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All Journal HAYATI Journal of Biosciences Bioscience Vektora : Jurnal Vektor dan Reservoir Penyakit Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Tropical and Infectious Disease BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati YARSI Medical Journal Jurnal Pembelajaran dan Biologi Nukleus Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Gunung Djati Conference Series SERVIRISMA: Jurnal Pengabdian kepada Masyarakat Jurnal MedScientiae Jurnal MedScientiae Jurnal Kedokteran Meditek
Susilowati, Rina Priastini
Universitas Kristen Krida Wacana
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The Role of Flavonoids as Immunomodulatory Agents: Therapeutic Potential and Mechanisms of Action Sabini, Jasmine Harumi; Susilowati, Rina Priastini; Sari, Monica Puspa
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3710

Abstract

Flavonoids are a group of polyphenolic compounds widely found in plants and have long been recognized for their biological activities, including antioxidant and anti-inflammatory effects. In recent years, increasing attention has been given to the potential of flavonoids as immunomodulatory agents. This review article aims to summarize and evaluate scientific evidence regarding the role of flavonoids in modulating both innate and adaptive immune responses. Several flavonoids, such as apigenin, genistein, quercetin, and naringenin, have been shown to suppress the production of proinflammatory cytokines, inhibit macrophage activation, and influence the differentiation of T cell subpopulations such as Th1, Th2, Th17, and Treg. In addition, some flavonoids have been found to inhibit inflammasome activation and may promote macrophage polarization toward either the M1 or M2 phenotype depending on the pathological context. Although preclinical data demonstrate promising results, challenges such as low bioavailability remain a major barrier to therapeutic application. Therefore, further research is needed to optimize the clinical potential of flavonoids as effective and safe immunomodulatory agents.
Protective effect of juwet fruit extract (Syzygium cumini L.) on duodenum histomorphometry and histopathology of male mice exposed to pyrantel pamoate Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
Biogenesis: Jurnal Ilmiah Biologi Vol 12 No 2 (2024)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v12i2.56552

Abstract

Pyrantel pamoate, known as an anthelmintic under the brand name Combantrin®, is effectively used to kill worms in the intestines. However, long-term use of it has been associated with side effects and risk of drug resistance. Syzygium cumini L.is known for its antioxidant and anti-inflammatory which may support antiparasitic effects and tissue healing. This study aims to examine the effect of juwet (S. cumini L.) fruit water extract (JFWE) on the duodenum structure of mice suspected to be infected with worm, through histomorphometric analysis and histopathological examination. The pyrantel pamoate was only administered once after the acclimatization period, while the JFWE was administered for 3 weeks. A total of 30 male mice were divided into six groups: negative control (aquadest), positive control (pyrantel pamoate, Combantrin® 20 mg/mL), and JFWE at doses of 5 mg/mL, 10 mg/mL, 20 mg/mL, and 40 mg/mL, administered for 3 weeks. Histomorphometric and histopathological evaluations were conducted by microscopically observing the duodenum structures, including intestinal villi, and the thickness of the mucosa, submucosa, and muscularis layers. The results showed a significant difference for the decrease in intestinal villi height and thickness of the mucosa, submucosa, and muscularis layers in JWFE doses of 5 mg/mL and 10 mg/mL administration group, compared to the negative control group (aquadest), the treatment groups of pyrantel pamoate, and JFWE doses of 20 mg/mL and 40 mg/mL (p<0.05). The conclusion is that the administration of juwet fruit water extract doses of 20 mg/mL and 40 mg/mL can improve the histomorphometry structure and also the histopathology of the duodenum of male mice.
EFFECT OF SYZYGIUM CUMINI AQUEOUS EXTRACT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR DAMAGE IN MICE: A HISTOMORPHOMETRY Susilowati, Rina Priastini; Santoso, Adit Widodo; Sabini, Jasmine Harumi
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 1 (2025): Biolink August
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i1.14506

