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All Journal Media Kedokteran Hewan Vitek : Bidang Kedokteran Hewan journal of Basic Medical Veterinary Indonesian Andrology and Biomedical Journal
Rahmatullah, Aldin Akbar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Veterinary

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Dayak Onion (Eleutherine palmifolia) Extract Reduces MSG-Induced Obesity in Mice Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Rahajeng, Anggreani Desi Ramadhani; Indrajaya, Putra; Firdaus, Ahmad Thoriqul; Hidayat, Rosid; Shaffirudin, Yosfiansya Fernandi; Zahli, Haikal Akmal; Irkhamy, Muhamad Naufal
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72346

Abstract

This study evaluated the anti-obesity effects of Dayak onion (Eleutherine palmifolia) extract in MSG-induced obese mice. Twenty-five male mice were divided into five groups: negative control (CMC-Na), positive control (MSG, 4 mg/g BW), and three groups receiving MSG plus Dayak onion extract at 30, 60, or 120 mg/kg BW for 52 days. Body weight was measured weekly, and abdominal fat (retroperitoneal, epididymal, peritoneal) was weighed using a digital scale on day 53. One-way ANOVA with Duncan’s post hoc test analyzed differences (p<0.05). MSG increased body weight (40.8 ± 1.1 g) and fat compared to the negative control (31.2 ± 0.5 g). Dayak onion extract dose-dependently reduced body weight (T1: 38.2 ± 0.6 g; T2: 36.0 ± 0.9 g; T3: 32.3 ± 0.6 g) and fat, with the 120 mg/kg dose nearing control levels. Flavonoids and anthraquinones in the extract likely drive these effects, suggesting Dayak onion’s potential as a natural anti-obesity agent. Human studies are needed to confirm these findings.
Amelioration of Cigarette Smoke-Induced Hepatic Injury by Green Tea (Camellia sinensis) Extract: Evidence from SGOT and SGPT Biomarkers in a Murine Model Indrajaya, Putra; Mudawamah, Mudawamah; Kalsum, Umi; Trisakti, Adinda Rizky; Rahmatullah, Aldin Akbar
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.72636

Abstract

This study investigated the hepatoprotective effects of green tea extract (GTE) against cigarette smoke-induced liver damage in mice. Twenty-five male mice (Mus musculus) were divided into five groups: negative control (C-), positive control exposed to cigarette smoke (C+), and three experimental groups exposed to cigarette smoke and treated with different doses of GTE: 20 mg/kg BW (T1), 40 mg/kg BW (T2), and 60 mg/kg BW (T3). Following 36 days of treatment, serum SGOT and SGPT levels were measured as biomarkers of hepatocellular injury. Results showed significant elevation of both enzymes in the C+ group (SGOT: 50.46 ± 2.49 U/L; SGPT: 19.48 ± 1.47 U/L) compared to the C- group (SGOT: 35.10 ± 2.49 U/L; SGPT: 10.22 ± 1.68 U/L), indicating cigarette smoke-induced hepatotoxicity. GTE administration demonstrated dose-dependent hepatoprotection, with the highest dose (T3) showing the most substantial effect (SGOT: 38.26 ± 1.25 U/L; SGPT: 11.01 ± 1.05 U/L). Statistical analysis revealed significant differences between groups (p<0.05). The hepatoprotective mechanisms of GTE likely involve its potent antioxidant properties, enhancement of endogenous antioxidant systems, anti-inflammatory effects, modulation of xenobiotic metabolism, and mitochondrial protection. These findings suggest that green tea extract may serve as a promising natural hepatoprotective agent against cigarette smoke-induced liver injury, with potential applications in preventive healthcare strategies.
Ameliorative Effects of Eleutherine palmifolia Extract on Monosodium Glutamate-Induced Reproductive Toxicity: Modulation of Oxidative Stress Markers and Spermatogenesis in a Murine Model Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Mustofa, Imam; Mulyati, Sri; Sugihartuti, Rahmi; susilowati, Suherni; Putri, Cindy Ercha Aulia
Indonesian Andrology and Biomedical Journal Vol. 6 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v6i1.72293

