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All Journal Science and Technology Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Mandala Pengabdian Masyarakat Global Abdimas: Jurnal Pengabdian Masyarakat Pharmacology And Pharmacy Scientific Journals (PAPS Journals)
Rifa’atul Mahmudah
Program Studi Farmasi, Fakultas Sains Dan Teknologi, Universitas Mandala Waluya
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Transportation Other

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Standarisasi dan Uji Aktivitas Antikolesterol Ekstrak Etanol Daun Labu Kuning (Cucurbita moschata Duch.) pada Mencit (Mus musculus) Mahmudah, Rifaatul; Himaniarwati , Himaniarwati; Imran, Shintia Agrifa Ali
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.486

Abstract

Kolesterol merupakan salah satu golongan lemak yang terdapat dalam tubuh. Namun, ketika kadarnya di atas normal, maka dapat meningkatkan resiko terkena penyakit jantung koroner, aterosklorosis, pankreatitis, DM, gangguan tiroid, penyakit hepar dan penyakit ginjal, sehingga diperlukan alternatif pengobatannya, di samping obat sintetis saat ini yang memiliki efek samping yang tidak sedikit. Penelitian ini bertujuan untuk menentukan standarisasi dan mengetahui aktivitas antikolesterol ekstrak etanol daun labu kuning (EELK) pada mencit jantan (Mus musculus Linn.) yang diinduksi high fat diet (HFD) dan propiltiouurasil. Standarisasi ekstrak meliputi parameter spesifik dan non-spesifik. Sedangkan pengujian aktivitas antikolesterol dilakukan dengan mengelompokkan mencit sebanyak 25 ekor ke dalam 5 kelompok, yang teridiri atas kelompok kontrol negatif (Na.CMC 0,5%), kelompok kontrol positif (Simvastatin), kelompok EEKL dosis 50 mg/kg BB, 100 mg/kg BB, dan 200 mg/kg BB. Analisis data uji aktivitas menggunakan metode One way Analysis of Variance (ANOVA) dan dilanjutkan dengan uji LSD. Dari hasil identifikasi metabolit sekunder, EEKL mengandung flavonoid, tanin, saponin dan triterpenoid. EEKL juga memenuhi standar parameter mutu ekstrak. Pada pengujian aktivitas, EEKL pada semua dosis menunjukkann aktivitas sebagai antikolesterol dengan rata-rata penurunan berturut-turut yaitu sebesar 114 mg/dL, 108 mg/dL dan 103 mg/dL, berbeda bermakna (p<0,05) dengan kelompok kontrol negatif, dan hampir serupa dengan kelompok kontrol positif. Dapat disimpulkan bahwa EEKL dapat digunakan sebagai obat antikolesterol dengan standarisasi mutu ekstrak yang telah ditetapkan.
Phytochemical Properties, In Silico and In Vitro Analysis of the Antibacterial Activity of Cinnamomum sulavesianum Bark from Sulawesi Hurria; Alfian, Anggra; Mahmudah, Rifa’atul
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.121-136

Abstract

Cinnamomum sulavesianum is an aromatic plant in Sulawesi, exhibiting significant potential as an antibacterial candidate. The ongoing search for new antibacterial agents, particularly from natural sources, is crucial due to the rising antibiotic resistance. This study aims to identify the essential oil composition of C. sulavesianum and evaluate its antibacterial properties in silico and in vitro. This study represents the first report on the essential oil content of C. sulavesianum bark and its associated antibacterial effects. The analysis of essential oil content was conducted using Gas Chromatography-Mass Spectrometry (GC-MS) with an Agilent Technologies 7890 Gas Chromatograph equipped with an Auto Sampler. The in silico analysis has been performed through molecular docking of compounds found in C. sulavesianum. Antibacterial testing was carried out using the disc diffusion method, targeting bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. The results from the GC-MS analysis revealed that the bark of C. sulavesianum consists of 10 essential oil compounds, with the primary constituents being Linalool (32.3%), Copaene (6.77%), Eugenol (5.05%), and Eucalyptol (3.17%). In silico evaluations suggest these compounds possess antibacterial potential against gram-positive and gram-negative pathogenic bacteria. Furthermore, in vitro assessments demonstrated that the bark extract of C. sulavesianum formed an inhibition zone that was, on average, categorized as strong based on its inhibitory efficacy. These findings indicate that C. sulavesianum bark holds promise for developing new antibiotics.
Co-Authors Abdul Malik Alfian, Anggra Asnah Marzuki Awaliyah Halid, Nur Hatidjah Ayu Pratiwi Bai Athur Ridwan Besse Yuliana Firdayana, Sunita Halid, Nur Hatidjah Awaliyah Himaniarwati , Himaniarwati Hurria Ibtisamatul Aminah Imran, Shintia Agrifa Ali Jabbar, Asriullah Jangga Jastria Pusmarani Pusmarani Juniarso, Arman Eko La Ode Hamiru Mansur Mansur Mansyur M, Mansyur Mouw, Susan Mubarak Mubarak Muhammad Asrhah Hidayah Muhammad Ilyas Y Muhammad Isrul Nasyruddin Abdullah Nurdin, Mufliha Padjalangi A, Andi Muh Yagkin Pakinde, Ayisti Putra, Agus Kuniawan Putra, Agus Kurniawan Rahmat Ismail Rismayanti Fauziah Saltar, La Ode Saltar, Laode Saparuddin Latu Trisnadeni, Sri Ulva, Sitti Marya Wa Ode Islami Nur Wa Ode Yuliastri Wanda Salsyafirah Yagkin Padjalangi, Andi Muh