Abstract

The juwet fruit (Syzygium cumini) is a type of fruit commonly found in Indonesia and is known to contain high levels of antioxidant compounds, potential for protecting reproductive organs from oxidative damage. This study aims to investigate the effects of juwet fruit in protecting the testes from damage caused by CCl4 toxicity in mice. A total of 30 mice were used and divided into six groups: distilled water, 12.5 mg/mL CCl₄, and S. cumini extract at doses of 5, 10, 20, and 40 mg/mL for three weeks.  Parameters assessed included body weight, serum testosterone levels, sperm count, and histomorphometry (seminiferous tubule diameter, germinal epithelium height, and spermatogenic cell counts). The results showed that CCl₄ significantly reduced body weight, the number of spermatogenic cells in the seminiferous tubules, seminiferous tubule diameter, germ cell height, and serum testosterone levels in the mice. The treatment groups receiving extract of juwet fruit at doses of 20 mg/mL and 40 mg/mL showed improvements in testicular function that were not significantly different from the distilled water group. In conclusion, reproductive toxicity induced by CCl₄ in male mice can be ameliorated by administering aqueous extract of juwet fruit at doses of 20 mg/mL and 40 mg/mL.
Uji Neurotoksin Insektisida Berbahan Ekstrak Daun Kemangi dan Piretrum terhadap Mortalitas Lalat Rumah (Musca domestica) Tanian, Michelle Amelia; Rumiati, Flora; Susilowati, Rina Priastini
Jurnal Kedokteran Meditek Vol 29 No 3 (2023): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i3.2636

Abstract

Lalat rumah (Musca domestica) berpotensi tinggi dalam menyebarkan patogen bagi manusia. Upaya pengendalian yang sering digunakan adalah insektisida sintetik berbahan kimia yang memiliki dampak negatif seperti pencemaran lingkungan. Flavonoid, eugenol, alkaloid dan piretrin  yang terkandung dalam ekstrak daun kemangi dan piretrum adalah neurotoksin terhadap serangga sehingga cocok digunakan sebagai insektisida nabati. Tujuan dilakukan penelitian adalah untuk mengetahui efektivitas neurotoksin insektisida berbahan ekstrak daun kemangi dan piretrum terhadap mortalitas lalat rumah. Penelitian menggunakan desain penelitian eksperimental dengan metode Rancangan Acak Lengkap. Uji neurotoksin dilakukan pada sepuluh lalat rumah di setiap gelas plastik dengan tiga kali ulangan. Kelompok perlakuan adalah kontrol negatif (tanpa paparan), kontrol positif (disemprot insektisida komersial), kelompok konsentrasi 10%, 20%, 30% dan 40%. Pengamatan dilakukan setelah penyemprotan tiap 10 menit selama 1 jam dan 24 jam. Diperoleh nilai LC50 sebesar 9,557%, dan LC90 sebesar 13,299 %. Berdasarkan uji one-way ANOVA diperoleh adanya perbedaan yang sangat bermakna (p<0,01), antara kelompok kontrol dengan kelompok perlakuan insektisida berbahan ekstrak campuran. Dapat disimpulkan bahwa Insektisida berbahan campuran ekstrak daun kemangi dan piretrum memiliki efek neurotoksin terhadap lalat rumah dan lebih efektif dalam membunuh 100% lalat rumah dengan waktu yang singkat daripada insektisida komersial yaitu dengan konsentrasi 30% dalam 10 menit.
Uji Toksisitas Obat Nyamuk Bakar Herbal Berbahan Ekstrak Daun Permot (Passiflora Foetida) : Kajian Histopatologis Hati dan Ginjal Mencit Susilowati, Rina Priastini
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1081.13 KB)

