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Parwanto, Edy
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Analysis of Pulmonary Function between E-Cigarette Users and Non-Smokers Aged 20–30 Years in Jakarta Digambiro, Reza Aditya; Parwanto, Edy; Tjahjadi, David; Ditriana, Ditriana
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.791

Abstract

Background: This study aimed to compare pulmonary function between e-cigarette users and non-smokers aged 20–30 years in Jakarta. Methods: A cross-sectional study was carried out between May 2023 and May 2024 at SMC Clinic Jakarta, Ibnusina Hospital Jakarta, and Naura Medika Clinic Depok. The sample consisted of 65 individuals who used e-cigarettes and 63 individuals who did not smoke. Spirometry was employed to evaluate pulmonary function by measuring forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The data were analyzed using independent t-tests using IBM SPSS software version 25.0. Results: The study revealed substantial disparities in pulmonary function between individuals who use e-cigarettes and those who do not smoke. Individuals who use e-cigarettes had significantly reduced FEV1 at 3.02±0.50 L and FVC at 4.00±0.47 L, in comparison to non-smokers (FEV1=3.51±0.57 L; FVC=4.57±0.50 L). E-cigarette users exhibited a considerably lower FEV1/FVC ratio (74.86±5.55) compared to non-smokers (79.29±5.11), suggesting a higher occurrence of obstructive airway diseases. Conclusion: Young adults aged 20-30 years in Jakarta who use e-cigarettes experience a decrease in pulmonary function. The results emphasize the possible respiratory hazards associated with the use of e-cigarettes and emphasize the necessity for greater awareness and regulatory actions to tackle these hazards.
D-dimer sebagai Biomarker Diagnostik Tuberkulosis Paru pada Efusi Pleura: Tinjauan Pustaka Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Parwanto, Edy
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1242

Abstract

Background: Tuberculosis (TB) remains a major health threat, especially in developing countries. Although the lungs are the most affected organ, systemic manifestations are quite significant. D-dimer, as one of the fibrin degradation products and also an indicator of coagulation activity, has been extensively researched for its predictive and diagnostic value in various diseases. This study aims to assess the effectiveness of D-dimer as a diagnostic biomarker for pulmonary tuberculosis (TB) in patients with pleural effusion compared to those with non-TB pleural effusion. Methods: The study was conducted as an observational case-control on 64 patients with pulmonary TB with pleural effusion were compared to 64 non-TB subjects with pleural effusion. Result: In the TB patient group, 62.5% of patients were smokers, 46.9% of patients had been exposed to TB. Patients were assessed based on the TB symptom scale and with radiological lung examinations, either x-rays or CT scans. D-dimer levels were correlated with the TB severity. D-dimer levels above the threshold value were significantly higher in patients with severe TB symptoms. Conclusion: A direct correlation was observed between the size of radiological lung lesions and D-dimer levels. The average D-dimer level in the control group was 220 ± 60 ng/mL, which increased to 450 ± 90 ng/mL in TB patients with severe lesions.
Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Abstract

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values ​​of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia
Edukasi Pencegahan Kanker Serviks Bagi Ibu PKK Jakarta Utara: Menyambut Bulan Kesadaran Kesehatan Reproduksi Digambiro, Reza Aditya; Parwanto, Edy; Setyaningrum, Dyah Ayu Woro; Chendrasari, Julian; Ilona, Florinda; Lestari, Indah Widya; Hastuty , Dewi
Jurnal Pengabdian Masyarakat Mandira Cendikia Vol. 3 No. 9 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kanker serviks merupakan masalah kesehatan yang signifikan di Indonesia dengan prevalensi tinggi. Edukasi pencegahan kanker serviks melalui deteksi dini dan vaksinasi HPV penting untuk menurunkan angka kejadian dan kematian akibat kanker ini. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran Ibu-Ibu PKK di Jakarta Utara mengenai pencegahan kanker serviks. Mitra pengabdian adalah Pemerintah Kotamadya Jakarta Utara dan Klinik SMC. Metode yang digunakan adalah presentasi interaktif dan simulasi, diikuti dengan diskusi dan evaluasi pre-test serta post-test untuk mengukur perubahan pengetahuan dan sikap. Hasil menunjukkan peningkatan signifikan pada pemahaman peserta, di mana 70% peserta siap melakukan Pap smear dan 55% siap untuk vaksinasi HPV. Hambatan yang ditemukan adalah waktu pelaksanaan yang terbatas dan masih adanya resistensi terhadap vaksinasi. Edukasi berkelanjutan dan peningkatan akses layanan kesehatan disarankan untuk meningkatkan keberhasilan program di masa mendatang
Co-Authors Alfred Pakpahan, Alfred Bernando Rajagukguk, James Chendrasari, Julian David Tjahjadi, David David Tjahyadi Ditriana, Ditriana Djebli, Noureddine Dwi Susanti, Alvina Gabrielle, Laurentia Ganeca Widyatama, Haryo Hairunisa, Nany Hariyanto, Yuanita Amalia Hastuty , Dewi Hosea Jaya Edy Husnun Amalia Ilona, Florinda Jaya Edy, Hosea Kusumaningrum, Dietha Larang Asri, Inaya Lestari, Indah Widya Marsiati, Himmi Mela Safitri, Mesty Monica Dwi Hartanti, Monica Dwi Oladimeji, Ashaolu Victoria Restu Syamsul Hadi Reza Aditya Digambiro Sembiring, Rinawati Setianingrum, Dyah Ayu Woro Setyaningrum, Dyah Ayu Woro Sisca Sisca, Sisca Sri Sudewi, Sri Tjahyadi, Joey Joshua Vidova Xavierees, Endrico