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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Notions Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Journal of Islamic Medicine An-Nadaa: Jurnal Kesehatan Masyarakat MAHESA : Malahayati Health Student Journal Al-Mutsla: Jurnal Ilmu-Ilmu Keislaman dan Kemasyarakatan Folia Medica Indonesiana
Samirah Samirah, Samirah
Departemen Farmasi Praktis, Fakultas Farmasi, Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effectiveness of Injectable Alendronat for Bone Defect due to Osteoporosis Aniek Setiya Budiatin; Cantika Suci Adlina Lasandara; Junaidi Khotib; Samirah Samirah
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.692 KB) | DOI: 10.33846/hn.v3i1.291

Abstract

Alendronate is a drug of the bisphosphonate group used for the treatment and prevention of osteoporosis in postmenopausal women. However, when given orally, alendronate can cause indigestion and osteonecrosis of the jaw. It also has a poor bioavailability. Taking these disadvantages into account, an injection formulation of alendronate was created in this study to act on the site locally. Beside alendronate, the injection also contains bovine hydroxyapatite and gelatin as alendronate carriers. Both, besides being able to act as carriers, are also able to reduce bone damage caused by osteoporosis. The aim of this study was to determine the effectiveness of alendronate injection for fractures caused by osteoporosis in mouse models that were ovariectomized. The parameters used in this study were ALP concentration in blood and bone radiology. The results of ALP concentration showed that there were no significant differences in each group. The average ALP concentration of the negative control group was 277.67 ± 46.090, in the positive control group 270.33 ± 189.716, in the BHA-Gel group 406.33 ± 212.547 and in the BHA-Gel Alendronate group 325.00 ± 73.750. Bone radiology results and macroscopic observations still showed bone defects in each group.Yet in the negative control group, the BHAGel-Alendronate group and the BHA-Gel group, bone defects were almost entirely ameliorated. On the contrary, bone defects were still present in the positive control group. Based on the results obtained, it was shown that the injection of alendronate has not been shown to significantly overcome osteoporosis fractures. Keywords: Osteoporosis, Alendronate, Ovariectomy, Bovine hydroxyapatite, Gelatin
Injektabel Komposit Hydroksiapatit-Gelatin sebagai Sistem Penghantaran Alendronat Aniek Setiya Budiatin; Junaidi Khotib; Didik Hasmono; Samirah Samirah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.226 KB) | DOI: 10.20473/jfiki.v3i12016.1-6

Abstract

Background: Bisphosphonates, such as alendronate (ALE), have been known to be effective in the treatment of bone cancer and osteoporosis. However, it has been reported that the systemic administration of ALE causes a considerable side effect. Thus, the formulation injectable bone substitute (IBS) for local administration of ALE, which functions as drug delivery system (DDS) as well as filling agent in osteoporosis-induced bone fracture, is needed. Objective: To establish the biodegradable and biocompatible formulation for ALE in injectable form which supports the drug delivery system and acts as filling agent in bone fracture. Methods: Hydroxyapatite (HA) was added to the mixture of gelatin and hydroxypropyl methyl cellulose (GEL-HPMC). ALE was added to the mixture and semisolid form was prepared for granulation. The dried granule, as injectable matrix, was grinded and mixed with appropriate amount of Na2HPO4. Results: Porosity of injectable form was higher than those of granule form. Injectable semisolid form was produced by adding 0.8 mL Na2HPO4 on each gram of granule with 10-12 min setting time. MTT assay showed that matrix was biocompatible showed by more than 100% viability. In vitro dissolution study showed that ALE was slowly released in more than 20 days. Conclusions: The formula of IBS using HA-GEL-HPMC may act as an effective drug delivery system for local administration of ALE in bone fracture.
Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia) Mareta Rindang Andarsari; Didik Hasmono; Samirah Samirah; Suharjono Suharjono; Dea Ayu Nabilah; Paulus Sugianto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 4 No. 2 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.691 KB) | DOI: 10.20473/jfiki.v4i22017.80-83

