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All Journal Jurnal Ilmu Pertanian Indonesia Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Berkala Epidemiologi Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT Journal of Tropical Biodiversity and Biotechnology Jurnal Farmasi Sains dan Komunitas International Journal of Science and Applied Science: Conference Series ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Borneo Journal Of Pharmascientech Biodiversitas Journal of Biological Diversity

Heru Sasongko

Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret

Author-ID : 845287

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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The Hypolipidemic Effect of Mountain Papaya and Bitter Melon Fruit Ethanolic Extract in Diabetic Rats Heru Sasongko; Ratih Guswinda Lestari; Rika Dwi Indasari; Risky Diah Wulandari; Salistia Musta’ani
Journal of Tropical Biodiversity and Biotechnology Vol 7, No 3 (2022): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.75349

Traditional medicine has been developed rapidly throughout the world to treat hyperlipidemia. However, the use of a single compound in hyperlipidemia treatment usually have low efficacy. Therefore, a combination of ingredients is bound to have more synergistic impact in therapy. This research aimed to examine the hypolipidemic potential of mountain papaya (MPE) and bitter melon fruit ethanolic extract (BME) in alloxan-induced rats. Forty rats divided into eight groups were used in this study. Groups are divided into normal control, negative control, positive control, as well as MPE and BME groups which divided into single doses and three combination doses. Induction of 150 mg/kg alloxan intraperitoneally were performed to generate a model of diabetes and hyperlipidemia. The treatment was carried out for four weeks of the experiment. The single and combination doses of both extracts sufficiently exhibited hypolipidemic activity (p < 0.05). The levels of lipid profiles total such as cholesterol, triacylglycerides, low-density lipoprotein, high-density lipoprotein, and very high-density lipoprotein were decreased after MPE and BME administration (p < 0.05). The combination of MPE and BME also has hypolipidemic action equivalent to simvastatin. The single and combined doses of mountain papaya, as well as bitter melon fruit ethanolic extracts, have the potential to improve the biochemical (lipid profile) modifications of alloxan-induced.

Eel Oil Attenuates Acetaminophen-Induced Acute Liver Injury Through Inhibition of Oxidative Stress in Rats Heru Sasongko; Renita Wahyu Nur Hidayati; Bayu Anggoro Saputro; Muhammad Fiqri Zulpadly Mahmud; Yeni Farida
Majalah Obat Tradisional Vol 28, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.81943

Health practitioners all over the world have studied liver injury caused by drug side effects. Excessive production of free radicals causes cell damage, which has implications for pathological conditions in both humans and animals. Omega-3 fatty acids are a component of fish that can work as hepatoprotective agents. Eel (Anguilla bicolor) is known to contain omega-3 including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This study aimed to evaluate the hepatoprotective activity of eel oil on rats via inhibiting oxidative stress. Methods: Acetaminophen-induced male Wistar rats were used as liver injury experimental models. Rats were divided into 5 groups, namely normal control, negative control, positive control (silymarin, 100 mg/kg), and two groups of eel oil dose (2000 mg/kg and 4000 mg/kg). The study was conducted for 14 days. The levels of serum glutamic pyruvic transaminase (SGPT), serum glutamic pyruvic transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, albumin, Malondialdehyde (MDA), and glutathione (GSH) levels of the liver organ were measured. The data were analyzed using statistics and analysis of variance. Results: The study showed that eel fish oil can reduce SGPT and total bilirubin levels of male Wistar rats induced by acetaminophen. Eel oil at a dose of 4000 mg/kg could significantly reduce SGPT and liver bilirubin levels in male Wistar rats (p<0.05). Eel oil is effective in reducing malondialdehyde (MDA) levels and increasing glutathione (GSH) levels at a dose of 2000 mg/kg. Conclusion: Eel oil has hepatoprotective activity by inhibiting SGPT, total bilirubin, MDA, and increasing GSH levels in rats.

