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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Biotropika Jurnal Jamu Indonesia Jurnal Biosense Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Maximus: Journal of Biological and Life Sciences Indonesian Journal of Jamu
Fatriani, Rizka
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Integrated Metabolite Profiling and Network Pharmacology Reveal the Multitarget Therapeutic Potential of Curcuma amada Rhizome Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur
Biotropika: Journal of Tropical Biology Vol. 14 No. 1 (2026)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Curcuma amada Roxb. (mango ginger) is a medicinal plant traditionally known for its antioxidant, anti-inflammatory, and anticancer effects, however, the underlying molecular mechanisms are not fully understood. In this study, we combined metabolite profiling with in silico analysis (network pharmacology and molecular docking) to understand the bioactivity of C. amada. Gas chromatography-mass spectrometry (GC-MS) revealed a diverse metabolite composition with fifty-two compounds detected in the ethanol extract. Target prediction of the compounds was performed using SwissTargetPrediction, BindingDB, and ChEMBL. Hub genes were identified using Maximum Clique Centrality (MCC), which identified ESR1, PPARG, and NR3C1 as the main hub genes. Enrichment analysis showed a strong association with cancer-related pathways, particularly the PI3K–Akt signalling, endocrine resistance, and cell senescence pathways, as well as the biological processes regulating apoptosis, stress response, and intracellular signalling. Molecular docking studies of PPARG and ESR1 showed that the metabolites retinal, coronarin E, and 1H-cycloprop[e]azulene derivatives had stable binding affinities and interacted with residues in the ligand-binding domain (LBD) of the target proteins. Our findings suggest that C. amada exerts therapeutic effects through multiple mechanisms. Not a single molecule or pathway, but a coordinated network of metabolites acting on multiple targets. This integrative approach provides a scientific basis for the traditional use of C. amada and highlights its potential as a promising resource for drug discovery, particularly in the field of cancer therapy.
Co-Authors Andriani, Silvia Aniesti, Frigia Rafilia Anisa, Hida Arliani Nur Annisa Annisa Arief, Barieq Farial Putra Astuti, Ayu Widia Balqis, Putri Azzahara Cindy Larasati, Cindy Desi Budiono Fajri Arif Wibawa Ferdinanda, Thierry Gres Maretta, Gres Hariyandi, Yopi Haryandi, Yopi I MADE ARTIKA Iffa Afiqa Khairani Insani, Fahma Alifia Jalloh, Mohammed A. Khaerunissa Anbar Istiadi LAKSMI AMBARSARI Mala Nurilmala Muhammad Fahrury Romdendine Nugraheni, Latif Sofiana Qiswatun Mukhoyyaroh Riana, Elisa Nurma Rini Anggi Arista Siti Nurjanah Utami, Noviani Wisnu Ananta Kusuma