Abstract

Background : Chronic monosodium glutamate (MSG) exposure is linked to testicular toxicity, impacting spermatogenesis and oxidative stress markers. Objective : This study investigated the protective effects of Dayak onion (Eleutherine palmifolia) extract against MSG-induced testicular damage in mice. Methods : Twenty-five male mice (11 weeks, ~20 g) were divided into five groups: negative control (C-, 0.5% CMC-Na), positive control (C+, MSG 4 mg/g BW), and treatment groups (T1, T2, T3) receiving MSG plus Dayak onion extract (30, 60, 120 mg/kg BW, respectively) for 52 days. On day 53, testicular histology and serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were analyzed. One-way ANOVA and Duncan’s post hoc test assessed differences (p<0.05). Results : Group C+ showed significantly reduced spermatogenic cell counts, elevated MDA, and decreased SOD compared to C-. Group T1 exhibited no significant improvement in spermatogonia and spermatocytes but increased spermatids. Groups T2 and T3 significantly improved spermatogenic cell counts, with T3 showing the closest recovery to C-. MDA levels decreased, and SOD activity increased dose-dependently, with T3 nearing C- levels. Conclusion : Dayak onion extract, particularly at 120 mg/kg BW, mitigates MSG-induced testicular toxicity, preserving spermatogenesis and balancing oxidative stress markers.
Surgical Management of Comminuted Distal Femoral Fracture Using Intramedullary Pin in a Cat Putri, Cindy Ercha Aulia; Rahmatullah, Aldin Akbar; Afandi, Mohammad Auzaie; Halim, Muhammad Al-Syafiq bin Abdul
Media Kedokteran Hewan Vol. 36 No. 3 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i3.2025.329-341

Abstract

A 3-year-old male domestic short-haired cat, weighing 3.8 kg, was presented with lameness, swelling in the left hind limb groin area, and pain upon palpation. Radiographic examination confirmed a comminuted fracture in the diaphysis of the left femur. This case report aims to document the diagnostic approach and surgical management using an intramedullary pin technique. Surgical intervention was performed to restore the anatomical alignment of the fracture fragments. The procedure involved open reduction and internal fixation using an intramedullary pin. Post-operative medication included tramadol (1 mg/kg BW) for analgesia, ceftriaxone (25 mg/kg BW) as antibiotic therapy, and dexamethasone (2 mg/kg BW) for anti-inflammatory effects. Femoral fractures account for 20-26% of fractures in cats, with various treatment options available including pins and wires, Rush pins, threaded intramedullary pins, interlocking pins, clamp rod internal fixators, and plate-rod systems. The intramedullary pin technique was selected for this case due to its suitability for comminuted diaphyseal fractures. This case highlights the efficacy of intramedullary pin fixation as a viable treatment option for comminuted femoral fractures in cats when appropriate surgical technique and post-operative care are implemented.
THE EFFECT OF Averrhoa bilimbi EXTRACT ON THE DUODENUM HISTOPATHOLOGY IN RATS INFECTED WITH Escherichia coli Rahmatullah, Aldin Akbar
VITEK : Bidang Kedokteran Hewan Vol. 14 No. 1 (2024): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v14i1.285

Abstract

This study aimed to prove the efficacy of Averrhoa bilimbi extract on histopathological changes in the duodenum of rats infected with Escherichia coli. It was a laboratory experimental study involving 30 male white rats aged 3 months, weight 250 g divided into six treatment groups: P0 (no E. coli induction + no Averrhoa bilimbi extract), P1 (E. coli induction + no Averrhoa bilimbi extract), and E. coli induction + various concentrations of Averrhoa bilimbi extract (20% in P2, 30% in P3, 50% in P4, and 60% in P5). All treatments lasted for 14 days. On the 15th day, necropsy was performed to collect duodenal tissues, which were then histologically examined using Hematoxylin-Eosin staining. Microscopic observations focused on detecting necrosis, inflammatory cell infiltration, and hemorrhage in the duodenal villi. Data were analyzed using the Kruskall-Wallis test, revealing significant differences between treatments (P < 0.05). The result show that the Averrhoa bilimbi extract did not demonstrate preventive effects against duodenal villi damage, including necrosis, inflammatory cell infiltration, and hemorrhage. In conclusion, the administration of Averrhoa bilimbi extract to rats infected with Escherichia coli did not show effectiveness in preserving the histopathological integrity of the duodenal small intestine in white rats.
THE EFFECT OF GREEN TEA (Camellia sinensis) EXTRACT ON THE THICKNESS OF BRONCHIAL EPITHELIUM AND PULMONARY ARTERY WALL OF MICE (Mus musculus) EXPOSED TO CIGARETTE SMOKE Rahmatullah, Aldin Akbar
VITEK : Bidang Kedokteran Hewan Vol. 14 No. 1 (2024): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jv.v14i1.287