Medication Adherence among Acute Coronary Syndrome Outpatients at Sardjito Hospital in 2019 M Fiqri Zulpadly; Dian Eka Ermawati; Heru Sasongko
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.17807

Worldwide, heart disease accounts for the majority of deaths. One of the indications of coronary illness is Acute Coronary Syndrom (ACS) STEMI. With a prevalence rate of 7.2%, Indonesia still has the highest ACS incidence, and it continues to rise annually. Several factors are involved in reducing the mortality rate of ACS, namely by controlling several risk factors that can reduce the incidence and improve treatment. This study aims to determine the level of adherence to drug use in patients who are registered with new STEMI and outpatients at Sardjito Hospital Yogyakarta. The research method used in this study was non-experimental analytic observational with a retrospective cohort design. Measurement using the Medication Possession Ratio (MPR) method. The study population was patients who were registered for the first ACS diagnosis since January 2017 and followed the course of their treatment until the patient stopped using the drug or the end of observation (31 December 2018). The number of samples obtained according to the inclusion criteria was 495 patients. Adherence to the use of antithrombotic drugs was greater in female patients (82.4%), age < 60 years (88.4%), and patients using combination antithrombotic therapy regimens (81.4%). Statistical significance was shown in the category of gender (Log Rank = 0.046) and treatment regimen (Log Rank = 0.005). However, the age category did not show statistical significance (Log Rank = 0.289). The conclusion of this study is that adherence to the use of antithrombotic drugs in STEMI patients is influenced by gender and therapeutic regimen.

HPLC Analysis with Evaluation of Antioxidant and Antisenescence Activities of Parijoto (Medinilla speciosa Reinw. ex Bl.) Methanolic Extract in Vero Cells Anif Nur Artanti; Sholichah Rohmani; Diyah Tri Utami; Nindita Clourisa Amaris Susanto; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Ulfa Afrinurfadhilah Darojati; Meta Kartika Untari; Heru Sasongko; Dian Eka Ermawati; Feri Setyawan
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp44-56

Parijoto (Medinilla speciosa Reinw. ex Bl.) is a traditional medicinal plant rich in polyphenolic compounds that are associated with antioxidant and cytoprotective activities. The present study aims to investigate the phytochemical profile, antioxidant capacity, cytotoxicity, and anti-senescence effects of parijoto methanolic extract. The methanolic extract of parijoto (MEP) was subjected to qualitative thin-layer chromatography (TLC) for the detection of flavonoids, quantitative high-performance liquid chromatography (HPLC) for the determination of quercetin and naringin, and antioxidant activity assessment using the DPPH method. The mobile phase for quercetin analysis was water: acetonitrile (45:55), while for naringin, it was acetonitrile:water: formic acid (21:78.8:0.2). Cytotoxicity was evaluated in Vero cells using the MTT assay, while senescence in normal kidney cells was assessed by senescence-associated β-galactosidase (SA-β-gal) staining. Results showed that the extract contained quercetin (5.76±0.11 ppm). The extract exhibited strong antioxidant activity with an IC₅₀ value of 40.46 ppm. Cytotoxicity testing of MEP on Vero cells revealed low toxicity (529±0.77 μM) at physiologically relevant concentrations, supporting its safety for normal kidney cells. Moreover, in normal kidney cells, the extract conferred cytoprotective effects by reducing oxidative stress–induced damage and attenuating senescence-associated β-galactosidase. Collectively, these findings suggest that MEP exhibits potent antioxidant, cytoprotective, and anti-senescence activity in vitro, warranting further in vivo studies to validate its potential effects on kidney health and age-related cellular damage.

