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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal Impresi Indonesia Heca Journal of Applied Sciences Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology
Kepel, Billy Johnson
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Analisis Faktor Risiko Konsumsi Alkohol terhadap Hipertensi pada Populasi Lansia (>50 Tahun) di Wilayah Kepulauan: Sebuah Studi Cross-sectional Binanti, Marnix Meiki; Nelwan, Jeini Ester; Kepel, Billy Johnson; Langi, Fima Lanra Fredrik G.; Lampus, Harsali Fransiscus
Jurnal Promotif Preventif Vol 8 No 6 (2025): Desember 2025: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

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Abstract

Hipertensi menjadi masalah kesehatan utama lansia yang berkontribusi besar terhadap penyakit kardiovaskular. Di wilayah kepulauan, konsumsi alkohol sebagai faktor risiko perilaku yang dapat dimodifikasi diduga berperan dalam kejadian hipertensi. Penelitian ini bertujuan menganalisis hubungan konsumsi alkohol dengan hipertensi pada lansia (>50 tahun) di Kepulauan Talaud. Desain penelitian menggunakan cross-sectional dengan sampel sebanyak 94 lansia yang dipilih secara total sampling di wilayah kerja Puskesmas Dapalan. Data dikumpulkan melalui wawancara terstruktur dan pengukuran tekanan darah menggunakan sfigmomanometer terkalibrasi. Analisis data menggunakan uji Chi-Square dan perhitungan odds ratio (OR). Hasil menunjukkan hubungan yang signifikan antara konsumsi alkohol dan hipertensi (p=0,003). Lansia yang mengonsumsi alkohol memiliki risiko 3,4 kali lebih tinggi mengalami hipertensi dibandingkan yang tidak mengonsumsi (OR=3,40). Disimpulkan bahwa konsumsi alkohol merupakan faktor risiko signifikan terhadap hipertensi pada lansia di wilayah kepulauan. Oleh karena itu, upaya pencegahan melalui edukasi kesehatan dan skrining tekanan darah rutin pada kelompok ini perlu diintensifkan di tingkat pelayanan primer.
Integrative Network Pharmacology Study of Cordyceps militaris Compounds for Prostate Cancer Treatment Laihad, Sarah Cecilia Astrid; Tallei , Trina Ekawati; Tendean , Lydia Estelina Naomi; Turalaki, Grace Lendawati Amelia; Marunduh, Sylvia Ritta; Purwanto , Diana Shintawati; Kepel, Billy Johnson; Abas, Abdul Hawil
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.382

Abstract

Prostate cancer remains one of the leading causes of cancer-related mortality in men, while adverse effects and the development of drug resistance often limit current therapeutic strategies. Natural products have gained increasing attention as potential sources of novel anticancer agents due to their multitarget properties and relatively low toxicity. Cordyceps militaris, a medicinal fungus rich in bioactive compounds, has been reported to exhibit anticancer activity; however, its compound-target interactions in prostate cancer have not been comprehensively elucidated. This study aimed to explore the interactions between C. militaris bioactive compounds and prostate cancer-associated targets using a pharmacology network-based in silico approach. A total of 50 bioactive compounds were collected from metabolite profiling studies, of which 19 compounds were selected based on high predicted TP53 expression enhancer activity (Pa ≥ 0.7) using WAY2DRUG PASS analysis. Protein targets were predicted using SwissTargetPrediction and the Similarity Ensemble Approach, and then intersected with prostate cancer-associated proteins retrieved from GEPIA2, GeneCards, and OMIM, yielding 499 overlapping targets. Protein interaction network analysis was performed using STRING and visualized in Cytoscape, enabling the identification of key hub proteins based on the applied parameters, highlighting ten key proteins, including SRC, ESR1, MAPK1, AKT1, HSP90AA1, MAPK3, HSP90AB1, EGFR, GRB2, and PRKACA, within the interaction network. Pathway enrichment analysis indicated that these targets were predominantly involved in cancer-associated signaling pathways, such as the EGFR tyrosine kinase inhibitor resistance pathway. Furthermore, the results revealed that the selected compounds interact with these key prostate cancer-associated proteins. Pharmacokinetic and toxicity evaluation predicted favorable drug-likeness and acceptable safety profiles for selected compounds. Overall, this study highlights the potential of C. militaris bioactive compounds as promising alternative for prostate cancer through multitarget modulation of clinically relevant signaling pathways. Further experimental validation is still required to confirm these findings.
Co-Authors Aaltje Manampiring Abas, Abdul Hawil B H. R. Kairupan Barasarathi , Jayanthi Binanti, Marnix Meiki Bodhi , Widdhi Bolang, Alexander Sam Leonard Budiarso, Fona Hermina Dwiana Celik, Ismail Fatimawali . Fona Budiarso Gemi Nastiti Hermina Budiarso, Fona Dwiana Laihad, Sarah Cecilia Astrid Lampus, Harsali Fransiscus Ley, Gabriella Therezia Ley Malino, Angeline Priscillia Manampiring, Aaltje Ellen Martha Marie Kaseke Marunduh, Sylvia Ritta Nelwan, Ester Jeini Niode, Nurdjannah Jane Paukiran, Degol Purwanto , Diana Shintawati Rumangu, Chrisa P. Salaki, Christina Leta Saragih, Nathin Loria , Sumakul, Gilbert Samuel Tallei , Trina Ekawati Tendean , Lydia Estelina Naomi Tendean, Lydia Estelina Naomi Tendean, Widya TRINA EKAWATI TALLEI Turalaki, Grace Lendawati Amelia Widdhi Bodhi Wijaya, Nur Anindhita Kurniawaty Wungouw, Herlina Ineke Surjane