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All Journal HAYATI Journal of Biosciences Bioscience Vektora : Jurnal Vektor dan Reservoir Penyakit Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Tropical and Infectious Disease BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati YARSI Medical Journal Jurnal Pembelajaran dan Biologi Nukleus Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Gunung Djati Conference Series Jurnal MedScientiae Jurnal MedScientiae Jurnal Kedokteran Meditek
Susilowati, Rina Priastini
Universitas Kristen Krida Wacana
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Efficacy of Shampoo Made from Bangle Rhizome Extract (Zingiber montanum) Against Head Lice (Pediculus humanus capitis) Susilowati, Rina Priastini; Sari, Monica Puspa; Santoso, Adit Widodo
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.54832

Abstract

Head lice is a major public health problem worldwide. Its treatment is challenging due to product failures resulting from rapidly emerging resistance to existing treatments, incorrect treatment application, and misdiagnosis. Various head lice treatments with different mechanisms of action have been developed and explored over the years, with limited reports on systematic assessments of their efficacy and safety. The head lice shampoo currently in circulation is 1% permethrin-based. Side effects of using permethrin-based shampoos include skin irritation and high resistance. The research conducted aims to present strong evidence that the use of shampoo made from bangle rhizome extract against head lice mortality is safer to use. The study used 240 head lice taken from elementary school students aged 8-12 years in a school in Bekasi. The study group was divided into 6 groups: negative control group (using baby shampoo), positive control group (using permethrin-based anti-lice shampoo), shampoo treatment group made from bangle rhizome extract with dose of 0.5%, 1%, 2% and 4%. In addition to calculating the number of head lice deaths per group, the time of death was also calculated to determine LC50 (Lethal Concentration 50), LC90 (Lethal Concentration 90), LT50 (Lethal Time 50), and LT90 (Lethal Time 90). The results showed a highly significant difference between the number of head lice deaths in the control group and the shampoo treatment group made from bangle rhizome extract (p<0.01). Likewise, there was a highly significant difference for the time of death of head lice in the control group and the shampoo treatment group made from bangle rhizome extract. Statistical analysis showed LC50 of 0.96%, LC90 of 2.84%, LT50 of 57.72 minutes, and LT90 of 28.79 minutes. It can be concluded that the effective dose of shampoo made from bangle rhizome extract is 4%, which can kill 100% of head lice within 27 minutes.
Case overview of children’s thalassemia at RSAB Harapan Kita Jakarta Susilowati, Rina Priastini; Pratanu, Lydia; Putri, Dyah Ayu Adella
Biogenesis: Jurnal Ilmiah Biologi Vol 12 No 1 (2024)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v12i1.41218

Abstract

Thalassemia is a hereditary blood disorder characterized by reduced alpha or beta globin chain synthesis, independent of sex or age. While thalassemia minor often presents with mild or no symptoms, thalassemia major manifests with severe anemia, pallor, fatigue, decreased appetite, and recurrent infections from birth. The aim of this research is to describe the description of cases of thalassemia children at RSAB Harapan Kita. This research is a descriptive study with a cross-sectional design regarding the description of cases of thalassemia children. Study participants were pediatric patients diagnosed with thalassemia at the hospital. Inclusion criteria encompassed individuals younger than 19 years with a documented history of comorbidities. Exclusion criteria included patients with incomplete or damaged medical records and those aged 19 years or older. Medical record data that met the inclusion criteria was 48 subjects with a minimum sample size of 41 subjects. The data used in this research was processed with SPSS ver. 25 and presented in table form. The results showed that the highest proportion of thalassemia children was in the age group 6-11 years (41.7%), male sex (56.3%), the main complaint was pallor (87.5%), type of β thalassemia (83, 3%), pre-transfusion Hb level <9 g/dL (79.2%), and without other comorbidities (64.6%).
Hubungan Kebiasaan Mengonsumsi Kopi Susu dan Kopi Hitam dengan Tekanan Darah Dewajanti, Anna Maria; Pratiwi, Indah; Susilowati, Rina Priastini; Rumiati, Flora
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2879

