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All Journal Agroprimatech Jurnal Prima Medika Sains Jurnal Ners PRIMER (Prima Medical Journal) Buletin Kedokteran dan Kesehatan Prima PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Vitamin: Jurnal Ilmu Kesehatan Umum Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal of Pharmascience
Finna Piska
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Uji Aktivitas Ekstrak Daun Salam (Syzygium Polyanthum) terhadap Bakteri Pseudomonas Aeruginosa Secara In Vitro Tice Lestari Ndruru; Muhammad Yunus; Finna Piska
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.180

Abstract

Pseudomonas aeruginosa merupakan bakteri patogen oportunistik yang sering menginfeksi luka kronis pada penderita diabetes melitus dan memiliki tingkat resistensi antibiotik yang tinggi. Daun salam (Syzygium polyanthum) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak daun salam terhadap Pseudomonas aeruginosa secara in vitro serta menentukan konsentrasi ekstrak yang paling efektif. Penelitian ini merupakan penelitian eksperimental laboratorium dengan metode difusi cakram (Kirby-Bauer) menggunakan ekstrak daun salam hasil maserasi etanol 96% pada konsentrasi 2,5%, 5%, 10%, 15%, 20%, dan 25%, dengan amoksisilin sebagai kontrol positif dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ekstrak daun salam memiliki aktivitas antibakteri yang ditandai dengan terbentuknya zona hambat pada seluruh konsentrasi uji, dengan daya hambat yang meningkat seiring peningkatan konsentrasi dan zona hambat terbesar pada konsentrasi 25%, meskipun masih lebih rendah dibandingkan kontrol positif.
Antioxidant Activity Assessment and Profiling of Total Phenolic and Flavonoid Contents in Bay Leaf Extract (Syzygium polyanthum Folium) Hutagaol, Cindy Jesika; Yunus, Muhammad; Piska, Finna
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 4 No. 02 (2026): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v4i02.152

Abstract

Bay leaf (Syzygium polyanthum (Wight) Walp.) is a traditional medicinal plant containing phenolic and flavonoid compounds with potential antioxidant properties. Free radicals contribute to various degenerative diseases, highlighting the need for safe and effective natural antioxidants. This study aimed to evaluate the antioxidant activity of ethanolic extract of bay leaves using the DPPH method and to determine its total phenolic and flavonoid contents. This experimental laboratory study employed maceration extraction using 96% ethanol. Antioxidant activity was assessed by the DPPH radical scavenging assay at 517 nm and expressed as IC₅₀ value. Total phenolic content was determined using the Folin–Ciocalteu method at 765 nm and expressed as mg gallic acid equivalents (GAE)/g extract, while total flavonoid content was measured using the AlCl₃ colorimetric method at 430 nm and expressed as mg quercetin equivalents (QE)/g extract. The results showed that the ethanolic extract exhibited a strong antioxidant activity with an IC₅₀ value of 33.43 ppm. The total flavonoid content was 14.4992 mg QE/g extract (1.4499%) with excellent linearity (r² = 0.99747), while the phenolic calibration curve showed good linearity (r² = 0.99045). In conclusion, the ethanolic extract of S. polyanthum leaves demonstrates strong antioxidant activity supported by its phenolic and flavonoid contents, indicating its potential as a natural antioxidant source.
Inhibisi Enzim α-Glukosidase oleh Bacillus Megaterium ITU 9 Isolat Sumber Air Panas Sumatera Utara Finna Piska; Chrismis Novalinda Ginting; Harmileni Harmileni; Edy Fachrial
Journal of Pharmascience Vol. 11 No. 1 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.17045

Abstract

Diabetes adalah penyakit multifaktor yang insidensinya meningkat dengan pesat di negara berkembang. Diabetes mellitus (DM) tipe 2 adalah jenis diabetes yang paling umum ditemui, dimana penyakit ini erat kaitannya dengan kemajuan industri dan teknologi sehingga mempengaruhi gaya hidup seseorang. Penanggulangan penyakit ini dapat dilakukan dengan menghambat aktivitas α-glukosidase. Beberapa mikroorganisme terutama dari sumber air panas dapat dimanfaatkan sebagai penghasil senyawa inhibitor α-glukosidase. Pada penelitian sebelumnya isolat Bacillus megaterium ITU 9 merupakan isolat yang diisolasi dari sumber air panas. Pada penelitian ini diuji kemampuan isolat Bacillus megaterium ITU 9 sebagai penghasil inhibitor α-glukosidase dengan metode sumur. Daya persen inhibisi supernatan B. megaterium ITU 9 terhadap kerja enzim α-glukosidase adalah sebesar 46,67%, sedangkan daya persen inhibisi acarbose yaitu 70%. Dalam hal ini B. megaterium ITU 9 termofilik memiliki daya inhibisi terhadap enzim α-glukosidase. Kata Kunci: Bakteri Termofilik, Inhibitor, Akarbose, Metode Sumur, Persen Inhibisi Diabetes is a multifactorial disease whose incidence is increasing rapidly in developing countries. Diabetes mellitus (DM) type 2 is the most common type of diabetes, where this disease is closely related to industrial and technological advances, thus affecting a person's lifestyle. This disease can be controlled by inhibiting α-glucosidase activity. Several microorganisms, especially from hot springs, can be used to produce α-glucosidase inhibitor compounds. In previous research, the Bacillus megaterium ITU 9 isolate was an isolate isolated from hot springs. In this study, the ability of the Bacillus megaterium ITU 9 isolate to produce α-glucosidase inhibitors was tested using the well method. The percent inhibition power of B. megaterium ITU 9 supernatant on the action of the α-glucosidase enzyme was 46.67%, while the percent inhibition power of acarbose was 70%. In this case, the thermophilic B. megaterium ITU 9 has inhibitory power against the α-glucosidase enzyme.
Co-Authors Astri Natalia Ginting Chrismis Novalinda Ginting Edy Fachrial Gadis Minanda Fauziah Purba Ginting, Chrismis Novalinda Harmileni Harmileni Harmileni Hutagaol, Cindy Jesika Hutauruk, Rico Halim Idaman Lase Jennie Try Varian Laoli Meutia , Rena Meutia, Rena Muhammad Yunus Muhammad Yunus Nainggolan , Intan Nerly Juli Pranita Simanjuntak Neswita, Elfia Novriani , Erida Nur Ariyani Agustina nurasni, nurasni Olivia Happy Novita Razoki Lubis Razoki Lubis Razoki, Razoki Reh Malem Br Karo Rico Halim Sati Agriani Zega Zega Septia, Evianti Dwi Simanjuntak, Nerly Juli Pranita Tesa, Catrin Angelica Putri Tice Lestari Ndruru Zega, Sati Angriani