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Effect of Moringa Leaf Extract in Inhibiting Lung Fibrosis in Wistar Rats with Diabetic Model Zaenab, Zahrina Isnandia; Suryono, Suryono; Aziz, Ayu Munawaroh
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.534

Background: Uncontrolled diabetes can lead to macrovascular and microvascular complications in various organs. Organ fibrosis is one of the microvascular complications due to diabetes. Hyperglycemia triggers ROS formation thereby causing oxidative stress. Oxidative stress enhances pro-inflammatory and pro-fibrotic activities. The lungs have a lot of vascularization and connective tissue, making them susceptible to diabetes complications. Moringa is called 'The Miracle Tree' because it has many properties. Moringa leaves are the most studied part, for their efficacy as antioxidants. This study examines the effect of moringa leaf extract (MLE) in inhibiting lung fibrosis in diabetic Wistar rats.Methods: A total of 27 male Wistar rats were randomized into three groups, K0, K1 and P. Group K0 was given saline (ip) and saline (orally); K1 was given Streptozotocin (STZ) (ip) and saline (orally); P was given STZ (ip) and MLE (orally). MLE was administered daily at 1000 mg/Kg BW dose for four weeks. Lung fibrosis assessment was carried out using a modified Ashcroft scale.Results: Lung fibrosis assessment showed that the K1 group had the highest mean of lung fibrosis and K0 had the lowest mean of lung fibrosis. Kruskal-Wallis test showed that there was a significant difference in the data comparison between the three groups. The post-hoc test showed that there was a significant difference in the data comparison between groups. Comparison of the K0-K1 group data showed the smallest significance value and comparison of the K0-P group data showed the highest significance value. Conclusion: MLE can inhibit lung fibrosis in diabetic Wistar rats.

Pendampingan Peningkatan Kapasitas Pencegahan Tengkes Pada Kader Rumah Desa Sehat di Jatisari Jember Pilar Menara Falah; Alifiah Zalika Azharra; Ralief Yusrial Fabiyyanza; Aynani Tajriyan; Arif Dwi WIcaksono; Ilham Fahmi Hadziqi; Nizar Arkana Abiyu; Joshua Revival Suhendro; Elang Avinindra Virgiananta Al-Hasany; Muhammad Naufal Maulana; Pradipta Pawitradyaka Wardhono; Muhammad Iqbal Allun Wicaksono; Ayu Munawaroh Aziz; Yudha Nurdian
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 9 (2024): Volume 7 No 9 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i9.16718

ABSTRAK Desa Jatisari memiliki prevalensi kasus berat bayi lahir rendah dan pengetahuan pola asuh rendah yang signifikan serta penyakit penyerta penyebab tengkes yang cukup tinggi. Oleh karena itu, tim Program Penguatan Kapasitas Organisasi Kemahasiswaan Badan Eksekutif Mahasiswa Fakultas Kedokteran Universitas Jember melaksanakan pengabdian masyarakat berupa program peningkatan kapasitas kader Rumah Desa Sehat. Upaya tersebut bertujuan untuk membekali pengetahuan dan keterampilan kepada kader kesehatan dalam rangka mengeliminasi tengkes. Program terdiri dari penyuluhan tengkes dan 1000 Hari Pertama Kehidupan, bimbingan teknis Pemberian Makanan Tambahan, pelatihan Perilaku Hidup Bersih dan Sehat, dan bimtek antropometri. Hasil dari kegiatan ini adalah peningkatan pengetahuan dan keterampilan para kader kesehatan mengenai upaya pencegahan dan penanganan serta deteksi dini tengkes. Kesimpulan dari program ini adalah peningkatan kemampuan dan keterampilan kader dalam upaya eliminasi tengkes diharapkan mampu menurunkan angka tengkes di Desa Jatisari. Peningkatan pengetahuan dan keterampilan kader mengenai tengkes masih memerlukan dukungan banyak pihak agar berkelanjutan. Kata Kunci: Kader, Rumah Desa Sehat, Tengkes ABSTRACT Jatisari Village has a significant prevalence of low birth weight cases and low parenting knowledge and quite high comorbidities causing stunting. Therefore, the Student Organization Capacity Building Program Team of the Student Executive Board of the Faculty of Medicine, University of Jember carried out community service in the form of a program to increase the capacity of Healthy Village House cadres. This effort aims to provide knowledge and skills to health cadres in order to eliminate stunting. The program consists of stunting and the First 1000 Days of Life education, technical guidance on Providing Additional Food, Clean and Healthy Living Behavior training, and anthropometry technical guidance.The result of this activity is an increase in the knowledge and skills of health cadres regarding prevention and handling efforts as well as early detection of stunting. The conclusion of this program is that increasing the ability and skills of cadres in efforts to eliminate stunting is expected to be able to reduce the number of stunting in Jatisari Village. Increasing the knowledge and skills of cadres regarding stunting still requires support from many parties in order to be sustainable Keywords: Cadres, Healthy Village House, Stunting

