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Dini Suryani, Dini
JKSG Universitas Muhammadiyah Yogyakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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THE THE POTENTIAL ROLE OF NRF2 AS A TARGET SITE FOR THERAPEUTIC INTERVENTIONS IN ALZHEIMER'S DISEASE Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Ocktaviana; Suryani, Dini; Rianawati, Sri Budhi
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.10

Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration leading to cognitive decline and memory impairment, affecting various cognitive functions. AD pathology involves the accumulation of neurotoxic substances such as amyloid beta (Aβ) and tau proteins, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation, resulting in synaptic loss and neuronal apoptosis. The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as a pivotal regulator of cellular defense mechanisms, including antioxidant response, autophagy, and inflammation. NRF2 not only inhibits Aβ synthesis and enhances tau protein clearance via autophagy but also reduces neuroinflammation by modulating microglial activation and cytokine production. Additionally, NRF2 activation preserves mitochondrial function by attenuating reactive oxygen species (ROS) production and sustaining mitochondrial biogenesis. Recent studies highlight the therapeutic potential of NRF2 activators, such as sulforaphane and echinacoside, in preclinical AD models, demonstrating reductions in Aβ and tau pathologies and improved cognitive outcomes. These findings underscore the multifaceted role of NRF2 in mitigating AD progression and its promise as a target for developing novel therapeutic interventions. By integrating NRF2-based strategies, future treatments may offer more effective approaches to combat the complex pathophysiology of AD.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ISPA PADA ANAK BALITA DI PUSKESMAS PUTRI AYU SURYANI, DINI; Sari AZ, Winna Kurnia; Mulyati, Sri
Jurnal Kesehatan Medika Saintika Vol 16, No 1 (2025): Juni 2025
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v16i1.3171

Abstract

Angka kematian anak dan balita di Indonesia masih cukup tinggi. Indonesia adalah negara dengan angka kematian anak dan balita tertinggi di ASEAN. Penyebab angka kesakitan dan kematian anak terbanyak saat ini masih diakibatkan oleh Infeksi Saluran Pernafasan Akut (ISPA) dan diare. ISPA adalah suatu kelompok penyakit yang menyerang saluran pernafasan. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan kejadian ISPA pada anak balita. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Sampel pada penelitian ini sebanyak 42 orang. Pemilihan sampel dilakukan dengan teknik accidental sampling.Hasil penelitian menunjukkan sebanyak 23 responden (54,8%) memiliki anak balita yang pernah menderita ISPA dan sebanyak 19 responden (45,2%) memiliki balita yang tidak pernah menderita ISPA di Puskesmas Putri Ayu Kota Jambi serta adanya hubungan yang bermakna antara berat badan lahir, status gizi, status imunisasi dan pemberian vitamin A dengan kejadian ISPA pada anak balita. Diharapkan tenaga kesehatan di Puskesmas Putri Ayu dapat  meningkatkan pemberian informasi kepada masyarakat terutama pada ibu balita melalui pamflet, leaflet atau poster dengan bahasa yang mudah dan didukung oleh gambar sehingga ibu-ibu balita tersebut lebih mudah dalam memahami faktor-faktor yang berhubungan dengan kejadian ISPA.
EDUKASI MENGENAI FAKTA DAN MITOS EPILEPSI DI POLI SARAF RUMAH SAKIT UNIVERSITAS MATARAM Wardi, Baiq Prita Riantiani; Harahap, Herpan Syafii; Putri, Setyawati Asih; Suryani, Dini; Fitriantoro, Santo; Putri, Siti Noururrifqiyati Juna; Landapa, Raditya Rachman; Linggabudi, I Gusti Bagus Widiamtara; Maharani, Amelia Wahyu; Syifa, R.R Ditya Mutiara; Anugrah, M. Fardi; Shafa C, Cloresta; Ismaya, Ferium Trah
Jurnal Abdi Insani Vol 12 No 1 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i1.1939

Abstract

Epileptic seizures have a significant negative impact on the lives of patients, especially those who frequently experience relapses due to low medication adherence. Epilepsy patients often face stigma and social discrimination. Misunderstandings and negative societal attitudes, influenced by myths surrounding epilepsy, can prevent patients from seeking treatment and living confidently. This community service activity aimed to provide information and education about epilepsy, covering topics from its definition to an in-depth discussion of myths and facts about the disease. The ultimate goal was to enhance the knowledge of patients, their families, and visitors at the neurology outpatient clinic of Mataram University Hospital. The activity was conducted through interactive counseling sessions using PowerPoint presentations. Participants completed a pre-test before the counseling session, followed by a question-and-answer discussion after the material was delivered, and concluded with a post-test. A total of 56 participants attended. Both pre-test and post-test consisted of five questions addressing basic knowledge about the definition of epilepsy, myths and facts, and appropriate actions when encountering an epileptic seizure. The average pre-test score was 68.57, while the average post-test score increased to 76.44 after the educational session and discussion. Effective communication, education, and information dissemination proved to be key solutions for improving participants' knowledge. These efforts are expected to help epilepsy patients avoid stigma, gain full support from family and their surroundings, ensure optimal treatment outcomes, and enable patients to live confidently. Effective education and communication are critical in improving understanding of epilepsy, reducing stigma, and fostering social support for epilepsy patients.
EDUKASI MENGENAI PENYAKIT GUILLAIN BARRE SYNDROME PADA KADER DI WILAYAH KERJA PUSKESMAS KARANG TALIWANG DAN PUSKESMAS TANJUNG KARANG Hunaifi, Ilsa; Krisna , I Gusti Lanang; Fitriantoro, Santo; Suryani, Dini; Wardi, Baiq Prita Riantiani; Putri, Siti Noururrifqiyati Juna
Jurnal Abdi Insani Vol 11 No 4 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i4.2056