Abstract

Background: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage become crucial to reduce morbidity and mortality. Objective: This study was aimed to assess the use of antibiotics, prescribed for patients with bacterial meningitis in Neurology Department of Dr. Soetomo General Hospital Surabaya from January 2010 until June 2015. Methods: Retrospective study using medical record of inpatients obtained from January 1st 2010 until June 30th 2015. The inclusion criteria were inpatients with bacterial meningitis (diagnosed by physician using CT scan data, lumbal puncture and clinical signs and symptoms) and prescribed with antibiotics. Patients with antibiotics therapy less than 3 days and infection other than bacterials were excluded. Results: From 85 patients, male to female ratio was 1.66. Meningitis appear to be mostly occured in productive age, 39 (45.88%) in 15 - 29 years old and 40 (47.06%) in 30 - 60 years old. Number of antibiotics prescribed were 130 prescriptions, as single and combination therapy. The most prescribed antibiotic was cephalosporins (97 prescriptions), dominated by 2 g twice daily ceftriaxone with 86 (66.15%) from overall prescriptions. Followed by metronidazole and fluoroquinolons,11 (8.46%) and 8 (6.15%) respectively. In addition, there were 26 prescriptions of combination therapy, mostly ceftriaxone and metronidazole. Conclusion: Bacterial meningitis are mostly treated using ceftriaxone which is an appropriate drug of choice.
The Assessment of Patient Safety Culture Among Doctors, Nurses, and Pharmacists in a Public Hospital in Indonesia Baiq Khuwailidia Kartikasari; Samirah Samirah; Elida Zairina, S.Si., MPH., Ph.D., Apt.
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.83575

Abstract

Understanding the patient safety culture is one step toward improving patient safety. Patient safety culture is the main foundation of patient safety arrangements that aim to improve the quality of service of healthcare facilities by implementing risk management in all service areas. This study aimed to determine the cultural picture of patient safety among health workers in a public hospital in East Lombok. This study was observational and cross-sectional, using the Hospital Survey of Patient Safety Culture (HSOPSC) questionnaire from the Association of Health Care and Research Quality (AHRQ.) The population of this study was healthcare professionals (doctors, dentists, pharmacists, pharmaceutical technical personnel, nurses, and midwives) at Dr. R. Soedjono Selong Hospital in East Lombok. Descriptive and inferential statistics were used to adjust frequency distribution tables to identify variable relationship differences. The results analysis followed the guidelines from AHRQ, and univariate analysis was carried out. Among the 250 employees invited to participate, 238 (95.2%) completed the surveys. The dimension with the highest percentage of positive responses was an organizational learning-continuous improvement (91.3%), and the dimension with the lowest positive responses was staffing (42.5%). Generally, the patient safety culture in health workers at Dr. R. Soejono belongs to the strong culture (70.34%). Hospital management needs to improve and evaluate dimensions with a low positive response. Building a strong patient safety culture is essential to enhance the quality of service. Creating a positive safety culture for patients is unavoidable by taking steps that support all dimensions of the safety culture.
Effect of Fenofibrate as PPARα Agonist in Suppressing the Development of Oxaliplatin-Induced Peripheral Neuropathy via TRPA1 Modulation Alma Nuril Aliyah; Pingkan Aprilia; Anak Agung Sagung Dyah Pramesti; Tarisya Dinda Saraya; Galuh Laksatrisna Pide; I Nengah Budi Sumartha; Luke Wongso; Samirah; Mahardian Rahmadi; Muhammad Zaki Bin Ramli; Chrismawan Ardianto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.257-265

