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All Journal Sari Pediatri Paediatrica Indonesiana AcTion: Aceh Nutrition Journal journal of Basic Medical Veterinary Narra J Journal of Health and Nutrition Research Narra X
Nora Sovira, Nora
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Nutritional status and laboratory characteristics of nephrotic syndrome in children undergoing steroid and non-steroid therapy at Dr. Zainoel Abidin Hospital, Banda Aceh Haris, Syafruddin; Riza, Fahrul; Thaib, T. M.; Anidar, Anidar; Thaib, Bakhtiar; Sovira, Nora
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2478

Abstract

Nephrotic syndrome (NS) is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema, and hypercholesterolemia. Frequently relapsing NS, steroid-dependent NS, and steroid-resistant NS are categorized as problematic owing to treatment difficulties. These patients require prolonged high-dose steroid therapy or immunosuppressants, resulting in significant side effects. This study evaluated the nutritional status and laboratory characteristics of NS in children undergoing steroid and non-steroid therapies. This study is the first to assess the nutritional status and laboratory characteristics of children with difficult-to-treat NS who received steroid and non-steroid therapy at RSUDZA Banda Aceh. A cross-sectional study was conducted at the outpatient clinic and pediatric ward of Dr. Zainoel Abidin General Hospital, Banda Aceh, in 2019, which was a limitation because it was conducted during the Covid-19 pandemic so that the number of research subjects was limited, which could have caused bias in the study. Statistical analyses included the chi-square test or Fisher’s exact test for categorical variables and the independent sample t-test or Mann-Whitney test for numerical variables, with a 95% significance level (p < 0,05). A total of 60 children aged 2–18 years participated in this study, with 29 receiving steroid therapy and 31 receiving non-steroid therapy. Urine protein levels and relapse incidence differed significantly between the groups (p < 0,001). However, the serum albumin, urea, creatinine, calcium, and total cholesterol levels were not significantly different. No significant differences were observed in the laboratory characteristics between the steroid and non-steroid therapy groups. However, the non-steroid group exhibited a better urine protein status and fewer relapses, indicating potential therapeutic advantages.
Risk factors for poor initial response to valproic acid therapy in children with epilepsy Sari, Eva Devita; Anidar, Anidar; Amna, Eka Yunita; Andid, Rusdi; Yusuf, Sulaiman; Sovira, Nora
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.286-90

Abstract

Background The initial response in the first three months of valproic acid therapy is a prognostic factor for predicting treatment success, and it is considered to be poor if seizures persist during the three months of valproic acid treatment. Several factors might influence the initial response to valproic acid therapy, including gender, age, family history of epilepsy, electroencephalogram (EEG), head circumference, type of seizure, cerebral palsy, and pre-therapy seizure frequency. Objective To determine the risk factors for poor early response to valproic acid therapy in children with epilepsy. Methods This retrospective cohort study was conducted in children newly diagnosed with epilepsy. Data were collected from medical records of patients who had been treated at the Pediatric Polyclinic of dr. Zainoel Abidin Hospital for one year. Results Of 90 subjects, most were male (58; 64.4%) and aged three years or older (79; 87.8%). Forty-five (50%) patients had a family history of epilepsy. More than a quarter of the subjects (35; 38.9%) showed initial poor responses to valproic acid therapy. Bivariate analysis revealed risk factors for poor initial response to valproic acid therapy were age ≥ 3 years, family history of epilepsy, normal EEG, normal head circumference, generalized seizure type, cerebral palsy, and pre-therapy seizure frequency. However, multivariate analysis revealed that risk factors for poor initial response to valproic acid therapy in children with epilepsy that retained significance were family history of epilepsy (RR 6.58; 95%CI 1.67 to 25.95; P=0,001), abnormal EEG (RR 5.27; 95%CI 1.16 to 23.87; P=0,000), focal seizures (RR 7.10; 95%CI 1.15 to 43.80; P=0,000), and cerebral palsy (RR 62.62; 95%CI 3.93 to 996.45; P=0,001). Conclusion The risk factors for poor initial response to valproic acid therapy in children with epilepsy are family history of epilepsy, abnormal EEG, focal seizures, and cerebral palsy.
Risk factors for progression of chronic kidney disease in children with nephrotic syndrome Adrian, Riki; Sovira, Nora; Haris, Syafruddin; Andid, Rusdi; Darnifayanti, Darnifayanti; Yusuf, Sulaiman
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.291-6

