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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana Journal of Marine Research Bioedukasi: Jurnal Pendidikan Biologi BIOMA : Jurnal Biologi Makassar Jurnal Akuakultur Sungai dan Danau BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains JURNAL PENDIDIKAN TAMBUSAI AL-HAYAT: Journal of Biology and Applied Biology EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Pembelajaran dan Biologi Nukleus Best Journal (Biology Education, Sains and Technology) Jurnal Biogenerasi IJOEP : International Journal of Ecophysiology Jurnal Riset Biologi dan Aplikasinya Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Biologi UMA (JIBIOMA) Bioscientist : Jurnal Ilmiah Biologi Mimbar Kampus Innovative: Journal Of Social Science Research Islamic Journal of Integrated Science Education Journal of Pharmaceutical and Sciences. BIO-CONS: Jurnal Biologi dan Konservasi Mimbar Kampus: Jurnal Pendidikan dan Agama Islam Jurnal Kedokteran Meditek Jurnal Sains dan Kesehatan Bionature
Husnarika Febriani, Husnarika
Universitas Islam Sumatera Utara
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Journal : Biopendix: Jurnal Biologi, Pendidikan dan Terapan

 1 
UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN PACAR AIR (Impatiens balsamina L.) TERHADAP GINJAL TIKUS WISTAR (Rattus novergicus L.) YANG DIINDUKSI ALOKSAN Fadillah, Nurul Maurito; Febriani, Husnarika; syukriah, Syukriah
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 11 No 1 (2024): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol11issue1page110-120

Abstract

Background: Diabetes mellitus is a serious, "chronic" condition that occurs when there is an increase in a person's blood sugar levels because the body is unable to produce enough insulin hormones/cannot effectively use the insulin produced. A lack of insulin, or the inability of cells to respond to it, causes high blood glucose levels (hyperglycemia), which causes clinical indicators of diabetes. Methods: This research is an experimental study using a completely randomized design. Twenty-four male white rats were divided into 6 groups consisting of normal controls (KN) who received no treatment, negative controls (K-) who were injected with alloxan at a dose of 150 mg/kg BW, positive controls (K+) who were injected with alloxan at a dose of 150 mg/kg BW. kg BW and glibenclamide at a dose of 0.09 mg/200 g BW, Treatment 1 (P1) was injected with alloxan at a dose of 150 mg/kg BW and ethanol extract of water henna leaves at a dose of 450 mg/KG BW, Treatment 2 (P2) was injected with alloxan with a dose of 150 mg/kg BW and ethanol extract of water henna leaves with a dose of 500 mg/KG BW, Treatment 3 (P3) was injected with alloxan at a dose of 150 mg/kg BW and ethanol extract of water henna leaves with a dose of 550 mg/KG BW. Mice blood glucose levels were measured on days 0 (after alloxan induction), 3, 7, and 14. Before the measurements, the mice were fasted for 8 hours. Results: Research shows that administration of water henna leaf extract has a significant effect in reducing urea and creatinine levels, as well as improving kidney morphology. However, it could not prevent the alloxan-induced increase in kidney weight in white mice. Conclusion: Administration of henna leaf extract (Impatiens balsamina L.) at a dose of 500 mg/kg BW had a significant effect on reducing urea and creatinine levels in white rats induced by alloxan. Administration of water henna leaf extract (Impatiens balsamina L.) at a dose of 450 mg/kg BW had a significant effect in improving kidney morphology in alloxan-induced white rats, whereas the organ index of water henna leaf extract could not prevent the increase in kidney weight in white mice induced alloxan
Effect of Giving Ethanol Extract of Palm Fruit (Arenga pinnata Merr.) on The Lipid Profile of White Rats (Rattus norvegicus L.) Induced by Carbon Tetrachloride (CCl4) Rambe, Rendi Ardiansyah; Febriani, Husnarika; Syukriah, Syukriah
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 1 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue1page1-6

Abstract

Carbon tetrachloride (CCl4) is a chemical substance in the form of a clear liquid, volatile and toxic with a sweet odor. Palm fruit (Arenga pinnata Merr.) is a plant that has high antioxidants and is able to reduce the effects of free radicals in the body. The purpose of this study was to evaluate the impact of ethanol administration of palm fruit (Arenga pinnata Merr.) on total cholesterol, triglyceride, HDL and LDL levels of white rats (Rattus norvegicus L.) which were induced by carbon tetrachloride (CCl4). This study used a completely randomized design with 20 mice divided into 5 treatments and 4 replications. Negative controls were given food and drink, positive controls were given carbon tetrachloride 1 mL/kg BW + olive oil ratio 1:3, Treatments 1,2, and 3 were given carbon tetrachloride 1 mL/kg BW + olive oil with a ratio 1:3 + palm fruit ethanol extract in graded doses (P1=90, P2=180, and P3=360 mg/kg BW) for 15 days. Data analysis used one way ANOVA and continued with the Duncan test. The results showed that 1 mL/kg BW of carbon tetrachloride could damage the lipid profile of white rats. Giving ethanol extract of palm fruit (Arenga pinnata Merr.) to P1 and P2 at a dose of 90 mg/kg BW and 180 mg/kg BW had no significant effect. Meanwhile, P3 with a dose of 360 mg/kg BW had a significant effect on reducing total cholesterol, triglyceride and LDL levels and could significantly increase HDL levels at a significant level (p<0.05).
Co-Authors Aisyah Hutasuhut, Melfa Aldyan, M Ardhi Amira, Siti Andrian, Luthfiyah Aprilianti, Intan Ariani, Liza Astuti, Mega Yulli Awaliah Sifa, Nurharija Ayunda, Sapna Azhari, Mhd Bayu Butar-Butar, Tri Novitashari Cutami, Ledia Fristia Damanik, Novita Fadillah, Nurul Maurito Gita Anggraini, Gita Harahap, Maisaroh Harahap, Nurbaiti Hasibuan, Turlan Rumaito Hutasuhut, Melfa Aisyah JS, Nurri Yusriyyah Khairuddin - Khairuna Khairuna Leni Widiarti, Leni Lestari, Sri Murni Ayu Lingga, Atika Mashitah, Ulfa Matondang, Indah Dinamayanti Mayasari, Ulfayani Muhammad Andry Nabila, Jihan Nasution, Nur Ainun Nasution, Putri Aminah Ningrum, Nurlian Augustin Nur Faizah, Ulinnuha Nurcahyani, Nadya Nurjannah, Suci Nurjannah Pakpahan, Sonia Faras Parinduri, Ayu Nurhabibah Pima Sari Tambunan, Efrida Puspita Sari Putri, Nesya Destika Rahmadani, Nurul Rahmadina, Rahmadina Rambe, Rendi Ardiansyah Rasyidah Rasyidah Riskiyah, Ainur Rohani Rohani Sahputra, Bagus Sajaratud Dur, Sajaratud Sari, Nada Aprilia Septiandi, Rigi Simamora, Indah Anda Rini Solin, Raslina Surbakti, Nur Anisah Br Syahfitri, Fazira Rahma Syahpitri, Juliana Syahputra, Akbar Syukriah Syukriah Syukriah, Syukriah Tambunan, Efrida Pima Tambunan, Efrida Pima Sari Triyudha, Garibaldi Ulfa, Syarifah Widya Zahratul Idami