Abstract

Guillain-Barré Syndrome (GBS) is a neurological disorder of the peripheral nervous system and is the most common cause of acute paralysis worldwide. Guillain Barre Syndrome occurs in 1 to 4 patients per 100,000 population worldwide per year and the highest incidence is around 30 - 50 years of age (productive age). Prevention, early detection, and early management of guillain barre syndrome are very important things to do, especially for medical personnel. Community Service for medical personnel of Public Health Care Karang Taliwang and Tanjung Karang began with the implementation of pretest, followed by counselling, and ended with a post test session. This educational activity is aimed at increasing the understanding of cadres in the working area of the karang taliwang health centre about guillain barre syndrome. Keywords: Guillain-Barré Syndrome, education, prevention, early detection
EDUKASI MENGENAI PENYAKIT ALZHEIMER PADA PENGUNJUNG POLI NEUROLOGI DI RSUD PROVINSI NUSA TENGGARA BARAT DAN RS UNIVERSITAS MATARAM fitriantoro, santo; Harahap , Herpan Syafii; Landapa, Raditya Rachman; Suryani, Dini; Wardi, Baiq Prita Riantiani; Putri, Siti Noururrifqiyati Juna; Anjani, Dewa Ayu Vania Novista; Fakar, Wina Arsylia; Wulandari, Rizka; Mawaddah, Alfia; Rahma, Elrica Nadia; Novsyaini, Zhayyin Palna Rial
Jurnal Abdi Insani Vol 11 No 4 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i4.2058

Abstract

Alzheimer’s disease is the most common form of dementia, characterized by progressive cognitive decline, affecting memory, thinking abilities, and behavior. Education about Alzheimer’s disease is crucial to raise awareness regarding early symptoms, risk factors, and appropriate management, especially among neurology clinic visitors who are at high risk. This study aims to evaluate the effectiveness of education about Alzheimer’s disease among visitors of the neurology clinics at the Provincial General Hospital of West Nusa Tenggara and Mataram University Hospital. Educational sessions were conducted at two locations: the Provincial General Hospital of West Nusa Tenggara and Mataram University Hospital. The sessions included visual presentations and Q&A sessions. The effectiveness of the education was assessed by comparing pre-test and post-test scores, which measured participants’ understanding of Alzheimer’s disease. The average post-test score at Mataram University Hospital increased to 88 from a pre-test score of 76. At the Provincial General Hospital of West Nusa Tenggara, the average post-test score increased to 72.3 from a pre-test score of 67.69. This improvement indicates that the educational sessions effectively enhanced participants’ understanding of Alzheimer’s disease. Educational sessions using presentations effectively increased the understanding of neurology clinic visitors regarding Alzheimer’s disease. There is a need for broader dissemination of information at various healthcare facilities to improve public awareness and promote early detection and better management of Alzheimer’s disease.
The Difference in Total Cholesterol Levels Between Male Smokers and Non-Smokers Aged 20-50 Years Humam, Anang Muh. Naufal; Bahraen, Raehanul; Suryani, Dini
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7711

Abstract

Indonesia is ranked third in the world after India and China with the largest number of smokers. LDL, triglyceride, total cholesterol, and HDL levels can all rise and fall due to smoking. While HDL serves to prevent the formation of atherosclerosis, high LDL levels can increase the risk of atherosclerosis. POCT (Point of Care Testing) is one procedure to check total cholesterol levels. The purpose of this study was to determine the difference in total cholesterol levels of male smokers and non-smokers aged 20-50 years in the Kopang Health Center work area in 2023. This study used a cross-sectional approach. The sampling technique in this study was purposive sampling. The results of this study showed that 63.3% were light smokers, 36.7% were moderate smokers and no heavy smokers. A total of 66.7% of smokers had normal total cholesterol levels while 33.3% experienced increased levels. Non-smokers as many as 96.7% had normal total cholesterol levels and 3.3% experienced increased levels. The results of the Chi-square test showed a P value of 0.010, which means P <0.05, so there is a significant difference between the cholesterol levels of smokers and non-smokers. The conclusion is that total cholesterol levels are normal in smoker respondents and total cholesterol levels are high in non-smoker respondents. The recommendation from this study is the importance of reducing cigarette consumption, controlling cholesterol levels regularly, and maintaining a healthy lifestyle to prevent a significant decrease in HDL levels.
Agreement of Non-Contact Infrared Thermometer Measurement Results with Digital Axillary Thermometer in Neonates at the Pejeruk Community Health Muttaqin, Syihabul; Dilaga, Marisa Syafitri; Suryani, Dini; Haq, Abiyyu Didar; Wiguna, Putu Aditya
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8136

