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All Journal Farmaka Jurnal Kesehatan Masyarakat Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Chimica et Natura Acta JSFK (Jurnal Sains Farmasi & Klinis) Indonesian Journal of Biological Pharmacy Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Global Farmasi Journal of Tropical Pharmacy and Chemistry
Sri Agung Fitri Kusuma, Sri Agung
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antibacterial Effect of Ethanol Extracts of Murraya paniculata Leaves, Smallanthus sonchifolius Leaves, Apis trigona Honey, and their Combination Against Staphylococcus epidermidis Kusuma, Sri Agung Fitri; Herawati, Irma Erika; Nugrahaningtiyas, Felika
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.55483

Abstract

Several studies have reported that combining plant extracts may enhance their efficacy against specific bacterial infections. This study aimed to analyze the antibacterial interaction of ethanol extracts of Murraya paniculata leaves, Smallanthus sonchifolius leaves, Apis trigona honey, and their combinations against Staphylococcus epidermidis ATCC 12228, as each component has shown individual antibacterial activity against this bacterium. The antibacterial interactions of the test materials, both individually and in combination, were evaluated using the agar diffusion method with clindamycin phosphate as the standard antibiotic. The minimum inhibitory concentration (MIC) of the most potent extract was determined through the microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, while the minimum bactericidal concentration (MBC) was assessed via subculture on solid media. Among all tested substances, the S. sonchifolius leaf extract exhibited the highest antibacterial activity, with similar MIC and MBC values ranging from 15.625 to 31.25 mg/mL. Interaction tests revealed a significant difference, showing that the combination of all three agents had an antagonistic effect, whereas the combination of both leaf extracts produced a synergistic antibacterial effect. However, the inhibitory effect of the combination was not greater than that of the yacon extract alone. In conclusion, S. sonchifolius leaf extract demonstrates strong potential as a single antibacterial agent against S. epidermidis.
Implementasi Sertifikasi Cara Distribusi Obat yang Baik (CDOB) Dalam Menjamin Mutu Obat pada Sarana Distribusi di Jawa Barat Noor Silmi Hermawan Ayodduki, Zahra; Agung Fitri Kusuma, Sri; Susanti, Marina
Farmaka Vol 23, No 3 (2025): Farmaka (November) (In Press)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v23i3.68985

Abstract

Obat merupakan komoditas kesehatan yang harus terjamin keamanan, efektivitas, dan mutunya sejak proses produksi hingga pendistribusian kepada masyarakat. Tahapan distribusi memegang peranan penting dalam menjaga mutu obat karena ketidaksesuaian pengelolaan pada tahap ini berpotensi menurunkan mutu dan efektivitas obat. Pedagang Besar Farmasi (PBF) sebagai sarana distribusi yang berwenang melakukan pengadaan, penyimpanan, dan penyaluran obat dalam jumlah besar wajib menerapkan standar Cara Distribusi Obat yang Baik (CDOB). Penerapan CDOB bertujuan untuk menjamin mutu obat selama proses distribusi dan dibuktikan melalui kepemilikan sertifikat CDOB. Balai Besar Pengawas Obat dan Makanan (BBPOM) di Bandung sebagai Unit Pelaksana Teknis Badan POM berperan dalam melaksanakan pelayanan sertifikasi CDOB bagi PBF di wilayah kerjanya. Artikel ini bertujuan untuk menjelaskan tahapan sertifikasi CDOB serta perannya dalam mendukung penjaminan mutu obat selama pendistribusian di Jawa Barat. Artikel ini disusun berdasarkan studi literatur terhadap berbagai referensi ilmiah dan regulasi terkait CDOB. Proses sertifikasi CDOB meliputi pendaftaran pemohon, pengajuan permohonan, evaluasi dokumen, pembayaran, pemeriksaan sarana, pelaksanaan Corrective and Preventive Action (CAPA), hingga penerbitan sertifikat CDOB. Penerapan sertifikasi CDOB yang dilaksanakan secara terstruktur dan sesuai ketentuan berkontribusi dalam memperkuat sistem penjaminan mutu distribusi obat oleh PBF sehingga mutu obat selama pendistribusian dapat tetap terjaga.
Nanoemulsion Purified Catechin Gambir (Uncaria gambir Roxb.): Formulation and Antimicrobial Activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterobacter aerogenes Muhtar, Nurul Inaya; Mita, Soraya Ratnawulan; Kusuma, Sri Agung Fitri
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1368

Abstract

Gambir (Uncaria gambir Roxb), a plant native to Indonesia, has long been recognized in traditional medicine. The primary active component in gambir is catechin, which possesses various biological activities, including broad-spectrum antimicrobial properties. However, catechin faces challenges related to low stability, necessitating its formulation into a nanoemulsion to enhance both its stability and effectiveness. This study aims to evaluate whether an optimized nanoemulsion formulation of catechin can improve its antimicrobial activity. The methodology includes assessing the antimicrobial effectiveness of catechin powder and catechin nanoemulsion using the agar diffusion method, as well as determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) through the microdilution method. Antimicrobial activity was tested against three bacterial strains: Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 9027, and Enterobacter aerogenes ATCC 13048. The optimal formulation consisted of a combination of Tween 80 and Span 80 as surfactants (15%), PEG 400 as a co-surfactant (7%), and isopropyl myristate (IPM) as the oil phase (10%). This nanoemulsion formulation demonstrated a transmittance value of 91,9%. Based on the antimicrobial activity results, the catechin nanoemulsion exhibited enhanced antimicrobial effects compared to catechin powder. The nanoemulsion containing 2% catechin showed the highest antimicrobial activity against all three tested bacteria. These findings are expected to provide new insights into the potential application of catechin nanoemulsion as a more effective antimicrobial agent.
Co-Authors Ade Zuhrotun Aliya Nur Hasanah Almeida, Maria Angga Cipta Narsa Anisa Desy Ariyanti Danni Ramdhani Devani Olivia Winardi Driyanti Rahayu Fadhlillah, Muhammad GARNIS SETYAJATI Helmi Helmi Henry Ng Henry Irma Erika Herawati Josi Meka Karen Low Ka Ling Kurniawan Kurniawan Meti Kusmiati, Meti MUHAMMED SUFFIAN ABD RAZAK Muhtar, Nurul Inaya Nimas Tika Inas Tarina Noor Silmi Hermawan Ayodduki, Zahra Nugrahaningtiyas, Felika NUR FITRIATUZZAKIYYAH NUR LIYANA BINTI RAHIM Nyi Mekar Saptarini Oktavelia, Wanda Patihul Husni Rahmadani, Agung Ramdan Pelana Rimadani Pratiwi RIZKA KHOIRUNNISA GUNTINA SARAH NURMALINDA Shelvy Elizabeth Suherman SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sriwidodo Sriwidodo Sukanda, Meira Dini Supriatno Salam Susanti, Marina TIANA MILANDA Tiara Anisya Rachman Tina Rostinawati Untung Kurnia Agung Yoshihito Shiono