The purpose of this study was to determine the entrepreneurial spirit, self-efficacy and personal characteristics on the interest in entrepreneurship in SMA sultan Iskandar muda medan. Methods of data collection using a questionnaire. Sampling with the slovin method. The results of this study indicate that the entrepreneurial spirit has a positive and significant effect on the interest in entrepreneurship in SMA sultan Iskandar muda medan. Self-efficacy has a positive and significant effect on the interest in entrepreneurship in SMA sultan Iskandar muda medan students. Personal characteristics have a positive and significant effect on the interest in entrepreneurship in SMA sultan Iskandar muda medan students. Simultaneously entrepreneurial spirit, self-efficacy and personal characteristics have a positive and significant effect on the interest in entrepreneurship in SMA sultan Iskandar muda medan students.