Abstract

The study aims to investigate the impact of green tea extract on the thickness of bronchial epithelium and pulmonary artery walls in mice lungs exposed to cigarette smoke. Twenty-five 12-week-old mice (Mus musculus) weighing between 20-25 grams were used in the experiment. The control group (K(-)) received no cigarette smoke exposure and was administered 0.5 mL of 1% Na-CMC, while the positive control group (K(+)) was exposed to cigarette smoke without green tea leaf extract and received 0.5 ml of 1% Na-CMC. Groups exposed to cigarette smoke (P1, P2, and P3) were given green tea extract at doses of 20 mg/kgBW, 40 mg/kgBW, and 60 mg/kgBW respectively, each in a daily dose of 0.5 ml. Mice were exposed to one cigarette per group per day. The findings indicate that administering green tea extract has the potential to reduce the thickening of both the bronchial epithelium and pulmonary artery walls, with the optimal dose being 40 mg/kgBW. Analysis using ANOVA revealed significant differences in the thickness of the bronchial epithelium and pulmonary artery walls among the groups (p < 0.05). This study demonstrates that administering green tea extract suspension (Camellia sinensis) can effectively mitigate the thickening of the bronchial epithelium and pulmonary artery walls in mice lungs exposed to cigarette smoke.
Effect of the Extract of Dayak Onions (Eleutherine palmifolia) on the Sperm Quality of Mice (Mus musculus) Induced with Monosodium Glutamate Rahmatullah, Aldin Akbar; Sugihartuti, Rahmi; Susilowati, Suherni; Hamid, Iwan Sahrial; Suprayogi, Tri Wahyu; Rachmawati, Kadek; Safitri, Erma; Mustofa, Imam; Mulyati, Sri
Media Kedokteran Hewan Vol. 35 No. 2 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i2.2024.113-122

Abstract

This study aims to determine the effect of the extract of Dayak onions (Eleutherine palmifolia) on the motility, viability, and concentration of spermatozoa in mice (Mus musculus) induced with monosodium glutamate (MSG). This study involved 25 male mice aged 11 weeks and weighing approximately 20 g. The mice were divided into five groups, namely C- (CMC-Na 0.5%), C+ (4 mg/g BW of MSG), T1 (4 mg/g BW of MSG and 30 mg/kg BW of Dayak onion extract), T2 (4 mg/g BW of MSG and 60 mg/kg BW of Dayak onion extract), and T3 (4 mg/g BW of MSG and 120 mg/kg BW of Dayak onion extract). All treatments were administered for 52 days. The results showed no significant differences in the motility and concentration of spermatozoa between the C- (81.50 ± 4.18; 7.21 ± 0.37) and T3 (77 ± 2.74; 7.04 ± 0.13) groups (p < 0.05). In addition, the results showed significant differences in the viability of spermatozoa between the C- (83.30 ± 3.40) and T3 (77.20 ± 4.06) groups. Therefore, it can be concluded that the administration of Dayak onion extracts orally to mice induced with MSG can maintain the motility, viability, and concentration of spermatozoa.
Protective Effect of The Extract of Dayak Onions (Eleutherine palmifolia) on Sertoli and Leydig Cell Necrosis in Mice (Mus Musculus) Induced with Monosodium Glutamate Rahmatullah, Aldin Akbar; Ratnaningtyas, Nurrohmah; Sugihartuti, Rahmi; Susilowati, Suherni; Safitri, Erma; Mulyati, Sri
Media Kedokteran Hewan Vol. 35 No. 2 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i2.2024.87-96

Abstract

This study aims to determine the effect of the extract of Dayak onions (Eleutherine palmifolia) on the number of necrotic Sertoli and Leydig cells in mice (Mus musculus) induced with monosodium glutamate (MSG). This study involved 25 male mice aged 11 weeks and weighing approximately 20 g. The mice were divided into five groups, namely C- (0.5% CMC-Na), C+ (4 mg/g BW of MSG and 0.5% CMC-Na), T1 (4 mg/g BW of MSG and 30 mg/kg BW of Dayak onion extract), T2 (4 mg/g BW of MSG and 60 mg/kg of Dayak onion extract), and T3 (4 mg/g BW of MSG and 120 mg/kg BW of Dayak onion extract). All treatments were administered for 52 days. The mice were euthanized on day 53 of the experiment. Their testicles were removed and used to prepare histological specimens with the H&E staining method. The results showed significant differences (p < 0.05) in the number of necrotic Sertoli and Leydig cells between the C+ group and the T1, T2, and T3 groups with gradually decreasing values. The results suggested that the administration of the extract of Dayak onions can prevent Sertoli and Leydig cell necrosis in mice induced with MSG at an optimal dose of 120 mg/kg BW.
Prevalence and Risk Factor of Repeat Breeder Syndrome in Dairy Cows in KUD Bebarengan Anggayuh Tentrem Urip, Batu City, East Java Province Frida Aulya Arningdiah; Rahmatullah, Aldin Akbar; Cindy Ercha Aulia Putri; Mufasirin; Hermin Ratnani; Rimayanti; Sri Pantja Madyawati; Tita Damayanti Lestari; Muhammad Al-Syafiq bin Abdul Halim; Nuurin Ajrin Karim
Media Kedokteran Hewan Vol. 35 No. 3 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i3.2024.232-242

