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All Journal VALENSI Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Kesehatan Bakti Tunas Husada JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA
Tita Nofianti, Tita
STIKes Bakti Tunas Husada Tasikmalaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Nursing Public Health Other

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Studi Ketercapaian Tujuan Terapi pada Pasien Hipertensi Geriatri dan Perbandingan Beberapa Obat Antihipertensi Sukmawan, Yedy Purwandi; Jahara, Syabila Arnika; Nofianti, Tita
Indonesian Journal of Clinical Pharmacy Vol 12, No 2 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.2.98

Abstract

Prevalensi penderita hipertensi kelompok geriatri di Indonesia mencapai 22,3% pada tahun 2018. Ketercapaian tujuan penurunan tekanan darah merupakan faktor utama dalam pencegahan kejadian penyakit kardiovaskular. Tujuan penelitian ini untuk mengetahui studi profil ketercapaian tujuan terapi dan perbandingan obat pada pasien geriatri dengan hipertensi. Penelitian ini merupakan studi observasional-longitudinal dengan pengambilan data secara retrospektif melalui rekam medis pasien rawat jalan pada 1 Januari 2021–30 Juni 2022. Kriteria inklusi meliputi pasien geriatri (≥60 tahun) yang didiagnosis hipertensi dan tersedia data tekanan darah pada hari ke-1 dan hari ke-30 sampai ke-40, kriteria eksklusi meliputi perubahan dosis atau jenis obat antihipertensi pada pasien. Data dianalisis menggunakan metode relative risk (RR, CI 95%). Penelitian ini melibatkan sebanyak 103 pasien, di mana jenis kelamin perempuan (53,43%), usia 60–74 tahun (87,38%) dan hipertensi tahap 1 (70,88%) mendominasi. Nilai ketercapaian tujuan terapi (<130/90 mmHg) mencapai 62,14%. Obat-obatan yang digunakan meliputi amlodipin, ramipril, kandesartan, valsartan, dan furosemid. Hasil perbandingan pengobatan monoterapi (ACE-I, ARB, CCB) tidak berbeda bermakna (p>0,05) dalam penurunan pencapaian tujuan terapi, begitupula dengan perbandingan obat kombinasi (CCB+ARB, ACE-I + loop diuretics, CCB+ACE-I). Meskipun demikian, CCB (amlodipin) atau CCB+ACE-I (amlodipin+ramipril) menunjukkan ketercapaian tujuan terapi lebih tinggi mencapai 76,90% dan 83,30%, secara berturut-turut. Selain itu, monoterapi CCB, dan kombinasi CCB+ACE-I mampu menurunakan risiko ketidaktercapaian tujuan terapi sebesar 53,85% (RR 0,4615; 95% CI: 0,1383-1,5406), dan 70.83% (RR 0,2917; 95% CI: 0,0436-1,9516). Kombinasi Penggunaan CCB (amlodipin) sebagai monoterapi dan CCB+ACE-I (amlodipin+ramipril) sebagai kombinasi direkomendasikan pada pasien geriatri dengan hipertensi.
Peningkatan Pengetahuan Masyarakat Lansia dalam Pencegahan dan Penanganan Osteoarthritis di Desa Cisayong Rahayuningsih, Nur; Nofianti, Tita; Sarah, Myra; Ngguwa Ari, Stephania Caecar; Pratidina, Reza; Talistra, Muhammad Royhan; Maharani, Teti; Prisnawati, Epi; Putri, Sherly Gautama
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 5 (2025): Volume 8 No 5 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i5.17990