Abstract

The habit of people who consume coffee will have an impact on increasing blood pressure, where if you drink 4 or more cups of coffee in one day, the systolic pressure will increase by approximately 10 mmHg and around 8 mmHg in diastolic blood pressure. The purpose of this study was to see the relationship between the habit of consuming milk coffee and black coffee with blood pressure in students of the Faculty of Medicine at Krida Wacana Christian University. This research used a cross-sectional approach with a population of 2020 Ukrida Faculty of Medicine students. The sample in this study was 102 people with a simple random sampling technique. It was found that the average 2020 Ukrida Faculty of Medicine student consumed coffee 1-2 times a day at a rate of 1-2 cups per day, but there were also some who consumed 3-4 cups of coffee a day. Data analysis used the Person Chi-Square and obtained the p-value for milk coffee: 0.126 and the p-value for black coffee: 0.656. So this shows that both milk coffee and black coffee have no significant relationship with an increase in blood pressure.
analisis respon imunitas terhadap infeksi sars-cov-2 pada manusia Nainggolan, Edward Anderson; Tamba, Ernawaty; Susilowati, Rina Priastini
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.2998

Abstract

Understanding the immune response to COVID-19 is critical to help develop appropriate management. Understand the description and response of the immune system that is formed in humans through COVID-19 infection. Conduct a critical review of research journals on the immune response to SARS-CoV-19. Search for articles in research journal databases using the keywords COVID-19, SARS-CoV-2, and Immunity. COVID-19 patients have increased serum cytokine levels (TNFα, IL-2, IL-6, IL-10, IFNγ) compared with healthy patients. IL-6, IL-10, and CRP increased significantly with disease severity. The number of T cells decreases in COVID-19 patients, especially those who are more severe. There were no significant differences in antibody titers based on gender, age, or BMI in post-vaccine individuals. Smokers had significantly lower antibody titers after the second dose of vaccination. COVID-19 patients experience a decrease in the number of lymphocytes and an increase in CRP and cytokines such as TNFα, IL-2, IL-6, IL-10, and IFNγ, especially in severe cases. A positive correlation exists between CRP and IL-10. The number of T cells such as CD4+T and CD8+T also decreases in COVID-19 patients, especially those who are more severe. This could be a diagnostic and prognostic marker for COVID-19.
Ginger Rhizome Extract (Zingiber officinale) as an Alternative Bioinsecticide Against The Mortality of German Cockroach (Blattella germanica): Indonesia Susanto, Inneke Kusumawati; Susilowati, Rina Priastini; Hidajat, Joshua Jean Michael
Jurnal MedScientiae Vol 3 No 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3053

Abstract

Cockroach is one of the types of insects that exists everywhere. Cockroach can live in a lot of places, such as the gutter, the trash, and even in the bathroom. Cockroach is one of the agents that is responsible for the spreading of diseases such as diarrhea, dysentery and cholera in children. In Indonesia, there exists a lot of different types of cockroach, one of it is the German Cockroach or Blattella germanica L., and the cockroach problem in Indonesia is mainly handled by using chemicals insecticides, this happens because there’s a lot and its commonly found in a lot of places. Pyrethroid based chemicals insecticides are one of the most common chemical insecticides used by the public. These chemical insecticides have various kinds of adverse effects because they leave residues that can be inhaled by humans and also consumed by humans through food products. Some of the effects of chemical insecticides are diseases of the liver, kidneys, and also problems with the central nervous system. Therefore, an alternative solution is needed in dealing with the cockroach problems in Indonesia, namely Bioinsecticides. Bioinsecticides are insecticides made using natural ingredients without the addition of chemical substances. Ginger is one of the spices that can be found anywhere, in ginger there are compounds called flavonoids, and these compounds can be used as bioinsecticides. Bioinsecticides are made by taking the ginger extract then putting the extract into a spray bottle according to the dose using a pasteur pipette.  
Histopathological Changes of Midgut Epithelial Cells of Aedes aegypti Larvae Exposed to Permot Leaf Extract (Passiflora foetida) Susilowati, Rina Priastini; Sari, Monica Puspa
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 8, No 1: Jurnal Pembelajaran Dan Biologi Nukleus Maret 2022
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v8i1.2465

Abstract

The Aedes aegypti mosquito is the main vector of dengue hemorrhagic fever (DHF). Various prevention efforts were carried out to reduce the population of Ae. aegypti. One way to break the chain of Ae. aegypti is to kill the development of its larvae, namely with synthetic or vegetable larvicides. Permot (Passiflora foetida) is one type of plant that can be used as a vegetable insecticide because it contains active chemical compounds such as alkaloids and flavonoids. Larvae of Ae. aegypti used was instar III with a total of 600, which was divided into 6 treatment groups (1 negative control group, 1 positive control group using 1% temephos, permot leaf extract with dose levels of 0.5%, 1%, 2% and 4% ) and 4 replicates. Data on mortality of Ae. aegypti was calculated to determine the effective dose (LC50 and LC90) using the Probit test, while histopathological changes were calculated to determine the toxicity of the permot leaf extract using the one-way Anova test. The results showed that the LC50 value was 1.85% and LC90 was 2.35%, which means that the effective dose of permot leaf extract was 2.35%. In the treatment of 4% permot leaf extract, it showed histopathological changes in the midgut epithelial cells of Ae. aegypti larvae, midgut epithelial cells became lysed, changed shape, cytoplasmic vacuolization, and separated from the basement membrane. Peritrophic membranes, microvilli and brush border were partially or totally damaged. 
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Caenorhabditis elegans sebagai Model Hewan Penelitian Biologi dan Biomedis Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3467

