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All Journal JURNAL KIMIA SAINS DAN APLIKASI Bulletin of Chemical Reaction Engineering & Catalysis Indonesian Journal of Chemistry Indonesian Journal of Natural Pigments Journal of Multidisciplinary Applied Natural Science Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Bioactivities Bulletin of Chemical Reaction Engineering & Catalysis
Kurniawan, Yehezkiel Steven
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Other

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Journal : Journal of Multidisciplinary Applied Natural Science

 1 
Green Chemistry Influences in Organic Synthesis : a Review Yehezkiel Steven Kurniawan; Krisfian Tata Aneka Priyangga; Philip Anggo Krisbiantoro; Arif Cahyo Imawan
Journal of Multidisciplinary Applied Natural Science Vol. 1 No. 1 (2021): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.v1i1.2

Abstract

Environmental pollution and global warming cause serious problems in human life. Since the demand for our human daily appliances had been increased by years, the organic chemical-based industries response that demand increment by increasing their production process. Because of that, the environmental pollution becomes worse and worse. Green chemistry thus was introduced to influence the chemical industries to strive for better environmental sustainability. Over 20 years, green chemistry principles have to influence the organic chemistry field especially as many researchers have put their attention on that field of research. So far, synthesis process involving organic compounds has been considered on waste prevention, safer solvents, design for high energy efficiency, and usage of renewable feedstocks. This review comprehensively discusses in brief about the implementation of green chemistry principle and their applications in the synthesis process of organic compounds.
Efficient and Low-Cost Removal of Methylene Blue using Activated Natural Kaolinite Material Christyowati Primi Sagita; Limpat Nulandaya; Yehezkiel Steven Kurniawan
Journal of Multidisciplinary Applied Natural Science Vol. 1 No. 2 (2021): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.v1i2.80

Abstract

Clays are low-price and very useful material for water treatment purpose. In this work, we reported the application of activated natural kaolinite material which obtained from Wediombo beach, Yogyakarta for methylene blue adsorption. The natural kaolinite material was activated under an acidic condition to obtain the activated kaolinite material. The activated kaolinite material was characterized using Fourier transform infrared, X-ray diffraction, scanning electron microscope, and surface analysis. From the adsorption experiment, the activated kaolinite material gave moderate adsorption percentages for methylene blue. The adsorption kinetics followed the Ho and McKay kinetic model while the adsorption isotherm followed Langmuir model. The qmax value for methylene blue adsorption using activated natural kaolinite material was at a moderate level (3.40 mg g-1). The plausible adsorption mechanism of methylene blue on the surface of activated kaolinite material happened through hydrogen bondings and/or electrostatic interactions. These findings are important for a wastewater treatment using a low-cost adsorbent material.
A Review on Calixarene Fluorescent Chemosensor Agents for Various Analytes Krisfian Tata Aneka Priyangga; Yehezkiel Steven Kurniawan; Keisuke Ohto; Jumina Jumina
Journal of Multidisciplinary Applied Natural Science Vol. 2 No. 1 (2022): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.101

Abstract

Calixarenes are well-known supramolecular host molecules with versatile applications. Over the past decades, hundreds of selective and sensitive detections of several analytes have been reported by employing calixarenes as the chemosensor agent. The detection and quantification of metal ions and anions are crucial as heavy metal ions are harmful to living organisms, while monitoring anions is pivotal in the environmental samples. On the other hand, detecting and quantifying biomolecules and neutral molecules are critical due to their irreplaceable role in human health. In this review, we summarized the application of calixarenes as the supramolecular chemosensor agent for detecting metal ions, anions, biomolecules, and neutral molecules through fluorescent spectroscopy to give brief information on the design and development of the chemosensor field. This review updates the world with the application of calixarene derivatives as fluorescent chemosensors and challenges researchers to design and develop better chemosensor agents in the future.
Effective Recovery of Palladium(II) Ions using Chitosan-Based Adsorbent Material Rokiy Alfanaar; Krisfian Tata Aneka Priyangga; Arif Cahyo Imawan; Jumina Jumina; Yehezkiel Steven Kurniawan
Journal of Multidisciplinary Applied Natural Science Vol. 3 No. 1 (2023): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.131