Abstract

Background: CIPN (Chemotherapy-induced Peripheral Neuropathy) primarily affects the sensory system and is accompanied by pain, autonomic dysfunction, and motor impairments. Alterations of intracellular second messengers at the supraspinal level in CIPN needed to be explored more. In addition, there is a lack of evidence regarding implications for the supraspinal area through the propagation of pain via the ascending pathway. Objective: In this study, we evaluated the effect of fenofibrate as a PPARα agonist in suppressing the development of CIPN. Methods: Twenty-four mice were distributed to the normal control group, neuropathy group, and neuropathy with the treatment of fenofibrate 75 and 150 mg/kg groups, resulting in 6 animals per group. Oxaliplatin was injected on days 0, 2, 4, and 6. The hot plate test was performed before the oxaliplatin administration and then continued on the 7th, 14th, and 21st days. Thalamus tissues were collected to measure the TRPA1 mRNA expression using qPCR. Results: Fenofibrate 75 mg/kg co-treatment with oxaliplatin tended to prevent the enhancement of oxaliplatin-induced thermal hyperalgesia in hind-paw withdrawal and rubbing responses. Furthermore, fenofibrate 75 and 150 mg/kg co-treatment with oxaliplatin significantly reduced the relative TRPA1 mRNA expression but did not modulate the relative BDNF mRNA expression in the thalamus. Conclusion: PPARα agonist has a potential effect in suppressing the development of CIPN. However, given the various perspectives on the role of neurotrophins in CIPN, additional non-clinical investigations, are needed to provide more insight into other mechanisms of CIPN and the role of PPAR agonists.
Profil Pengetahuan Penyakit Kanker Dan Dampak Bahan Berbahaya Di Lingkungan Masyarakat Pengrajin Sandal Mahardian R, Mahardian R; Ratri, Dinda Monika Nusantara; Yusfar, Yunarti; Samirah, Samirah; Chrismawan A, Chrismawan A; Suharjono, Suharjono
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 10, No 2 (2023): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v10i2.9801

Abstract

Penelitian ini menunjukkan pemahaman dan sikap peserta sudah baik mengenai penyakit kanker, pencegahan kanker dan dampak cemaran bahan berbahaya yang mempengaruhi kesehatan. Namun, masih terdapat masyarakat yang menunjukkan  dari peserta perlu meningkatkan pengetahuan mereka tentang pola hidup sehat, pola hidup sehat untuk mencegah kanker dan dampak cemaran serta bahan – bahan yang mencemari lingkungan
Aktivitas Anti Trombotik dari Genus Curcuma : Kajian Sistematik Sandhori, Fajar Jamaluddin; Kusumawati, Idha; Samirah, Samirah; Rullyansyah, Subhan; Ramadhani, Firmansyah Ardian; Prasetyawan, Hanif Rifqi; Warsito, Mega Ferdina
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.25929

Abstract

Background : The Curcuma genus has various pharmacological activities, one of these is antithrombotic activity by preventing thrombus formation. Some of its chemical contents are also known to inhibit thrombus formation including curcumin, bisdemethoxycurcumin, ar-turmerone, and xanthorrizhol compounds. Antithrombotic drugs are used for the prevention and treatment of thrombosis whose mechanisms are divided into anticoagulants, thrombolytics, and antiplatelets. Objective: This review article discusses the potential of Curcuma genus as antithrombotic, including anticoagulant, antiplatelet, and thrombolytic, Methods: This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method using four databases : PubMed, ScienceDirect, Scopus, and Google Scholar from July to December 2023. The inclusion criteria used were articles on antithrombotic activity, including anticoagulants, antiplatelets, and thrombolytics from the genus Curcuma. Results: The number of articles obtained from four databases was 3413 articles. Furthermore, based on the results of filtering duplicate articles from all databases, 2771 articles were selected and then continued with screening based on inclusion and exclusion criteria until 15 articles were selected as material for systematic review. Conclusion: Curcuma species that have potential as antithrombotic are Curcuma longa, Curcuma zedoaria Rosc., Curcuma amada, Curcuma caesia, Curcuma aeruginosa, Curcuma latifolia, Curcuma aromatica Salisb, Curcuma wenyujin, and Curcuma xanthorrhiza
Recruiting in Labor Markets Samirah, Samirah; Wijaya, Meliana Esmiralda; Wijaya, Rika Dwi Ayu Parmitasari; Wijaya, Alim Syariati
AL-MUTSLA Vol. 7 No. 1 (2025): Jurnal Al Mutsla
Publisher : STAIN MAJENE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46870/jstain.v7i1.1640

