Article Per Year (5 Year)
p-Index From 2021 - 2026
2.203
P-Index
This Author published in this journals
All Journal Damianus Journal of Medicine Jurnal Manajemen Kesehatan Indonesia The Indonesian Biomedical Journal Jurnal Kesehatan Interdental Jurnal Kedokteran Gigi (IJKG) Journal of Urban Health Research Jurnal Kedokteran Meditek Journal of Medicine and Health Cermin Dunia Kedokteran Jurnal Kesehatan Masyarakat
Lonah, Lonah
Department Of Pharmacology, School Of Medicine And Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jl. Pluit Raya No 2, Jakarta 14440
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Hubungan Keaktifan Berorganisasi Terhadap Tingkat Self-esteem Mahasiswa Kedokteran Tingkat Preklinik Hendrik, Antonia J; Budiyanti, Ecie; Santosa, Mariani; Lonah
Journal of Medicine and Health Vol 7 No 1 (2025)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v7i1.8822

Abstract

Self-esteem berperan penting dalam mempertahankan identitas dan rasa harga diri seseorang yang membantunya untuk berkembang serta juga berperan dalam menjaga pandangan positif terhadap diri sendiri dan meningkatkan empati bagi mahasiswa kedokteran yang merupakan calon dokter. Rendahnya self-esteem berdampak buruk bagi kesehatan jiwa dan menghambat seseorang untuk berkembang. Manfaat yang didapatkan dari aktif berorganisasi dipandang berkaitan erat dengan self-esteem. Studi yang membahas hubungan antara keaktifan berorganisasi dan self-esteem pada mahasiswa kedokteran masih terbatas. Penelitian ini bertujuan untuk melihat hubungan antara kedua variabel tersebut pada mahasiswa kedokteran. Penelitian dengan desain cross-sectional pada 106 mahasiswa preklinik Fakultas Kedokteran dan Ilmu Kesehatan Atma Jaya (FKIK UAJ) angkatan 2021-2022. Alat ukur berupa kuesioner keaktifan berorganisasi oleh Rahmawati (2020) dan Rosenberg Self-esteem Scale (RSES). Analisis data menggunakan uji Kruskal-Wallis. Skor kuesioner keaktifan berorganisasi pada responden memiliki nilai median cukup tinggi (61,0) dan mayoritas tergolong memiliki tingkat self-esteem sedang (75,5%). Analisis data Kruskal-Wallis menunjukkan adanya hubungan signifikan antara keaktifan berorganisasi terhadap tingkat self-esteem pada mahasiswa (p=0,007). Simpulan penelitian ini menyatakan adanya hubungan signifikan antara keaktifan berorganisasi terhadap tingkat self-esteem mahasiswa preklinik FKIK UAJ.
Hubungan Perilaku Konsumsi Makanan Cepat Saji terhadap Tingkat Keparahan Akne Vulgaris pada Mahasiswa Laki-Laki: Hasil Penelitian Santosa, Mariani; Anastasia, Cindy; Lonah; Yuliana; Yantho, Erwin; Budiyanti, Ecie
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1291

Abstract

Introduction: Acne vulgaris has the highest prevalent skin disease in the world, with food is one of the most common triggers in adolescents. Availability of fast food has influenced young adults eating pattern. This study aims to determine the relationship between frequency of fast food consumption and severity of acne vulgaris in male students. Methods: This cross-sectional study was conducted on 129 male students. Frequency of fast food consumption and severity of acne vulgaris was measured using a modified FFQ questionnaire and GAGS score. Data were processed with STATA and analyzed using Chi-square. Results: The result showed that 65.89% male students often consumed fast food and the majority of respondents experienced mild acne vulgaris (55.81%). There was a significant relationship between frequency of fast food consumption and severity of acne vulgaris (p=0.020). Conclusion: The results of this study suggest a significant relationship between frequency of fast food consumption and severity of acne vulgaris among male students.
Transcriptional Regulation of CYP2D6 by Nrf2 and Its Implications in Breast Cancer Therapy: Bioinformatics and Experimental Evidence Ferbian Milas Siswanto; Maria Dara Novi Handayani; Lonah Lonah; Rita Dewi; Zita Arieselia; Linawati Hananta; Putu Suwarastra Andarisuta
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3194

