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All Journal Jurnal Ilmu Pertanian Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Berkala Epidemiologi Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT Journal of Tropical Biodiversity and Biotechnology Jurnal Farmasi Sains dan Komunitas International Journal of Science and Applied Science: Conference Series ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Borneo Journal Of Pharmascientech Biodiversitas Journal of Biological Diversity
Heru Sasongko
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Potential Fish Oil as Acute Hepatitis Candidate by Hepatoprotective Mechanism: A-review Heru Sasongko; Muhammad Fiqri Zulpadly; Yeni Farida
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.68523

Abstract

Acute hepatitis is a health concern that emerged during the COVID-19 outbreak. Toxic drugs, infections, autoimmune diseases, and other causes may induce acute hepatitis, which is deadly. Acute hepatitis isn't treatable. Renewable natural products, such as fish, are used in complementary treatment. This paper mentions current preclinical and clinical studies of omega-3 fatty acids (N-3 FAs) for hepatoprotection. The mechanism of inhibition of oxidative stress and inflammation in the liver is the subject of discussion associated with its potential as a treatment for acute hepatitis. This review article on acute hepatitis treatment analyzed original articles, books, and other relevant material from the Web of Science, Scopus, and PubMed. The literature search was conducted in April-July 2022. The keywords explored during the literature investigation were "omega-3 or EPA or DHA or fish oil," "hepatoprotective," "acute hepatitis," "inflammatory", and "stress oxidative". The study's results show that N-3 FAs can protect against liver damage through inflammation and oxidative stress pathways. Enzyme parameters of liver damage, proinflammatory cytokines, and oxidative stress can be inhibited by the administration of fish oil and its derivatives. Even though not all clinical trial parameters are directly related to animal tests, the results of this study show that omega-3 fatty acids should be considered a treatment option for acute hepatitis.
Caesalpinia sappan Reduce Fever with An Anti-inflammatory and Antioxidant Mechanism: A Review Heru Sasongko; Delia Putri Hedianti; Listiyana Ika Safitri
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.79562

Abstract

Caesalpinia sappan L (Sappan wood) is an herbal plant that has long been trusted by the public as an herbal medicine for tuberculosis, diarrhea, dysentery, skin infections, anemia, and other diseases by utilizing the decoction of C.sappan. Sappan wood is an herbal plant widely used as a raw material for traditional medicinal products. Sappan wood has been reported to have substantial pharmacological effects in analgesic, antioxidant, antibacterial, anti-inflammatory, and anti-viral. Fever is a clinical manifestation of certain conditions or diseases characterized by increased body temperature above the normal range (36.5–37.5 °C). Many studies declare that antioxidant and anti-inflammatory activity in C.sappan reduces oxidative stress and pro-inflammatory cytokines. This literature review shows that the antioxidant and anti-inflammatory properties of C.sappan are linked to fever as a sign of illness. Literature review using the last ten years' Scopus, ScienceDirect, and Pubmed databases. There are as many as 20 journals regarding sappan wood's antioxidant and anti-inflammatory effects. Sappan wood has been shown to have an antioxidant effect by lowering reactive oxygen species levels via SOD, GPx, or CAT markers. It inhibits inflammation cytokines such as IL-1, IL-6, TNF-?, and INF produced during fever. Sappan wood also has an anti-inflammatory effect by inhibiting PGE2 production when someone has a fever. The findings of our review state that C.sappan can be used to treat fever for both of these reasons. The use of C.sappan as a component in producing traditional health beverages has potential.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Dian Eka Ermawati; Yavi Hanuriansyah; Nindita Clourisa Amaris Susanto; Sholichah Rochmani; Diyah Tri Utami; M. Fiqri Zulpadly; Heru Sasongko; Ulfa Afrinurfadhilah Darojati; Annisa Diyan Meitasari; Meta Kartika Untari
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Penguatan Resiliensi Anak Pekerja Migran Indonesia Tanpa Status Hukum Melalui Pelatihan Pengasuh di Harmony Home Anis Laela Megasari; Ika Subekti Wulandari; Heru Sasongko; Nindita Clourisa Amaris Susanto; Vivin Sulistyowati; Herliana Riska; Fiddin Yusfida A’la; Hanum Kartikasari; Muhamad Reznu Firsyawardana; Aan Andri Yano; Novi Ria Rahmawati; Hanif Maulana Tomera; Naswya Sausan Aqila Sausan
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 7 (2026): Volume 9 Nomor 7 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i7.26625