Abstract

ABSTRAK Osteoarthritis atau radang pada sendi merupakan suatu penyakit degeneratif atau penyakit yang timbul dengan seiring bertambahnya usia terutama pada lansia. Dengan bertambahnya usia, risiko terjadinya osteoarthritis semakin meningkat yang dapat mempengaruhi kualitas hidup seseorang. Osteoarthritis terjadi karena rusaknya jaringan tulang rawan sendi yang dapat menyerang sendi lutut, jari-jari kaki dan tangan, tulang punggung serta panggu. Oleh karena itu, edukasi terkait pencegahan dan penanganan terhadap kejadian osteoarthritis sangat penting untuk meningkatkan pemahaman mengenai osteoarthritis agar memperlambat progresivitasnya. Tujuan dari promosi Kesehatan ini adalah untuk meningkatkan pemahaman terhadap penanganan dan pencegahan osteoarthritis. Metode yang dilakukan pada promosi Kesehatan ini adalah dengan penjelasan atau ceramah dengan bantuan media leaflet yang dilakukan oleh pemateri kepada peserta secara langsung dan dilanjutkan dengan sesi tanya jawab. Berdasarkan hasil dari analisis terhadap pre-test dan post-test terdapat peningkatan pemahaman peserta terkait pencegahan dan penanganan osteoarthritis dengan perolehan pre-test sebesar 43,33% meningkat menjadi 50%. Dari hasil kegiatan promosi Kesehatan ini metode ceramah dengan bantuan media leaflet dan tanya jawab secara langsung dapat meningkatkan pemahaman peserta terkait pecegahan dan penanganan osteoarthritis yang dibuktikan dengan peningkatan pada nilai post-test. Kata Kunci: Osteoarthritis, Promosi Kesehatan, Lansia  ABSTRACT Osteoarthritis or joint inflammation is a degenerative disease or a disease that arises with aging, especially in the elderly. As people age, the risk of developing osteoarthritis increases, which can affect a person's quality of life. Osteoarthritis occurs due to the damage of joint cartilage tissue that can affect the knee joints, toes and fingers, spine, and pelvis. Therefore, education related to the prevention and management of osteoarthritis incidents is very important to enhance understanding of osteoarthritis in order to slow its progression. The goal of this health promotion is to enhance understanding of the management and prevention of osteoarthritis. The method used in this health promotion was an explanation or lecture with the aid of leaflets, conducted by the speaker to the participants directly, followed by a question-and-answer session. Based on the analysis results of the pre-test and post-test, there was an increase in participants' understanding of the prevention and management of osteoarthritis, with the pre-test score of 43.33% increasing to 50%. From the results of this health promotion activity, the lecture method with the aid of leaflets and direct question-and-answer sessions can enhance participants' understanding of the prevention and management of osteoarthritis, as evidenced by the increase in post-test scores. Keywords: Osteoarthritis, Health Promotion, Elderly
Siapkan Masa Depan Sehat: Cegah Penyakit Degeneratif Sejak Dini Salasanti, Citra Dewi; Rahmawati, Rahmawati; Nofianti, Tita
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 5 (2025): Volume 8 No 5 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i5.19941

Abstract

ABSTRAK Penyakit degeneratif menjadi tantangan kesehatan yang semakin meningkat di Indonesia akibat perubahan gaya hidup yang tidak sehat. Pencegahan sejak usia remaja merupakan langkah strategis untuk mengurangi risiko penyakit tidak menular, seperti diabetes, hipertensi, dan penyakit kardiovaskular. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran dan pemahaman siswa mengenai pencegahan penyakit degeneratif melalui edukasi kesehatan di lingkungan sekolah. Sebanyak 77 siswa kelas XII SMA Negeri 1 Jatiwaras, Kabupaten Tasikmalaya, berpartisipasi dalam kegiatan ini. Penyuluhan interaktif dilakukan menggunakan media leaflet dan video edukatif yang dirancang agar mudah dipahami dan menarik bagi remaja. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur peningkatan pemahaman peserta. Hasil evaluasi menunjukkan peningkatan skor rata-rata dari 3,89 menjadi 5,04, dengan uji Wilcoxon yang menghasilkan nilai signifikansi 0,000 (p < 0,05). Hasil ini menunjukkan adanya peningkatan pemahaman yang signifikan setelah penyuluhan. Penyuluhan berbasis media edukatif terbukti efektif dalam meningkatkan kesadaran siswa mengenai pencegahan penyakit degeneratif. Edukasi kesehatan sejak dini memiliki peran penting dalam membentuk pola hidup sehat di kalangan remaja, sehingga perlu terus dikembangkan di lingkungan sekolah guna menciptakan generasi yang lebih sehat dan produktif di masa depan. Kata Kunci: Degeneratif, Pencegahan, Remaja  ABSTRACT Degenerative diseases have become an increasing health challenge in Indonesia due to unhealthy lifestyle changes. Prevention during adolescence is a strategic step in reducing the risk of non-communicable diseases such as diabetes, hypertension, and cardiovascular diseases. This community service activity aimed to increase students' awareness and understanding of degenerative disease prevention through health education in the school environment. A total of 77 twelfth-grade students from SMA Negeri 1 Jatiwaras, Kabupaten Tasikmalaya, participated in this program. The interactive counseling was conducted using leaflets and educational videos designed to be easily understood and engaging for teenagers. Evaluation was carried out using pre-test and post-test assessments to measure students' knowledge improvement. The evaluation showed an increase in the average score from 3.89 to 5.04, with the Wilcoxon test yielding a significance value of 0.000 (p < 0.05), indicating a significant improvement in students' understanding after the intervention. Conclusion: Educational media-based counseling proved to be effective in enhancing students' awareness of degenerative disease prevention. Early health education plays a crucial role in shaping a healthy lifestyle among adolescents. Therefore, continuous development of health education programs in schools is essential to create a healthier and more productive generation in the future. Keywords : Degeneratif, Prevention, Adolescents
Radiolabeling and In-Silico Study of 131I-(4-fluorobenzoyl-3-methylthiourea) as Radiopharmaceuticals for Breast Cancer Theranostics Pratama, Febby; Ruswanto, Ruswanto; Nofianti, Tita; Pratita, Anindita Tri Kusuma; Daruwati, Isti; Susilo, Veronika Yulianti; Holik, Holis Abdul
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.34258