Abstract

Caenorhabditis elegans is a microscopic nematode, with a transparent body, short life span, self-fertilization ability. C. elegans is easy to be cultured and has been used as an animal model for molecular research, medicine, pharmacology, and toxicology. In addition, C. elegans was the first animal to have its genome completely sequenced and has played a major role in understanding apoptosis and RNA interference. The use of C. elegans as a biological model in environmental toxicology assessments has allowed for the determination of several endpoints. Some of these utilize effects on the biological functions of the nematode and others use molecular markers. Furthermore, C. elegans has enabled the assessment of neurotoxic effects for pesticides and heavy metals, since this nematode has a very well-defined nervous system. Overall, almost every known toxin has been tested in this animal model. In the near future, the knowledge available about the life cycle of C. elegans will allow for more studies on reproduction, transgenerational toxicity for newly developed chemicals and materials, and detailing the signaling pathways involved in the mechanisms of toxicity. C. elegans is an important animal model for research into the identification and understanding of the machinery of nuclear transport. This has helped elucidate biochemical pathways involved in diseases such as obesity, diabetes, and Alzheimer's disease. C. elegans is an excellent animal model for studying aging because of its short lifespan, susceptibility to oxidative stress, and similarity to the human aging process.
The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol 4 No 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Protective effect of juwet fruit extract (Syzygium cumini L.) on duodenum histomorphometry and histopathology of male mice exposed to pyrantel pamoate Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Biogenesis: Jurnal Ilmiah Biologi Vol 12 No 2 (2024)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v12i2.56552

Abstract

Pyrantel pamoate, known as an anthelmintic under the brand name Combantrin®, is effectively used to kill worms in the intestines. However, long-term use of it has been associated with side effects and risk of drug resistance. Syzygium cumini L.is known for its antioxidant and anti-inflammatory which may support antiparasitic effects and tissue healing. This study aims to examine the effect of juwet (S. cumini L.) fruit water extract (JFWE) on the duodenum structure of mice suspected to be infected with worm, through histomorphometric analysis and histopathological examination. The pyrantel pamoate was only administered once after the acclimatization period, while the JFWE was administered for 3 weeks. A total of 30 male mice were divided into six groups: negative control (aquadest), positive control (pyrantel pamoate, Combantrin® 20 mg/mL), and JFWE at doses of 5 mg/mL, 10 mg/mL, 20 mg/mL, and 40 mg/mL, administered for 3 weeks. Histomorphometric and histopathological evaluations were conducted by microscopically observing the duodenum structures, including intestinal villi, and the thickness of the mucosa, submucosa, and muscularis layers. The results showed a significant difference for the decrease in intestinal villi height and thickness of the mucosa, submucosa, and muscularis layers in JWFE doses of 5 mg/mL and 10 mg/mL administration group, compared to the negative control group (aquadest), the treatment groups of pyrantel pamoate, and JFWE doses of 20 mg/mL and 40 mg/mL (p<0.05). The conclusion is that the administration of juwet fruit water extract doses of 20 mg/mL and 40 mg/mL can improve the histomorphometry structure and also the histopathology of the duodenum of male mice.
Co-Authors Adit Widodo Santoso Alexander Anna Maria Dewajanti Beatrix Clarissa Gunarta Bryan Reyes Stephen Budiman Hartono Budiman Hartono Dwi Anggraini Ernawaty Tamba Flora Rumiati Flora Rumiati Flora Rumiati Henricho Himawan Hidajat, Joshua Jean Michael Indah Pratiwi Inggrid Osya Farfar Inneke Kusumawati Susanto Jasmine Harumi Sabini Jodie Josephine Kris Herawan Timotius Liauw Djai Yen Makatita, Cindy Pricillia Vika Vebriza Marcel Antoni maria caecaelia botoor Monica Puspa Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Nainggolan, Edward Anderson Nanik Siti Aminah Pratanu, Lydia Puspa Sari, Monica Putri, Dyah Ayu Adella Sabini, Jasmine Harumi Sancia Nathania Legenie Banuang Santoso, Adit Widodo Tanian, Michelle Amelia Tekege, Maryana Yenieke Win Darmanto Yanto Hindrawan