Abstract

Background Nephrotic Syndrome (NS) is a progressive kidney disease in children that can lead to chronic kidney disease (CKD). Understanding the interactions between various risk factors is critical in developing new strategies to prevent the progression of CKD in pediatric patients with NS. Objective To determine the risk factors for the progression of CKD in children with nephrotic syndrome at Dr. Zainoel Abidin Public Hospital, Banda Aceh. Methods This analytical observational study with a cross-sectional approach was conducted from September 2021 to September 2023. Data were obtained from medical records of 52 children aged 2 to 18 years in the inpatient and outpatient wards of Dr. Zainoel Abidin Public Hospital, Banda Aceh who met the inclusion criteria. Bivariate analysis using the Chi-square and Fisher's tests and multivariate analysis using logistic regression test were performed. Results Of 52 subjects, most were male and over ten years of age; 53.8% of subjects had Stage 1 CKD. The majority of stage 3-5 of CKD cases had immunosuppressive toxicity and anemia, while the majority of all subjects had hyperfiltration and proteinuria. Risk factors for CKD progression in children with NS are Hypertension (OR 2.54; 95%CI 0.32 to 20.1; P=0.003), immunosuppressant toxicity with (OR 33.67; 95%CI 2.59 to 437.5; P=0.007) and anemia (OR 33.92; 95%CI 2.77 to 414.5; P=0.006). Conclusion Hypertension, immunosuppressant toxicity and anemia for CKD progression in children with NS.
Vitamin D and calcium status in children with thalassemia beta major: A cross sectional study in Banda Aceh Fiska, RR. Rima Aulia; Edward, Eka Destianti; Amna, Eka Yunita; Herdata, Heru Noviat; Sovira, Nora; Ismy, Jufitriani
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2486

Abstract

Frequent blood transfusions in children with beta-thalassemia major result in iron overload, leading to hemosiderosis in various body tissues, and impair the function of these organs, disrupting vitamin D metabolism, which contributes to osteoporosis and other morbidities, which are believed to be associated with hypocalcemia, which significantly affects growth. This study aimed to investigate the relationship between vitamin D and calcium status in children with β-thalassemia major at dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. Methods: An analytical observational study employed a cross-sectional design involving 40 children aged 2–18 years with a beta-thalassemia major attending the Children's Thalassemia Clinic at dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. from July to November, 2024. Categorical data were analyzed using the Spearman test, with a p-value of <0,05. Results, of the 40 subjects, 55% subjects were male, in 45% of subjects, there was Vitamin D deficiency, 25% was vitamin D insufficiency, hypocalcemia in 77,5% subjects. Among subjects with vitamin D deficiency, 94,4% also had hypocalcemia (r = 0,037, p = 0,017). In conclusion, there was a significant association between vitamin D and calcium status in children with beta-thalassemia major.
Nutritional status, age and gender factors associated on pneumonia in congenital heart disease: A hospital-based cross-sectional study in Banda Aceh, Indonesia Sovira, Nora; Dimiati, Herlina; Yusuf, Sulaiman; Bakhtiar, Bakhtiar; Ismy, Jufitriani
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2442

Abstract

Pneumonia is a leading cause of morbidity and mortality in children with congenital heart disease (CHD). Risk factors for pneumonia in these children include anemia, hypoxemia, nutritional status, congestive heart failure, and neuromuscular disorders. This study aimed to determine the risk factors for pneumonia in children with CHD at the Dr. Zainoel Abidin Public Hospital, Banda Aceh, Indonesia. This analytical, observational study employed a cross-sectional approach. This study included children aged 1 month to 18 years who were treated at the Dr. Zainoel Abidin Public Hospital from January 2022 to December 2023. Data were collected from medical records of 121 children who met the inclusion and exclusion criteria. Data were analyzed using bivariate analysis with the chi-square test and multivariate analysis with logistic regression. Pneumonia was observed in 66 (54,5%) patients. The majority of children with critical illnesses who developed pneumonia were between 1 month and 5 years of age (60%), female (61,7%), had poor nutritional status (53,2%), and had a birth weight ≥ 2500 g (54,5%). The type of CHD was found to be a significant risk factor for pneumonia (p = 0,024), with an odds ratio of 3,16 (95% CI: 1,162–8,617). In conclusion, the CHD type is a risk factor for pneumonia in children with CHD.
Penjepitan Tali Pusat Tertunda Terhadap Kadar Hemoglobin dan Hematokrit pada Bayi Baru Lahir Fariyasni, Fariyasni; Darnifayanti, Darnifayanti; Anidar, Anidar; Andid, Rusdi; Sovira, Nora; Herdata, Heru Noviat
Sari Pediatri Vol 27, No 3 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp27.3.2025.153-8

