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All Journal HAYATI Journal of Biosciences Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM FITOFARMAKA: Jurnal Ilmiah Farmasi Current Research on Biosciences and Biotechnology Indonesian Journal of Biological Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Sciences of Pharmacy Public Health Risk Assesment Journal Medical Sains : Jurnal Ilmiah Kefarmasian

Melisa Intan Barliana

Fakultas Farmasi Universitas Padjadjaran

Author-ID : 604734

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Literature Review:Inovasi Terapi Polycystic Ovary Syndrome (PCOS) Menggunakan Targeted Drug Therapy Gen CYP19 rs2414096 ELLENA MAGGYVIN; Melisa Intan Barliana
Farmaka Vol 17, No 1 (2019): Farmaka (Februari)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Latar belakang: Polycystic Ovary Syndrome (PCOS) adalah kelainan endokrin yang berdampak pada sistem reproduksi wanita. Wanita dengan penyakit PCOS memiliki risiko infertilitas yang tinggi. Terapi yang saat ini digunakan berupa terapi hormon, laparoscopic ovarian drilling, dan in-vitro fertilization. Akan tetapi, ketiga terapi tersebut terfokus pada terapi simptomatis dan kurang efektif dalam mengatasi infertilitas terkait PCOS.Metode: Penulisan secara literature review dengan mencari jurnal-jurnal relevan yang berkaitan dengan PCOS pada Google Scholar, Pubmed, Medline, Biomed Central, NCBI, dengan kata kunci seperti polysystic ovary syndrome, infertility,dan gene therapy untuk pengobatan PCOS berbasis gen.Hasil dan Pembahasan: Terapi yang lebih sensitif, spesifik, dan akurat dibutuhkan dalam penanganan infertilitas terkait PCOS. Targeted drug therapy gen CYP19 rs2414096 merupakan inovasi terapi yang sensitif, spesifik, dan akurat pada penderita PCOS. Gen CYP19 bertanggung jawab terhadap sintesis enzim aromatase yang berkaitan erat dengan tingkat hormon androgen. Abnormalitas pada gen CYP19 menyebabkan kegagalan sintesis enzim aromatase, berdampak pada penyakit PCOS dan infertilitas. Prinsip dari targeted drug therapy gen CYP19 rs2414096 adalah memperbaiki gen CYP19 abnormal pada rs2414096 dengan menyisipkan urutan basa normal DNA gen CYP19 dalam vektor adenovirus yang bekerja spesifik terhadap target gen CYP19 pada ovarium.Simpulan: Inovasi targeted drug therapy gen CYP19 rs2414096 diharapkan dapat menjadi terapi yang sensitif, spesifik, dan akurat dalam pengobatan PCOS serta mencegah infertilitas penderita PCOS. Kata kunci: Infertilitas, Gen CYP19 rs2414096, PCOS, Targeted Drug Therapy

Pemanfaatan Selulosa Dari Limbah Jerami Padi (Oryza sativa) Sebagai Bahan Bioplastik Rimadani Pratiwi; Driyanti Rahayu; Melisa Intan Barliana
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 3 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Jerami padi (Oryza sativa) memiliki kandungan selulosa yang cukup tinggi. Selulosa merupakan biopolimer alami yang dapat digunakan sebagai bahan bioplastik. Penelitian ini bertujuan untuk mengetahui apakah selulosa dari limbah jerami padi dapat dimanfaatkan sebagai bahan bioplastik dan bagaimana karakterisasi bioplastik yang dihasilkan dari limbah jerami padi tersebut. Penelitian ini dilakukan dalam beberapa tahapan, yaitu preparasi bahan, pembuatan pulp, pembuatan bioplastik dengan metode inversi fasa dengan variasi jumlah kitosan dan pulp selulosa 3:10, 4:10, dan 5:10, serta karakterisasi bioplastik. Bioplastik yang dihasilkan dari berbagai perbandingan pulp selulosa dan kitosan memiliki karakterisitik yang berbeda-beda. Analisis morfologi menunjukkan bahwa bioplastik yang terbentuk belum homogen dan pada analisis gugus fungsi, tidak ditemukan adanya gugus fungsi baru dalam bioplastik dibandingkan terhadap gugus fungsi yang ada pada bahan pembentuknya. Nilai penyerapan air pada bioplastik dengan perbandingan kitosan dengan pulp selulosa 3:10, 4:10 dan 5:10 adalah 154.65%, 119. 21%, dan 93.873 % . Hasil pengujian sifat mekanik yaitu kuat tarik secara berturut-turut adalah 4.2 MPa, 13.8 MPa, dan 4,1 MPa. Dari hasil penelitian dapat disimpulkan bahwa selulosa dari limbah jerami padi dapat dimanfaatkan sebagai bahan bioplastik.

