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All Journal HAYATI Journal of Biosciences Bioscience Vektora : Jurnal Vektor dan Reservoir Penyakit Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Tropical and Infectious Disease BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati YARSI Medical Journal Jurnal Pembelajaran dan Biologi Nukleus Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Gunung Djati Conference Series SERVIRISMA: Jurnal Pengabdian kepada Masyarakat Jurnal MedScientiae Jurnal MedScientiae Jurnal Kedokteran Meditek
Susilowati, Rina Priastini
Universitas Kristen Krida Wacana
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Efficacy of Shampoo Made from Bangle Rhizome Extract (Zingiber montanum) Against Head Lice (Pediculus humanus capitis) Susilowati, Rina Priastini; Sari, Monica Puspa; Santoso, Adit Widodo
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.54832

Abstract

Head lice is a major public health problem worldwide. Its treatment is challenging due to product failures resulting from rapidly emerging resistance to existing treatments, incorrect treatment application, and misdiagnosis. Various head lice treatments with different mechanisms of action have been developed and explored over the years, with limited reports on systematic assessments of their efficacy and safety. The head lice shampoo currently in circulation is 1% permethrin-based. Side effects of using permethrin-based shampoos include skin irritation and high resistance. The research conducted aims to present strong evidence that the use of shampoo made from bangle rhizome extract against head lice mortality is safer to use. The study used 240 head lice taken from elementary school students aged 8-12 years in a school in Bekasi. The study group was divided into 6 groups: negative control group (using baby shampoo), positive control group (using permethrin-based anti-lice shampoo), shampoo treatment group made from bangle rhizome extract with dose of 0.5%, 1%, 2% and 4%. In addition to calculating the number of head lice deaths per group, the time of death was also calculated to determine LC50 (Lethal Concentration 50), LC90 (Lethal Concentration 90), LT50 (Lethal Time 50), and LT90 (Lethal Time 90). The results showed a highly significant difference between the number of head lice deaths in the control group and the shampoo treatment group made from bangle rhizome extract (p<0.01). Likewise, there was a highly significant difference for the time of death of head lice in the control group and the shampoo treatment group made from bangle rhizome extract. Statistical analysis showed LC50 of 0.96%, LC90 of 2.84%, LT50 of 57.72 minutes, and LT90 of 28.79 minutes. It can be concluded that the effective dose of shampoo made from bangle rhizome extract is 4%, which can kill 100% of head lice within 27 minutes.
Case overview of children’s thalassemia at RSAB Harapan Kita Jakarta Susilowati, Rina Priastini; Pratanu, Lydia; Putri, Dyah Ayu Adella
Biogenesis: Jurnal Ilmiah Biologi Vol 12 No 1 (2024)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v12i1.41218

Abstract

Thalassemia is a hereditary blood disorder characterized by reduced alpha or beta globin chain synthesis, independent of sex or age. While thalassemia minor often presents with mild or no symptoms, thalassemia major manifests with severe anemia, pallor, fatigue, decreased appetite, and recurrent infections from birth. The aim of this research is to describe the description of cases of thalassemia children at RSAB Harapan Kita. This research is a descriptive study with a cross-sectional design regarding the description of cases of thalassemia children. Study participants were pediatric patients diagnosed with thalassemia at the hospital. Inclusion criteria encompassed individuals younger than 19 years with a documented history of comorbidities. Exclusion criteria included patients with incomplete or damaged medical records and those aged 19 years or older. Medical record data that met the inclusion criteria was 48 subjects with a minimum sample size of 41 subjects. The data used in this research was processed with SPSS ver. 25 and presented in table form. The results showed that the highest proportion of thalassemia children was in the age group 6-11 years (41.7%), male sex (56.3%), the main complaint was pallor (87.5%), type of β thalassemia (83, 3%), pre-transfusion Hb level <9 g/dL (79.2%), and without other comorbidities (64.6%).
Hubungan Kebiasaan Mengonsumsi Kopi Susu dan Kopi Hitam dengan Tekanan Darah Dewajanti, Anna Maria; Pratiwi, Indah; Susilowati, Rina Priastini; Rumiati, Flora
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2879