Antibiofilm Activity of Ethanolic Extract of Zingiber officinale against Aggregatibacter actinomycetemcomitans ATCC 43718 (serotype B) Putri Cahaya Situmorang; Dian Eka Ermawati; Nindita Clourisa Amaris Susanto; Diyah Tri Utami; Heru Sasongko; Sholichah Rohmani; M Fiqri Zulpadly; Anif Nur Artanti; Ulfa Afrinurfadhilah Darojati; Annisa Diyan Meitasari; Meta Kartika Untari
Jurnal Ilmu Pertanian Indonesia Vol. 31 No. 3 (2026): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.31.3.435

Red ginger plays a role in bacterial infection, diarrhea, and cough. Therefore, this study aims to evaluate the ethanolic extract of Zingiber officinale for its antibiofilm activity against Aggregatibacter actinomycetemcomitans ATCC 43718 (serotype B). The extraction process of Zingiber officinale is carried out by maceration. An antibiofilm activity assay was used with the dilution method with the various formulas of 20;10;5;2,5;1,25 % w/v. The biofilm inhibition concentration (MBIC50) was calculated. The SEM analysis was conducted to evaluate biofilm bacterial growth after the treatment. The data was then analyzed with IBM SPSS Statistics version 21.0 using one-way ANOVA (Analysis of Variance). The results showed that the ethanolic extract of Zingiber officinale had an inhibitory effect on A. actinomycetemcomitans ATCC 43718 (serotype B). This proved that the biofilm bacterial growth was effectively inhibited by the chemical compound of red ginger. The extracellular polymeric substance (EPS) matrix degraded after treating the cell biofilm. It can be concluded that the ethanolic extract of Zingiber officinale has potential against A. actinomycetemcomitans. Further research is needed to determine the safety and efficacy of A. actinomycetemcomitans ATCC 43718 (serotype B) can be developed as an alternative antibiofilm

In-vivo Antipyretic Effect of Eel (Anguilla bicolor bicolor) Oil on Yeast-induced Fever on Mice Heru Sasongko; Aulia Ayu Rahmawati; Yeni Farida; Sugiyarto Sugiyarto
ALCHEMY Jurnal Penelitian Kimia Vol 15, No 2 (2019): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Fish oil has been studied for medicinal purposes, including its antipyretic properties. Eel (Anguilla bicolor bicolor) oil, which contains vitamins and fatty acids, including Omega-3 (EPA and DHA), is also expected to have the antipyretic effect. This research aimed to examine the antipyretic activity of eel oil on white mice (Mus musculus L.). An in-vivo study was done on thirty Swiss-Webster strain males mice that previously got 20% yeast-induced fever. Six treatments were applied including normal group (untreated), a negative control group (yeast-treated), a positive control group treated with acetaminophen (1.764 mg/20 g body weight), and three groups treated with eel oil (0.048, 0.096 and 0.192 g/20 g body weight, respectively). The data was analyzed statistically using one way ANOVA then was continued with LSD post hoc test. The results showed that eel oil has significantly reduced yeast-induced hyperthermia on mice five hours after application at doses 0.096 and 0.192 g/20 g body weight. Our finding suggests that eel oil possess antipyretic properties when was applied in certain doses, and this effect is presumably attributed to its high content of fatty acid, including EPA and DHA.

The Effect of Co-Processed Excipient and Mannitol on Physical Properties and Release Test of Flavonoid Total of Bajakah Root (Spatholobus littoralis Hassk.) Water Extract in Effervescent Granule Dian Eka Ermawati; Nur Cahyo Fajar Trihantono; Ulfa Afrinurfadhilah Darojati; Nindita Claurisa Amaris Susanto; Sholichah Rohmani; M. Fiqri Zulpadly; Annisa Diyan Meitasari; Diyah Tri Utami; Anif Nur Artanti; Heru Sasongko; Meta Kartika Untari
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.94157.148-156