Abstract

The chemicals produced from thiourea are actively being studied as anticancer possibilities. In complexes with radionuclides like Iodine-131, the 1-(4-Fluorobenzoyl)-3-methyl thiourea is a promising ligand for theragnostic applications. This study aimed to label 1-(4-fluorobenzoyl-3-methylthiourea) with iodine-131 and observe its interaction with breast cancer receptors. The radiolabeling of 131I-(4-fluorobenzoyl-3-methylthiourea) uses the radioiodination method with Chloramine-T, and an in-silico investigation of breast cancer receptors was conducted. According to the results of molecular docking using AutoDockTools, this radiopharmaceutical molecule has the best activity on the HER2 receptor (PDB ID: 3PP0) compared to the native ligand and control positive, with a binding affinity of -6.13 kcal/mol and a Ki value of 32.05 mM. According to the molecular dynamics data using Desmond, the radiopharmaceutical molecule 131I-(4-Fluorobenzoyl-3-methylthiourea) displays good stability starting from the 50ns range. The indirect radioiodination method has successfully labeled 1-(4-Fluorobenzoyl-3-methylthiourea) with iodine-131.
The relationship between family support and compliance of chronic kidney failure patients in undergoing hemodialysis therapy at Ciamis District Hospital Lidiasari, Alda; Rahayuningsih, Nur; Nofianti, Tita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1659

Abstract

Chronic kidney disease (CKD) is a persistent and permanent decline in kidney function, disrupting metabolism and fluid and electrolyte balance, resulting in an increase in ureum levels. This study aims to analyze the relationship between family support and compliance of CKD patients in undergoing hemodialysis therapy at Ciamis Hospital. This study is descriptive quantitative using a cross sectional approach with accidental sampling technique in January-March 2025, involving 40 inpatient respondents. Data were collected through the Familly Suppot Scale (FSS) questionnaire to measure family support variables and the Morisky Medication 8-item Adherence Scale (MMAS-8) to see hemodialysis therapy compliance. Data testing was conducted with validity, reliability, and R-Square analysis and T-test using Partial Least Squares (PLS) model. The results showed that all instruments were valid and reliable, with AVE Validity > 0.5, Cronbach Alpha and Composite Reliability > 0.7. R-Square analysis, a combination of five family support variables obtained 88.1% of patients had a high level of compliance in following hemodialysis. The T-test results show that there is a significant relationship between instrumental support, informational support, emotional support, appreciation support and self-esteem support with hemodialysis therapy adherence in CKD patients. This is the role of the family is very important in supporting the patient's adherence to hemodialysis therapy.
Co-Authors Citra Dewi Salasanti Darajatun, Laila Awaliyah Devi Windiarti, Devi FAJAR SETIAWAN Fathurohman, Mochamad Fitria Intan Sari, Fitria Intan Gatut Ari Wardani Holis Abdul Holik, Holis Abdul Ilham Alifiar, Ilham Ira Rahmiyani Isti Daruwati Jahara, Syabila Arnika Lidiasari, Alda Lilis Tuslinah, Lilis Lusi Nurdianti, Lusi Maharani, Teti Ngguwa Ari, Stephania Caecar Nur Laili D H, Nur Laili Nur Rahayuningsih, Nur Nurmalik, Dudi Pratama, Febby Pratidina, Reza Pratita, Anindita Tri Kusuma Prisnawati, Epi Putri, Sherly Gautama Rahmawati, Rahmawati Richa Mardianingrum Ruswanto, Ruswanto Sarah, Myra Talistra, Muhammad Royhan Tresna Lestari, Tresna Vera Nurviana Veronika Yulianti Susilo Yedy Purwandi Sukmawan Yulius Prasetyo, Yulius