Abstract

The habit of people who consume coffee will have an impact on increasing blood pressure, where if you drink 4 or more cups of coffee in one day, the systolic pressure will increase by approximately 10 mmHg and around 8 mmHg in diastolic blood pressure. The purpose of this study was to see the relationship between the habit of consuming milk coffee and black coffee with blood pressure in students of the Faculty of Medicine at Krida Wacana Christian University. This research used a cross-sectional approach with a population of 2020 Ukrida Faculty of Medicine students. The sample in this study was 102 people with a simple random sampling technique. It was found that the average 2020 Ukrida Faculty of Medicine student consumed coffee 1-2 times a day at a rate of 1-2 cups per day, but there were also some who consumed 3-4 cups of coffee a day. Data analysis used the Person Chi-Square and obtained the p-value for milk coffee: 0.126 and the p-value for black coffee: 0.656. So this shows that both milk coffee and black coffee have no significant relationship with an increase in blood pressure.
analisis respon imunitas terhadap infeksi sars-cov-2 pada manusia Nainggolan, Edward Anderson; Tamba, Ernawaty; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2998

Abstract

Understanding the immune response to COVID-19 is critical to help develop appropriate management. Understand the description and response of the immune system that is formed in humans through COVID-19 infection. Conduct a critical review of research journals on the immune response to SARS-CoV-19. Search for articles in research journal databases using the keywords COVID-19, SARS-CoV-2, and Immunity. COVID-19 patients have increased serum cytokine levels (TNFα, IL-2, IL-6, IL-10, IFNγ) compared with healthy patients. IL-6, IL-10, and CRP increased significantly with disease severity. The number of T cells decreases in COVID-19 patients, especially those who are more severe. There were no significant differences in antibody titers based on gender, age, or BMI in post-vaccine individuals. Smokers had significantly lower antibody titers after the second dose of vaccination. COVID-19 patients experience a decrease in the number of lymphocytes and an increase in CRP and cytokines such as TNFα, IL-2, IL-6, IL-10, and IFNγ, especially in severe cases. A positive correlation exists between CRP and IL-10. The number of T cells such as CD4+T and CD8+T also decreases in COVID-19 patients, especially those who are more severe. This could be a diagnostic and prognostic marker for COVID-19.
Ginger Rhizome Extract (Zingiber officinale) as an Alternative Bioinsecticide Against The Mortality of German Cockroach (Blattella germanica): Indonesia Susanto, Inneke Kusumawati; Susilowati, Rina Priastini; Hidajat, Joshua Jean Michael
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3053

Abstract

Cockroach is one of the types of insects that exists everywhere. Cockroach can live in a lot of places, such as the gutter, the trash, and even in the bathroom. Cockroach is one of the agents that is responsible for the spreading of diseases such as diarrhea, dysentery and cholera in children. In Indonesia, there exists a lot of different types of cockroach, one of it is the German Cockroach or Blattella germanica L., and the cockroach problem in Indonesia is mainly handled by using chemicals insecticides, this happens because there’s a lot and its commonly found in a lot of places. Pyrethroid based chemicals insecticides are one of the most common chemical insecticides used by the public. These chemical insecticides have various kinds of adverse effects because they leave residues that can be inhaled by humans and also consumed by humans through food products. Some of the effects of chemical insecticides are diseases of the liver, kidneys, and also problems with the central nervous system. Therefore, an alternative solution is needed in dealing with the cockroach problems in Indonesia, namely Bioinsecticides. Bioinsecticides are insecticides made using natural ingredients without the addition of chemical substances. Ginger is one of the spices that can be found anywhere, in ginger there are compounds called flavonoids, and these compounds can be used as bioinsecticides. Bioinsecticides are made by taking the ginger extract then putting the extract into a spray bottle according to the dose using a pasteur pipette.  
Histopathological Changes of Midgut Epithelial Cells of Aedes aegypti Larvae Exposed to Permot Leaf Extract (Passiflora foetida) Susilowati, Rina Priastini; Sari, Monica Puspa
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 8, No 1: Jurnal Pembelajaran Dan Biologi Nukleus Maret 2022
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v8i1.2465