Stevia rebaudiana Bertoni Leaves Extract as a Nutraceutical with Hypoglycemic Activity in Diabetic Rats Keri Lestari; Abdurahman Ridho; Nuning Nurcayani; Zelika Mega Ramadhania; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.686

BACKGROUND: The prevalence of diabetes mellitus is growing every year, including in Indonesia. Medicinal herbs were used empirically for lowering blood glucose. One of potential herb to have hypoglycemic activity is Stevia. Stevia rebaudiana Bertoni leaves contain stevoside, a natural, low-calorie sweetener that is 300 times sweeter than saccharose. In this study, we aimed to explore the hypoglycemic activity of S. rebaudiana Bertoni leaves extract in a rat model of type 2 diabetes mellitus (T2DM). METHODS: Male Wistar rats were feed high-fat, high-carbohydrate feed and sugar solution for 74 days to induce a diabetic rat model. The animals were then divided into five groups consisting of a negative control group treated with 2% Pulvis Gom Arabicum; a positive control group treated with Metformin 45 mg/kg body weight (BW); and three test groups treated with aqueous extract of S. rebaudiana Bertoni leaves at doses of 3.125, 6.25 and 12.5 mg/kg BW for 36 days. Blood glucose was measured on days 14, 28 and 36.RESULTS: The results showed that blood glucose levels over 36 days were significantly (p=0.043) lower in the group treated with S. rebaudiana Bertoni leaves extract. Further Newman-Keuls analysis suggested that the hypoglycemic activity of S. rebaudiana Bertoni leaves extract was dose-dependent. CONCLUSION: Our results indicate that S. rebaudiana Bertoni leaves extract has a potential role as a hypoglycemic agent in the treatment of T2DM.KEYWORDS: Stevia rebaudiana Bertoni, nutraceuticals, hypoglycemic, diabetic rats

Correlation of Moderate-Intensity Physical Exercise on Irisin, Oxidized-LDL and HDL Level in ≥50 Years Old Obese Men Made Putra Semadhi; Melisa Intan Barliana; Dewi Muliaty; Andi Wijaya
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.619

BACKGROUND: Irisin is secreted by our muscle during physical exercise, which has been recently studied to be linked with lipid metabolism. The aim of this study was to investigate the role of irisin that interact with the oxidized-low density lipoprotein (ox-LDL) and high density lipoprotein cholesterol (HDL-C) levels that are affected by moderate intensity exercise in obese men aged ≥50 years.METHODS: This was a cross-sectional study with 70 obese men whose age ≥50 years old as participants. Participants were classified into two groups of men with and without physical exercised, based on American College of Sports Medicine (ACSM). Irisin and ox-LDL plasma levels were analyzed using enzyme-linked immunosorbent assay (ELISA), meanwhile the HDL-C serum level was analyzed using homogenous enzymatic methods.RESULTS: The result showed an association between the duration of physical exercise per week and irisin level (R=0.584, p<0.01), also between the duration of physical excercise per week and ox-LDL level (R=-0.274, p<0.05). Meanwhile, there was a negative association between irisin levels and ox-LDL (R=-0.294, p<0.05). Irisin indicated to be correlated with HDL-C (R=0.215, p>0.05).CONCLUSION: Moderate-intensity physical exercise may decrease cardiovascular risk and improve the quality of life among obese subjects aged ≥50 years old, which was indicated by the decrease of ox-LDL and the increase of irisin level. In addition, it can be concluded that the higher the irisin level showed the lower levels of ox-LDL and higher level of HDL-C.KEYWORDS: obesity, elderly, irisin, ox-LDL, HDL-C, physical exercise