Bajakah root is traditionally used in herbal medicine and exhibits notable antioxidant activity (IC₅₀ = 0.155 mg/mL) with a total flavonoid content of 32.49 ppm. However, conventional consumption by boiling is limited by poor taste, odor, and low stability. To overcome these limitations, this study developed effervescent granules to enhance acceptability and absorption. The effect of combining co-processed excipients (lactose–manihot starch in a ratio of 64.32:35.68) with mannitol on granule characteristics and flavonoid release was investigated. Bajakah root extract was prepared by hot water infusion (90 °C, 15 min; ratios 1:10 and 1:20) followed by freeze-drying. Phytochemical contents were analyzed using UV–Vis spectrophotometry. Co-processed excipients were prepared via wet granulation and characterized by SEM. Formulations with co-processed excipient–mannitol ratios of 3:1, 2:2, and 1:3 were evaluated for physicochemical properties and flavonoid release. Results showed total flavonoid and tannin contents in the extract of 2.19% and 9.04%, respectively. Excipient ratios significantly affected flow rate, angle of repose, moisture content, and disintegration time (p < 0.05), but not pH. All formulations met pharmacopoeial requirements for ≥80% flavonoid release within 60 min. The optimal formulation (1:3) demonstrated excellent properties, supporting its potential as an effective herbal delivery system.

Hematology Toxicities in Paclitaxel-Carboplatin Cancer Regiment Annisa Diyan Meitasari; Dian Eka Ermawati; Sholichah Rohmani; Heru Sasongko; Muhammad Fiqri Zulpadly; Diyah Tri Utami; Nindita Clourisa Amaris Susanto; Meta Kartika Untari; Ulfa Afrinurfadhilah Darojati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007064

Chemotherapy is one of therapy for patients with cancer. Treatment carboplatin paclitaxel regimen is usually use for cervix, breast, and ovarium cancer. But the data of ADRs in hematology toxicity caused paclitaxel-carboplatin regiment is minimal, so it is required to do research. The aim of this research is can give information about the hematology toxicity, incident, severity, relationship between risk factor due incident of myelosuppression, and relationship between pre post chemotherapy due the myelosuppression. The severity ADRs use CTCAE 5.0. The ADRs were evaluated by severity, descriptive statistics, and some bivariate analysis. Anemia (66.46%) has a highest incident and followed by leukopenia (18.18%), neutropenia (13.22%), and thrombocytopenia (9.09%). Type of cancer associate with incident of anemia, leukopenia, and thrombocytopenia. The number of cycle chemotherapy use carboplatin paclitaxel regiments affects significant with the incidence of anemia. Patients who use paclitaxel-carboplatin as a regimen chemotherapy confirmed decrease in hematologic data such as hemoglobin, leukocyte, and thrombocyte.

Hepatoprotective Effects of Milkfish (Chanos chanos) Oil and Silymarin Against Isoniazid–Rifampicin-Induced Liver Injury in Rats Heru Sasongko; Mikael Hovhanness; Arinda Handiyah Sawitri; Aulia Hanundita Maharani; Delia Putri Hedianti; Josua Arianto Hutasoit; Lathyfa Asyraq; Listiyana Ika Safitri; Lois Elda Zai; Sutarno Sutarno
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101531

The objectives of the present research were to assess the hepatoprotective activities of milkfish oil (MFO) and silymarin (SL) against rifampicin (RFP) and isoniazid (INH) induced hepatotoxicity. Rats were divided into seven groups: normal control, negative control (INH+RFP), silymarin alone (50 mg/kg BW/day), low-dose MFO (MFO-L), high-dose MFO (MFO-H), low-dose combination (SL+MFO-L), and high-dose combination (SL+MFO-H). Rats receiving RFP and INH showed raised liver enzymes and typical signs of hepatotoxicity. Analyzed parameters comprised proinflammatory mediators (tumor necrosis factor-alpha and interleukin-6), antioxidant markers (catalase, glutathione, malondialdehyde, and superoxide dismutase), cytochrome P450, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin. Treatment with a combination of MFO plus SL remarkably decreased hepatic enzyme activities, oxidative stress and inflammation, and suggested a prevention effect against the drug-induce liver injury.