Abstract

ABSTRAK Anak pekerja migran Indonesia (PMI) tanpa status hukum di Taiwan merupakan kelompok rentan yang menghadapi tantangan multidimensional, meliputi pemisahan keluarga, ketidakpastian identitas, hambatan akses layanan dasar, dan stigma sosial. Kondisi ini berdampak langsung pada perkembangan psikososial dan kapasitas resiliensi anak. Pengasuh di lembaga perlindungan anak memegang peran strategis sebagai faktor pelindung utama, namun sebagian besar belum memiliki bekal pengetahuan dan keterampilan yang memadai dalam pengasuhan berbasis resiliensi. Kegiatan ini bertujuan meningkatkan pengetahuan dan keterampilan pengasuh Harmony Home Taiwan dalam mendukung penguatan resiliensi anak PMI tanpa status hukum. Kegiatan pengabdian kepada masyarakat internasional ini dilaksanakan secara hybrid pada Juni 2026 dalam bentuk pelatihan, melibatkan 21 pengasuh. Evaluasi dilakukan melalui pre-post-test. Terdapat peningkatan signifikan rata-rata skor pengetahuan pengasuh dari 58,35 (SD±8,42) menjadi 81,70 (SD±6,15) dengan selisih rerata 23,35 poin. Pelatihan pengasuh berbasis pendekatan holistik yang diselenggarakan secara hybrid terbukti efektif meningkatkan pengetahuan pengasuh dalam mendukung resiliensi anak PMI tanpa status hukum. Intervensi berbasis kapasitas pengasuh merupakan strategi yang feasible dan berdampak langsung dalam konteks lembaga perlindungan anak diaspora. Kata Kunci: Resiliensi Anak, Pengetahuan, Penguatan, Pelatihan Pengasuh, Taiwan ABSTRACT Children of Indonesian migrant workers (PMI) without legal status in Taiwan are a vulnerable group facing multidimensional challenges, including family separation, identity uncertainty, barriers to accessing basic services, and social stigma. These conditions directly impact children's psychosocial development and resilience capacity. Caregivers in child protection institutions play a strategic role as the main protective factor, but most do not have adequate knowledge and skills in resilience-based care. This activity aims to improve the knowledge and skills of Harmony Home Taiwan caregivers in supporting the strengthening of resilience of PMI children without legal status. This international community service activity was carried out in a hybrid manner in June 2026 in the form of training, involving 21 caregivers. Evaluation was carried out through a pre-post-test. There was a significant increase in the average knowledge score of caregivers from 58.35 (SD±8.42) to 81.70 (SD±6.15) with a mean difference of 23.35 points. Caregiver training based on a holistic approach conducted in a hybrid manner has been proven effective in improving caregivers' knowledge in supporting the resilience of PMI children without legal status. Caregiver capacity-based interventions are a feasible and immediately impactful strategy in the context of diaspora child protection agencies. Keywords: Child Resilience, Knowledge, Strengthening, Caregiver Training, Taiwan.
Morphological diversity of culturable cyanobacteria from habitats in Segara Anakan, Central Java, Indonesia SITI GIA SYAUQIYAH FITRI; SUTARNO SUTARNO; HERU SASONGKO; HASBIYAN ROSYADI; MEI RATNASARI; SAFIRA CHAIRUNISA
Biodiversitas Journal of Biological Diversity Vol. 22 No. 12 (2021)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d221258

Abstract

Abstract. Fitri SGS, Sutarno, Sasongko H, Rosyadi H, Ratnasari M, Chairunisa S. . 2021. Morphological diversity of culturable cyanobacteria from habitats in Segara Anakan, Central Java, Indonesia. Biodiversitas 22: 5617-5626. Cyanobacteria are Gram-negative bacteria that can undertake oxygenic photosynthesis. This ancient group of microorganisms is ubiquitous, occurs in freshwater, marine, cold, hot, and terrestrial habitats. Can survive on a minimum requirement of light, carbon dioxide (CO2), and water, and able to fix the atmospheric N2 are among of their unique characteristics. These have collectively offered these bio-agents as the precious bio-resource for sustainable development. A variety of cyanobacterial strains promise further advances in biotechnology, including as an alternative source of energy. Before its final use, cyanobacteria undergo several necessary bioprocesses, including strain isolation and selection. This study aims to isolate and identify culturable-cyanobacteria from several habitats in Segara Anakan, Cilacap, Indonesia. The current study is an outset step to obtain potential and suitable agents for biofuel production. Morphological identification using light microscopy showed that cyanobacteria found in samples from different habitats varied. There are 39 cyanobacterial isolates obtained from freshwater, brackish water, and rhizosphere-mangrove soil habitats. Some cyanobacteria are unicellular (Order Chroococcales, Synechococcales, Pleurocapcales), the others are filamentous cyanobacteria (Order Oscillatoriales). These cyanobacteria grow well on BG-11 media. Numerous re-streakings on fresh medium and treatments of ampicillin and nystatin as antibiotic and antifungal, respectively, were carried out to obtain pure cultures. The classification of cultured cyanobacteria has been problematic and complicated. The polyphasic approach was applied to justify the taxonomic classification of the isolates. It is a combination of different methods based on modern molecular, cytomorphological, and ecological methods.
THE HEPATOTOXICITY EFFECT POST-CHEMOTHERAPY WITH GEMCITABINE-CARBOPLATIN REGIMEN: Efek Hepatotoksisitas Pasca Kemoterapi dengan Regimen Gemcitabine-Carboplatin Annisa Diyan Meitasari; Jihan Nabila; Ulfa Afrinurfadhilah Darojati; M. Fiqry Zulpadly M H; Nindita Clourisa Amaris Susanto; Heru Sasongko; Diyah Tri Utami; Sholichah Rohmani; Anif Nur Artanti; Meta Kartika Untari; Dian Eka Ermawati
Jurnal Berkala Epidemiologi Vol. 14 No. 2 (2026): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V14I22026.193-201