Nutritional Biomarkers for Predicting Pancreatic Beta Cell Failure in Central Obesity Miftakh Nur Rahman; Ajeng Diantini; Miswar Fattah; Melisa Intan Barliana
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1440

BACKGROUND: There is a continuous rise in the prevalence of central obesity and become a pressing health problem in the world. Central obesity followed by many metabolic disorders especially Type 2 Diabetes Mellitus (T2DM). The pathogenesis started from overnutrition signal that force pancreatic beta cells to produce a large number of insulin. Low-grade chronic inflammation that occurred also affects the organs sensitivity against insulin and caused beta cells to compensated this situation and at the end become exhausted and loss its function.CONTENT: Along compensation mechanism, certain nutrients were support the beta cells to maintain their mass and function to produce insulin. Short chain fatty acids (SCFAs) are gut microbiota fermentation product that act as nutrient and give an advantage to the proliferation and survivability of the beta cells. Zinc (Zn) also plays an important role in every step of insulin production. Moreover, these nutrients protecting pancreas against inflammation and oxidative stress through certain mechanism. Most of patients with central obesity are unaware of the presence of this disturbance at early stage. Whereas, at molecular level there is a magnitude of SCFAs and Zn level in the blood that would become an early signal and predict the damage of beta cells.SUMMARY: Quantification of these two nutrients in the blood expected to provide an early warning tool to maintain insulin adequacy and predict the possibility of beta cell failure in central obesity with promising performance.KEYWORDS: central obesity, T2DM, SCFAs, Zinc, beta cell failure

Apoptosis and Efferocytosis in Inflammatory Diseases Chandra Agung Purnama; Anna Meiliana; Melisa Intan Barliana; Keri Lestari Dandan; Andi Wijaya
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1608

BACKGROUND: Millions of cells in multicellular organisms regenerate every day to replace aged and died cells. Effective cell clearance (efferocytosis) is critical for tissue homeostasis, as the human body recycles its cellular components. We summarize what is known about the mechanisms of efferocytosis and how it impacts the physiology of the organism, effects on inflammation and the adaptive immune response, as well as the consequences of defects in this critical homeostatic mechanism in this review.CONTENT: Cell death is the process by which the human body replaces aged or damaged cells with new ones. It can be triggered by genetically encoded machinery or regulated cell death, or by specific pharmacologic or genetic interventions, resulting in accidental cell death. Dying cells release signals that entice phagocytes to engulf them in a process known as efferocytosis. Efferocytosis is a multistep process involving the release of “find me” and “eat me” signals and destruction of death cells by phagocytes. Different types of cell death including apoptosis and necroptosis can express pro- or anti-inflammatory signals via macrophage activity modulation.SUMMARY: Failed or ineffective efferocytosis can result in disruption of tissue homeostasis, which can contribute to the development of chronic inflammatory diseases such as atherosclerosis, obesity, diabetes, and heart failure. Therefore, any therapeutic strategy that enhances efferocytosis will have a beneficial effect on the treatment of these metabolic disorders.KEYWORDS: apoptosis, necroptosis, phagocytosis, efferocytosis, macrophage.

REVIEW ARTICLE : AKTIVITAS SITOKTOSIK MANGGU LEWEUNG (Garcinia celebica L.) PADA BERRBAGAI LINI SEL KANKER Komang Suma Triyasa; Ajeng Diantini; Melisa Intan Barliana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 5 No 1 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

ABSTRAKKanker merupakan penyakit yang mengancam jiwa yang sangat serius bagi semua manusia. Menurut data GLOBOCAN 2018 kasus populasi kanker masih meningkat menjadi 18,1 juta dan 9,6 juta dan kematian dan hampir dari setengah populasi terjadi di Asia.Â Ekstrak, fraksi hingga isolat Garcinia CelebicaÂ (manggis hutan) dilaporkan mempunyai aktivitas sitoktosik yang dapat menghambat pertumbuhan dalam berbagai sel kanker diantaranya MCF-7 (kanker payudara), A549 (kanker paru), Â Hela (kanker servik), Â KB (karsinoma epidermoid), B16F10 (melanoma), DBTRG (glioma).