Abstract

Aedes aegypti adalah nyamuk yang berperan sebagai vector penyakit demam berdarah dengue (DBD). Salah satu upaya untuk mengendalikan populasi Aedes aegypti menurunkan angka kematian karena penyakit DBD melalui pemanfaatan bioinsektisida. Ekstrak biji krisan yaitu piretrin telah banyak digunakan sebagai bahan dasar obat nyamuk bakar, sedangkan ekstrak daun permot (Passiflora foetida) belum banyak diteliti dan dimanfaatkan sebagai salah satu bahan aktif obat nyamuk. Uji toksisitas obat nyamuk bakar berbahan ekstrak daun permot (Passiflora foetida) dilakukan pada hewan mencit jantan (Mus musculus). Penelitian ini dilakukan untuk mengetahui efek organ hati dan ginjal mencit jantan yang diberi paparan obat nyamuk bakar berbahan ekstrakdaun permot. Satu kelompok kontrol (tanpa paparan obat nyamuk bakar) dan lima kelompok perlakuan paparan obat nyamuk bakar berbahan ekstrak daun permot dengan dosis 500 ppm, 1000 ppm, 2000 ppm, 3000 ppm dan 4000 ppm. Sediaan hati dan ginjal dibaca dan dianalisis dengan menggunakan mikroskop cahaya pembesaran 400x untuk melihat perubahan gambaran histopatologisnya. Data dianalisis dengan uji Anova dilanjutkan dengan uji Post Hoc bila berdistribusi normal atau dengan uji Kruskal Wallis yang dilanjutkan dengan uji Mann Whitney bila tidak berdistribusi normal. Tidak ada mencit yang mati maupun menunjukkan gejala toksikseperti hiperagresifitas maupun kepasifan setelah paparan obat nyamuk bakar berbahan ekstrak daun permot. Secara histopatologis pemberian paparan obat nyamuk bakar berbahan ekstrak daun permot dosis 500 ppm hingga 3000 ppm tidak menunjukkan kerusakan jaringan di hati maupun ginjal seperti halnya kelompok kontrol, sedangkan dosis 4000 ppm menyebabkan hati dan ginjalmencit jantan mengalami nekrosis sel parenkim.
EFIKASI EKSTRAK DAUN PERMOT (Passiflora foetida) SEBAGAI PEDIKULISIDA Rina Priastini Susilowati; Adit Widodo Santoso; Jasmine Harumi Sabini
Gunung Djati Conference Series Vol. 59 (2025): Prosiding Seminar Nasional Biologi (SEMABIO) ke-10 Tahun 2025
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Salah satu masalah kesehatan di Indonesia adalah pediculosis capitis atau infestasi rambut dan kulit kepala oleh kutu rambut (Pediculus humanus capitis) yang pengobatannya tergandung pada senyawa kimia golongan piretroid. Penelitian ini bertujuan untuk mengetahui efikasi ekstrak daun permot (Passiflora foetida) sebagai pedikulisida (anti-kutu manusia). Penelitian bersifat eksperimental dengan desain posttest only with control group design. Sampel kutu rambut yang digunakan diperoleh dari anak sekolah dasar berusia 9-12 tahun di wilayah Bekasi Jawa Barat. Kutu rambut dibagi menjadi 6 kelompok, yaitu kelompok 1 adalah kontrol negatif (diberi akuades), kelompok 2 adalah kontrol positif (diberi permethrin 1%), dan kelompok 3, 4, 5, 6 masing diberi ekstrak etanol daun permot dengan konsentrasi 1%, 2%, 4%, dan 8%). Masing-masing kelompok diberi 10 ekor kutu rambut, dengan 3 kali replikasi dan diamati selama 1 jam (60 menit). Data yang terkumpul dianalisis menggunakan uji satu arah Anova, dan uji Probit untuk menentukan konsentrasi letalnya (LC50). Penelitian dilakukan di Laboratorium Riset FKIK Ukrida Jakarta dari bulan Januari 2025 hingga Maret 2025. Hasil penelitian memperlihatkan kematian kutu rambut 100% pada perlakuan permetrin 1% dan ekstrak daun permot konsentrasi 8%, dengan waktu kematian yang berbeda. Waktu kematian pada perlakuan permetrin 1% adalah 40,25 menit, dan ekstrak daun permot 8% selama 30,43 menit. Sedangkan konsentrasi kematian ekstrak daun permot yang efektif untuk LC50 adalah 4,148%, dan untuk LC90 adalah 6,027%. Kesimpulannya ekstrak daun permot dengan dosis lebih dari 8% dapat digunakan sebagai pedikulisida yang efektif.
Effects of Passiflora foetida on the Number of Purkinje Cells in the Cerebellum of Albino Rats Susilowati, Rina Priastini; Hartono, Budiman
Jurnal Biodjati Vol 7 No 2 (2022): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i2.14298

