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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN E-Jurnal Medika Udayana Journal of Marine Research Bioedukasi: Jurnal Pendidikan Biologi BIOMA : Jurnal Biologi Makassar Jurnal Akuakultur Sungai dan Danau BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains JURNAL PENDIDIKAN TAMBUSAI AL-HAYAT: Journal of Biology and Applied Biology EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Pembelajaran dan Biologi Nukleus Best Journal (Biology Education, Sains and Technology) Jurnal Biogenerasi IJOEP : International Journal of Ecophysiology Jurnal Riset Biologi dan Aplikasinya Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Biologi UMA (JIBIOMA) Bioscientist : Jurnal Ilmiah Biologi Mimbar Kampus Innovative: Journal Of Social Science Research Islamic Journal of Integrated Science Education Journal of Pharmaceutical and Sciences. BIO-CONS: Jurnal Biologi dan Konservasi Mimbar Kampus: Jurnal Pendidikan dan Agama Islam Jurnal Kedokteran Meditek Jurnal Sains dan Kesehatan Bionature
Husnarika Febriani, Husnarika
Universitas Islam Sumatera Utara
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Journal : Jurnal Ilmiah Biologi UMA (JIBIOMA)

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Efektivitas Ekstrak Etanol Daun Karanda (Carissa carandas L.) Terhadap Histopatologi Hepar Tikus Putih (Rattus norvegicus) Diabetes Melitus Parinduri, Ayu Nurhabibah; Febriani, Husnarika; Syukriah, Syukriah
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 6, No 1 (2024): Mei
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v6i1.4010

Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by impaired insulin secretion in the target organs, especially hepar. Diabetes mellitus can be treated by giving traditional medicine extract of ethanol karanda leaves (Carissa carandas). The purpose of the study was to find out the effectiveness of karanda leaf ethanol extract on the morphology and histopathology of hepar white mouse diabetes mellitus. The study used a Complete Random Design (RAL) with 6 treatments and 4 repeats. The treatment consists of normal control (feed and drink), negative control (120mg/kgBB), positive control (120mg/kgBB+glibenklamid 0.45mg/kgBB, and treatment of karanda leaf ethanol extract at graded doses of 500mg/kgBB, 750mg/kgBB, and 1000mg/kgBB. The manufacture of hepar histology uses the paraffin method with hematoxylin-eosin (HE) staining. The data was analyzed using the ANOVA test at a 5% confidence level. The results showed significant differences (p0.05) in normal cells, parenkimatous degeneration, hydropic degeneration, and necrosis and had an effect on improving the diameter of the centralist vein. Administration of ethanol extract of karanda leaves dose of 750mg / kgBB has the potential as a hepatoprotector in white rats with diabetes mellitus. Further testing is needed regarding the optimum limit of the dose of karanda leaf ethanol extract (Carissa carandas) and the toxicity test of karanda leaves.
Pengaruh Ekstrak Daun Kenikir (Cosmos caudatus Kunth.) pada Histopatologi Hepar Tikus Putih (Rattus norvegicus L.) Induksi Aspirin Ayunda, Sapna; Febriani, Husnarika; Syukriah, Syukriah
Jurnal Ilmiah Biologi UMA (JIBIOMA) Vol 6, No 2 (2024): November
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/jibioma.v6i2.5185

Abstract

Aspirin is one of the most commonly used nonsteroidal anti-inflammatory drugs (NSAIDs); however, long-term use and high doses can damage liver function and structure. To reduce aspirin’s side effects, kenikir leaves (Cosmos caudatus K.) are used as an alternative treatment. This study aims to evaluate the effects of kenikir leaf extract on liver damage caused by aspirin, both morphologically and histopathologically. A total of 25 male white rats were divided into 5 groups: KN (control), KP (aspirin 200 mg/kg BW for 10 days), P1 (aspirin + kenikir extract 700 mg/kg BW for 14 days), P2 (aspirin + kenikir extract 800 mg/kg BW for 14 days), and P3 (aspirin + kenikir extract 900 mg/kg BW for 14 days). Liver cell damage was analyzed using scoring and histomorphometry methods, followed by one-way ANOVA and Duncan’s test. The results showed that kenikir leaf extract significantly improved the morphology and histopathology of rat livers induced by aspirin, including parenchymal degeneration, hydropic degeneration, and necrosis. The most effective dose was 800 mg/kg BW, which also improved the diameter of the central vein and the width of the liver sinusoids.
Co-Authors Aisyah Hutasuhut, Melfa Aldyan, M Ardhi Amira, Siti Andrian, Luthfiyah Aprilianti, Intan Ariani, Liza Astuti, Mega Yulli Awaliah Sifa, Nurharija Ayunda, Sapna Azhari, Mhd Bayu Butar-Butar, Tri Novitashari Cutami, Ledia Fristia Damanik, Novita Fadillah, Nurul Maurito Gita Anggraini, Gita Harahap, Maisaroh Harahap, Nurbaiti Hasibuan, Turlan Rumaito Hutasuhut, Melfa Aisyah JS, Nurri Yusriyyah Khairuddin - Khairuna Khairuna Leni Widiarti, Leni Lestari, Sri Murni Ayu Lingga, Atika Mashitah, Ulfa Matondang, Indah Dinamayanti Mayasari, Ulfayani Muhammad Andry Nabila, Jihan Nasution, Nur Ainun Nasution, Putri Aminah Ningrum, Nurlian Augustin Nur Faizah, Ulinnuha Nurcahyani, Nadya Nurjannah, Suci Nurjannah Pakpahan, Sonia Faras Parinduri, Ayu Nurhabibah Pima Sari Tambunan, Efrida Puspita Sari Putri, Nesya Destika Rahmadani, Nurul Rahmadina, Rahmadina Rambe, Rendi Ardiansyah Rasyidah Rasyidah Riskiyah, Ainur Rohani Rohani Sahputra, Bagus Sajaratud Dur, Sajaratud Sari, Nada Aprilia Septiandi, Rigi Simamora, Indah Anda Rini Solin, Raslina Surbakti, Nur Anisah Br Syahfitri, Fazira Rahma Syahpitri, Juliana Syahputra, Akbar Syukriah Syukriah Syukriah, Syukriah Tambunan, Efrida Pima Tambunan, Efrida Pima Sari Triyudha, Garibaldi Ulfa, Syarifah Widya Zahratul Idami