Respon Sel Darah Putih tikus BALB/C pada Paparan Radiasi Medan Magnet Extremely Low-Frequency (ELF) Jangka Lama Kurniawan, Aditya; Sudarti, Sudarti; Helianti, Dina; Aziz, Ayu Munawaroh; Elfiah, Ulfa
Jambura Edu Biosfer Journal Vol 6, No 2 (2024): Jambura Edu Biosfer Journal
Publisher : Fakultas MIPA Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jebj.v6i2.28432

Sel darah putih merupakan sel yang sensitif terhadap infeksi dan perubahan lingkungan. Penelitian ini menyelidiki efek paparan jangka panjang terhadap medan Extremely Low-Frequency (ELF-MF) pada 50 Hz dan 100 μT terhadap komposisi leukosit mencit BALB/C, dengan fokus pada neutrofil, monosit, dan limfosit. Dua puluh empat tikus BALB/C jantan dibagi menjadi kelompok kontrol, 15 hari, dan 30 hari paparan, dengan paparan intermiten setiap hari selama 2 jam. Jumlah leukosit dianalisis menggunakan ANOVA satu arah.Hasilnya menunjukkan perubahan signifikan pada populasi leukosit. Jumlah neutrofil meningkat secara progresif setelah 30 hari, yang menunjukkan adanya potensi respons inflamasi. Tingkat monosit menunjukkan dua tahap, awalnya menurun pada hari ke-15 lalu melonjak 82,3% pada hari ke-30, yang menunjukkan aktivasi kekebalan adaptif. Sebaliknya, jumlah limfosit tetap stabil hingga hari ke-15 tetapi menurun secara signifikan sebesar 2,14% pada hari ke-30, yang berpotensi mencerminkan modulasi kekebalan yang diinduksi oleh stres.Temuan ini menyoroti radiasi ELF-MF dapat mengubah dinamika leukosit, kemungkinan dimediasi melalui jalur stres oksidatif dan respons inflamasi yang berkepanjangan. Perubahan ini menggarisbawahi pentingnya penelitian lebih lanjut tentang implikasi kesehatan jangka panjang dari paparan ELF-MF, mengingat meningkatnya prevalensi radiasi elektromagnetik di lingkungan modern.

Integrating Extremely Low Frequency Magnetic Field Studies in Science Education: “A Case Study on 500 kV Extra High Voltage Transmission Lines" Sudarti Sudarti; Sumardi Sumardi; Singgih Bektiarso; Wahyu Muldayani; Dina Helianti; Ayu Munawaroh Aziz; Aditya Kurniawan; Rio Dermawan; Tania Ardiani; Rista Setiani
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9948

