisa Ardi Sandriya Ariska, Risya Chuchita Dongoran, Junita Elfrida Ratnawati Elfrida Roulina Simanjuntak Fajar Rakhman Wibowo Fariz Noorrahman, Nabil Ferry Purwanto Gracia, Amanda Natania Hanna Esrani Togatorop Husna Syaima Imelya, Marsya Iqbal, Rendy Muhamad Irmawan, Muhammad Jeddah Yanti Jesika Nababan Jumiati Maknun, Luluil Mokhamat Ariefin Nababan, Jesika Ozi Adi Saputra, Ozi Adi Paksi, Pandu Gizta Rapi Pramudita, Dimas Pratika, Remi Ayu Qonita Awliya Hanif Rafsanjani, Muhamad Arief Rafsanjani, Muhammad Arief Rahman, Sudarman Remi Ayu Pratika Riandy Putra Rizki Rachmad Saputra Safitriono, Wahyu Nur Sari Namarito Simarmata Septaria Yolan Kalalinggi Simangunsong, Sri Yulandari Sipayung, Ronald Regen Siska, Amelia Siti Unvaresi Misonia Beladona Siti Unvaresi Misonia Beladona Sugiyani, Tina Sulistiawati, Putri Tampubolon, Mulani Jeni Lestari Tesalonika, Lidya Venty Suryanti Wenika Simbolan Wulandari, Oktavia Rahmi Ysrafil, Ysrafil Yuni Damayanti Nainggolan Zahrotun Nafisah Zimon Pereiz