Abstract

Chitosan is one of the naturally abundant, biodegradable, and low-cost adsorbent materials for metal adsorption purposes. In this work, we evaluated the application of chitosan materials derived from seafood wastes in Depok beach, Yogyakarta, for an effective recovery of the palladium(II) ions. First of all, the seafood wastes were treated to obtain chitin and then followed by the deacetylation process to produce chitosan material with a deacetylation degree of 78.42%. The chitosan material was characterized using Fourier transform infrared (FTIR) spectrophotometer. It was found that chitosan gave high adsorption percentage (90%) for palladium(II) ions due to the complexation with hydroxyl, amino and carbonyl functional groups. The palladium(II) adsorption onto chitosan material followed the pseudo-second-order (R2 = 0.9978) and Langmuir (R2 = 0.9979) models for kinetic and isotherm experiments, respectively, with a maximum adsorption capacity value of 0.70 mmol g-1. The palladium(II) ions could be easily desorbed in 90% percentage using 1.0 M HCl solution from metal-laden chitosan to regenerate the adsorbent material. The chitosan-based adsorbent material did not lose its adsorption capability after three consecutive cycles with no significant structural change as revealed from the FTIR data. These results showed the potential application of natural chitosan materials derived from seafood wastes for the effective recovery of palladium(II) ions.
Evaluation of The Anticancer Activity of Hydroxyxanthones Against Human Liver Carcinoma Cell Line Yehezkiel Steven Kurniawan; Nela Fatmasari; Jumina Jumina; Harno Dwi Pranowo; Eti Nurwening Sholikhah
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.165

Abstract

Nowadays, cancer is one of the most fatal diseases in developed and developing countries. Therefore, it is an urgent need to find more effective anticancer drugs among the recent commercially available standard drugs. Xanthone derivatives have been researched as anticancer drugs due to their ease of synthesis and structure modification, as well as their excellent anticancer activity. In this work, the in vitro anticancer activity of hydroxyxanthones against the human liver carcinoma cell line (HepG2) was evaluated. Among the twenty-two hydroxyxanthones, 1,3,6,8-tetrahydroxyxanthone was found as the most active anticancer agent with an IC50 value of 9.18 μM, which was better than doxorubicin as the standard drug. From the molecular docking studies against topoisomeraseIIα and two c-KIT protein kinases, 1,3,6,8-tetrahydroxyxanthone yielded strong binding energy in a range of -25.48 to -30.42 kJ/mol. The 1,3,6,8-tetrahydroxyxanthone could bind on the active site of these protein receptors through hydrogen bonds with key amino acid residues (Glu640, Cys673, Gln767, Met769, Asp810, and Asp831), as well as nitrogen bases (Adenine12 and Guanine13), thus leading to the death of HepG2 cancer cells through the apoptosis mechanism.
Catalytic Reduction of 4-Nitrophenol and Methylene Blue with Silver Nanoparticles Decorated with Drymoglossum piloselloides Extract Awalul Fatiqin; Rokiy Alfanaar; Sudarman Rahman; Yahya Febrianto; Shesanthi Citrariana; Mu’afa Purwa Arsana; Thathit Suprayogi; Yehezkiel Steven Kurniawan
Journal of Multidisciplinary Applied Natural Science Vol. 4 No. 2 (2024): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.210

Abstract

Drymoglossum piloselloides is one of the epiphytic plants that is commonly found in Southeast Asia region. In this study, the ethanol extract of D. piloselloides plant has been used in the green synthesis of silver nanoparticles. The synthesized silver nanoparticles were characterized by ultraviolet-visible (UV-Vis) spectrophotometry, X-ray diffraction (XRD),Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM) measurements. The UV-Vis spectrum of silver nanoparticles showed a maximum wavelength at 453 nm. The XRD measurement showed the silver nanoparticles peaks at 38.38°, 44.60°, 64.76°, and 77.62°. The FTIR spectra provided evidence of the interaction between silver and chemicals in the plant extract as a weak signal at 682 cm-1. Meanwhile, TEM revealed an average size of 12.63nm. The synthesised silver nanoparticles were utilised for the reduction of 4-nitrophenol with a conversion percentage of up to 100% with a reduction reaction rate constant of 7.104 s-1. In addition, methylene blue was also successfully reduced with the synthesised silver nanoparticles as the catalyst with a reduction reaction rate constant (k) of 21.150 s-1. This study highlights the superior advantage of utilizing ethanolic extract of D. piloselloides to prepare silver nanoparticles with promising catalytic reduction purposes.
Evaluation of Xanthone and Cinnamoylbenzene as Anticancer Agents for Breast Cancer Cell Lines through In Vitro and In Silico Assays Yehezkiel Steven Kurniawan; Hanif Amrulloh; Ervan Yudha; Nela Fatmasari; Faris Hermawan; Anggit Fitria; Harno Dwi Pranowo; Eti Nurwening Sholikhah; Jumina Jumina
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.231