Abstract

Latar belakang. Anemia pada anak dengan penyebab utama kekurangan zat besi. Salah satu faktor yang memengaruhi jumlah total besi dalam sirkulasi sebagai hemoglobin saat lahir adalah waktu penjepitan tali pusat. Delayed cord clamping (DCC) meningkatkan simpanan zat besi. Penjepitan dan pemotongan tali pusat saat lahir merupakan intervensi paling lama, tetapi tidak ada definisi pasti mengenai waktu optimal untuk penjepitan tali pusat.Tujuan. Mengetahui pengaruh waktu DCC terhadap kadar hemoglobin (Hb) dan hematokrit (Ht) pada bayi baru lahir.Metode. Penelitian kuasi eksperimen ini dengan rancangan nonequivalent control group posttest-only pada kelahiran pervaginam di Rumah Sakit dr. Zainoel Abidin Banda Aceh sejak Juli 2023 hingga September 2023 yang memenuhi kriteria penelitian. Sampel kelompok I DCC ?30- – 60 detik dan kelompok II DCC >1-3 menit. Nilai Hb dan Ht bayi diukur maksimal 2 jam setelah lahir. Analisis data menggunakan independent t-test.Hasil. Empat puluh bayi baru lahir dilibatkan dalam penelitian ini, 20 kelompok I dan 20 kelompok II. Karakteristik dasar kedua kelompok sebanding. Rerata kadar Hb pada kelompok I 16,41±1,16 g/dL dan kelompok II 19,79±1,51 g/dL (p=0,001; IK95%: 2,5-4,2). Rerata kadar Ht pada kelompok I 50,07±4,57% dan kelompok II 61,06±4,53% (p=0,001; IK95%: 8,06-13,9). Menunjukkan perbedaan yang signifikan secara statistik antara kedua kelompok.Kesimpulan. Penundaan penjepitan tali pusat >1-3 menit memiliki rerata kadar Hb dan Ht yang lebih tinggi
Pengaruh Diare dan Konstipasi Kronis Terhadap Kejadian Infeksi Saluran Kemih pada Anak di Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh Muslim, Muslim; Yusuf, Sulaiman; Haris, Syafruddin; Anidar, Anidar; Sovira, Nora; Thaib, Teuku Muhammad
Sari Pediatri Vol 26, No 5 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.5.2025.277-83

Abstract

Latar belakang. Infeksi saluran kemih merupakan salah satu infeksi bakteri yang paling sering terjadi pada anak. Diare dan konstipasi merupakan faktor risiko terjadinya Infeksi Saluran Kemih (ISK).Tujuan. Untuk mengetahui hubungan antara konstipasi kronis dan diare dengan kejadian Infeksi Saluran Kemih pada anak yang dirawat di Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh.Metode. Studi observasional analitik dengan desain potong lintang. Sampel adalah pasien anak usia satu sampai lima tahun di tempat perawatan anak Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh yang mengalami diare atau kontipasi. Sampel dipilih dengan menggunakan metode consecutive sampling dan yang memenuhi kriteria inklusi.Hasil. Lima puluh enam total sampel dikumpulkan. Sebagian besar anak (12 subjek, 66,7%) pada kelompok diare berjenis kelamin laki-laki, berusia antara 1 sampai 5 tahun (6 subjek, 33,3%), dan memiliki status gizi normal (11 subjek, 61,1%). Anak pada kelompok diare terbanyak berjenis kelamin laki-laki (13 subjek, 72,2%), usia 1 sampai 5 tahun (8 subjek, 44,4%), dan dalam rentang gizi normal (subjek 11; 61,1%). Rentang usia 1 sampai 5 tahun memiliki angka kejadian ISK tertinggi, sebanyak 13 orang (39,4%), dan mayoritas subjek berjenis kelamin laki-laki 20 subjek (60,6%), 21 subjek (63,6%) berstatus gizi normal. Sebagian besar bakteri pada ISK (7 pasien, 12,1%) adalah Gram negatif. Pada penelitian ini, konstipasi dan diare tidak berhubungan dengan prevalensi ISK (masing-masing p=0,114 dan 0,065).Kesimpulan. Pada penelitian ini menemukan bahwa diare dan konstipasi tidak berhubungan signifikan secara statistik terhadap kejadian ISK. Etiologi ISK tersering pada penelitian ini adalah Gram negatif.
Neutrophil Gelatinase-Associated Lipocalin Plasma sebagai Prediktor Gangguan Fungsi Ginjal pada Anak dengan Penyakit Jantung Bawaan Asianotik di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh Safrizal, Safrizal; Dimiati, Herlina; Amna, Eka Yunita; Sovira, Nora; Haris, Syafruddin; Darussalam, Dora
Sari Pediatri Vol 26, No 4 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.4.2024.218-23