Abstract

Background: One of the main therapies for cancer is chemotherapy, however the administration is often accompanied by a wide range of Adverse Drug Reactions. Gemcitabine-carboplatin is one of the chemotherapy regimens frequently used in cancer treatment. Purpose: This study aims to determine the incidence, severity, and risk factors associated with the occurrence of hepatotoxicity after gemcitabine-carboplatin use. Methods: This study uses prospective observational research methods, including medical records and in-person interviews, with laboratory data (SGPT and SGOT) as the primary outcome. The sampling technique was purposive—the severity of hepatotoxicity was classified using the CTCAE instrument. The data obtained were then analyzed using bivariate and multivariate methods. Results: The incidence of ADRs was 16.66% in SGPT, with higher rates in grades 1 (14.44%) and 3 (2.22%). While the incidence of ADRs on SGOT increased by 22.22% across severity grades: 1 (15.56%), 2 (2.22%), and 3 (4.44%). Comorbidity is a significant risk factor for ADR incidence (p-value < 0.05). Conclusion: Patients with comorbidities had 8.076 times the tendency to experience ADRs as increased SGPT and 6.729 times the tendency to experience ADRs as increased SGOT. Results: The incidence of ADRs was 16.66% in SGPT increased with severity grade 1 (14.44%) and grade 3 (2.22%). While the incidence of ADRs on SGOT increased by 22.22% with severity grade 1 (15.56%), grade 2 (2.22%), and grade 3 (4.44%). Comorbidity is one of the risk factors that has a significant value on the incidence of ADRs with a p value <0.05. Conclusion: Patients with comorbidities had 8.076 times the tendency to experience ADRs in the form of increased SGPT and 6.729 times to experience ADRs in the form of increased SGOT.
Co-Authors Aan Andri Yano Adistyara Nur Faizah Agung Budiharjo Agung Putu S.P.Kristyawan Ahmad Dwi Setyawan Andarini Siwi Mumpuni Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anis Laela Megasari Annisa Diyan Meitasari Annisa Diyan Meitasari Arinda Handiyah Sawitri Aulia Ayu Rahmawati Aulia Ayu Rahmawati Aulia Hanundita Maharani Bayu Anggoro Saputro Bayu Anggoro Saputro Delia Putri Hedianti Delia Putri Hedianti Diah Pratiwi Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami ERMAWATI, DIAN EKA Feri Setyawan Fiddin Yusfida A’la Gea Ros Alifa Gea Ros Alifa Hanif Maulana Tomera Hanum Kartikasari HASBIYAN ROSYADI Herliana Riska Ika Subekti Wulandari Jevi Ramadhan Berliani Jihan Nabila Josua Arianto Hutasoit Karimah Umar Aidid Lathyfa Asyraq Listiyana Ika Safitri Listiyana Ika Safitri Lois Elda Zai M Fiqri Zulpadly M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqry Zulpadly M H MEI RATNASARI Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Mikael Hovhanness Muhamad Reznu Firsyawardana Muhammad Fiqri Zulpadly Muhammad Fiqri Zulpadly Muhammad Fiqri Zulpadly Mahmud Mumpuni, Andarini Siwi Naswya Sausan Aqila Sausan Natasya Advaita Nindita Claurisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nining Sugihartini Novi Ria Rahmawati Nur Cahyo Fajar Trihantono Nur Indria Kusumastuti Nur Indriana Kusumastuti Nur Rohman Efendi Nur Rohman Efendi Okky Mareta Octadevi Pratiwi Hening Puspitaningtyas Pujaningsih Pebriana Putri Cahaya Situmorang Raka Sukmabayu W.S Ratih Guswinda Lestari Ratih Guswinda Lestari Renita Wahyu Nur Hidayati Renita Wahyu Nur Hidayati Rika Dwi Indasari Rindy Fidestia Anjaini Risky Diah Wulandari SAFIRA CHAIRUNISA Salistia Musta’ani Sholichah Rochmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani SITI GIA SYAUQIYAH FITRI Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sutanto Sutanto SUTARNO SUTARNO Sutarno Sutarno Tetri Widiyani Ulfa Afrinurfadhilah Darojati Ulfa Afrinurfadhilah Darojati Villian Septiana Vivin Sulistyowati Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Yavi Hanuriansyah Yeni Farida Yeni Farida Yeni Farida Yumna Zulfa Salsabila