Abstract

This study aims to contribute valuable insights to readers and serve as a reference for dairy farmers looking to enhance their operations. By examining the prevalence and risk factors associated with repeat breeder syndrome in dairy cows within the Village Unit Cooperation (KUD) Bebarengan Anggayuh Tentrem Urip, Batu City, East Java Province, this study aims to aid in preventing such occurrences and ultimately improve dairy cow productivity. The survey method was employed, utilizing data sourced from cooperative and farmer records, as well as observations, interviews, and questionnaire responses. Analysis revealed that out of 50 farmers owning a total of 281 cows, 30 farmers possessed a combined total of 58 dairy cows classified as repeat breeders. Consequently, the prevalence rate of repeat breeders among farmers was found to be 20.64%. Descriptive analysis was conducted on the collected data, with additional SPSS Chi-Square (X²) analysis performed to identify risk factors associated with repeat breeders. These risk factors include breeder experience, knowledge of reproduction and estrus phases, communication with artificial inseminators and veterinarians, housing conditions, as well as factors related to livestock feed and water.
Management of Fibroadenoma in a 12-Year-Old Dachshund Mix Dog Rahmatullah, Aldin Akbar; Putri, Cindy Ercha Aulia; Ratnaningtyas, Nurrohmah; Pratama, Syifa Ramadhan; Karim, Nuurin Ajrin; Akintunde, Adeyinka Oye
Media Kedokteran Hewan Vol. 37 No. 1 (2026): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v37i1.2026.73-84

Abstract

Mammary tumors are a significant concern in canine veterinary medicine, with fibroadenoma being a rare benign subtype. This case report details the successful management of fibroadenoma in a 12-year-old, non-spayed, female Dachshund mix presenting with multiple abdominal masses (3–6 cm in diameter). Clinical examination showed stable vital signs (body temperature 38.5°C, pulse 110 bpm, respiratory rate 30 breaths/min). Diagnostic workup included ultrasonography, hematology, and histopathology, confirming fibroadenoma characterized by adenoma clusters within dense connective tissue. The term "adenomer" was clarified as a non-standard variant of adenoma, and consistent terminology was applied throughout. Treatment involved ovariohysterectomy and mastectomy, followed by post-operative administration of ceftriaxone, dexamethasone, amoxicillin, and metronidazole. The patient recovered without complications, underscoring the efficacy of early surgical intervention to prevent metastasis. This case highlights a comprehensive diagnostic and therapeutic approach for managing canine fibroadenoma.
Co-Authors Afandi, Mohammad Auzaie Akintunde, Adeyinka Oye Cindy Ercha Aulia Putri Erma Safitri Firdaus, Ahmad Thoriqul Frida Aulya Arningdiah Halim, Muhammad Al-Syafiq bin Abdul Hermin Ratnani Hidayat, Rosid IMAM MUSTOFA Indrajaya, Putra Irkhamy, Muhamad Naufal Iwan Sahrial Hamid Kadek Rachmawati Karim, Nuurin Ajrin Mudawamah Mudawamah Mufasirin Muhammad Al-Syafiq bin Abdul Halim Nuurin Ajrin Karim Pratama, Syifa Ramadhan Putri, Cindy Ercha Aulia Rahajeng, Anggreani Desi Ramadhani Rahmi Sugihartuti, Rahmi Ratnaningtyas, Nurrohmah Rimayanti Shaffirudin, Yosfiansya Fernandi Sri Mulyati Sri Pantja Madyawati Suherni Susilowati Tita Damayanti Lestari Tri Wahyu Suprayogi Trisakti, Adinda Rizky Umi Kalsum Zahli, Haikal Akmal