Abstract

Breast cancer is a severe global disease for women as the number of deaths increases annually. Therefore, attempts to find new anticancer agents are critical and inevitable. In this work, we report the investigation on the anticancer activity of xanthone and cinnamoylbenzene compounds against two breast cancer cell lines, i.e., T47D and MCF-7, through experimental in vitro and theoretical in silico assays. Xanthone and cinnamoylbenzene exhibit anticancer activity with a half-maximal inhibitory concentration (IC50) of 136.7–194.3 and 235.8–262.4 µg/mL against T47D and MCF-7 cancer cells, respectively. Cinnamoylbenzene generates less cytotoxicity to normal Vero cells with a selectivity index of 1.095–2.102. The molecular docking studies agree with the experimental data in which cinnamoylbenzene is more active against T47D with an IC50 of 136.7 µg/mL due to Topoisomerase II inhibition through π-π stacked interactions with Adenine12 and Guanine13 nitrogen bases. Meanwhile, xanthone is more active against MCF-7 with an IC50 of 235.8 µg/mL due to EGFR inhibition through van der Waals interaction and hydrogen bond with Glutamic acid767 and Methionine769 amino acid residues, respectively. Additionally, the pharmacokinetic parameters of xanthone and cinnamoylbenzene are predicted through absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis, and they show better suitability than doxorubicin as the commercial anticancer drug.
Allyl-Modified of Calix[4]resorcinarene Derivatives for HER2 Inhibition Agents: An In Silico Study Fitria, Anggit; Kurniawan, Yehezkiel Steven; Ananto, Agus Dwi; Jumina, Jumina; Sholikhah, Eti Nurwening; Pranowo, Harno Dwi
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.250

Abstract

Breast cancer is one of the deathliest cancer diseases for women, with high mortality cases. Since breast cancer cells overexpressed HER2 receptors, a computerized structure-based screening was conducted to identify potential HER2 inhibitors as an anti-breast cancer agent. This method can investigate the potency of proposed compounds as potential protein inhibitors. Researchers were interested in studying some synthetic macromolecules, i.e., allyl-modified calix[4]resorcinarenes, through in silico studies as HER2 inhibitors using molecular docking studies. Prospective protein-ligand complexes for HER2 inhibition were further investigated by molecular dynamics simulations for 200 ns on different binding pockets. The allyloxycalix[4]resorcinarene derivative (5A) was identified as the most potential HER2 inhibitor through a computational approach, including molecular docking studies and molecular dynamics simulations. The HER2-5A complex was relatively stable during the 200 ns molecular dynamics run. In addition, the hydrogen bonds formed between blind docking and molecular dynamics simulations are almost unchanged for the HER2-5A complex. The HER2-5A formed with two crucial amino acid residues, i.e., Asp845 and Asn850. Moreover, the data of the molecular dynamics simulations of compounds 5A and 2A demonstrate the stability of both complexes in different binding sites of HER2. These computational results are preliminary data for further synthesis and in vitro evaluation.
Design of Hydroxyxanthone Derivatives as Breast Cancer Inhibitors: A QSAR Modeling, Molecular Docking, Molecular Dynamics, MM-PBSA and ADMET Prediction Fatmasari, Nela; Hermawan, Faris; Jumina, Jumina; Kurniawan, Yehezkiel Steven; Pranowo, Harno Dwi; Puspitasari, Anita Dwi; Hastuti, Lathifah Puji; Marlina, Lala Adetia; Putra, Nicky Rahmana
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.283