Anti-hypercholesterolemia effects and quality of eel (Anguilla bicolor) oil Heru Sasongko; Sugiyarto Sugiyarto; Agung Budiharjo; Nur Rohman Efendi
International Journal of Science and Applied Science: Conference Series Vol 2, No 1 (2018): International Journal of Science and Applied Science: Conference Series
Publisher : Universitas Sebelas Maret

Eel (Anguilla bicolor) is a general fish consumption in many countries. Besides its vitamin rich, eel oil is also known to contain fatty acids like oleic acid and palmitic acid. That is necessary for traditional medicine and as food a supplement. It is known that polyunsaturated fatty acids are recognized to lower blood cholesterol. In this study, fresh eels were extracted using reflux methods. The study was conducted on rat test animals given high-fat diet and PTU (Propylthiouracil). Treatment was given eel fish oil with dose 0.5 ml / kg BW; 1 ml / KgBW and 2 ml / KgBW. The results of eel extraction showed that the metal content is undetectable except Zn metal 11.72 ppm. Eel fish oil affects the total cholesterol decrease at each dose (h <0.05). Known percent increase in total cholesterol after 14 days at a dose of 0.5 ml / kg body weight (-14.10%); 1 ml / kg BW (2.12%) and 2 ml / kg BW (11.37%).

Co-Authors Aan Andri Yano Adistyara Nur Faizah Agung Budiharjo Agung Putu S.P.Kristyawan Ahmad Dwi Setyawan Andarini Siwi Mumpuni Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anis Laela Megasari Annisa Diyan Meitasari Annisa Diyan Meitasari Arinda Handiyah Sawitri Aulia Ayu Rahmawati Aulia Ayu Rahmawati Aulia Hanundita Maharani Bayu Anggoro Saputro Bayu Anggoro Saputro Delia Putri Hedianti Delia Putri Hedianti Diah Pratiwi Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Dian Eka Ermawati Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami Diyah Tri Utami ERMAWATI, DIAN EKA Feri Setyawan Fiddin Yusfida A’la Gea Ros Alifa Gea Ros Alifa Hanif Maulana Tomera Hanum Kartikasari HASBIYAN ROSYADI Herliana Riska Ika Subekti Wulandari Jevi Ramadhan Berliani Jihan Nabila Josua Arianto Hutasoit Karimah Umar Aidid Lathyfa Asyraq Listiyana Ika Safitri Listiyana Ika Safitri Lois Elda Zai M Fiqri Zulpadly M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqry Zulpadly M H MEI RATNASARI Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Mikael Hovhanness Muhamad Reznu Firsyawardana Muhammad Fiqri Zulpadly Muhammad Fiqri Zulpadly Muhammad Fiqri Zulpadly Mahmud Mumpuni, Andarini Siwi Naswya Sausan Aqila Sausan Natasya Advaita Nindita Claurisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nindita Clourisa Amaris Susanto Nining Sugihartini Novi Ria Rahmawati Nur Cahyo Fajar Trihantono Nur Indria Kusumastuti Nur Indriana Kusumastuti Nur Rohman Efendi Nur Rohman Efendi Okky Mareta Octadevi Pratiwi Hening Puspitaningtyas Pujaningsih Pebriana Putri Cahaya Situmorang Raka Sukmabayu W.S Ratih Guswinda Lestari Ratih Guswinda Lestari Renita Wahyu Nur Hidayati Renita Wahyu Nur Hidayati Rika Dwi Indasari Rindy Fidestia Anjaini Risky Diah Wulandari SAFIRA CHAIRUNISA Salistia Musta’ani Sholichah Rochmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani SITI GIA SYAUQIYAH FITRI Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sugiyarto Sutanto Sutanto SUTARNO SUTARNO Sutarno Sutarno Tetri Widiyani Ulfa Afrinurfadhilah Darojati Ulfa Afrinurfadhilah Darojati Villian Septiana Vivin Sulistyowati Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Yavi Hanuriansyah Yeni Farida Yeni Farida Yeni Farida Yumna Zulfa Salsabila

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