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All Journal ACTA VETERINARIA INDONESIANA ARSHI Veterinary Letters Vitek : Bidang Kedokteran Hewan Veterinary Biomedical and Clinical Journal Jurnal Veteriner dan Biomedis Current Biomedicine Genbinesia Journal of Biology
Amaq Fadholly
Division Of Pharmacology And Toxicology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : ACTA VETERINARIA INDONESIANA

 1 
Effectivity and Safety of Endo-1,4 -xylanase (Xylanase), Endo-1,3(4) beta-glucanase (Beta-glucanase), Endo-1,4 beta-glucanase (Cellulase), and α Amylase as A Growth Promoter in Broiler Chickens Fadholly, Amaq; Aurellia, Sharon
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.37-43

Abstract

This study evaluates the effectivity and safety of Endo-1,4 -xylanase (Xylanase), Endo-1,3(4) beta-glucanase (Beta-glucanase), Endo-1,4 beta-glucanase (Cellulase), and α Amylase that packed in Ronozyme-AX ct (MGHSPHYT+) as an alternative to antibiotic growth promoter. A total of 64 chickens were used, divided into four groups, with each group divided into two replicates, 8 chickens per replicate. The groups were divided into treatment group, and groups administered with the different dosage of supplementation, namely 184, 230, and 276 gram/ton feed for 28 days, consecutively. Parameters such as weekly weight gain, final weight, feed conversion ratio (FCR), and carcass weight were observed to determine growth performance. Meanwhile, parameters such as mortality, blood hematology and biochemistry were observed to determine the safety of the supplementation. Based on the results, there was a significant difference on weekly weight gain, particularly in the second week, and in the final weight, with the group administered with 184 gram/ton feed showing the highest result. Meanwhile, other parameters such as FCR and carcass weight did not show any significant difference. This may be due to the enzymes not working directly to increase feed utilization but work with improving nutrient digestibility and utilization in the body. The safety parameters showed that the supplementation was relatively safe as no significant difference was observed in mortality, blood constituents and biochemistry.
The Effect of Endo-1,4-β-xylanase as a Feed Additive on the Growth and Overall Health of Broiler Chickens Fadholly, Amaq; Aurellia, Sharon
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.16-21

Abstract

Enzyme has been used widely as a feed additive to complement poultry needs of nutrition. Endo-1,4 beta-xylanase as its main component, which is effective in digesting non-starch polysaccharides (NSPs), hence improving the digestive system. This research aims to observe the efficacy of Endo-1,4-β-xylanase as a growth promotor and its safety. A total of 96 chickens were used in this research, divided into four groups. Administration depending on each group was conducted for 28 days, consecutively. Growth parameters that were observed includes body weight gain and feed conversion ratio, meanwhile for safety assessment, the parameters used were mortality rate, and blood profile. Based on the results, the enzyme was proven to enhance growth performance through the increased body weight gain and final weight. This is due to the enzyme’s mechanism which improves nutrient utilization. Based on the safety assessment, Endo-1,4-β-xylanase was also proven to be safe, not causing any inflammation responses in the body nor organ damage based on the blood assessment.
Uji Toksisitas Akut Ekstrak Daun Ketepeng Cina (Cassia alata) pada Tikus (Rattus norvegicus) Ramadhan, Maharani Kartika; Fadholly, Amaq
Acta VETERINARIA Indonesiana Vol. 13 No. 2 (2025): Juli 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.2.%p

Abstract

The leaves of Cassia alata exhibit potential properties as antioxidants, immunostimulants, antimicrobials, anti-dengue agents, and laxatives. This study aimed to determine the LD50 value of the administration of Cassia alata leaves extract using the Thompson-Weil method. A total of 25 rats (Rattus norvegicus) were utilized in the study, divided into five dose groups. One group served as the control (P0), receiving only distilled water, while the four treatment groups were administered doses of 500 (P1), 1000 (P2), 1500 (P3), and 2000 (P4) mg/kg BW. Toxic symptoms and changes in body weight were observed for 14 days. The results showed that there was one death at a dose of 1500 mg/kg BW and two deaths at a dose of 2000 mg/kg BW. The administration of Cassia alata leaf extract resulted in toxic symptoms, including reduced motor activity, respiratory difficulties, and weight loss. The LD50 value obtained was 1.9 g/kg BW. The extract of Cassia alata leaves exhibit a toxic effect on rats.
Co-Authors Adi Sofyan Ansori, Muhammad Andriyanto Andriyanto Anggraeni, Henny Endah Anisa Rahma, Anisa Aulia Andi Mustika Aurellia, Sharon Calista, Pradnya Dhea Kharisma, Viol Diah Nugrahani Pristihadi Dings, Tim Godefridus Antonius Dwi Budiono Fedik Abdul Rantam Firdaus, Munira Laeli Hanum, Nur Aisah Heryudianto Vibowo Iryanto, Anetonia Felicia Istiqmal, Kahfi Aulia Kurniasih Lina Noviyanti Sutardi Nugraha, Ivan Taufiq Purohita, Adwisto Saktika Putri, Imelya Andira Putri, Ramadita Aisyah Rahadian Zainul Rahmat, Kukuh Amru Dhiya Ramadhan, Maharani Kartika Rasyadan Taufiq Probojati Sajidah, Halilah Wafa’ Saragih, Mariah Mada Rahma Nauli Srihadi Agungpriyono Tacharina, Martia Rani Tekad Urip Pambudi Sujarnoko Tri Untari Turista, Dora Dayu Rahma Ullah, Md. Emdad Zonathan, Hendri