Abstract

A comprehensive QSAR analysis, in conjunction with molecular docking, molecular dynamics simulations, MM-PBSA binding energy estimations, and ADMET profiling, was conducted to facilitate the development of novel anticancer agents based on hydroxyxanthone derivatives. Molecular and electronic descriptors were calculated using the DFT method with the 3-21G basis set. The best QSAR model identified several descriptors that significantly influence anticancer activity, including the atomic charges at positions C1, C3, C4a, and C7, as well as the highest occupied molecular orbital (HOMO), surface area (SA), molecular volume (VOL), and molecular weight (MW). This model was used to design novel hydroxyxanthone derivatives (X27 to X47). The docking result showed that compounds 7-bromo-3-hydroxy-1-(methylamino)-9H-xanthen-9-one (X43), 6-hydroxy-8-(methylamino)-9-oxo-9H-xanthene-2-carbonitrile (X44), and 3-hydroxy-7-mercapto-1-(methylamino)-9H-xanthen-9-one (X45) had stronger binding energy values than gefitinib as a native ligand. Gefitinib had a binding energy of -6.84 kcal/mol, while those compounds had values of -6.92, -7.12, and -6.92 kcal/mol, respectively. In a molecular dynamics simulation of 100 ns, compounds X43, X44, and X45 exhibited stability comparable to that of gefitinib against the EGFR protein. Additionally, the binding energy MM-PBSA of compound X43 was the lowest (-29.18 kcal/mol), followed by X44 (-27.11 kcal/mol), gefitinib (-26.06 kcal/mol), and X45 (-25.21 kcal/mol). Furthermore, these compounds met Lipinski's rule parameters and the minimal standard parameters in terms of ADMET characteristics, as predicted by physicochemical properties. In conclusion, compounds X43, X44, and X45 are potential anticancer agents for MDA-MB-231 breast cancer cells.
Co-Authors Abdul Karim Zulkarnain Adhi Dwi Hatmanto Adhiwibawa, Marcelinus Alfasisurya Setya Agus Dwi Ananto, Agus Agustinus Winarno Ahmad Bikharudin Alfanaar, Rokiy Amrulloh, Hanif Anggit Fitria Anggraeni, Putri Dian Anita Dwi Puspitasari Arif Cahyo Imawan Arif Cahyo Imawan Awalul Fatiqin Bambang Purwono Chairil Anwar Christyowati Primi Sagita Citrariana, Shesanthi Danny Nur Wahyu Hidayat Diah Kartika Sari Dita Ariyanti Dwi Rahmasari Fatmawati Dwi Siswanta Dyah Iswantini Edi Setiyono Ervan Yudha Ervan Yudha Eti Nurwening Sholikhah Eti Nurwening Sholikhah Eti Nurwening Sholikhah Eti Nurwening Sholikhah Fahmi, Muhammad Riza Ghulam Faris Hermawan Faris Hermawan, Faris Fatimi, Hana Anisa Fatmasari, Nela Fitria, Anggit Gerry Nugraha Ghozali, Ali Aulia Hana Anisa Fatimi Harizal Harizal Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Hefni Effendi Hendra Hendra Hendrik Oktendy Lintang Hidetaka Kawakita Iksen Iksen Indriana Kartini Jeffry Julianus Johan Syafri Mahathir Ahmad Joko Waluyo Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Kasta Gurning Keisuke Ohto Keisuke Ohto Kesuma, Ruth Febriana Kevin Thomas Krisfian Tata Aneka Priyangga Krisfian Tata Aneka Priyangga Krisfian Tata Aneka Priyangga Krisfian Tata Aneka Priyangga Krisfian Tata Aneka Priyangga Langit Cahya Adi Lathifah Puji Hastuti Leny Yuliati Limpat Nulandaya Lintang, Hendrik Oktendy Marlina, Lala Adetia Masatoshi Maeki Masaya Miyazaki Mizuki Ryu Muhammad Fernadi Lukman Muhammad Idham Darussalam Mardjan Mu’afa Purwa Arsana Nela Fatmasari Nela Fatmasari Nisa, Siti Astika Novik Nurhidayat Nursofia, Baiq Ike Philip Anggo Krisbiantoro Priastomo, Yoga Priyangga, Krisfian Tata Aneka Purnomo, Tantyo Ardy Bintoro Purwantiningsih Sugita Putra, Nicky Rahmana Rahman, Sudarman Ramachandra Rao Sathuluri Rizky Riyami Putri Rizky Riyami Putri Rokiy Alfanaar Shintaro Morisada Tantiana Indriani Thathit Suprayogi Triyono Triyono Tutik Dwi Wahyuningsih Tutik Dwi Wahyuningsih Tutik Dwi Wahyuningsih Vina Aida Roza Wataru Iwasaki Wibowo, Susalit Setya Yahya Febrianto Yudha Ramanda Yudha, Ervan