Abstract

BACKGROUND: Tamoxifen (TAM) resistance in patient with breast cancer is the leading cause of mortality among women globally. Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of TAM, and recently NF-E2-related factor 2 (Nrf2) has recently been found as its regulator. However, the impact of Nrf2-mediated CYP2D6 regulation in the context of breast cancer and TAM resistance are currently unknown. Therefore, this study was conducted to examine the role of CYP2D6 and Nrf2 in breast cancer prognosis. MEDTHODS: The roles of CYP2D6 and Nrf2 were investigated in the T47D breast cancer cell line and T47D-derived TAM-resistant cells by examining the gene expression, cell viability, and transcriptional regulation by quantitative reverse transcription polymerase chain reaction (qRT-PCR), MTT, and reporter gene assay, respectively. Additionally, comprehensive in silico analysis of the transcriptomic and clinical data from The Cancer Genome Atlas database were performed to uncover the prognostic role of CYP2D6 and its regulator in breast cancer patients. RESULTS: CYP2D6 mRNA was low and Nrf2 protein was high in TAM-resistant T47D cells compared to parental cells. Nrf2 knockdown upregulated CYP2D6 mRNA levels and enhanced the cytotoxicity of TAM. Similarly, in silico analysis revealed that low CYP2D6 mRNA and high Nrf2 protein were related to a lower probability of survival. The rs1238662089 within the identified Nrf2-binding site was found to greatly affect CYP2D6 expression levels, indicating its role as predictor for better prognosis. CONCLUSION: This study revealed for the first time that Nrf2 regulates CYP2D6expression in breast cancer and is involved in TAM sensitivity; thus, plays a role in breast cancer patient prognosis.KEYWORDS: breast cancer, CYP2D6, Nrf2, pharmacoepigenetics, SNPs
Hubungan Kebisingan terhadap Gangguan Fungsi Pendengaran pada Karyawan Perusahaan X di Cikarang Tampubolon, Kiaranisa A C; Evans, Gunterus; Situmorang, Evi U M; Lonah, Lonah; Hadiyanto, Hadiyanto
Journal of Medicine and Health Vol 8 No 1 (2026)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v8i1.10756

Abstract

Excessive noise exposure can lead to permanent hearing damage over time. Noise-induced hearing loss (NIHL), caused by occupational noise exposure, is a common health issue. Many studies focus on occupational noise exposure that exceeds exposure limits; yet, few focus on the impact of exposure duration on hearing function. This study aims to analyze the relationship between the duration of noise exposure and loss of hearing function among employees of Company X. This cross-sectional study involved 61 employees of Company X. Company X is a multinational glass company that produces glass and glass ceramics, including syringes, eyeglasses, vials, and ampoules. Data was collected using a noise exposure characteristics questionnaire, a sound level meter for noise level measurement, and audiometry to assess hearing function. Subjects with a prior diagnosis of hearing disorders, hypertension, obesity, and those aged over 65 were excluded from this study. Audiometry results were grouped into categories, with 57 subjects (93.44%) categorized as “normal”, 3 subjects (4.92%) as “mild”, and 1 subject (1.64%) as “moderate”. Chi-square analysis with a P-value of 0.495 (>0.05) indicated that there is no statistically significant relationship between the duration of noise exposure and loss of hearing function among employees of Company X.
Co-Authors Anastasia, Cindy Andrew Liputra Budiyanti, Ecie Divara Ariesta Sekar Suryadi, Made Edward Surjono Edward Surjono, Edward Evans, Gunterus Evi Ulina Margaretha Situmorang Fan, Tan Fei Fenny Mariska Ferbian Milas Siswanto Freggy Spicano Joprang Hadiyanto Hadiyanto Halilintar, Via Dolorosa Hendrik, Antonia J Irawan, Robi Jennifer Jhonvini, Lessya Jonny Setiawan Jonny Setiawan Jonny Setiawan Jonny Setiawan Kurniawan, Sandy Vitria Latumahina, Cleo Michaela Laurentius Aswin Pramono Lauwly, Edlyn Edrea Lieputra, Andrew Adhytia Linawati Hananta Linawati Hananta, Linawati Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Meiliyana Wijaya Monalisa Heryani Muhaji, J. Antonio Nathaniel, Bryan Oktaria, Indriani Prayoga Tjendratama, Jason Pujiyanto Pujiyanto Puspa Bunardi, Dewi Putu Suwarastra Andarisuta Rita Dewi Rita Dewi Rita Dewi Rita Dewi Dewi Situmorang, Evi U M Tampubolon, Kiaranisa A C Vallerie Satyadi, Richelle Via Dolorosa Halilintar Wijaya, Meiliyana Yantho, Erwin Yuliana Yuliana Zita Arieselia