Abstract

The Aedes aegypti mosquito is the main vector of dengue hemorrhagic fever (DHF). Various prevention efforts were carried out to reduce the population of Ae. aegypti. One way to break the chain of Ae. aegypti is to kill the development of its larvae, namely with synthetic or vegetable larvicides. Permot (Passiflora foetida) is one type of plant that can be used as a vegetable insecticide because it contains active chemical compounds such as alkaloids and flavonoids. Larvae of Ae. aegypti used was instar III with a total of 600, which was divided into 6 treatment groups (1 negative control group, 1 positive control group using 1% temephos, permot leaf extract with dose levels of 0.5%, 1%, 2% and 4% ) and 4 replicates. Data on mortality of Ae. aegypti was calculated to determine the effective dose (LC50 and LC90) using the Probit test, while histopathological changes were calculated to determine the toxicity of the permot leaf extract using the one-way Anova test. The results showed that the LC50 value was 1.85% and LC90 was 2.35%, which means that the effective dose of permot leaf extract was 2.35%. In the treatment of 4% permot leaf extract, it showed histopathological changes in the midgut epithelial cells of Ae. aegypti larvae, midgut epithelial cells became lysed, changed shape, cytoplasmic vacuolization, and separated from the basement membrane. Peritrophic membranes, microvilli and brush border were partially or totally damaged. 
Exposure to Shampoo Made from Bangle Rhizome Extract (Zingiber montanum) to Histopathological Changes in the Kidney of Mice (Mus musculus) Susilowati, Rina Priastini; Santoso, Adit Widodo; Hartono, Budiman
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i2.5554

Abstract

Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the pyrethroid active substances that is widely used as an ingredient in anti-human lice shampoo (Pediculus humanus capitis) is permethrin 1%. The poisoning effect of permethrin-based shampoo as an anti-lice shampoo has been little studied, and there is a need to find alternative active ingredients from plants as a substitute for 1% permethrin, namely bangle (Zingiber montanum). The purpose of this study was to determine the toxicity of using shampoo made from 1% permethrin and made from bangle rhizome extract with graded doses through changes in kidney histopathology. The type of research was post test only control complete randomized design using 25 male mice, which were randomly divided into 5 groups, namely negative control (baby shampoo), positive control (1% permethrin shampoo), shampoo treatment made from bangle rhizome extract with graded doses (0.5%, 1%, and 2%). The shampoo was applied topically on the head for 14 days. After the mice were sacrificed, the kidneys were processed into tissues by paraffin method and stained with HE. Renal tubular injury was examined using a 400x magnification light microscope. The results showed the average changes in kidney histopathology in mice treated with 1% permethrin shampoo and 2% bangle rhizome extract shampoo, although not significantly different (p>0.05). Histopathological changes in the kidneys of mice that were seen were fatty degeneration which caused swelling of the proximal tubules and necrosis of kidney cells
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.
SKRINING PESTISIDA, PARASIT PADA BUAH DAN SAYUR PADA IBU-IBU PKK GUJI BARU KEPA DURI, KEBUN JERUK, JAKARTA BARAT Monica Puspa Sari; Susilowati, Rina Priastini
Servirisma Vol. 3 No. 1 (2023): Servirisma : Jurnal Pengabdian kepada Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/servirisma.2023.31.30

Abstract

Fruits and vegetables are foods that are rich in nutrients such as vitamin and minerals, which are good for the body to consume to improve health. However, what should be a concern for the consumption of fruits and vegetables is the presence of contaminants such as pesticide residues and the presence of parasites in fruits and vegetables. The purpose of this community service is to provide counseling and demonstrations on how to screen vegetables and fruits from pesticides and parasites to PKK Guji Baru women with a community based research approach. A total of 49 mothers participated in this community service activity. A total of 16 (55,17%) counseling participants were aged between 41-50 years, while based on education, the average education level was high school completion as many as 20 people (40,81%) and based on occupation as many as 42 (85,71%) participants were housewife. Based on the level of knowledge of the 7 questions, the average level of knowledge of PKK mothers is 79% while the level of behavior is 68,18%. It is hoped that there will be change in the behavior of PKK mothers in processing vegetables and fruits properly so as to produce healthy food for the family.
Co-Authors Adit Widodo Santoso Alexander Anna Maria Dewajanti Beatrix Clarissa Gunarta Bryan Reyes Stephen Budiman Hartono Budiman Hartono Budiman Hartono Dwi Anggraini Ernawaty Tamba Flora Rumiati Flora Rumiati Flora Rumiati Henricho Himawan Hidajat, Joshua Jean Michael Indah Pratiwi Inggrid Osya Farfar Inneke Kusumawati Susanto Jasmine Harumi Sabini Jodie Josephine Kris Herawan Timotius Liauw Djai Yen Marcel Antoni maria caecaelia botoor Monica Puspa Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Nainggolan, Edward Anderson Nanik Siti Aminah Pratanu, Lydia Puspa Sari, Monica Putri, Dyah Ayu Adella Sabini, Jasmine Harumi Sancia Nathania Legenie Banuang Santoso, Adit Widodo Tanian, Michelle Amelia Win Darmanto Yanto Hindrawan