Abstract

Latar belakang. Penyakit jantung bawaan asianotik merupakan kelainan struktur dan fungsi jantung sejak lahir yang tidak ditandai dengan sianosis. Morbiditas PJB asianotik signifikan, dengan prevalensi 69,3-78,5%. Pada PJB dapat terjadi gangguan fungsi ginjal yang dapat meningkatkan mortalitas pada anak. Neutrophil Gelatinase-Associated Lipocalin (NGAL) plasma merupakan penanda prediktor gangguan fungsi ginjal pada anak. Tujuan. Mengetahui kadar NGAL plasma sebagai prediktor gangguan fungsi ginjal pada anak dengan penyakit jantung bawaan asianotik.Metode. Penelitian ini merupakan studi observasional analitik dengan pendekatan prospektif pada anak usia 1 tahun sampai 10 tahun dengan diagnosis PJB asianotik yang melakukan rawat jalan maupun rawat inap di Rumah Sakit Umum Daerah dr Zainoel Abidin Banda Aceh pada bulan Februari hingga Juni 2024 yang memenuhi kriteria penelitian.Hasil. Dari 35 anak dengan PJB asianotik, terbanyak berusia usia 1 tahun sampai dengan kurang dari 5 tahun (41,7%). Sebanyak 31,2% anak dengan diagnosis defek septum atrium terdapat gangguan fungsi ginjal. Kadar NGAL plasma sebesar 100,18 ng/ml menjadi cut-off point gangguan fungsi ginjal pada anak dengan PJB asianotik. Pada nilai AUC sebesar 0,95 didapat nilai sensitivitas, spesifisitas, PPV dan NPV masing-masing sebesar 100%; 94,73%; 94,1%; dan 100%. Kadar NGAL plasma pada anak dengan PJB asianotik memiliki hubungan signifikan (p=0,001) dengan gangguan fungsi ginjal.Kesimpulan. Neutrophil Gelatinase-Associated Lipocalin plasma dapat digunakan sebagai prediktor gangguan fungsi ginjal pada anak dengan PJB asianotik.
Correlation between Platelet Indices and PELOD-2 Score as Prognostic Markers in Pediatric Sepsis at Dr. Zainoel Abidin Hospital Pratiwi, Sari Novita; Sovira, Nora; Edward, Eka Destianti; Herdata, Heru Noviat; Safri, Mulya; Ismy, Jufitriani
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.613

Abstract

To determine the correlation between Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) with Pediatric Logistic Organ Dysfunction (PELOD-2) scores as prognostic markers in pediatric sepsis. This prospective cohort study included 44 pediatric sepsis patients admitted to the PICU at Dr. Zainoel Abidin Hospital from July to September 2024. PELOD-2 scores and blood indices were assessed on admission (Day 1) and Day 3. Pearson correlation was used to analyze the relationship between variables. The majority of patients were female (59.1%) and under one year old (31.8%). By Day 3, 68.2% of patients exhibited MPV levels exceeding 10.4 fL. Significant moderate correlations were found between Day 3 MPV and PELOD-2 (r=0.410; p=0.006), Day 3 PDW and PELOD-2 (r=0.518; p=0.001), and the changes ($\Delta$) in PDW versus PELOD-2 scores (r=0.471; p=0.005). Increases in MPV and PDW are significantly correlated with PELOD-2 scores, suggesting their potential utility as accessible prognostic markers in pediatric sepsis management.
Co-Authors Adrian, Riki Amna, Eka Yunita Anidar Anidar, Anidar Bakhtiar Bakhtiar Carolina, Infra Yunita Chalisah, Lilis Darnifayanti, Darnifayanti Dora Darussalam, Dora Edward, Eka D. Edward, Eka Destianti Fahrul Riza Fajar, Sukmawan Fajri, Fauzan Fajri, Rizky Fariyasni, Fariyasni Fiska, RR. Rima Aulia Gunawan, Aris Hasan, Denny I. Hasan, Denny Irmawati Haypheng, Te Herdata, Heru N. Herlina Dimiati, Herlina Heru Noviat Herdata, Heru Noviat Ismy, Jufitriani Kowita, Nurul Huda Mulya Safri, Mulya Munawarah, Syifa Muslim Muslim Nadia, Nurul Nuriyanto, Alivia Rizky Pratiwi, Sari Novita Raihani, Rifa Rusdi Andid, Rusdi Safrizal Safrizal Sari, Eva Devita Sentosa, Sukmawan F. Srikandi, Mira Sulaiman Yusuf Syafruddin Haris, Syafruddin Thaib, Bakhtiar Thaib, T. M. Thaib, T.M. Thaib, Teuku Muhammad