Abstract

 Permot (Passiflora foetida) is one type of plant that has been used as a mosquito coil. Besides being effective at killing Aedes aegypti mosquitoes, mosquito coils made from permot leaf extract are also effective at killing German cockroaches and house flies. Until now there have been no reports stating the side effects of using permot leaf extract in humans. This study was designed to demonstrate the harmful side effects of inhalation of smoked mosquito coils made from permot leaf extract on the cerebellar cortex of adult male rats. Thirty-five adult male rats were used in this study. Rats were divided into 7 groups, namely group 1 as a negative control (without exposure), group 2 as a positive control (transfluthrin exposure 3000 ppm), groups 3 to 7 were treatment groups of permot leaf extract with graded doses (500 ppm, 1000 ppm, 2000 ppm, 3000 ppm, and 4000 ppm), and was treated for 12 weeks. All rats were sacrificed in a timely manner and cerebellar specimens were taken, prepared and observed using a light microscope. Previously, rats were weighed periodically to determine the effect of toxicity. The results showed that exposure to mosquito coil smoke made from 3000 ppm Transflutrin and 4000 ppm permot leaf extract caused weight loss in rats. Likewise on the weight of the rat cerebellum. The effect of decreasing the number of Purkinje cells also occurred in the group exposed to mosquito coils made from Transflutrin 3000 ppm and permot leaf extract 4000 ppm. Therefore, the safe and effective dose of mosquito coils made from permot leaves is less than 4000 ppm, because exposure to doses of more than 4000 ppm can cause degenerative changes in the cerebellar cortex.
Hubungan Kecacingan dan Status Gizi Balita Usia 2-5 Tahun di Beberapa Posyandu di Wilayah Kebon Jeruk, Kota Jakarta Barat Sari, Monica Puspa; Susilowati, Rina Priastini; Tekege, Maryana Yenieke; Makatita, Cindy Pricillia Vika Vebriza
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): Maret
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.3925

Abstract

Introduction: Soil-transmitted helminth (STH) infections are a global health problem, especially among young children in developing countries. These infections affect children's nutritional status through various mechanisms, such as impaired nutrient absorption and chronic blood loss.  Purpose: This study aims to analyze the relationship between STH infection and the nutritional status of children aged 2–5 years at several integrated Posts in the Kebon Jeruk subdistrict of West Jakarta. Method: This study used an analytic descriptive design with a cross-sectional design.  A total of 153 toddlers were selected through a total sampling technique from six health posts. Worm infestation status was determined through stool examination using the Kato-Katz method. Nutritional status was assessed using three anthropometric indicators: weight for age, height for age and weight for height based on the World Health Organization Child Growth Standards. Data analysis was performed using the Fisher test.  Results: The prevalence of worm infection in toddlers was 5,2%. Ascaris lumbricoides was the most common cause, with mild infection rates. Based on nutritional status, most toddlers infected with STH had normal weight for age, normal height for age, and good nutritional weight for height. There was no significant relationship between STH infections and nutritional status (p>0.05). Conclusion: The prevalence of STH infections in toddlers in the study was quite low. There was no significant association between STH infections and nutritional status in toddlers.  Continuous prevention and control interventions for worm infection, along with routine monitoring of nutritional status, are needed to ensure worm-free status.  
Co-Authors Adit Widodo Santoso Alexander Anna Maria Dewajanti Beatrix Clarissa Gunarta Bryan Reyes Stephen Budiman Hartono Budiman Hartono Budiman Hartono Dwi Anggraini Ernawaty Tamba Flora Rumiati Flora Rumiati Flora Rumiati Henricho Himawan Hidajat, Joshua Jean Michael Indah Pratiwi Inggrid Osya Farfar Inneke Kusumawati Susanto Jasmine Harumi Sabini Jodie Josephine Kris Herawan Timotius Liauw Djai Yen Makatita, Cindy Pricillia Vika Vebriza Marcel Antoni maria caecaelia botoor Monica Puspa Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Monica Puspa Sari Nainggolan, Edward Anderson Nanik Siti Aminah Pratanu, Lydia Puspa Sari, Monica Putri, Dyah Ayu Adella Sabini, Jasmine Harumi Sancia Nathania Legenie Banuang Santoso, Adit Widodo Tanian, Michelle Amelia Tekege, Maryana Yenieke Win Darmanto Yanto Hindrawan