APLIKASI FLOW CYTOMETRY DALAM BIDANG IMUNOLOGI: REVIEW Munir Alinu Mulki; Tiana Milanda; Melisa Intan Barliana
Jurnal Kesehatan Vol. 8 No. 2 (2020): Oktober : Health Journal “Love That Renewed”
Publisher : Sekolah Tinggi Ilmu Kesehatan Santo Borromeus

Flow cytometry merupakan suatu instrumen canggih yang dapat digunakan untuk analisis cepat multi-parameter berbagai karakteristik fisik sel tunggal dalam suatu larutan. Sistem kerja flow cytometry bergantung pada karakteristik fluoresen atau hamburan cahaya dari suatu sel, kemudian dikonversi menjadi sinyal elektronik, dan dianalisis menggunakan komputer. Pendekatan tersebut menjadikan flow cytometry sebagai suatu alat yang baik untuk analisis secara detail suatu populasi sel yang kompleks dalam waktu singkat. Review artikel ini menjelaskan tentang prinsip dasar termasuk komponen dan cara kerja dari flow cytometry, juga menjelaskan tentang analisis data dan aplikasinya dalam bidang imunologi, yaitu immunophenotyping, analisis respon spesifik antigen, analisis sitokin intraseluler, analisis proliferasi, dan analisis apoptosis.

SITOTOKSISITAS KOMBINASI EKSTRAK PUSPA (Schiima wallichii) DANKECAMBAH BROKOLI iv (Brassica olerasea) TERHADAP SEL KANKER PAYUDARA MCF-7 Ajeng Diantini; Maya Febriyanti; Melisa Intan Barliana; Rizky Abdulah
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 3, No 1 (2013): FITOFARMAKA
Publisher : Universitas Pakuan

Puspa (Schiima wallichii) diketahui memiliki aktivitas antikanker melalui mekanismemenginduksi apoptosis pada sel kanker payudara MCF-7, sedangkan kecambah brokoli(Brassica olerasea) dilaporkan dapat menghambat proliferasi sel-sel kanker kandung kemihdan prostat secara in vitro. Pada penelitian ini dilakukan pengujian sitotoksisitas kombinasiekstrak puspa (EP) dan ekstrak kecambah brokoli (EKB) terhadap sel kanker payudaraMCF-7. EP memberikan nilai IC5060,76 g/ml, sedangkan EKB tidak memberikan persentasi inhibisi lebih besar dari 50% pada rentang konsentrasi uji. Sitotoksisitas kombinasi EP-EKB dengan perbandingan IC50 1:2 memiliki nilai Indeks Kombinasi 0,9 menunjukkan bahwa kombinasi EP-EKB memberikan efek sinergisme.Kata kunci :puspa, kecambah brokoli, sinergisme, MCF-7

Pelatihan Online Pembuatan Makanan Fermentasi Wadi Yulistia Budianti Soemarie; Tiana Milanda; Karina Erlianti; Muhammad Fauzi; Didi Susanto; Melisa Intan Barliana
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 1 (2022): Volume 5 No 1 Januari 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i1.5459

