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All Journal Jurnal Pendidikan Kimia Indonesia AKADEMIKA Elkawnie Chemistry Indonesian Journal of Chemical Research Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia AR-RAZI Jurnal Ilmiah Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) JCER (Journal of Chemistry Education Research) Acta Chimica Asiana Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Hydrogen: Jurnal Kependidikan Kimia Indonesian Journal of Pharmaceutical Education JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Molekul: Jurnal Ilmiah Kimia Jurnal Sains dan Kesehatan
Jafar La Kilo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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The Type Fragmentation Patterns Confirmed Acetaminophen By Using Liquid Chromatography-Mass Spectroscopy (LCMS) From Herbal Medicine (Jamu) Muhammad Taupik; Endah Nurrohwinta Djuwarno; Moh Adam Mustapa; Wiwin R Kunusa; Jafar La Kilo; Muhamad Handoyo Sahumena
Elkawnie Vol. 7 No. 2 (2021)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i2.7492

Abstract

Abstract: The Jamu or herbal medicine were adulterated with chemical drugs in the last twenty years. One of the chemical drugs that are commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered an analgesic-antipyretic drug. The research aims to identify the content of paracetamol and its amount added to the jamu. This study consisted of 6 jamu or herbal medicine samples with different brands. The TLC method conducted the qualitative analysis using the mobile phase n-hexane: ethyl acetate (1:1). Three positive samples containing acetaminophen were obtained: D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 µL, it was obtained the levels of acetaminophen in sample D as much as  0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and sample F of 0.56 g/7 g of sample. Although the acetaminophen content in herbal medicine is relatively small, according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.Abstrak: Dalam dua puluh tahun terakhir, banyak jamu yang dipalsukan dengan obat-obatan kimia. Salah satu obat kimia yang biasa ditambahkan pada jamu adalah asetaminofen. Acetaminophen umumnya dianggap sebagai obat analgesik-antipiretik. Penelitian ini bertujuan untuk mengetahui kandungan parasetamol dan jumlah yang ditambahkan pada jamu. Sampel penelitian ini terdiri dari 6 sampel jamu dengan merek yang berbeda. Analisis kualitatif dilakukan dengan metode KLT menggunakan fase gerak n-heksana: etil asetat (1:1). Diperoleh tiga sampel positif mengandung asetaminofen, yaitu sampel D, E, dan F. Tiga sampel positif mengandung asetaminofen dihitung menggunakan metode LCMS. Analisis kuantitatif dilakukan dengan LCMS menggunakan fase terbalik dengan fase gerak asetonitril: air (15%>:85%> v/v) pada laju alir 0,2 mL/menit dan volume injeksi 5 µL. Diperoleh kadar asetaminofen pada sampel D sebanyak 0,16 g/2 g sampel, pada sampel E sebesar 0,63 g/7 g sampel, dan pada sampel F sebesar 0,56 g/7 g sampel. Meskipun kandungan asetaminofen dalam jamu relatif sedikit, namun menurut Peraturan Menteri Kesehatan RI No. 007 Tahun 2012, obat tradisional atau jamu tidak boleh mengandung bahan kimia sintetik.
Co-Authors A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Adam Mustapa, Muhammad Ahmad Kadir Kilo Akram La Kilo Alberto Costanzo Andi Makkulawu Andimala, Febriyanti Anita Muhammad Annisa Untuba Arviani Arviani Bumulo, Nuraini Christopel, Nelpiani Christopel, Nelpiani Damayanti, Elok Dandi Saputra Halidi Daniele Mazza Deasy N Botutihe Deasy Natalia Botutihe Dilapanga, Harsya Wiriawan Eka Anggraini Odja Endah Nurrohwinta Djuwarno Erni Mohamad Hendri Iyabu Ibrahim, Indriyanti Ishak Isa Julhim S Tangio Kupang, Sri Revayana La Alio La Ode Aman Lukman A. R. Laliyo Mangara Sihaloho Mantuli, Mohamad Alan Mardjan Paputungan Maryam Padi Mian Kau Muhamad Handoyo Sahumena Muhammad Taupik Naim, Fitria Najmah Najmah Najmah, Najmah Nelpiani Christopel Netty Ino Ischak Nita Suleman Nurhayati Bialangi Opir Rumape Padi, Maryam Patilima, Rusmiyati Rahmawati Hilala Ramona Nintias R. Abas Riskah Fitriani Adam Rusmiyati Patilima Sabihi, Ismail Samsul Bahri Badjeber Saprini Hamdiani Sri Wanti Sappe Viviane Annisa Weny J.A. Musa Wiwin Rewini Kunusa Wiwit Zuriati Uno Yuszda K Salimi Zainudin, Farnawaty Zulfikar Ahmad