Abstract

Proses rekrutmen yang efektif merupakan fondasi bagi keberhasilan manajemen sumber daya manusia dalam suatu organisasi. Penelitian ini membahas berbagai faktor yang berkontribusi terhadap efektivitas rekrutmen, termasuk pentingnya employer branding, proses onboarding yang baik, penggunaan teknologi dalam perekrutan, dan metode wawancara yang tepat. Pemasaran employer branding yang kuat dapat menarik lebih banyak kandidat berkualitas, sementara pengalaman positif selama proses onboarding berpengaruh signifikan terhadap retensi karyawan. Dengan penerapan teknologi, perusahaan dapat memperluas jangkauan pencarian talenta serta meningkatkan efisiensi dalam menemukan kandidat yang sesuai. Selain itu, pendekatan wawancara yang tepat memainkan peran sentral dalam menentukan kecocokan kandidat terhadap posisi yang ditawarkan. Penelitian ini menekankan perlunya strategi terintegrasi dalam proses rekrutmen untuk mencapai hasil yang optimal bagi perusahaan.
Do We Need Supplements? Puspitasari, Arina Dery; Samirah, Samirah; Asmad, Asma; Widyasari, Sekar Arum; Afrilla, Dian; Hakim, Lukman Nul; Mawaddah, Midfa'ul Haawan Fitayaatin; Leliga, Fenny Kusuma; Yusfar, Yunarti; Oktavia, Maria
MAHESA : Malahayati Health Student Journal Vol 5, No 2 (2025): Volume 5 Nomor 2 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i2.16684

Abstract

ABSTRACT Dietary supplements are produced in capsules, tablets, pills, and other similar forms, which are designed to be consumed as a dietary supplement. Most people today are aware of the role of nutrition in health, and they take supplements to improve the quality of their health, prevent diseases, supplement their diet, and boost their immunity. This study aims to analyze the knowledge of pharmacy students throughout Indonesia regarding the correct use of supplements. This study uses descriptive studies and administration of study instruments with a cross-sectional approach. The study instrument was a questionnaire with 10 questions. This study was conducted at Tanjung Pura University Pontianak in September 2023. The sampling method was random sampling with an accidental sampling technique. The number of samples collected for this study was 140 respondents. Almost all respondents had taken supplements, (99%; n=138). Based on the knowledge assessment score obtained through the questionnaire, it was found that 87% of pharmacy students throughout Indonesia had good knowledge of the correct selection and use of supplements and as many as 13% of students had poor knowledge of the correct selection and use of supplements. As many as 87% of respondents already knew about how to choose/use supplements correctly. Keywords: Supplement, Nutrition, Multivitamin, Mineral
Acceleration of Bone Fracture Healing through the Use of Natural Bovine Hydroxyapatite Implant on Bone Defect Animal Model Khotib, Junaidi; Lasandara, Cantika SC; Samirah, Samirah; Budiatin, Aniek S
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.
Co-Authors Afrilla, Dian Alim Syariati Alma Nuril Aliyah Anak Agung Sagung Dyah Pramesti Aniek S Budiatin Arina Dery Puspitasari Arya Sigit K Asmad, Asma Baiq Khuwailidia Kartikasari Budiatin, Aniek Setiya Cantika SC Lasandara Cantika Suci Adlina Lasandara Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Didik Hasmono Dinda Monika Nusantara Ratri Elida Zairina Firmansyah Ardian Ramadhani Galuh Laksatrisna Pide I Nengah Budi Sumartha Idha Kusumawati Junaidi Khotib Lasandara, Cantika SC Leliga, Fenny Kusuma Luke Wongso Lukman Nul Hakim Mahardian R, Mahardian R Mahardian Rahmadi Mareta Rindang Andarsari Mawaddah, Midfa'ul Haawan Fitayaatin Muhammad Zaki Bin Ramli Naning Ni'mawati Nitralia Prameswari, Samirah, Nitralia Novita Arbianti Nur Palestin A Oktavia, Maria Paulus Sugianto Pingkan Aprilia Prasetyawan, Hanif Rifqi Rika Dwi Ayu Parmitasari Sandhori, Fajar Jamaluddin Subhan Rullyansyah Suharjono Tarisya Dinda Saraya Warsito, Mega Ferdina Widyasari, Sekar Arum Wijaya, Meliana Esmiralda Yusfar, Yunarti