Introduction: Until now, the impact of Extremely Low Frequency electromagnetic field radiation (ELF-EMF) by extra high voltage transmission lines (500 kV-EHVTL) is still debated. While WHO recommends a threshold of magnetic field exposure of 100 µT for up to 24 hours/day is declared safe for health. This study aims to examine the Integration of Extremely Low Frequency Magnetic Field Studies in Science Education: "Case Study on 500 kV-EHVTL". This study is important to support literacy in Environmental Physics and Environmental Radiation courses. The location of the study is a 500 kV EHVTL building located in Gondang Wetan District, Pasuruan Regency, East Java, Indonesia. Measurement of ELF magnetic field intensity using the EMF Tester-827 tool. The measurement position is at point 0 (directly below), and lateral distances of 50m, 100m, 150m, 200m, and 250m from the EHVTL power grid cable, as well as distances of 0m, 1m, 5m, 10m, and 15m from the EHVTL power grid tower. The intensity of ELF magnetic field exposure just below the EHVTL reached a value of 5.73 µT-10,085 µT (increased 170-234 times) compared to the natural magnetic field. While several research results prove that exposure to magnetic fields with an intensity of around 10 µT in vitro causes an increase in cell proliferation. Increased cell proliferation in the human body can have negative effects on health. Based on the research results it was concluded that an increase in the intensity of ELF magnetic field exposure up to 170-234 times can cause biological effects at the cellular level and has the potential to cause health impacts on humans. it is advisable to avoid living under the EHVTL network, and the WHO recommendation that the threshold exposure value of 100 µT is declared safe for humans exposed for up to 24 hours/day needs to be reviewed

Menopausal Status and Lung Function among Female Tobacco Factory Workers Rumman Karimah; Madha Qoyyulledy Tursina; Ida Srisurani Wiji Astuti; Ayu Munawaroh Aziz
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.5634

Tobacco factory workers face significant occupational health risks, particularly with respect to respiratory function. Female workers may be especially vulnerable to physiological factors, including hormonal status. Objective: To investigate differences in forced expiratory volume in 1 s (FEV1) between menopausal and reproductive-aged women working in tobacco factory production sectors and assess associated risk factors. Methods: This cross-sectional study involved 30 female tobacco factory workers (15 menopausal and 15 reproductive) in Jember, Indonesia. Pulmonary function was assessed via spirometry to measure FEV1. Participant characteristics, including age, work duration, and use of respiratory protective equipment, were collected. The data were analyzed via independent t tests and risk assessment calculations. Results: Menopausal women had significantly lower FEV1 values (67.33 ± 14.351%) than reproductive-age women did (79.13 ± 6.346%; p = 0.007). Overall, 60% of the participants exhibited varying degrees of airway obstruction. Compared with reproductive-aged workers, menopausal workers had a threefold greater risk (OR = 3.143) of developing lung obstruction. Notably, 76.67% of workers reported never using respiratory protective equipment. Conclusions: Menopausal status significantly affects respiratory function among female tobacco factory workers, with a combination of occupational exposure and hormonal changes potentially accelerating lung function decline. These findings emphasize the need for enhanced occupational health measures, particularly for menopausal workers in tobacco production facilities.

Effect of Moringa Leaf Extract in Inhibiting Lung Fibrosis in Wistar Rats with Diabetic Model Zahrina Isnandia Zaenab; Suryono Suryono; Ayu Munawaroh Aziz
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.534

Background: Uncontrolled diabetes can lead to macrovascular and microvascular complications in various organs. Organ fibrosis is one of the microvascular complications due to diabetes. Hyperglycemia triggers ROS formation thereby causing oxidative stress. Oxidative stress enhances pro-inflammatory and pro-fibrotic activities. The lungs have a lot of vascularization and connective tissue, making them susceptible to diabetes complications. Moringa is called 'The Miracle Tree' because it has many properties. Moringa leaves are the most studied part, for their efficacy as antioxidants. This study examines the effect of moringa leaf extract (MLE) in inhibiting lung fibrosis in diabetic Wistar rats.Methods: A total of 27 male Wistar rats were randomized into three groups, K0, K1 and P. Group K0 was given saline (ip) and saline (orally); K1 was given Streptozotocin (STZ) (ip) and saline (orally); P was given STZ (ip) and MLE (orally). MLE was administered daily at 1000 mg/Kg BW dose for four weeks. Lung fibrosis assessment was carried out using a modified Ashcroft scale.Results: Lung fibrosis assessment showed that the K1 group had the highest mean of lung fibrosis and K0 had the lowest mean of lung fibrosis. Kruskal-Wallis test showed that there was a significant difference in the data comparison between the three groups. The post-hoc test showed that there was a significant difference in the data comparison between groups. Comparison of the K0-K1 group data showed the smallest significance value and comparison of the K0-P group data showed the highest significance value. Conclusion: MLE can inhibit lung fibrosis in diabetic Wistar rats.

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