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All Journal JURNAL FARMASIMED (JFM) Fakumi Medical Journal The Indonesian Journal of General Medicine KREATIF: Jurnal Pengabdian Masyarakat Nusantara
Irna Diyana Kartika Kamaluddin
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Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Veterinary

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Journal : JURNAL FARMASIMED (JFM)

 1 
Antibacterial Activity Test of 96% Ethanol Extract of Red Ginger (Zingiber officinale var. rubrum) Against the Growth of StreptococcusPneumoniae Bacteria Harry Nugraha Bachtiar; Irna Diyana Kartika Kamaluddin; Iin Widya Ningsi; Adriani; Dwi Anggita
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6z84gr80

Abstract

Abstract Background: Pneumonia is an infectious disease with a high global prevalence that contributes significantly to mortality in children and adults. Red ginger (Zingiber officinale var. rubrum), a traditional Indonesian medicinal plant, has been identified as having antibacterial, antioxidant, and anti-inflammatory properties. Some of its natural constituents, such as flavonoids, have shown antimicrobial activity with a low toxicity profile. Therefore, the phytochemical content in red ginger is assumed to be able to combat Streptococcus pneumoniae bacteria, which is one of the main etiologies of Pneumonia. Objective: Evaluating the potential of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an antimicrobial agent in inhibiting the growth of Streptococcus pneumoniae bacteria. Method: This study applied a true experimental approach with a post-test design to evaluate the effectiveness of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an agent that inhibits the growth of Streptococcus pneumoniae bacteria. The method used was the disc diffusion method (Kirby-Bauer). Results: The study showed that the ethanol extract of red ginger (Zingiber officinale var. rubrum) exhibited antibacterial activity; however, its effectiveness in inhibiting the growth of Streptococcus pneumoniae was not significant.Conclusion: The 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) demonstrated resistance, showing only minimal inhibitory activity against Streptococcus pneumoniae. This condition contrasts with the positive control, chloramphenicol, which produced a significant inhibition zone and was categorized as sensitive. Therefore, the effectiveness of red ginger extract in inhibiting the growth of this bacterium is considerably lower than that of chloramphenicol.
The Effectiveness of Red Ginger (Zingiber officinale var. rubrum) Extract Administration on Weight Reduction in Obese Mice (Mus musculus) Muhammad Erlangga Dewantara djoharam; Andi Alamanda Irwan; Asrini Safitri; Sigit Dwi Pramono; Irna Diyana Kartika Kamaluddin
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d4pdxz92

Abstract

Background: Obesity is a complex condition influenced by various factors, including an imbalance between caloric intake and energy expenditure. Red ginger contains bioactive compounds such as gingerol, flavonoids, and essential oils that have the potential to reduce body weight through mechanisms related to fat metabolism regulation and anti-inflammatory activity. However, studies on the effectiveness of red ginger in reducing body weight in obese mice (Mus musculus) are still limited, thus further research is needed to confirm its benefits. Objective: To evaluate the effectiveness of red ginger extract in reducing body weight in obese mice (Mus musculus). Methods: This study employed a true experimental research design with full control over research variables, allowing direct observation of cause-and-effect relationships. The treatment was administered to obese mice to determine the impact of red ginger extract on body weight reduction. Results: The results showed that red ginger extract was effective in reducing the body weight of obese mice. The bioactive compounds in red ginger act through anti-obesity mechanisms, particularly by regulating fat metabolism, indicating its potential use as a phytotherapeutic agent in managing obesity. Conclusion: Administration of red ginger extract (Zingiber officinale var. rubrum) proved effective in reducing the body weight of obese mice, evidenced by a significant difference between body weight before and after treatment, with greater weight reduction observed in the treatment groups compared to the control group.
Co-Authors Abdul Mubdi Ardiansar Adriani Andi Alamanda Irwan Anna Sari Dewi Asrini Safitri Astra Budiati Nusrat Berry Erida Hasbi Dwi Anggita Faizul A Harry Nugraha Bachtiar Ida Royani Iin Widya Ningsi Indah Lestari Daeng Kanang Irmayanti Haidir Bima M. Hamsah Mohammad Reza Zainal Abidin Mufthiar Muhtar Muhammad Erlangga Dewantara djoharam Muhammad Fauzul Azhim Muhammad Irsan Muflih Mundzir Mustari, Ikhsanul Fauzi Nadila Ardyani Nahardi Nasrudin Andi Mappaware Nevi sulvita karsa Nurfadhillah Khalid Prema Hapsari Rizky Nurhumairah Sarifuddin Sidrah Darma Sigit Dwi Pramono Sri Julyani Waode Inayatu Zahra Khairunnufus Wawan Susilo Wulan Purnamasyani S Zulfikri Khalil Novriansyah