Abstract

NCIT has several advantages, such as quick measurement time, no need for contact between the device and the patient, and greater comfort for patients compared to measuring temperature using TDA or rectal digital thermometers. These advantages make NCIT suitable for use in PKM. However, previous research on the comparability of NCIT measurement results with TDA in neonates is limited and shows varying results. This study aims to determine the agreement of NCIT measurement results with TDA measurement results in neonates. The study is an analytical observational study with a cross-sectional design. 25 neonates participated in this study, with some having their temperature measured only once and others more than once, according to an agreement with their guardians. A total of 62 temperature measurement samples were taken after going through the inclusion and exclusion process. The measuring instrument used was the digital axillary thermometer (TDA), which served as the reference. Additionally, three types of non-contact infrared thermometers (NCITs) were used to assess their agreement for this study. The sample data was analyzed using the One-Sample T-test, Intraclass Correlation Coefficient (ICC) method, and Bland Altman Plot. The ICC results indicated poor agreement of each NCIT with the TDA. The One Sample T-test indicates that of of the NCIT used does not have statistically significant differences compared to TDA, whereas two other types of NCIT do have statistically significant differences compared to TDA, The Bland Altman Plot analysis shows that the Limits of Agreement for each type of NCIT with TDA are still wide. From these results, it is concluded that these three types of NCIT cannot replace TDA as a body temperature measurement tool for neonates.
Risk Factors for Cognitive Impairment in Adult Population of Coastal Area: A Cross-Sectional Study in Maringkik Island, Indonesia Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati, Nurhidayati; Zubaidi, Fitriannisa Faradina; Suryani, Dini; Saputri, Legis Ocktaviana; Indrayana, Yanna; Andhera, Athalita; Hilam, Muhammad; Haq, Abiyyu Didar
Kesmas Vol. 19, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cognitive impairment is a medical condition commonly found in elderly populations, which can be due to vascular risk factors in patients. There remains limited data on risk factors for cognitive impairment among coastal region populations. This study aimed to investigate risk factors for cognitive impairment in the adult population of Maringkik Island, West Nusa Tenggara Province, Indonesia. Data collected were age, sex, education level, hypertension, antihypertensive treatment, diabetes mellitus, cigarette smoking, and body mass index status. A total of 114 participants were recruited using a consecutive sampling method. The participants’ cognitive function assessment used the Mini-Cog instrument. The cognitive impairment frequency in the island’s adult population was approximately 48.2%. The final model of multiple regression analysis showed that hypertension (OR: 2.3; 95%CI: 1.0 – 5.0; p-value: 0.045) was a characteristic associated with the cognitive impairment frequency. Thus, the high frequency of cognitive impairment and hypertension frequency as primary risk factors for cognitive impairment in the island’s adult population implies the need to develop strategies for detecting and managing hypertension and hypertension-related cognitive impairment in the population by local health authorities.
Co-Authors . NURHAYATI Andhera, Athalita Anjani, Dewa Ayu Vania Novista Anugrah, M. Fardi Arnawati, Ida Ayu Arnawati Aryasta, Ida Bagus Putra Bayu Aulia, Dian Aziz, Nyimas Latifah Letty Bahraen, Raehanul Damayanti, Ida Ayu Andara Dilaga, Marisa Syafitri Elizar, Lale Justin Amelinda Fakar, Wina Arsylia Fitriantoro, Santo Haq, Abiyyu Didar Harahap , Herpan Syafii Herpan Syafii Harahap Heru Cahyono Hilam, Muhammad Humam, Anang Muh. Naufal Ilsa Hunaifi, Ilsa Indrayana, Yanna Ismaya, Ferium Trah Krisna , I Gusti Lanang Landapa, Raditya Rachman Linggabudi, I Gusti Bagus Widiamtara Maharani, Amelia Wahyu Mawaddah, Alfia Muttaqin, Syihabul Novsyaini, Zhayyin Palna Rial Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Putri, Setyawati Asih Putri, Siti Noururrifqiyati Juna Putu Aditya Wiguna R. Siti Zuhro Rahma, Elrica Nadia Riantiani, Baiq Prita Rivarti, Arina Windri Sanjaya, I Kadek Ari Sari AZ, Winna Kurnia Sari, Putri Minas Sari.AZ, Winna Kurnia Shafa C, Cloresta Sri Budhi Rianawati, Sri Budhi Sri Mulyati Syifa, R.R Ditya Mutiara Wardi, Baiq Prita Riantiani Wulandari, Rizka Yusuf Maulana, Yusuf Zubaidi, Fitriannisa Faradina