ABSTRAKSalah satu penerapan proses fermentasi terjadi pada produk perikanan. Wadi merupakan hasil fermentasi ikan yang banyak sekali diminati oleh masyarakat Kalimantan Selatan. Wadi merupakan salah satu proses fermentasi ikan atau daging secara tradisional yang berbentuk ikan utuh semi basah, berwarna agak hitam (mendekati warna ikan segar), bertekstur liat dengan aroma ikan khas fermentasi serta mempunyai cita rasa yang asin. Wadi memiliki waktu simpan yang lama sekitar 6 sampai 12 bulan. Kurangnya keterampilan dalam pengolahan wadi mengakibatkan wadi tidak bisa tahan lama sehingga wadi menjadi cepat busuk. Selain itu, belum ada wadi kemasan yang beredar dipasaran sehingga untuk masyarakat luar Kalimantan Selatan sulit untuk mendapatkan produk wadi ini. Pelatihan ini menggunakan metode ceramah, diskusi, tanya jawab serta demonstrasi atau praktek secara daring/online. Pelatihan ini menghasilkan pengetahuan dan pemahaman yang baik bagi peserta pelatihan. Hal ini dapat dilihat dari antusias peserta pelatihan dalam sesi diskusi dan tanya jawab untuk mencari informasi yang lengkap mengenai teknik fermentasi serta pelatihan dalam pembuatan wadi. Kata kunci: Fermentasi, Wadi, Pelatihan Online ABSTRACTOne of the processes of applying the fermentation process occurs in fishery products. Wadi is a fermented fish product that is in great demand by the people of South Kalimantan. Wadi is one of the traditional fish or meat fermentation processes in the form of semi-wet whole fish, slightly black (close to the color of fresh fish), clay texture with a distinctive fermented fish aroma, and has a salty taste. Wadi has a long shelf life of about 6 to 12 months. Lack of skills in wadi processing resulted in wadi not being able to last long so that the wadi rotted quickly. In addition, there is no packaged wadi on the market so it is difficult for people outside South Kalimantan to get this wadi product. This training uses lecture, discussion, question and answer methods as well as online demonstrations or practice. This training resulted in good knowledge and understanding for the participants of the wadi making training. This can be seen from the enthusiasm of the training participants in the discussion and question and answer sessions to seek complete information about fermentation techniques and training in wadi making. Keywords: Fermentation, Wadi, Online Training

Co-Authors Abdurahman Ridho Afifah, Nadya Nurul AGATHA VIKA PURWANINGTYAS Ahmad Faried Ahmad Muhtadi Ajeng Diantini, Ajeng Aliya Nur Hasanah Among, Sayyid ANDI WIJAYA Andi Wijaya Andi Wijaya Angliana Chouw, Angliana Anna Meiliana Anna Meiliana ARNANDA, QUINZHEILLA PUTRI Balqist, Syara Nur Fitri Bonor, Toga Chandra Agung Purnama Cissy Bana Kartasasmita Cynthia Retna Sartika, Cynthia Retna Dedi Suyatno Dewi Muliaty Didi Susanto Driyanti Rahayu Edhyana Sahiratmadja Effendi, M. Fariz ELLENA MAGGYVIN Erizal Sugiono Eva Feriadi Fajar, Desi Reski Febio Gutama Febriyanti, Maya Haifa, Rima HISBAN HAMID ARIFKI Ida Paulina Sormin Imas Maesaroh Indradi, Raden Bayu Intania, Ruri Irma Melyani Puspitasari Irma Rahayu Latarissa Irmansyah Irmansyah Ivan Pradipta Ivan Surya Pradipta Karina Erlianti Kennardi, Gabriel Bagus Keri Lestari Khaira, Syifa Komang Suma Triyasa Laniyati Hamijoyo, Laniyati LILY CYNTIA FAUZI Luki Yogaswara Yusuf Made Putra Semadhi Maisyarah, Intan Timur Maya Febriyanti Miftakh Nur Rahman Miswar Fattah Moses Prasetio Muhaimin Muhaimin Muhammad Fauzi Munir Alinu Mulki Mustikawati, Bunga Nadiya Nurul Afifah Nuning Nurcayani Peratiwi, Shafira Galuh Permatasari, Lany Indah Pratama, Muhammad Syawal Prayudi Santoso Putri Maharani Putri, Nazwa Septiriana Qolbina, Shofura Marsa Raden Maya Febriyanti Rendrayani, Farida Rimadani Pratiwi Rizki Rahmadi Pratama Rizky Abdulah Sahila, Elma N. M. R. Sartika Aprianti Shelly Iskandar Soemarie, Yulistia Budianti Syahrina, Nadira Alvi Tahara, Nabila Theresia Ratnadevi TIANA MILANDA Tina Rostinawati Widya Naftalia Wijasa Yudisia Ausi Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yuni Elsa Hadisaputri Zakiyah, Neily Zelika Mega Ramadhania

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